Research Topics
Species | Carolyn SmithSummaryAffiliation: Baylor College of Medicine Country: USA Publications
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Publications
Marinobufagenin interferes with the function of the mineralocorticoid receptorCarolyn L Smith
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Biochem Biophys Res Commun 356:930-4. 2007..Thus, the ability of MBG to cause a natriuresis may be due, not only to inhibition of Na+/K+-ATPase activity, but also to its ability to interfere with MR-dependent expression of the Na/K/H exchanger in the late distal nephron...- Identification of four novel phosphorylation sites in estrogen receptor alpha: impact on receptor-dependent gene expression and phosphorylation by protein kinase CK2Christopher C Williams
1Division of Basic Pharmaceutical Sciences, College of Pharmacy, Xavier University of Louisiana, New Orleans, LA, USA
BMC Biochem 10:36. 2009..To determine if additional ERalpha phosphorylation sites exist, COS-1 cells expressing human ERalpha were labeled with [32P]H3PO4 in vivo and ERalpha tryptic phosphopeptides were isolated to identify phosphorylation sites... - Cross-talk between peptide growth factor and estrogen receptor signaling pathwaysC L Smith
Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030 3498, USA
Biol Reprod 58:627-32. 1998..Thus, steroid receptor function may be regulated by estrogenic ligands as well as by pathway "cross-talk" from membrane receptors for growth factors... - Transcriptional regulation by steroid receptor coactivator phosphorylationRay Chang Wu
Molecular and Cellular Biology, One Baylor Plaza, Houston, Texas 77030, USA
Endocr Rev 26:393-9. 2005.... - Coregulator function: a key to understanding tissue specificity of selective receptor modulatorsCarolyn L Smith
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Endocr Rev 25:45-71. 2004..Increased understanding of the effect of cellular environment on nuclear receptors and their coregulators has the potential to open the field of SRM discovery and research to many members of the nuclear receptor superfamily... - Genetic ablation of the steroid receptor coactivator-ubiquitin ligase, E6-AP, results in tissue-selective steroid hormone resistance and defects in reproductionCarolyn L Smith
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030 3498, USA
Mol Cell Biol 22:525-35. 2002.... - Ligand-independent interactions of p160/steroid receptor coactivators and CREB-binding protein (CBP) with estrogen receptor-alpha: regulation by phosphorylation sites in the A/B region depends on other receptor domainsMartin Dutertre
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Mol Endocrinol 17:1296-314. 2003.... - Rapid estrogen-induced phosphorylation of the SRC-3 coactivator occurs in an extranuclear complex containing estrogen receptorFuzhong F Zheng
Molecular and Cellular Biology, One Baylor Plaza, Houston, TX 77030, USA
Mol Cell Biol 25:8273-84. 2005..Our results provide evidence for an early nongenomic action of ER on SRC-3 that supports the well-established downstream genomic roles of estrogen and coactivators... - Implementation of Texas Senate Bill 19 to increase physical activity in elementary schoolsSteven H Kelder
School of Public Health, University of Texas at Houston, Austin Regional Campus, Austin, TX 78701, USA
J Public Health Policy 30:S221-47. 2009..Results underscore the importance of continued monitoring of enacted legislation, and that legislation for child health that focuses on school programs and policies requires funding and refinement to produce the intended effect... - Senate Bill 42: implementation and impact on physical activity in middle schoolsCristina S Barroso
Hispanic Health Research Center, Michael and Susan Dell Center for Advancement of Healthy Living, University of Texas School of Public Health, Brownsville Regional Campus, Brownsville, Texas 78520, USA
J Adolesc Health 45:S82-90. 2009..The purpose of this study was to assess awareness of and adherence to SB42 in Texas middle schools, and to assess the impact of SB42 on the frequency and quality of structured physical activity... - Unique roles of p160 coactivators for regulation of breast cancer cell proliferation and estrogen receptor-alpha transcriptional activitySudipan Karmakar
Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Endocrinology 150:1588-96. 2009.... - SRA coactivation of estrogen receptor-alpha is phosphorylation-independent, and enhances 4-hydroxytamoxifen agonist activityKevin M Coleman
