Eva M Sevick-Muraca

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. pmc Molecular imaging with optics: primer and case for near-infrared fluorescence techniques in personalized medicine
    Eva M Sevick-Muraca
    Baylor College of Medicine, Department of Radiology, Division of Molecular Imaging, Houston, Texas 77030, USA
    J Biomed Opt 13:041303. 2008
  2. ncbi request reprint Quantitative imaging of lymph function
    Ruchi Sharma
    Division of Molecular Imaging, Department of Radiology, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Physiol Heart Circ Physiol 292:H3109-18. 2007
  3. doi request reprint Tumor margin detection using quantitative NIRF molecular imaging targeting EpCAM validated by far red gene reporter iRFP
    Banghe Zhu
    Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, 1825 Pressler Street, Houston, TX, 77030, USA
    Mol Imaging Biol 15:560-8. 2013
  4. pmc In vivo imaging of orthotopic prostate cancer with far-red gene reporter fluorescence tomography and in vivo and ex vivo validation
    Yujie Lu
    University of Texas Health Science Center at Houston, The Brown Foundation Institute of Molecular Medicine, Center for Molecular Imaging, 1825Pressler Street SRB 330, Houston, Texas 77030, USA
    J Biomed Opt 18:101305. 2013
  5. ncbi request reprint Comparison of mAbs targeting epithelial cell adhesion molecule for the detection of prostate cancer lymph node metastases with multimodal contrast agents: quantitative small-animal PET/CT and NIRF
    Mary A Hall
    Center for Molecular Imaging, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, Houston, Texas 77030, USA
    J Nucl Med 53:1427-37. 2012
  6. doi request reprint Multimodal chelation platform for near-infrared fluorescence/nuclear imaging
    Sukhen C Ghosh
    Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Med Chem 56:406-16. 2013
  7. pmc Near-infrared fluorescence imaging of lymphatics in head and neck lymphedema
    Erik A Maus
    Division of Cardiology and Hyperbaric Medicine, Department of Internal Medicine at The University of Texas Health Science Center, Houston, Texas, USA
    Head Neck 34:448-53. 2012
  8. ncbi request reprint Fully adaptive FEM based fluorescence optical tomography from time-dependent measurements with area illumination and detection
    Amit Joshi
    Division of Molecular Imaging, Department of Radiology, Baylor College of Medicine, Houston, Texas 77030, USA
    Med Phys 33:1299-310. 2006
  9. pmc Near infrared fluorescent optical imaging for nodal staging
    Lakshmi Sampath
    Baylor College of Medicine, Division of Molecular Imaging, Department of Radiology, Houston, Texas 77030, USA
    J Biomed Opt 13:041312. 2008
  10. doi request reprint Quantifying multimodal contrast agent biological activity using near-infrared flow cytometry
    Mary A Hall
    Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine at The University of Texas Health Science Center, Houston, TX 77030, USA
    Contrast Media Mol Imaging 7:338-45. 2012

Research Grants

  1. FREQUENCY DOMAIN LIFETIME SPECTROSCOPY AND IMAGING
    Eva Sevick Muraca; Fiscal Year: 2003
  2. Small animal fluorescence enhanced optical tomography
    Eva Sevick Muraca; Fiscal Year: 2006

Collaborators

Detail Information

Publications73

  1. pmc Molecular imaging with optics: primer and case for near-infrared fluorescence techniques in personalized medicine
    Eva M Sevick-Muraca
    Baylor College of Medicine, Department of Radiology, Division of Molecular Imaging, Houston, Texas 77030, USA
    J Biomed Opt 13:041303. 2008
    ..Finally, we comment on the challenges and progress for translating near-infrared (NIR) molecular imaging agents for personalized medicine...
  2. ncbi request reprint Quantitative imaging of lymph function
    Ruchi Sharma
    Division of Molecular Imaging, Department of Radiology, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Physiol Heart Circ Physiol 292:H3109-18. 2007
    ..Our results suggest that microgram quantities of NIR optical imaging agents and their conjugates have a potential to image lymph function in patients suffering from lymph-related disorders...
