Research Topics
| Hiroaki SaitoSummaryAffiliation: Baylor University Medical Center Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
Cancer immunotherapy via dendritic cellsKarolina Palucka
Baylor Institute for Immunology Research, 3434 Live Oak Avenue, Dallas, Texas 75204, USA
Nat Rev Cancer 12:265-77. 2012..Thus, DCs are an essential target in efforts to generate therapeutic immunity against cancer...- A systematic approach to biomarker discovery; preamble to "the iSBTc-FDA taskforce on immunotherapy biomarkers"Lisa H Butterfield
Department of Medicine, Division of Hematology Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, 15213, USA
J Transl Med 6:81. 2008..This foreword provides an overview of the task force and invites feedback from readers that might be incorporated in the discussions and in the final document... - Emerging concepts in biomarker discovery; the US-Japan Workshop on Immunological Molecular Markers in OncologyHideaki Tahara
Department of Surgery and Bioengineering, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
J Transl Med 7:45. 2009..The institution of an interactive consortium for high throughput molecular monitoring of clinical trials with voluntary participation might provide cost-effective solutions... - Cross-priming of cyclin B1, MUC-1 and survivin-specific CD8+ T cells by dendritic cells loaded with killed allogeneic breast cancer cellsHiroaki Saito
Baylor Institute for Immunology Research, Live Oak, Dallas, Texas 75024, USA
Breast Cancer Res 8:R65. 2006..CONCLUSION: This ability of DCs loaded with killed allogeneic breast cancer cells to elicit multiantigen specific immunity supports their use as vaccines in patients with breast cancer... - Dendritic cells loaded with killed breast cancer cells induce differentiation of tumor-specific cytotoxic T lymphocytesEve Marie Neidhardt-Bérard
Centre Leon Berard, Laboratoire de thérapie cellulaire et greffes hématopoiètiques, Lyon, France
Breast Cancer Res 6:R322-8. 2004.... - Dendritic cells: are they clinically relevant?Karolina Palucka
Baylor Institute for Immunology Research, Dallas, TX 75204, USA
Cancer J 16:318-24. 2010.... - Spontaneous proliferation and type 2 cytokine secretion by CD4+T cells in patients with metastatic melanoma vaccinated with antigen-pulsed dendritic cellsA Karolina Palucka
Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX 75204, USA
J Clin Immunol 25:288-95. 2005..The index of spontaneous proliferation correlates with antigen-specific PBMC proliferation to the vaccine antigen KLH. Furthermore, both spontaneous- and antigen-specific proliferation in PBMC cultures are dependent on blood myeloid DCs... - Dendritic cells loaded with killed allogeneic melanoma cells can induce objective clinical responses and MART-1 specific CD8+ T-cell immunityAnna K Palucka
Baylor Institute for Immunology Research, Sammons Cancer Center, 3434 Live Oak, Dallas, TX 75204, USA
J Immunother 29:545-57. 2006..Thus, the present results justify the design of larger follow-up studies to assess the clinical response to DC vaccines loaded with killed allogeneic tumor cells in patients with metastatic melanoma... - Dendritic cells: a critical player in cancer therapy?Anna Karolina Palucka
Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX 75204, USA
J Immunother 31:793-805. 2008.... - Taming cancer by inducing immunity via dendritic cellsA Karolina Palucka
Baylor Institute for Immunology Research and Baylor Research Institute, Dallas, TX, USA
Immunol Rev 220:129-50. 2007..Therapeutic vaccination protocols will combine improved ex vivo DC vaccines with therapies that offset the suppressive environment established by tumors... - Dendritic cells and immunity against cancerK Palucka
Baylor Institute for Immunology Research, Baylor University Medical Center, Dallas, TX, USA
J Intern Med 269:64-73. 2011..We foresee that these novel cancer vaccines will be used as monotherapy in patients with resected disease and in combination with drugs targeting regulatory/suppressor pathways in patients with metastatic disease... - Designing vaccines based on biology of human dendritic cell subsetsKarolina Palucka
