Hiroaki Saito

Summary

Affiliation: Baylor University Medical Center
Country: USA

Publications

  1. pmc Dendritic-cell-based therapeutic cancer vaccines
    Karolina Palucka
    Ralph M Steinman Center for Cancer Vaccines, Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, TX 75204, USA
    Immunity 39:38-48. 2013
  2. pmc Human dendritic cell subsets in vaccination
    Karolina Palucka
    Ralph M Steinmann Center for Cancer Vaccines, Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, TX, USA
    Curr Opin Immunol 25:396-402. 2013
  3. doi request reprint Humanized mice for the development and testing of human vaccines
    Caroline Aspord
    Baylor Institute for Immunology Research and Baylor NIAID Cooperative Center for Translational Research on Human Immunology and Biodefense, Dallas, TX75204, USA 1 214 820 7450 1 214 820 4813
    Expert Opin Drug Discov 2:949-60. 2007
  4. pmc Cancer immunotherapy via dendritic cells
    Karolina Palucka
    Baylor Institute for Immunology Research, 3434 Live Oak Avenue, Dallas, Texas 75204, USA
    Nat Rev Cancer 12:265-77. 2012
  5. pmc A systematic approach to biomarker discovery; preamble to "the iSBTc-FDA taskforce on immunotherapy biomarkers"
    Lisa H Butterfield
    Department of Medicine, Division of Hematology Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, 15213, USA
    J Transl Med 6:81. 2008
  6. pmc Emerging concepts in biomarker discovery; the US-Japan Workshop on Immunological Molecular Markers in Oncology
    Hideaki Tahara
    Department of Surgery and Bioengineering, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    J Transl Med 7:45. 2009
  7. pmc Dendritic cells loaded with killed breast cancer cells induce differentiation of tumor-specific cytotoxic T lymphocytes
    Eve Marie Neidhardt-Bérard
    Centre Leon Berard, Laboratoire de thérapie cellulaire et greffes hématopoiètiques, Lyon, France
    Breast Cancer Res 6:R322-8. 2004
  8. pmc Dendritic cells: a critical player in cancer therapy?
    Anna Karolina Palucka
    Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX 75204, USA
    J Immunother 31:793-805. 2008
  9. ncbi request reprint Taming cancer by inducing immunity via dendritic cells
    A Karolina Palucka
    Baylor Institute for Immunology Research and Baylor Research Institute, Dallas, TX, USA
    Immunol Rev 220:129-50. 2007
  10. ncbi request reprint Dendritic cells loaded with killed allogeneic melanoma cells can induce objective clinical responses and MART-1 specific CD8+ T-cell immunity
    Anna K Palucka
    Baylor Institute for Immunology Research, Sammons Cancer Center, 3434 Live Oak, Dallas, TX 75204, USA
    J Immunother 29:545-57. 2006

