Research Topics
Species | Steven S ShenSummaryAffiliation: Baylor College of Medicine Country: USA Publications
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Recently described and emphasized entities of renal neoplasmsSteven S Shen
Department of Pathology, The Methodist Hospital, 6565 Fannin St, Houston, TX 77030, USA
Arch Pathol Lab Med 131:1234-43. 2007..In addition, rare nonepithelial renal neoplasms are identified and characterized. Familiarity with these entities will help make the most accurate diagnosis and guide the treatment and follow-up of patients with renal neoplasm...- Prostatic transitional cell carcinoma: pathologic features and clinical managementSteven S Shen
Department of Pathology, The Methodist Hospital and Weill Medical College of Cornell University, 6565 Fannin Street, Houston, TX 77030, USA
Expert Rev Anticancer Ther 7:1155-62. 2007..A rational approach for management of pTCC in patients with bladder cancer will be proposed on the basis of our experience and our review of literature... - Mucinous tubular and spindle cell carcinoma of kidney is probably a variant of papillary renal cell carcinoma with spindle cell featuresSteven S Shen
Department of Pathology, The Methodist Hospital and Research Institute, Houston, TX 77030, USA
Ann Diagn Pathol 11:13-21. 2007.... - Prostatic involvement by transitional cell carcinoma in patients with bladder cancer and its prognostic significanceSteven S Shen
Department of Pathology, The Methodist Hospital, Houston, TX 77030, USA
Hum Pathol 37:726-34. 2006..In summary, presence of prostatic TCC involvement and levels of involvement are significant prognostic factors in patients with bladder cancer... - Kidney-specific cadherin, a specific marker for the distal portion of the nephron and related renal neoplasmsSteven S Shen
Department of Pathology, The Methodist Hospital, Baylor College of Medicine, Houston, TX 77030, USA
Mod Pathol 18:933-40. 2005..These results demonstrated high sensitivity and specificity of Ksp-cadherin for distal convoluted tubules, which can be used as adjunct for diagnosis of chromophobe RCC... - Synchronous renal and adrenal masses: an analysis of 80 casesArmita Bahrami
Baylor College of Medicine, Houston, TX, USA
Ann Diagn Pathol 13:9-15. 2009..Rare unusual combinations of renal and adrenal lesions such as RCC and adrenal histoplasmosis, RCC and adrenal myelolipoma, renal oncocytoma, and adrenal pheochromocytoma are also described... - PAX-2 expression in non-neoplastic, primary neoplastic, and metastatic neoplastic tissue: A comprehensive immunohistochemical studyQihui Jim Zhai
Departments of Pathology, The Methodist Hospital, Houston, TX 77030, USA
Appl Immunohistochem Mol Morphol 18:323-32. 2010..PAX-2 is a sensitive and specific marker for tumors of renal or Müllerian origin in both primary and metastatic contexts... - PAX-2 is a helpful marker for diagnosing metastatic renal cell carcinoma: comparison with the renal cell carcinoma marker antigen and kidney-specific cadherinAyhan Ozcan
Department of Pathology, The Methodist Hospital, Houston, TX 77030, USA
Arch Pathol Lab Med 134:1121-9. 2010..The diagnosis of metastatic renal cell carcinoma (RCC) remains problematic... - Reappraisal of T3N0/NxM0 renal cell carcinoma: significance of extent of fat invasion, renal vein invasion, and adrenal invasionSoo Jin Jung
Department of Pathology, The Methodist Hospital and Research Institute, and Weill Medical College of Cornell University, Houston, TX 77030, USA
Hum Pathol 39:1689-94. 2008..In contrast, tumors with adrenal gland invasion carry a far worse prognosis than perinephric fat or renal vein invasion and thus supporting a separate stage category... - Virtual-karyotyping with SNP microarrays in morphologically challenging renal cell neoplasms: a practical and useful diagnostic modalityHyun Jung Kim
The Methodist Hospital Research Institute, Houston, TX, USA
Am J Surg Pathol 33:1276-86. 2009..We consider that this technique is a feasible and practical approach for resolving difficult-to-diagnose renal tumors in clinical practice... - Muscularis mucosae versus muscularis propria in gallbladder, cystic duct, and common bile duct: smoothelin and desmin immunohistochemical studyKirtee Raparia
Department of Pathology, The Methodist Hospital, Weill Medical College, Cornell University, Houston, TX 77030, USA
Ann Diagn Pathol 14:408-12. 2010..Differentiating these anatomical muscle structures may be important for the pathologic staging of carcinoma in these organs... - PAX 8 expression in non-neoplastic tissues, primary tumors, and metastatic tumors: a comprehensive immunohistochemical studyAyhan Ozcan