Baylor Institute for Immunology Research, 3434 Live Oak Avenue, Dallas, TX 75204, USA
Immunity 33:464-78. 2010..In addition, we foresee that this increased knowledge will permit us to design vaccines that will reprogram the immune system to intervene therapeutically in cancer, allergy, and autoimmunity... - Human dendritic cell subsets in NOD/SCID mice engrafted with CD34+ hematopoietic progenitorsA Karolina Palucka
Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX 75204, USA
Blood 102:3302-10. 2003..Injection of influenza virus into reconstituted mice triggers IFN-alpha release and maturation of mDCs. Thus, these mice may provide a model to study the pathophysiology of human DC subsets... - Dendritic cell subsets as vectors and targets for improved cancer therapyKarolina Palucka
Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX 75204, USA
Curr Top Microbiol Immunol 344:173-92. 2011.... - Building on dendritic cell subsets to improve cancer vaccinesKarolina Palucka
Baylor Institute for Immunology Research, Dallas, TX, USA
Curr Opin Immunol 22:258-63. 2010..The increased knowledge of the DC system, including the existence of distinct DC subsets is leading to new trials which aim at improved immune and clinical outcomes... - Immunotherapy via dendritic cellsA Karolina Palucka
Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX 75204, USA
Adv Exp Med Biol 560:105-14. 2005..Indeed, what we learn from studying autoimmunity will help us induce strong vaccine specific immunity, either protective, as in the case of microbes, or therapeutic, as in the case of tumors... - Single injection of CD34+ progenitor-derived dendritic cell vaccine can lead to induction of T-cell immunity in patients with stage IV melanomaA Karolina Palucka
Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, Texas 75204, USA
J Immunother 26:432-9. 2003..Thus, a single injection of CD34 HPC-derived DCs can lead to rapid immune response to CD4 epitopes or to melanoma antigens... - Harnessing dendritic cells to generate cancer vaccinesKarolina Palucka
Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, TX 75204, USA
Ann N Y Acad Sci 1174:88-98. 2009.... - IL-15-induced human DC efficiently prime melanoma-specific naive CD8+ T cells to differentiate into CTLPeter Dubsky
Baylor Institute for Immunology Research, Baylor NIAID Cooperative Center for Translational Research on Human Immunology and Biodefense, Dallas, TX 75204, USA
Eur J Immunol 37:1678-90. 2007..Therefore, membrane-bound IL-15 might contribute to enhanced priming by IL15-DC. Thus, IL-15 induces myeloid DC that are efficient in priming and maturation of melanoma antigen-specific CTL... - Measuring melanoma-specific cytotoxic T lymphocytes elicited by dendritic cell vaccines with a tumor inhibition assay in vitroSophie Paczesny
Baylor Institute for Immunology Research, Baylor University Medical Center, Dallas, Texas 75204, USA
J Immunother (1997) 28:148-57. 2005..Thus, TIA might prove valuable for measuring spontaneous and induced antigen-specific cytotoxic T cells... - Boosting vaccinations with peptide-pulsed CD34+ progenitor-derived dendritic cells can expand long-lived melanoma peptide-specific CD8+ T cells in patients with metastatic melanomaA Karolina Palucka
Baylor Institute for Immunology Research, Dallas, Texas 75204, USA
J Immunother (1997) 28:158-68. 2005..In two patients boosted over 15 months, induced melanoma peptide-specific recall memory CD8+ T cells lasted at least 6 months. Thus, boosting vaccination with peptide-loaded CD34-DCs can expand long-lived tumor peptide-specific immunity... - Dendritic cell-based vaccination against cancerHiroaki Saito
Baylor Institute for Immunology Research, Dallas, TX 75204, USA
Hematol Oncol Clin North Am 20:689-710. 2006..A better understanding of how dendritic cells regulate immune responses would allow clinicians to exploit them better to induce effective immunity against cancer... - Circulating tumor antigen-specific regulatory T cells in patients with metastatic melanomaLuis Vence