Collaborators

Detail Information

Publications64

  1. pmc Dendritic-cell-based therapeutic cancer vaccines
    Karolina Palucka
    Ralph M Steinman Center for Cancer Vaccines, Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, TX 75204, USA
    Immunity 39:38-48. 2013
    ....
  2. pmc Human dendritic cell subsets in vaccination
    Karolina Palucka
    Ralph M Steinmann Center for Cancer Vaccines, Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, TX, USA
    Curr Opin Immunol 25:396-402. 2013
    ..DCs are thus key targets for both preventive and therapeutic vaccination. Herein, we will discuss recent progresses in our understanding of DC subsets physiology as it applies to vaccination. ..
  3. doi request reprint Humanized mice for the development and testing of human vaccines
    Caroline Aspord
    Baylor Institute for Immunology Research and Baylor NIAID Cooperative Center for Translational Research on Human Immunology and Biodefense, Dallas, TX75204, USA 1 214 820 7450 1 214 820 4813
    Expert Opin Drug Discov 2:949-60. 2007
    ..Such Humouse models could permit us to generate and test novel human vaccines...
  4. pmc Cancer immunotherapy via dendritic cells
    Karolina Palucka
    Baylor Institute for Immunology Research, 3434 Live Oak Avenue, Dallas, Texas 75204, USA
    Nat Rev Cancer 12:265-77. 2012
    ..Thus, DCs are an essential target in efforts to generate therapeutic immunity against cancer...
  5. pmc A systematic approach to biomarker discovery; preamble to "the iSBTc-FDA taskforce on immunotherapy biomarkers"
    Lisa H Butterfield
    Department of Medicine, Division of Hematology Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, 15213, USA
    J Transl Med 6:81. 2008
    ..This foreword provides an overview of the task force and invites feedback from readers that might be incorporated in the discussions and in the final document...
  6. pmc Emerging concepts in biomarker discovery; the US-Japan Workshop on Immunological Molecular Markers in Oncology
    Hideaki Tahara
    Department of Surgery and Bioengineering, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    J Transl Med 7:45. 2009
    ..The institution of an interactive consortium for high throughput molecular monitoring of clinical trials with voluntary participation might provide cost-effective solutions...
  7. pmc Dendritic cells loaded with killed breast cancer cells induce differentiation of tumor-specific cytotoxic T lymphocytes
    Eve Marie Neidhardt-Bérard
    Centre Leon Berard, Laboratoire de thérapie cellulaire et greffes hématopoiètiques, Lyon, France
    Breast Cancer Res 6:R322-8. 2004
    ....
  8. pmc Dendritic cells: a critical player in cancer therapy?
    Anna Karolina Palucka
    Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX 75204, USA
    J Immunother 31:793-805. 2008
    ....
  9. ncbi request reprint Taming cancer by inducing immunity via dendritic cells
    A Karolina Palucka
    Baylor Institute for Immunology Research and Baylor Research Institute, Dallas, TX, USA
    Immunol Rev 220:129-50. 2007
    ..Therapeutic vaccination protocols will combine improved ex vivo DC vaccines with therapies that offset the suppressive environment established by tumors...
  10. ncbi request reprint Dendritic cells loaded with killed allogeneic melanoma cells can induce objective clinical responses and MART-1 specific CD8+ T-cell immunity
    Anna K Palucka
    Baylor Institute for Immunology Research, Sammons Cancer Center, 3434 Live Oak, Dallas, TX 75204, USA
    J Immunother 29:545-57. 2006
    ..Thus, the present results justify the design of larger follow-up studies to assess the clinical response to DC vaccines loaded with killed allogeneic tumor cells in patients with metastatic melanoma...
  11. ncbi request reprint Spontaneous proliferation and type 2 cytokine secretion by CD4+T cells in patients with metastatic melanoma vaccinated with antigen-pulsed dendritic cells
    A Karolina Palucka
    Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX 75204, USA
    J Clin Immunol 25:288-95. 2005
    ..The index of spontaneous proliferation correlates with antigen-specific PBMC proliferation to the vaccine antigen KLH. Furthermore, both spontaneous- and antigen-specific proliferation in PBMC cultures are dependent on blood myeloid DCs...
  12. ncbi request reprint Single injection of CD34+ progenitor-derived dendritic cell vaccine can lead to induction of T-cell immunity in patients with stage IV melanoma
    A Karolina Palucka
    Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, Texas 75204, USA
    J Immunother 26:432-9. 2003
    ..Thus, a single injection of CD34 HPC-derived DCs can lead to rapid immune response to CD4 epitopes or to melanoma antigens...
  13. pmc Harnessing dendritic cells to generate cancer vaccines