Departments of Pathology, The Methodist Hospital, Houston, TX 77030, USA
Mod Pathol 24:751-64. 2011..This tissue/cell-specific expression is maintained during both neoplastic transformation and metastasis. PAX 8 is a sensitive and specific marker for tumors of renal, Müllerian, or thyroid origin in both primary and metastatic sites... - Galectin-3 expression is associated with tumor progression and pattern of sun exposure in melanomaVictor G Prieto
Department of Pathology, The University of Texas M D Anderson Cancer Center, The Methodist Hospital, Houston 77030, USA
Clin Cancer Res 12:6709-15. 2006.... - Lymphovascular invasion in micropapillary urothelial carcinoma: a study of 22 casesElizabeth McQuitty
Department of Pathology and Genomic Medicine, The Methodist Hospital, 6565 Fannin Street, Houston, TX 77030, USA
Arch Pathol Lab Med 136:635-9. 2012..Micropapillary urothelial carcinoma (MPUC) is a known aggressive variant of urothelial carcinoma. However, the reasons for its aggressiveness remain unclear... - Plasmacytoid transitional cell carcinoma of urinary bladder: a clinicopathologic study of 9 casesJae Y Ro
Department of Pathology, The Methodist Hospital and Weill Medical College of Cornell University, Houston, TX 77030, USA
Am J Surg Pathol 32:752-7. 2008..Morphologic recognition and distinction from other plasmacytoid malignant neoplasms is critical for its clinical management and immunohistochemical studies may be required for differential diagnosis... - Expression of Galectin-3 in renal neoplasms: a diagnostic, possible prognostic markerJane Y Dancer
Department of Pathology, The Methodist Hospital and Research Institute and Weill Medical College of Cornell University, Houston, Texas, USA
Arch Pathol Lab Med 134:90-4. 2010..Galectin-3, a member of the lectin family, was shown to be expressed in normal distal tubular cells and in renal cell carcinomas (RCC). However, its diagnostic and prognostic significance in RCC is as yet undefined... - Diagnosing nonneoplastic lesions in nephrectomy specimensLuan D Truong
Department of Pathology, The Methodist Hospital and Research Institute, 6565 Fannin Street, Houston, TX 77030, USA
Arch Pathol Lab Med 133:189-200. 2009.... - Mixed epithelial and stromal tumor of kidney with malignant transformation: report of two cases and review of literatureSoo Jin Jung
Department of Pathology, Weill Medical College of Cornell University, The Methodist Hospital, Houston, TX 77030, USA
Hum Pathol 39:463-8. 2008..We report 2 additional cases of sarcomatous transformation in mixed epithelial and stromal tumor of the kidney... - Mixed epithelial and stromal tumors of the kidney: evidence for a single cell of origin with capacity for epithelial and stromal differentiationJennifer Bup Jong Kum
Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Am J Surg Pathol 35:1114-22. 2011..Our data support the theory that the stroma and epithelium arise from a common cell of origin... - Number of lymph nodes examined and associated clinicopathologic factors in colorectal carcinomaSteven S Shen
Department of Pathology, The Methodist Hospital and Research Institute, Weill Medical College of Cornell University, Houston, Texas 77030, USA
Arch Pathol Lab Med 133:781-6. 2009..The number of lymph nodes recovered and examined in resection specimens has been recently shown to be critical for proper staging and is associated with survival... - Sunitinib malate is active against human urothelial carcinoma and enhances the activity of cisplatin in a preclinical modelGuru Sonpavde
Texas Oncology, P A and U S Oncology Research, Houston, TX 77030, USA
Urol Oncol 27:391-9. 2009..Angiogenesis and VEGF expression correlate with poor outcomes in human urothelial carcinoma. We designed a preclinical study to examine the efficacy of sunitinib alone and in combination with cisplatin against human urothelial carcinoma... - Diagnostic utility of antibody to smoothelin in the distinction of muscularis propria from muscularis mucosae of the urinary bladder: a potential ancillary tool in the pathologic staging of invasive urothelial carcinomaGladell P Paner
Department of Pathology, Urology, Loyola University Medical Center, Maywood, IL, USA
Am J Surg Pathol 33:91-8. 2009.... - Calcium oxalate deposition in renal cell carcinoma associated with acquired cystic kidney disease: a comprehensive studyNorbert Sule
Department of Pathology, Renal Section, Baylor College of Medicine, Houston, TX, USA