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030 3498, USA
Biochem Biophys Res Commun 323:332-8. 2004..Thus, SRA is an ERalpha AF-1-specific coactivator that enhances the agonist activity of tamoxifen-bound ERalpha and may contribute to tamoxifen resistance... - Molecular perspectives on selective estrogen receptor modulators (SERMs): progress in understanding their tissue-specific agonist and antagonist actionsDavid M Lonard
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Steroids 67:15-24. 2002..These aspects of the molecular biology of estrogen receptor action may help clarify the mechanism(s) of SERM biologic action and will be addressed in further detail in this review... - Reduction of coactivator expression by antisense oligodeoxynucleotides inhibits ERalpha transcriptional activity and MCF-7 proliferationIlaria T R Cavarretta
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030 3498, USA
Mol Endocrinol 16:253-70. 2002.... - Mechanistic differences in the activation of estrogen receptor-alpha (ER alpha)- and ER beta-dependent gene expression by cAMP signaling pathway(s)Kevin M Coleman
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030 3498, USA
J Biol Chem 278:12834-45. 2003.... - The silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) corepressor is required for full estrogen receptor alpha transcriptional activityTheresa J Peterson
Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Mol Cell Biol 27:5933-48. 2007..Taken together, these data indicate that SMRT, in conjunction with gene-specific and cell-dependent factors, is required for positively regulating agonist-dependent ERalpha transcriptional activity... - Cooperative activation of cyclin D1 and progesterone receptor gene expression by the SRC-3 coactivator and SMRT corepressorSudipan Karmakar
Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Mol Endocrinol 24:1187-202. 2010.... - Evolutionary identification of a subtype specific functional site in the ligand binding domain of steroid receptorsMichele Raviscioni
W. M. Keck Center for Computational and Structural Biology, Baylor College of Medicine, Houston Texas 77030, USA
Proteins 64:1046-57. 2006..This highlights the power of evolutionary information for the identification of new functional sites even in a protein family as well studied as NRs... - The pure estrogen receptor antagonist ICI 182,780 promotes a novel interaction of estrogen receptor-alpha with the 3',5'-cyclic adenosine monophosphate response element-binding protein-binding protein/p300 coactivatorsBasem M Jaber
Molecular and Cellular Biology, One Baylor Plaza, Houston, Texas 77030, USA
Mol Endocrinol 20:2695-710. 2006..Taken together, these data indicate that recruitment of the CBP coactivator/cointegrator without steroid receptor coactivator 1 to ERalpha is insufficient to promote transcription of ERalpha target genes... - Estradiol downregulation of the tumor suppressor gene BTG2 requires estrogen receptor-alpha and the REA corepressorSudipan Karmakar
Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Int J Cancer 124:1841-51. 2009..The ability of E2-bound ERalpha and REA to suppress BTG2 expression indicates a positive role for this corepressor in regulation of breast cancer cell proliferation... - Role of SRC-1 in the promotion of prostate cancer cell growth and tumor progressionIrina U Agoulnik
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Cancer Res 65:7959-67. 2005.... - Tensile forces attenuate estrogen-stimulated collagen synthesis in the ACLChun-Yi Lee
Department of Cell Biology, Baylor College of Medicine, Houston, TX, USA
Biochem Biophys Res Commun 317:1221-5. 2004..These findings suggest that estrogen may directly regulate ligament structure and function by alteration of Type I and III collagen synthesis. This regulation is dependent on mechanical loading... - Expression of estrogen receptors-alpha and -beta in bladder cancer cell lines and human bladder tumor tissueSteven S Shen
Department of Pathology, The Methodist Hospital and Baylor College of Medicine, Houston, Texas 77030, USA
Cancer 106:2610-6. 2006..In a previous study the selective ER modulator raloxifene was shown to induce apoptosis in an ERbeta-positive bladder cancer cell line. However, the expression of ERbeta in human bladder cancer has not been thoroughly investigated... - SKF-82958 is a subtype-selective estrogen receptor-alpha (ERalpha ) agonist that induces functional interactions between ERalpha and AP-1Marian R Walters