    Karolina Palucka
    Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, TX 75204, USA
    Ann N Y Acad Sci 1174:88-98. 2009
    ....
  14. pmc Dendritic cell subsets as vectors and targets for improved cancer therapy
    Karolina Palucka
    Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX 75204, USA
    Curr Top Microbiol Immunol 344:173-92. 2011
    ....
  15. ncbi request reprint Human dendritic cell subsets in NOD/SCID mice engrafted with CD34+ hematopoietic progenitors
    A Karolina Palucka
    Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX 75204, USA
    Blood 102:3302-10. 2003
    ..Injection of influenza virus into reconstituted mice triggers IFN-alpha release and maturation of mDCs. Thus, these mice may provide a model to study the pathophysiology of human DC subsets...
  16. ncbi request reprint Immunotherapy via dendritic cells
    A Karolina Palucka
    Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX 75204, USA
    Adv Exp Med Biol 560:105-14. 2005
    ..Indeed, what we learn from studying autoimmunity will help us induce strong vaccine specific immunity, either protective, as in the case of microbes, or therapeutic, as in the case of tumors...
  17. pmc Dendritic cells and immunity against cancer
    K Palucka
    Baylor Institute for Immunology Research, Baylor University Medical Center, Dallas, TX, USA
    J Intern Med 269:64-73. 2011
    ..We foresee that these novel cancer vaccines will be used as monotherapy in patients with resected disease and in combination with drugs targeting regulatory/suppressor pathways in patients with metastatic disease...
  18. pmc Designing vaccines based on biology of human dendritic cell subsets
    Karolina Palucka
    Baylor Institute for Immunology Research, 3434 Live Oak Avenue, Dallas, TX 75204, USA
    Immunity 33:464-78. 2010
    ..In addition, we foresee that this increased knowledge will permit us to design vaccines that will reprogram the immune system to intervene therapeutically in cancer, allergy, and autoimmunity...
  19. pmc Dendritic cells: are they clinically relevant?
    Karolina Palucka
    Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    Cancer J 16:318-24. 2010
    ....
  20. pmc Building on dendritic cell subsets to improve cancer vaccines
    Karolina Palucka
    Baylor Institute for Immunology Research, Dallas, TX, USA
    Curr Opin Immunol 22:258-63. 2010
    ..The increased knowledge of the DC system, including the existence of distinct DC subsets is leading to new trials which aim at improved immune and clinical outcomes...
  21. ncbi request reprint IL-15-induced human DC efficiently prime melanoma-specific naive CD8+ T cells to differentiate into CTL
    Peter Dubsky
    Baylor Institute for Immunology Research, Baylor NIAID Cooperative Center for Translational Research on Human Immunology and Biodefense, Dallas, TX 75204, USA
    Eur J Immunol 37:1678-90. 2007
    ..Therefore, membrane-bound IL-15 might contribute to enhanced priming by IL15-DC. Thus, IL-15 induces myeloid DC that are efficient in priming and maturation of melanoma antigen-specific CTL...
  22. ncbi request reprint Measuring melanoma-specific cytotoxic T lymphocytes elicited by dendritic cell vaccines with a tumor inhibition assay in vitro
    Sophie Paczesny
    Baylor Institute for Immunology Research, Baylor University Medical Center, Dallas, Texas 75204, USA
    J Immunother 28:148-57. 2005
    ..Thus, TIA might prove valuable for measuring spontaneous and induced antigen-specific cytotoxic T cells...
  23. pmc Cross-priming of cyclin B1, MUC-1 and survivin-specific CD8+ T cells by dendritic cells loaded with killed allogeneic breast cancer cells
    Hiroaki Saito
    Baylor Institute for Immunology Research, Live Oak, Dallas, Texas 75024, USA
    Breast Cancer Res 8:R65. 2006
    ..The ability of dendritic cells (DCs) to take up whole tumor cells and process their antigens for presentation to T cells ('cross-priming') is an important mechanism for induction of tumor specific immunity...
  24. ncbi request reprint Boosting vaccinations with peptide-pulsed CD34+ progenitor-derived dendritic cells can expand long-lived melanoma peptide-specific CD8+ T cells in patients with metastatic melanoma
    A Karolina Palucka
    Baylor Institute for Immunology Research, Dallas, Texas 75204, USA
    J Immunother 28:158-68. 2005
    ..In two patients boosted over 15 months, induced melanoma peptide-specific recall memory CD8+ T cells lasted at least 6 months. Thus, boosting vaccination with peptide-loaded CD34-DCs can expand long-lived tumor peptide-specific immunity...
  25. ncbi request reprint Dendritic cell-based vaccination against cancer
    Hiroaki Saito
    Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    Hematol Oncol Clin North Am 20:689-710. 2006