  3. doi request reprint Tumor margin detection using quantitative NIRF molecular imaging targeting EpCAM validated by far red gene reporter iRFP
    Banghe Zhu
    Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, 1825 Pressler Street, Houston, TX, 77030, USA
    Mol Imaging Biol 15:560-8. 2013
    ..We hypothesize that near-infrared fluorescence (NIRF) imaging can enable accurate detection of tumor margins for image-guided resection...
  4. pmc In vivo imaging of orthotopic prostate cancer with far-red gene reporter fluorescence tomography and in vivo and ex vivo validation
    Yujie Lu
    University of Texas Health Science Center at Houston, The Brown Foundation Institute of Molecular Medicine, Center for Molecular Imaging, 1825Pressler Street SRB 330, Houston, Texas 77030, USA
    J Biomed Opt 18:101305. 2013
    ..These results represent the first tomography of a living animal using far-red gene reporters...
  5. ncbi request reprint Comparison of mAbs targeting epithelial cell adhesion molecule for the detection of prostate cancer lymph node metastases with multimodal contrast agents: quantitative small-animal PET/CT and NIRF
    Mary A Hall
    Center for Molecular Imaging, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, Houston, Texas 77030, USA
    J Nucl Med 53:1427-37. 2012
    ..Herein, we developed and quantitatively compared dual-labeled monoclonal antibodies (mAbs) of varying affinities against EpCAM for both noninvasive and intraoperative detection of metastatic LNs in prostate cancer...
  6. doi request reprint Multimodal chelation platform for near-infrared fluorescence/nuclear imaging
    Sukhen C Ghosh
    Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Med Chem 56:406-16. 2013
    ..Further evaluation in different EpCAM-expressing cell lines is warranted as well as application of the MMC dual labeling approach with other monoclonal antibodies...
  7. pmc Near-infrared fluorescence imaging of lymphatics in head and neck lymphedema
    Erik A Maus
    Division of Cardiology and Hyperbaric Medicine, Department of Internal Medicine at The University of Texas Health Science Center, Houston, Texas, USA
    Head Neck 34:448-53. 2012
    ....
  8. ncbi request reprint Fully adaptive FEM based fluorescence optical tomography from time-dependent measurements with area illumination and detection
    Amit Joshi
    Division of Molecular Imaging, Department of Radiology, Baylor College of Medicine, Houston, Texas 77030, USA
    Med Phys 33:1299-310. 2006
    ..The results demonstrate the first clinically relevant noncontact fluorescence tomography with adaptive finite element methods...
  9. pmc Near infrared fluorescent optical imaging for nodal staging
    Lakshmi Sampath
    Baylor College of Medicine, Division of Molecular Imaging, Department of Radiology, Houston, Texas 77030, USA
    J Biomed Opt 13:041312. 2008
    ..The requirement for long clearance times from normal, cancer-negative nodes presents challenges for nuclear imaging agents with limited half-lives but does not hamper NIR optical imaging...
  10. doi request reprint Quantifying multimodal contrast agent biological activity using near-infrared flow cytometry
    Mary A Hall
    Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine at The University of Texas Health Science Center, Houston, TX 77030, USA
    Contrast Media Mol Imaging 7:338-45. 2012
    ..In summary, NIR FC is an alternative with similar specificity and sensitivity, and greater reproducibility relative to the Lindmo assay for quantifying biological activity of NIR fluorophore-labeled, multimodal imaging agents...
  11. doi request reprint Imaging prostate cancer lymph node metastases with a multimodality contrast agent
    Mary A Hall
    Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, Texas, USA
    Prostate 72:129-46. 2012
    ..Pelvic LN dissection is commonly performed during prostatectomy, but often followed by morbid complications. More refined methods for detecting LN invasion are needed...
  12. ncbi request reprint A new optical and nuclear dual-labeled imaging agent targeting interleukin 11 receptor alpha-chain
    Wei Wang
    Department of Radiology, Division of Molecular Imaging, Baylor College of Medicine, Houston, Texas 77030, USA
    Bioconjug Chem 18:397-402. 2007
    ..The cross validation and direct comparison of optical and nuclear imaging of a tumor was achieved using a single injection, and the preliminary results show the conjugate has tumor targeting capabilities in vivo...