Department of Physiology, Tulane Medical School, New Orleans, Louisiana 70112, USA
J Biol Chem 277:1669-79. 2002.... - Synthetic 19-nortestosterone derivatives as estrogen receptor alpha subtype-selective ligands induce similar receptor conformational changes and steroid receptor coactivator recruitment than natural estrogensRocío García-Becerra
Department of Reproductive Biology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga No 15, Mexico City 14000, Mexico
J Steroid Biochem Mol Biol 99:108-14. 2006..Our data indicate that A-ring 3beta,5alpha-tetrahydro-reduced 19-nortestosterone-derived progestins behave as selective ERalpha agonists with ligand-receptor structural and functional responses similar to those induced with natural E(2)... - Identification of target genes in breast cancer cells directly regulated by the SRC-3/AIB1 coactivatorPaul Labhart
Genpathway, Inc, San Diego, CA 92121, USA
Proc Natl Acad Sci U S A 102:1339-44. 2005.... - Efficacy of selective estrogen receptor modulators in nude mice bearing human transitional cell carcinomaGuru Sonpavde
U S Oncology Research, Webster, Texas, USA
Urology 69:1221-6. 2007..To evaluate estrogen receptors as a therapeutic target for human bladder cancer... - The efficiency of protein compartmentalization into the secretory pathwayCorinna G Levine
Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Mol Biol Cell 16:279-91. 2005..These findings imply that protein compartmentalization can be modulated in a substrate-specific manner to generate biologically significant quantities of cytosolically available secretory and membrane proteins... - Syntabulin is a microtubule-associated protein implicated in syntaxin transport in neuronsQingning Su
Synaptic Function Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 35, Room 3B203, MSC 3701, 35 Convent Drive, Bethesda, MD 20892 3701, USA
Nat Cell Biol 6:941-53. 2004..These findings suggest that syntabulin functions as a linker molecule that attaches syntaxin-cargo vesicles to kinesin I, enabling the transport of syntaxin-1 to neuronal processes... - Rapid glucocorticoid receptor exchange at a promoter is coupled to transcription and regulated by chaperones and proteasomesDiana A Stavreva
Laboratory of Receptor Biology and Gene Expression, Center for Cancer Research, National Cancer Institute Light Imaging Facility, National Institute for Neurological Disorders and Stroke, Bethesda, Maryland 20892, USA
Mol Cell Biol 24:2682-97. 2004..Moreover, our results reveal that longer GR residence times are consistently associated with greater transcriptional output, suggesting a new paradigm in which the rate of rapid exchange provides a means to tune transcriptional levels... - Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosisMariusz Karbowski
Biochemistry Section, SNB, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
J Cell Biol 159:931-8. 2002..Surprisingly, Drp1 and Mfn2, but not other proteins implicated in the regulation of mitochondrial morphology, colocalize with Bax in these foci. We suggest that Bax participates in apoptotic fragmentation of mitochondria...
Research Grants
- Estrogen Receptor-Coregulator Functional InteractionsCarolyn Smith; Fiscal Year: 2009..g. tissue selectivity) and pathophysiological scenarios (e.g. breast cancer), and ultimately provide new approaches for identification and characterization of ER-based therapeutics. ..
- Negative Regulation of Estrogen ReceptorsCarolyn Smith; Fiscal Year: 2007..abstract_text> ..
- Estrogen Receptor-Coregulator Functional InteractionsCarolyn Smith; Fiscal Year: 2005..Our studies will therefore provide mechanistic information on 4HT's ability to modulate ERalpha activity in a gene or cell specific manner. ..
- ESTROGEN RECEPTOR COACTIVATOR FUNCTIONAL INTERACTIONSCarolyn Smith; Fiscal Year: 2001..It is anticipated that these studies will further our understanding of the regulation of ER action and provide insight that may allow ER-coactivator interactions to be exploited in the development of new strategies to block ER action. ..
- Estrogen Receptor-Coregulator Functional InteractionsCarolyn L Smith; Fiscal Year: 2010..g. tissue selectivity) and pathophysiological scenarios (e.g. breast cancer), and ultimately provide new approaches for identification and characterization of ER-based therapeutics. ..