Baylor Institute for Immunology Research and Baylor Research Institute, Baylor University, Dallas, TX 75204, USA
Proc Natl Acad Sci U S A 104:20884-9. 2007..Such tumor antigen-specific T regs were not detected in healthy individuals. These tumor antigen-specific T regs might thus represent another target for immunotherapy of metastatic melanoma... - Broad influenza-specific CD8+ T-cell responses in humanized mice vaccinated with influenza virus vaccinesChun I Yu
Baylor National Institute of Allergy and Infectious Diseases NIAID Cooperative Center for Translational Research on Human Immunology, Baylor Institute for Immunology Research, Dallas, TX 75204, USA
Blood 112:3671-8. 2008..This, in turn, will allow a new approach to the rational design and preclinical testing of vaccines that cannot be tested in human volunteers... - Dendritic cells: controllers of the immune system and a new promise for immunotherapyJacques Banchereau
Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX 75204, USA
Novartis Found Symp 252:226-35; discussion 235-8, 257-67. 2003..50% of SLE patients have high serum levels of IFNalpha, which could explain T/B lymphopenia. Yet, plasmacytoid DCs, a major IFNalpha source, are 80% decreased. pDCs and IFNalpha may play a role in SLE pathogenesis and therapy... - Both Langerhans cells and interstitial DC cross-present melanoma antigens and efficiently activate antigen-specific CTLTinghua Cao
Baylor Institute for Immunology Research, Dallas, TX 75204, USA
Eur J Immunol 37:2657-67. 2007..Thus, this study provides the rationale to use CD34-DC loaded with necrotic/apoptotic allogeneic melanoma cells in a clinical trial... - Breast cancer instructs dendritic cells to prime interleukin 13-secreting CD4+ T cells that facilitate tumor developmentCaroline Aspord
Baylor Institute for Immunology Research and Baylor National Institute of Allergy and Infectious Diseases Cooperative Center for Translational Research on Human Immunology and Biodefense, Baylor University Medical Center, Dallas, TX 75204, USA
J Exp Med 204:1037-47. 2007..There, CD4(+) T cells promote early tumor development. This is dependent on DCs and can be partially prevented by administration of IL-13 antagonists. Thus, breast cancer targets DCs to facilitate its development... - Influenza virus and poly(I:C) inhibit MHC class I-restricted presentation of cell-associated antigens derived from infected dead cells captured by human dendritic cellsDavor Frleta
Baylor National Institute of Allergy and Infectious Diseases Cooperative Center for Translational Research on Human Immunology and Biodefense, Dallas, Texas 75204, USA
J Immunol 182:2766-76. 2009..Thus, DCs have a mechanism that prevents MHC class I-restricted cross-presentation of cell-associated Ag when they have captured dead infected cells... - Cross-priming CD8+ T cells by targeting antigens to human dendritic cells through DCIREynav Klechevsky
Baylor Institute for Immunology Research and INSERM U899, Dallas, TX 75204, USA
Blood 116:1685-97. 2010..Thus, antigen targeting via the human DCIR receptor allows activation of specific CD8(+) T-cell immunity... - Dendritic cells as vectors for immunotherapy of cancerSophie Paczesny
Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX 75204, USA
Semin Cancer Biol 13:439-47. 2003.... - Understanding human myeloid dendritic cell subsets for the rational design of novel vaccinesEynav Klechevsky
Baylor Institute for Immunology Research, Dallas, Texas, USA
Hum Immunol 70:281-8. 2009..The biologic raison d'être for separate DC subsets has been the focus of many studies including our own and is being reviewed with an emphasis on human skin DCs... - A modular analysis framework for blood genomics studies: application to systemic lupus erythematosusDamien Chaussabel
Baylor NIAID Cooperative Center for Translational Research on Human Immunology and Biodefense, Baylor Institute for Immunology Research and Baylor Research Institute, Dallas, TX 75204, USA