  13. pmc Assessment of lymphatic contractile function after manual lymphatic drainage using near-infrared fluorescence imaging
    I Chih Tan
    Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, TX, USA
    Arch Phys Med Rehabil 92:756-764.e1. 2011
    ..To investigate the feasibility of assessing the efficacy of manual lymphatic drainage (MLD), a method for lymphedema (LE) management, by using near-infrared (NIR) fluorescence imaging...
  14. pmc A parallel adaptive finite element simplified spherical harmonics approximation solver for frequency domain fluorescence molecular imaging
    Yujie Lu
    Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, 1825 Pressler Street, Houston, TX 77030, USA
    Phys Med Biol 55:4625-45. 2010
    ..This solver is a promising platform for fluorescence molecular tomography using high-order approximations to the radiative transfer equation...
  15. pmc Functional lymphatic imaging in tumor-bearing mice
    Sunkuk Kwon
    Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, 1825 Pressler Street, SRB 330A, Houston, TX 77030, USA
    J Immunol Methods 360:167-72. 2010
    ..Therefore, transient changes in the regional lymphatic architecture and function that occur with progressive disease, can be imaged using NIR fluorescence, and may provide a new method to stage disease...
  16. pmc Imaging of lymph flow in breast cancer patients after microdose administration of a near-infrared fluorophore: feasibility study
    Eva M Sevick-Muraca
    Department of Radiology, Division of Molecular Imaging, Baylor College of Medicine, One Baylor Plaza, BCM 360, Houston, TX 77030, USA
    Radiology 246:734-41. 2008
    ....
  17. ncbi request reprint Monte Carlo simulation of time-dependent, transport-limited fluorescent boundary measurements in frequency domain
    Tianshu Pan
    Department of Radiology, Baylor College of Medicine, One Baylor Plaza, MS BCM 360, Houston, Texas 77030, USA
    Med Phys 34:1298-311. 2007
    ..The Monte Carlo simulations validates and guides the future development of an appropriate RTE solver for deployment in small animal optical tomography...
  18. ncbi request reprint Comparison of visible and near-infrared wavelength-excitable fluorescent dyes for molecular imaging of cancer
    Kristen E Adams
    Baylor College of Medicine, Department of Radiology, One Baylor Plaza, MS 360, Houston, Texas 77030, USA
    J Biomed Opt 12:024017. 2007
    ..5. Immunohistochemistry shows that EGF causes activation of the EGFr signaling pathway, suggesting that prior to use as a targeting, diagnostic agent, potential deleterious effects should be considered...
  19. pmc Albumin-binding domain conjugate for near-infrared fluorescence lymphatic imaging
    Cynthia A Davies-Venn
    The Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030, USA
    Mol Imaging Biol 14:301-14. 2012
    ....
  20. ncbi request reprint Plane-wave fluorescence tomography with adaptive finite elements
    Amit Joshi
    Photon Migration Laboratories, Department of Radiology, Baylor College of Medicine, Houston, Texas 77030, USA
    Opt Lett 31:193-5. 2006
    ..Tomographic images of fluorescent targets buried at 1-2 cm depths from the illumination surface demonstrate the feasibility of fluorescence tomography from reflectance tomography in clinically relevant tissue volumes...
  21. pmc Improvement of fluorescence-enhanced optical tomography with improved optical filtering and accurate model-based reconstruction algorithms
    Yujie Lu
    University of Texas Health Science Center at Houston, Center for Molecular Imaging, Institute of Molecular Medicine, 1825 Pressler Street, SRB 330A, Houston, Texas 77030, USA
    J Biomed Opt 16:126002. 2011
    ..Improvements in FEOT are demonstrated experimentally using a mouse-shaped phantom with targets of pico- and subpico-mole NIR fluorescent dye...
  22. pmc Targeting pili in enterococcal pathogenesis
    Kenneth L Pinkston
    Center for Molecular Imaging, Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center at Houston, Houston, Texas, USA
    Infect Immun 82:1540-7. 2014
    ....