Am J Surg Pathol 29:443-51. 2005..Proximal tubular cell differentiation in conjunction with ESRD-mediated high serum level may be pathogenetically important for intratumoral CaOx deposition. These RCCs seems to have a relatively good prognosis... - Lymphoid cell proliferation in renal transplants: biologic and diagnostic implicationsHulya Akgun
Department of Pathology, The Methodist Hospital, Houston, TX, USA
Clin Transplant 21:472-80. 2007..Proliferation of IIC involves predominantly T lymphocytes. These observations provide support for the concept of in situ alloimmunization, and facilitate the diagnosis of ACR... - Small cell carcinoma of the kidney: a clinicopathologic study of 14 casesQiusheng Si
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Hum Pathol 42:1792-8. 2011..The frequent coexistence of small cell carcinoma with urothelial carcinoma suggests that renal small cell carcinomas may evolve from a preexisting urothelial carcinoma... - Intraluminal polypoid metastasis of renal cell carcinoma in gallbladder mimicking gallbladder polypXueping Fang
Department of Pathology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Arch Pathol Lab Med 134:1003-9. 2010..Metastatic renal cell carcinoma (RCC) in gallbladder is rare with only 18 cases published in the English literature... - Expression of GLUT1 in primary renal tumors: morphologic and biologic implicationsAyhan Ozcan
Department of Pathology, Methodist Hospital, Houston, TX 77030, USA
Am J Clin Pathol 128:245-54. 2007..GLUT1 may be a novel target for immunotherapy and a useful marker in the differential diagnosis and classification of renal tumors... - Role of immunohistochemistry in diagnosing renal neoplasms: when is it really useful?Steven S Shen
Department of Pathology and Genomic Medicine, The Methodist Hospital, Houston, Texas 77030, USA
Arch Pathol Lab Med 136:410-7. 2012..The number of useful markers in our routine practice continues to increase. The challenge will be to choose among them and to decide in which situations immunohistochemistry will be truly useful... - Immunohistochemical analysis in a morphologic spectrum of urachal epithelial neoplasms: diagnostic implications and pitfallsGladell P Paner
Department of Pathology, University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
Am J Surg Pathol 35:787-98. 2011..Knowledge of the similarity in immunostaining to its different morphologic mimics may help avoid misdiagnosis in urachal adenocarcinoma... - Immunohistochemical diagnosis of renal neoplasmsLuan D Truong
Department of Pathology, The Methodist Hospital, 6565 Fannin St, Houston, TX 77030, USA
Arch Pathol Lab Med 135:92-109. 2011.... - Interobserver reproducibility in the diagnosis of invasive micropapillary carcinoma of the urinary tract among urologic pathologistsAnkur R Sangoi
Department of Pathology, Stanford University, Stanford, CA, USA
Am J Surg Pathol 34:1367-76. 2010..These findings suggest that more study of IMPC is needed to identify the individual pathologic features that might potentially correlate with an aggressive outcome and response to intravesical therapy... - Muscularis mucosae of the urinary bladder revisited with emphasis on its hyperplastic patterns: a study of a large series of cystectomy specimensFunda Vakar Lopez
Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Ann Diagn Pathol 11:395-401. 2007..Pathologists should be aware of its occurrence and morphologic patterns to accurately assess the depth of invasion of bladder tumors and avoid misinterpreting HMM as the muscularis propria... - Colorectal adenocarcinoma with micropapillary pattern and its association with lymph node metastasisBisong Haupt
Department of Pathology, The Methodist Hospital, Houston, TX 77030, USA
Mod Pathol 20:729-33. 2007..311). Multivariate regression analysis demonstrated that the presence of micropapillary component, as well as tumor stage and lymphovascular invasion are independent predictors of regional nodal metastasis... - Use of frozen section in genitourinary pathologySteven S Shen
Department of Pathology and Genomic Medicine, The Methodist Hospital, Houston, Texas 77030, USA
Pathology 44:427-33. 2012.... - Optical coherence tomography as an adjunct to white light cystoscopy for intravesical real-time imaging and staging of bladder cancerAlvin C Goh
Scott Department of Urology, Baylor College of Medicine, Houston, Texas 77030 2706, USA
Urology 72:133-7. 2008..The purpose of this study was to examine the application of OCT in augmenting the diagnosis and staging of bladder lesions... 