Immunity 29:150-64. 2008..Thus, this work describes the implementation and application of a methodology designed to support systems-scale analysis of the human immune system in translational research settings... - The interplay of dendritic cell subsets in systemic lupus erythematosusA Karolina Palucka
Baylor Institute for Immunology Research and University of Texas Southwestern Medical Center, Dallas 75204, USA
Immunol Cell Biol 80:484-8. 2002..Thus, interplay between DC subsets might represent a key component of SLE pathogenesis... - Expansion of melanoma-specific cytolytic CD8+ T cell precursors in patients with metastatic melanoma vaccinated with CD34+ progenitor-derived dendritic cellsSophie Paczesny
Baylor Institute for Immunology Research, Dallas, TX 75204, USA
J Exp Med 199:1503-11. 2004..These results justify the design of larger follow-up studies to assess the immunological and clinical response to peptide-pulsed CD34-DC vaccines... - Dendritic cells as therapeutic vaccines against cancerJacques Banchereau
Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, Texas 75204, USA
Nat Rev Immunol 5:296-306. 2005..A better understanding of how dendritic cells regulate immune responses will allow us to better exploit these cells to induce effective antitumour immunity... - The central role of dendritic cells and interferon-alpha in SLEVirginia Pascual
Baylor Institute for Immunology Research, Dallas, Texas 75204, USA
Curr Opin Rheumatol 15:548-56. 2003..This review summarizes the recently uncovered role of dendritic cell subsets and one of their products, interferon-alpha, in the pathophysiology of systemic lupus erythematosus... - Dendritic cells and humoral immunity in humansHideki Ueno
Baylor Institute for Immunology Research and INSERM U899, Dallas, TX 75204, USA
Immunol Cell Biol 88:376-80. 2010..We will also discuss the mechanisms whereby DCs induce CD4(+) T cells associated with aiding B-cell response, including T follicular helper (Tfh) cells, and why human LCs lack this ability... - Analysis of significance patterns identifies ubiquitous and disease-specific gene-expression signatures in patient peripheral blood leukocytesDamien Chaussabel
The Baylor NIAID Cooperative Center for Translational Research on Human Immunology and Biodefense and Baylor Institute for Immunology Research, 3434 Live Oak Street, Suite 205, Dallas, TX 75204, USA
Ann N Y Acad Sci 1062:146-54. 2005..These findings bring new perspectives for the application of blood leukocyte expression signatures for diagnosis and early disease detection... - Long-term outcomes in patients with metastatic melanoma vaccinated with melanoma peptide-pulsed CD34(+) progenitor-derived dendritic cellsJoseph W Fay
Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX 75204, USA
Cancer Immunol Immunother 55:1209-18. 2006..The present results therefore justify the design of larger follow-up studies to assess the immunological and clinical outcomes in patients with metastatic melanoma vaccinated with peptide-pulsed CD34-derived DCs... - Immune and clinical outcomes in patients with stage IV melanoma vaccinated with peptide-pulsed dendritic cells derived from CD34+ progenitors and activated with type I interferonJacques Banchereau
Baylor Institute for Immunology Research, Dallas, TX, USA
J Immunother 28:505-16. 2005..Overall, these results suggest that IFN-alpha-activated CD34-DCs are safe but elicit only limited immune responses, underscoring the need to test different DC maturation factors... - Interferon and granulopoiesis signatures in systemic lupus erythematosus bloodLynda Bennett
Baylor Institute for Immunology Research, Dallas, TX 75204, USA
J Exp Med 197:711-23. 2003..Therefore, while the IFN signature confirms the central role of this cytokine in SLE, microarray analysis of blood cells reveals that immature granulocytes may be involved in SLE pathogenesis... - Functional specializations of human epidermal Langerhans cells and CD14+ dermal dendritic cellsEynav Klechevsky