  23. pmc New horizons for imaging lymphatic function
    Ruchi Sharma
    Division of Molecular Imaging, Department of Radiology, Baylor College of Medicine, One Baylor Plaza, BCM 360, Houston, TX 77030, USA
    Ann N Y Acad Sci 1131:13-36. 2008
    ....
  24. pmc Lymphatic abnormalities are associated with RASA1 gene mutations in mouse and man
    Patricia E Burrows
    Department of Diagnostic and Interventional Imaging, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 110:8621-6. 2013
    ....
  25. pmc A compact frequency-domain photon migration system for integration into commercial hybrid small animal imaging scanners for fluorescence tomography
    Chinmay D Darne
    Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, 1825 Pressler Street, Houston, TX 77030, USA
    Phys Med Biol 57:8135-52. 2012
    ..The obtained results validate the integration of time-dependent fluorescence tomography system within a commercial microPET/CT scanner for multimodality small animal imaging...
  26. pmc Human Lymphatic Architecture and Dynamic Transport Imaged Using Near-infrared Fluorescence
    John C Rasmussen
    Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine at the University of Texas Health Science Center at Houston, Houston, TX, USA
    Transl Oncol 3:362-72. 2010
    ....
  27. pmc Reduction of excitation light leakage to improve near-infrared fluorescence imaging for tissue surface and deep tissue imaging
    Banghe Zhu
    Center of Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    Med Phys 37:5961-70. 2010
    ..In this article, the authors present a systematic method for improving sensitivity and validating the NIRF optical imager currently used for clinical imaging of human lymphatic function...
  28. ncbi request reprint Fluorescence-enhanced optical tomography of a large tissue phantom using point illumination geometries
    Ranadhir Roy
    Baylor College of Medicine, Photon Migration Laboratory, Houston, Texas 77030, USA
    J Biomed Opt 11:044007. 2006
    ..Targets of 0.5, 0.6, and 1.0 cm3 at depths of 1.4-2.8 cm from the phantom surface were tomographically reconstructed. This work demonstrates the practicality of fluorescence-enhanced tomography in clinically relevant volumes...
  29. ncbi request reprint Dual-labeled trastuzumab-based imaging agent for the detection of human epidermal growth factor receptor 2 overexpression in breast cancer
    Lakshmi Sampath
    Division of Molecular Imaging, Department of Radiology, Baylor College of Medicine, Houston, TX 77030, USA
    J Nucl Med 48:1501-10. 2007
    ..The stoichiometric ratios "n" and "m" refer to the number of diethylenetriaminepentaacetic acid dianhydride (DTPA) and IRDye 800CW molecules bound per trastuzumab molecule, respectively...
  30. pmc Altered lymphatic function and architecture in salt-induced hypertension assessed by near-infrared fluorescence imaging
    Sunkuk Kwon
    University of Texas Health Science Center, Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, Houston, TX 77030, USA
    J Biomed Opt 17:080504-1. 2012
    ..Lymphatic contractile function and vessel remodeling occurs in response to salt-induced hypertension suggesting a possible role for the lymphatics in the regulation of vascular blood pressure...
  31. pmc The role of lymphatics in cancer as assessed by near-infrared fluorescence imaging
    John C Rasmussen
    Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, TX 77030, USA
    Ann Biomed Eng 40:408-21. 2012
    ..We then present recent NIRF lymphatic imaging for non-invasive assessment of lymphatics both in preclinical melanoma models and in human subjects with melanoma...
  32. doi request reprint Noninvasive quantitative imaging of lymph function in mice
    Sunkuk Kwon
    Division of Molecular Imaging, Department of Radiology, Baylor College of Medicine, Houston, TX 77030 3411, USA
    Lymphat Res Biol 5:219-31. 2007
    ..Herein, we present a noninvasive and rapid approach to measure lymphatic function in a rodent model using a near-infrared (NIR) dye to minimize background autofluorescence and maximize tissue penetration...