Useful immunohistochemical markers in differentiating hemangioblastoma versus metastatic renal cell carcinomaAndreana L Rivera
Department of Pathology, Ohio State University Medical Center, Columbus, Ohio, USA
Neuropathology 30:580-5. 2010..Fli-1 failed to stain tumor cells in both HBs and RCC. Inhibin A, in combination with PAX-2, showed to be the most useful markers to differentiate HB from metastatic RCC...- Napsin A, a new marker for lung adenocarcinoma, is complementary and more sensitive and specific than thyroid transcription factor 1 in the differential diagnosis of primary pulmonary carcinoma: evaluation of 1674 cases by tissue microarrayBradley M Turner
Department of Pathology, University of Texas Health Science Center, San Antonio, USA
Arch Pathol Lab Med 136:163-71. 2012..TTF-1 is a favored marker for lung ACA but has limited sensitivity and specificity. Napsin A (Nap-A) is a functional aspartic proteinase that may be an alternative marker for primary lung ACA... - Renal cystic neoplasms and renal neoplasms associated with cystic renal diseases: pathogenetic and molecular linksLuan D Truong
Departments of Pathology, Baylor College of Medicine, The Methodist Hospital, Houston, Texas 77030, U S A
Adv Anat Pathol 10:135-59. 2003..This article reviews the differential diagnoses among cystic neoplasms. It also focuses on the underlying genetic and molecular mechanisms for the relationship between cystic renal diseases and renal neoplasms... - Expression of estrogen receptors-alpha and -beta in bladder cancer cell lines and human bladder tumor tissueSteven S Shen
Department of Pathology, The Methodist Hospital and Baylor College of Medicine, Houston, Texas 77030, USA
Cancer 106:2610-6. 2006..In a previous study the selective ER modulator raloxifene was shown to induce apoptosis in an ERbeta-positive bladder cancer cell line. However, the expression of ERbeta in human bladder cancer has not been thoroughly investigated... - Intraoperative pathology consultation for kidney and urinary bladder specimensLuan D Truong
Department of Pathology, The Methodist Hospital, Baylor College of Medicine, Houston, Texas, USA
Arch Pathol Lab Med 129:1585-601. 2005..Intraoperative pathology consultation for kidney and urinary bladder specimens is relatively infrequent. Scant literature is devoted to this topic... - Granulomatous pyelitis associated with urinary obstruction: a comprehensive clinicopathologic studyGulfiliz Gonlusen
Department of Pathology, The Methodist Hospital, Houston, TX 77030, USA
Mod Pathol 19:1130-8. 2006..Awareness of this entity and its characteristic clinicopathologic features also helps eliminate an infectious etiology with obvious treatment and prognostic implications... - Loss of claudin-1 expression in tumor-associated vessels correlates with acquisition of metastatic phenotype in melanocytic neoplasmsMichael L Cohn
Department of Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
J Cutan Pathol 32:533-6. 2005..Cohn ML, Goncharuk VN, Diwan AH, Zhang PS, Shen SS, Prieto VG. Loss of claudin-1 expression in tumor-associated vessels correlates with acquisition of metastatic phenotype in melanocytic neoplasms... - Invasive ductal carcinoma of the breast with a microglandular adenosis patternSteven S Shen
Department of Pathology, The Methodist Hospital and Baylor College of Medicine, Houston, TX, USA
Ann Diagn Pathol 8:39-42. 2004..We report a case of a 64-year-old woman with breast carcinoma of no special type with areas having features with resemblance to microglandular adenosis. Differential diagnosis and their histologic features are discussed... - Human kidney injury molecule-1 (hKIM-1): a useful immunohistochemical marker for diagnosing renal cell carcinoma and ovarian clear cell carcinomaFan Lin
Department of Laboratory Medicine, Geisinger Medical Center, 100 N Academy Avenue, Danville, PA 17822, USA
Am J Surg Pathol 31:371-81. 2007.... - Efficacy of selective estrogen receptor modulators in nude mice bearing human transitional cell carcinomaGuru Sonpavde
U S Oncology Research, Webster, Texas, USA
Urology 69:1221-6. 2007..To evaluate estrogen receptors as a therapeutic target for human bladder cancer... 
Protein 4.1B suppresses prostate cancer progression and metastasisSunny Y Wong
Howard Hughes Medical Institute, Massachusetts Institute of Technology Center for Cancer Research, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 104:12784-9. 2007..1B as a negative regulator of cancer progression to metastatic disease...- Diagnostic value of microtubule-associated protein-2 (MAP-2) for neuroendocrine neoplasmsYulin Liu
Department of Pathalogy and Laboratory Medicine, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
Adv Anat Pathol 10:101-6. 2003..This report details the diagnostic value of MAP-2 on tumors with neuroendocrine differentiation and neoplasms derived from the neural crest...