Baylor Institute for Immunology Research and Baylor Research Institute, Dallas, TX 75204, USA
Immunity 29:497-510. 2008..Thus, the human skin displays three DC subsets, two of which, i.e., CD14(+) DCs and LCs, display functional specializations, the preferential activation of humoral and cellular immunity, respectively... - Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6Gaetan Jego
Baylor Institute for Immunology Research, 3434 Live Oak Street, Dallas, Texas 75204, USA
Immunity 19:225-34. 2003..These plasma cells display the high levels of CD38 found on tissue plasma cells. Thus, pDCs are critical for the generation of plasma cells and antibody responses... - Dendritic cell subsets generated from CD34+ hematopoietic progenitors can be transfected with mRNA and induce antigen-specific cytotoxic T cell responsesHideki Ueno
Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX 75204, USA
J Immunol Methods 285:171-80. 2004..Thus, RNA can be used to deliver antigens to two distinct myeloid DC subsets in CD34-DC cultures... - CD2 distinguishes two subsets of human plasmacytoid dendritic cells with distinct phenotype and functionsToshimichi Matsui
Baylor National Institute of Allergy and Infectious Diseases, Cooperative Center for Translational Research on Human Immunology and Biodefense, Dallas, TX 75204, USA
J Immunol 182:6815-23. 2009..Thus, human blood pDCs are composed of subsets with specific phenotype and functions... - How the study of children with rheumatic diseases identified interferon-alpha and interleukin-1 as novel therapeutic targetsVirginia Pascual
Baylor Institute for Immunology Research and Baylor Research Institute, Dallas, TX 75204, USA
Immunol Rev 223:39-59. 2008..Finally, our pilot clinical trials using IL-1 blockers have shown remarkable clinical benefits in SoJIA patients refractory to other medications... - Blood dendritic cells and DC-poietins in systemic lupus erythematosusMichelle A Gill
Baylor Institute for Immunology Research, Dallas, Texas, USA
Hum Immunol 63:1172-80. 2002..Although IFN-alpha remains at the center of immunologic aberrations in SLE, it remains to be determined whether increased shedding of soluble TNF receptors could also be ascribed to IFN-alpha... - Dendritic cell subsets in health and diseaseHideki Ueno
Baylor Institute for Immunology Research, Dallas, TX 75204, USA
Immunol Rev 219:118-42. 2007..Alterations of the DC system result in diseases such as autoimmunity, allergy, and cancer. Conversely, DCs can be exploited for vaccination, and novel vaccines that directly target DCs in vivo are being designed... - Dendritic cells control B cell growth and differentiationGaetan Jego
Baylor Institute for Immunology Research and Baylor NIAID Cooperative Center for Translational Research on Human Immunology and Biodefense, Dallas, TX 75204, USA
Curr Dir Autoimmun 8:124-39. 2005..It may also provide an explanation for spreading of the autoimmune repertoire as autoimmunity develops... - Gene expression patterns in blood leukocytes discriminate patients with acute infectionsOctavio Ramilo
Baylor National Institute of Allergy and Infections Diseases NIAID Cooperative Center for Translational Research on Human Immunology and Biodefense and Baylor Institute for Immunology Research, Dallas, TX 75204, USA
Blood 109:2066-77. 2007..Thus, microarray analyses of patient peripheral blood leukocytes might assist in the differential diagnosis of infectious diseases... - Dendritic cells: controllers of the immune system and a new promise for immunotherapyJacques Banchereau
Baylor Institute for Immunology Research, Dallas, Texas 75204, USA
Ann N Y Acad Sci 987:180-7. 2003..Another pathway includes plasmacytoid DCs, which promptly secrete large amounts of IFN-alpha/beta viral encounter. Thus, insights into in vivo DC functions are important to understand the launching and modulation of immunity... - Hyperthermia enhances CTL cross-primingHongzhen Shi
Baylor Institute for Immunology Research, Dallas, TX 75204, USA