  33. pmc Radiative transport-based frequency-domain fluorescence tomography
    Amit Joshi
    Division of Molecular Imaging, Department of Radiology, Baylor College of Medicine, Houston, TX 77030, USA
    Phys Med Biol 53:2069-88. 2008
    ..Finally, we demonstrate fluorescence tomography on a realistic computational mouse model to locate nM to microM fluorophore concentration distributions in simulated mouse organs...
  34. pmc Direct visualization of changes of lymphatic function and drainage pathways in lymph node metastasis of B16F10 melanoma using near-infrared fluorescence imaging
    Sunkuk Kwon
    Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, TX 77030, USA
    Biomed Opt Express 4:967-77. 2013
    ..In addition, this novel technique can be used as a diagnostic method to non-invasively assess lymphatic response as mechanism of therapeutic action...
  35. pmc Dual-labeling strategies for nuclear and fluorescence molecular imaging: a review and analysis
    Ali Azhdarinia
    Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, TX 77030, USA
    Mol Imaging Biol 14:261-76. 2012
    ..We also summarized our findings on several commercially available NIRF dyes and offer perspectives for developing a toolkit to select the optimal NIRF dye and radiometal combination for multimodality imaging...
  36. doi request reprint Matrix metalloproteinase-9 is a diagnostic marker of heterotopic ossification in a murine model
    Eric Rodenberg
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030, USA
    Tissue Eng Part A 17:2487-96. 2011
    ....
  37. doi request reprint Assessment of free dye in solutions of dual-labeled antibody conjugates for in vivo molecular imaging
    Melissa B Aldrich
    Division of Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Sciences Center Houston, Houston, TX, USA
    Mol Imaging Biol 13:32-42. 2011
    ..A method for quantifying free dye molecules in antibody conjugate preparations is required for agent batch release and for translation into the clinic...
  38. pmc Single-dose intravenous toxicity study of IRDye 800CW in Sprague-Dawley rats
    Milton V Marshall
    Baylor College of Medicine, Houston, TX, USA
    Mol Imaging Biol 12:583-94. 2010
    ..Following conjugation or breakdown of a labeled ligand, excess NHS ester is converted to the carboxylate form. To prepare for clinical use as a near-infrared fluorophore, a toxicity study was conducted on IRDye 800CW carboxylate...
  39. ncbi request reprint Near-infrared optical imaging of epidermal growth factor receptor in breast cancer xenografts
    Shi Ke
    Division of Diagnostic Imaging, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 63:7870-5. 2003
    ..In MDA-MB-468 tumors, our data suggest that EGF-Cy5.5 may be used as a specific NIR contrast agent for noninvasive imaging of EGFr expression and monitoring of responses to molecularly targeted therapy...
  40. ncbi request reprint Radiative transport in fluorescence-enhanced frequency domain photon migration
    John C Rasmussen
    Department of Radiology, Baylor College of Medicine, One Baylor Plaza, MS BCM 360, Houston, Texas 77030, USA
    Med Phys 33:4685-700. 2006
    ..This work demonstrates the use of an appropriate RTE solver for deployment in small animal optical tomography...
  41. doi request reprint Detection of lymphangiogenesis by near-infrared fluorescence imaging and responses to VEGF-C during healing in a mouse full-dermis thickness wound model
    Mary A Hall
    Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas, Houston, TX 77030, USA
    Wound Repair Regen 21:604-15. 2013
    ..NIRF imaging can be utilized to detect lymphangiogenesis during wound healing, and offers a promising platform to complement current methods for monitoring wound status and studying the effects of growth factors on healing. ..
  42. doi request reprint Reconstruction of sectional images in frequency-domain based photoacoustic imaging
    Banghe Zhu
    Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    Opt Express 19:23286-97. 2011
    ..The results demonstrate that the proposed method with appropriate data post-processing is capable of recovering sectional images while suppressing the defocused noise resulting from the other sections...
  43. ncbi request reprint Near-infrared optical imaging of integrin alphavbeta3 in human tumor xenografts
    Wei Wang
    Department of Experimental Diagnostic Imaging, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Imaging 3:343-51. 2004
    ..Our data suggest that near-infrared fluorescence imaging may be applied to the detection of tumors expressing integrin alphavbeta3 and to the assessment of the optimal biological dose and schedule of targeted therapies...
  44. pmc A matter of collection and detection for intraoperative and noninvasive near-infrared fluorescence molecular imaging: To see or not to see?
    Banghe Zhu
    Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, Texas 77030
    Med Phys 41:022105. 2014
    ....
  45. pmc Lymphatic vascular response to acute inflammation
    Pier Anne Lachance
    The Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, Texas, United States of America Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 8:e76078. 2013
    ..Our results indicate that VEGF-C and VEGF-D are not the only players and other factors may be responsible for the LECs proliferation and altered lymphatic function in acute CHS. ..
  46. pmc Characterization of chemical, radiochemical and optical properties of a dual-labeled MMP-9 targeting peptide
    Ali Azhdarinia
    Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, TX 77030, USA
    Bioorg Med Chem 19:3769-76. 2011
    ..This attests to the feasibility of using (68)Ga/NIR for dual-labeling of other peptides or small molecules for multimodality molecular imaging...
  47. pmc Detection of Cancer Metastases with a Dual-labeled Near-Infrared/Positron Emission Tomography Imaging Agent
    Lakshmi Sampath
    Center for Molecular Imaging, Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX, USA
    Transl Oncol 3:307-217. 2010
    ....
  48. pmc Lymphatic imaging in humans with near-infrared fluorescence
    John C Rasmussen
    Center of Molecular Imaging, Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Curr Opin Biotechnol 20:74-82. 2009
    ....
  49. pmc Advancing the translation of optical imaging agents for clinical imaging
    Eva M Sevick-Muraca
    The University of Texas Health Science Center at Houston, Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, 1825 Pressler Street, Houston, TX 77030, USA
    Biomed Opt Express 4:160-70. 2013
    ....
  50. pmc Virus-like particle (VLP) lymphatic trafficking and immune response generation after immunization by different routes
    Rafael Cubas
    Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Frensley Center for Imaging Research, Houston, TX 77030, USA
    J Immunother 32:118-28. 2009
    ..Intradermal immunization showed improved responses and might be a preferable delivery route to use for viral and cancer immunotherapeutic studies involving VLPs...
  51. pmc Mouse phenotyping with near-infrared fluorescence lymphatic imaging
    Sunkuk Kwon
    Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX 77584, USA
    Biomed Opt Express 2:1403-11. 2011
    ..NIR fluorescence imaging provides a method for quantifying lymphatic function for future studies designed to discern differences in lymphatic function in murine models of human lymphatic disease...
  52. ncbi request reprint Determination of optical properties in semi-infinite turbid media using imaging measurements of frequency-domain photon migration obtained with an intensified charge-coupled device
    Michael Gurfinkel
    Texas A and M University, Photon Migration Laboratories, Department of Chemical Engineering, College Station, Texas 77843 3122, USA
    J Biomed Opt 9:1336-46. 2004
    ....
  53. ncbi request reprint Fluorescence-enhanced three-dimensional lifetime imaging: a phantom study
    Ranadhir Roy
    Mathematics Department University of Texas Pan American Edinburg, TX 78541, USA
    Phys Med Biol 52:4155-70. 2007
    ..1:1 in lifetimes are successfully reconstructed. Our results show that image reconstruction is possible when there is (i) a longer lifetime in a target than the background and (ii) a shorter lifetime in a target than the background...
  54. ncbi request reprint Fluorescence-enhanced, near infrared diagnostic imaging with contrast agents
    Eva M Sevick-Muraca
    The Photon Migration Laboratory, Texas A and M University, College Station 77845 3122, USA
    Curr Opin Chem Biol 6:642-50. 2002
    ....
  55. ncbi request reprint Near-infrared fluorescence contrast-enhanced imaging with intensified charge-coupled device homodyne detection: measurement precision and accuracy
    Alan B Thompson
    Texas A and M University, Department of Chemical Engineering, 337 Zachry Engineering Center, College Station, Texas 77843 3122, USA
    J Biomed Opt 8:111-20. 2003
    ..0 cm from the point source, measurements of fluorescence modulation amplitude and phase exhibit a mean accuracy of 5.4% and 0.30 deg, respectively...