J Immunol 176:2134-41. 2006..Thus, heat treatment of tumor cells permits enhanced cross-priming, possibly via up-regulation of both HSPs and tumor Ag expression... - Increased blood myeloid dendritic cells and dendritic cell-poietins in Langerhans cell histiocytosisAlexandre Rolland
Baylor Institute for Immunology Research, Dallas, TX 75204, USA
J Immunol 174:3067-71. 2005..Thus, early hemopoietic cytokines such as FLT3-L, stem cell factor, and M-CSF maybe relevant in LCH pathogenesis and might be considered as novel therapeutic targets... - Autoimmunity through cytokine-induced dendritic cell activationJacques Banchereau
Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX 75204 USA
Immunity 20:539-50. 2004..This model complements the Type 1/Type 2 paradigm. Therefore, immunity can be viewed as a dynamic system driven by two sets of opposite vectors: IFN-alpha/beta/TNF and IFN-gamma/IL-4... - Cross-regulation of TNF and IFN-alpha in autoimmune diseasesA Karolina Palucka
Baylor Institute for Immunology Research, 3434 Live Oak Street, Dallas, TX 75214, USA
Proc Natl Acad Sci U S A 102:3372-7. 2005..These results, therefore, might provide a mechanistic explanation for the development of anti-dsDNA antibodies and lupus-like syndrome in patients undergoing anti-TNF therapy... - TNF skews monocyte differentiation from macrophages to dendritic cellsPascale Chomarat
Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX 75204, USA
J Immunol 171:2262-9. 2003..Thus, TNF facilitates the induction of adaptive immunity by promoting DC differentiation not only from CD34+ progenitors but also from CD14+ blood precursors... - Mobilization of plasmacytoid and myeloid dendritic cells to mucosal sites in children with respiratory syncytial virus and other viral respiratory infectionsMichelle A Gill
Baylor Institute for Immunology Research, and Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas and Children's Medical Center Dallas, Dallas, Texas 75204, USA
J Infect Dis 191:1105-15. 2005..Immunochemistry analysis of respiratory samples has demonstrated the presence of the RSV fusion protein within HLA-DR-positive cells. CONCLUSION: Infection with RSV and other respiratory viruses mobilizes DCs to the site of viral entry... - Dendritic cells and cytokines in human inflammatory and autoimmune diseasesPatrick Blanco
CHU Bordeaux, 33076 Bordeaux, France
Cytokine Growth Factor Rev 19:41-52. 2008.... - Langerhans cells: daughters of monocytesA Karolina Palucka
Nat Immunol 7:223-4. 2006 - Humanized mice: are we there yet?Francesca Macchiarini
Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
J Exp Med 202:1307-11. 2005.... - Tumour immunity: effector response to tumour and role of the microenvironmentAlberto Mantovani
Istituto Clinico Humanitas and Institute of Pathology, University of Milan, Milan, Italy
Lancet 371:771-83. 2008....
Research Grants
- Dendritic Cells and Breast Cancer ImmunityA Palucka; Fiscal Year: 2004..Overall, this proposal will permit us to demonstrate that efficient breast cancer immunity can be generated and used to reject the tumor thus permitting development of novel treatment modalities in breast cancer. ..
- Mice with Human Dendritic Cells to Test Vaccine PotencyA Palucka; Fiscal Year: 2004..The experiments proposed here would lay ground for further use of SCID-hu/DCs mice to study other vaccines and demonstrate development of protective immunity upon in vivo rechallenge. ..
- Diversification of Cytotoxic Effector Cells Via LPS-activated DCsAnna Karolina Palucka; Fiscal Year: 2010..Vaccination with DCs could become an option for patients with earlier disease stages. ..
- Vaccination with IL-15 DC to Generate Melanoma-specific Protective Memory T CellsAnna Karolina Palucka; Fiscal Year: 2010..Current therapies have the potential to improve outcome in a fraction of patients but are associated with considerable toxicity. Vaccination with melanoma antigen-loaded dendritic cells (DCs) could improve outcomes without toxicity. ..