  56. ncbi request reprint Near-infrared fluorescence contrast-enhanced imaging with area illumination and area detection: the forward imaging problem
    Alan B Thompson
    Photon Migration Laboratories, Texas A and M University, 3573 TAMU, College Station, Texas 77843 3573, USA
    Appl Opt 42:4125-36. 2003
    ..Results also demonstrate that target-to-background ratios of fluorescence yield and fluorescence lifetime significantly affect target detectability...
  57. ncbi request reprint Fluorescence-enhanced optical imaging in large tissue volumes using a gain-modulated ICCD camera
    Anuradha Godavarty
    Department of Chemical Engineering, Texas A and M University, College Station, TX 77843 3122, USA
    Phys Med Biol 48:1701-20. 2003
    ....
  58. ncbi request reprint Fluorescence-enhanced optical tomography using referenced measurements of heterogeneous media
    Ranadhir Roy
    The Photon Migration Laboratories, Texas A and M University, College Station, TX 77843 3573, USA
    IEEE Trans Med Imaging 22:824-36. 2003
    ..Furthermore, we demonstrate the performance of the bounding parameter for rejection of background artifacts owing to background tissue heterogeneity...
  59. pmc Near-infrared fluorescence optical imaging and tomography
    Michael Gurfinkel
    Department of Chemical Engineering, Texas A and M University, College Station, TX 77843 3122, USA
    Dis Markers 19:107-21. 2003
    ..Finally, a critical evaluation of the limitations and the opportunities for future translation of fluorescence-enhanced optical imaging of deep tissues is presented...
  60. ncbi request reprint Three-dimensional fluorescence lifetime tomography
    Anuradha Godavarty
    Department of Computer Science, University of Vermont, Burlington, Vermont 05405, USA
    Med Phys 32:992-1000. 2005
    ..1:1) contrasts at target depths of 1.4-2 cm. The Bayesian tomography algorithm was employed to obtain three-dimensional images of lifetime and absorption owing to the fluorophores...
  61. ncbi request reprint Quality analysis of in vivo near-infrared fluorescence and conventional gamma images acquired using a dual-labeled tumor-targeting probe
    Jessica P Houston
    Texas A and M University, Photon Migration Laboratory, College Station, Texas 77842 3012, USA
    J Biomed Opt 10:054010. 2005
    ....
  62. ncbi request reprint Detection of single and multiple targets in tissue phantoms with fluorescence-enhanced optical imaging: feasibility study
    Anuradha Godavarty
    Photon Migration Laboratories, Texas A and M University, PO Box 30012, College Station, TX 77842 3012, USA
    Radiology 235:148-54. 2005
    ..To evaluate the feasibility of reconstructing single and multiple targets by using fluorescence-enhanced tomography of a breast tissue phantom...
  63. ncbi request reprint Imaging dose-dependent pharmacokinetics of an RGD-fluorescent dye conjugate targeted to alpha v beta 3 receptor expressed in Kaposi's sarcoma
    Sunkuk Kwon
    Texas A and M University, TX 77842 3012, USA
    Mol Imaging 4:75-87. 2005
    ..5 nmol/mouse, the uptake no longer increased with dose, suggesting integrin receptor saturation. In normal tissues, the PK uptake parameters were not influenced by Cy5.5-c(KRGDf) dose nor by the preadministration of c(KRGDf)...
  64. ncbi request reprint Quantifying molecular specificity of alphavbeta3 integrin-targeted optical contrast agents with dynamic optical imaging
    Michael Gurfinkel
    Texas A and M University, Photon Migration Laboratories, College Station, Texas 77843 3012, USA
    J Biomed Opt 10:034019. 2005
    ..In vivo pharmacokinetic analysis based on rapid and dynamic optical imaging may be potentially useful for evaluating the presence and turnover rate of disease markers that are potential targets of molecular medicine...
  65. ncbi request reprint Improved excitation light rejection enhances small-animal fluorescent optical imaging
    Kildong Hwang
    Texas A and M University, USA
    Mol Imaging 4:194-204. 2005
    ....
  66. pmc Three-dimensional, Bayesian image reconstruction from sparse and noisy data sets: near-infrared fluorescence tomography
    Margaret J Eppstein
    Department of Computer Science, 327 Votey Building, University of Vermont, Burlington, VT 05405, USA
    Proc Natl Acad Sci U S A 99:9619-24. 2002
    ..The results demonstrate that, to employ NIR fluorescence-enhanced optical imaging for large volumes, reconstruction approaches must account for the large range of signal-to-noise ratio associated with the measurements...
  67. pmc Fluorescence lifetime spectroscopy in multiply scattering media with dyes exhibiting multiexponential decay kinetics
    Eddy Kuwana
    Department of Chemistry, Texas A and M University, College Station, Texas 77843 3122, USA
    Biophys J 83:1165-76. 2002
    ..Our results suggest the high sensitivity of phase-modulation measurements in scattering solutions may provide greater opportunities for fluorescence lifetime spectroscopy...
  68. ncbi request reprint Volume of pharmaceutical powders probed by frequency-domain photon migration measurements of multiply scattered light
    Tianshu Pan
    Department of Chemical Engineering, Texas A and M University, College Station 77843 3122, USA
    Anal Chem 74:4228-34. 2002
    ..8 and 1.5 cm3 at modulated frequencies of 50 and 100 MHz, respectively. Experimental measurements in lactose powder confirm the predictions...
  69. ncbi request reprint Fluorescence lifetime spectroscopy of a pH-sensitive dye encapsulated in hydrogel beads
    Eddy Kuwana
    The Photon Migration Laboratories, Texas A and M University, College Station, Texas 77843 3573, USA
    Biotechnol Prog 20:1561-6. 2004
    ..When extended to the immobilized fluorophore-enzymatic systems, fluorescence lifetime spectroscopy with multiply scattered light may provide a new ultrasensitive approach for analyte or toxin screening...
  70. ncbi request reprint Evaluation of ingredient concentration in powders using two-speed photon migration theory and measurements
    Tianshu Pan
    The Photon Migration Laboratories, Department of Chemistry, Texas A and M University, College Station, 77843, USA
    J Pharm Sci 95:530-41. 2006
    ....
  71. ncbi request reprint Three-dimensional fluorescence enhanced optical tomography using referenced frequency-domain photon migration measurements at emission and excitation wavelengths
    Jangwoen Lee
    School of Electrical and Computer Engineering, Purdue University, West Lafayette, Indiana 47907, USA
    J Opt Soc Am A Opt Image Sci Vis 19:759-71. 2002
    ..Finally, in light of our results, we demonstrate the method for eliminating the influence of source strength and instrument functions for effective fluorescence-enhanced optical tomography using FDPM...
  72. ncbi request reprint Validating the assumption to the interference approximation by use of measurements of absorption efficiency and hindered scattering in dense suspensions
    Yingqing Huang
    Photon Migration Laboratories, Texas A and M University, Mailstop 3573, College Station, Texas 77843 3573, USA
    Appl Opt 43:814-9. 2004
    ..Furthermore, owing to the accuracy of FDPM absorption measurements, the imaginary refractive indices for both particles and their suspending fluid were determined and were found to compare favorably with literature values...
  73. ncbi request reprint Measurements of FRET in a glucose-sensitive affinity system with frequency-domain lifetime spectroscopy
    Feng Liang
    The Photon Migration Laboratory, Department of Chemistry, Texas A and M University, College Station, USA
    Photochem Photobiol 81:1386-94. 2005
    ..09 microM dextran to labeled concanavalin A at a solution concentration of 10.67 microM in the presence of glucose at concentrations ranging from 0 to 224 mg/dL...

Research Grants2

  1. FREQUENCY DOMAIN LIFETIME SPECTROSCOPY AND IMAGING
    Eva Sevick Muraca; Fiscal Year: 2003
    ..Our work focuses on Con A/Dextran moieties for diabetic glucose sensing. ..
  2. Small animal fluorescence enhanced optical tomography
    Eva Sevick Muraca; Fiscal Year: 2006
    ..If successful, this project will provide the first validation of optical tomography in a preclinical model of metastatic cancer. ..