    ..A better understanding of how dendritic cells regulate immune responses would allow clinicians to exploit them better to induce effective immunity against cancer...
  26. pmc Circulating tumor antigen-specific regulatory T cells in patients with metastatic melanoma
    Luis Vence
    Baylor Institute for Immunology Research and Baylor Research Institute, Baylor University, Dallas, TX 75204, USA
    Proc Natl Acad Sci U S A 104:20884-9. 2007
    ..Such tumor antigen-specific T regs were not detected in healthy individuals. These tumor antigen-specific T regs might thus represent another target for immunotherapy of metastatic melanoma...
  27. ncbi request reprint Dendritic cells as vectors for immunotherapy of cancer
    Sophie Paczesny
    Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX 75204, USA
    Semin Cancer Biol 13:439-47. 2003
    ....
  28. pmc Influenza virus and poly(I:C) inhibit MHC class I-restricted presentation of cell-associated antigens derived from infected dead cells captured by human dendritic cells
    Davor Frleta
    Baylor National Institute of Allergy and Infectious Diseases Cooperative Center for Translational Research on Human Immunology and Biodefense, Dallas, Texas 75204, USA
    J Immunol 182:2766-76. 2009
    ..Thus, DCs have a mechanism that prevents MHC class I-restricted cross-presentation of cell-associated Ag when they have captured dead infected cells...
  29. pmc Breast cancer instructs dendritic cells to prime interleukin 13-secreting CD4+ T cells that facilitate tumor development
    Caroline Aspord
    Baylor Institute for Immunology Research and Baylor National Institute of Allergy and Infectious Diseases Cooperative Center for Translational Research on Human Immunology and Biodefense, Baylor University Medical Center, Dallas, TX 75204, USA
    J Exp Med 204:1037-47. 2007
    ..There, CD4(+) T cells promote early tumor development. This is dependent on DCs and can be partially prevented by administration of IL-13 antagonists. Thus, breast cancer targets DCs to facilitate its development...
  30. pmc Cross-priming CD8+ T cells by targeting antigens to human dendritic cells through DCIR
    Eynav Klechevsky
    Baylor Institute for Immunology Research and INSERM U899, Dallas, TX 75204, USA
    Blood 116:1685-97. 2010
    ..Thus, antigen targeting via the human DCIR receptor allows activation of specific CD8(+) T-cell immunity...
  31. ncbi request reprint Dendritic cells: controllers of the immune system and a new promise for immunotherapy
    Jacques Banchereau
    Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX 75204, USA
    Novartis Found Symp 252:226-35; discussion 235-8, 257-67. 2003
    ..50% of SLE patients have high serum levels of IFNalpha, which could explain T/B lymphopenia. Yet, plasmacytoid DCs, a major IFNalpha source, are 80% decreased. pDCs and IFNalpha may play a role in SLE pathogenesis and therapy...
  32. pmc Broad influenza-specific CD8+ T-cell responses in humanized mice vaccinated with influenza virus vaccines
    Chun I Yu
    Baylor National Institute of Allergy and Infectious Diseases NIAID Cooperative Center for Translational Research on Human Immunology, Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    Blood 112:3671-8. 2008
    ..This, in turn, will allow a new approach to the rational design and preclinical testing of vaccines that cannot be tested in human volunteers...
  33. ncbi request reprint Both Langerhans cells and interstitial DC cross-present melanoma antigens and efficiently activate antigen-specific CTL
    Tinghua Cao
    Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    Eur J Immunol 37:2657-67. 2007
    ..Thus, this study provides the rationale to use CD34-DC loaded with necrotic/apoptotic allogeneic melanoma cells in a clinical trial...
  34. pmc Understanding human myeloid dendritic cell subsets for the rational design of novel vaccines
    Eynav Klechevsky
    Baylor Institute for Immunology Research, Dallas, Texas, USA
    Hum Immunol 70:281-8. 2009
    ..The biologic raison d'être for separate DC subsets has been the focus of many studies including our own and is being reviewed with an emphasis on human skin DCs...
  35. ncbi request reprint The interplay of dendritic cell subsets in systemic lupus erythematosus
    A Karolina Palucka
    Baylor Institute for Immunology Research and University of Texas Southwestern Medical Center, Dallas 75204, USA
    Immunol Cell Biol 80:484-8. 2002
    ..Thus, interplay between DC subsets might represent a key component of SLE pathogenesis...
  36. pmc Dendritic cells and humoral immunity in humans
    Hideki Ueno
    Baylor Institute for Immunology Research and INSERM U899, Dallas, TX 75204, USA
    Immunol Cell Biol 88:376-80. 2010
    ..We will also discuss the mechanisms whereby DCs induce CD4(+) T cells associated with aiding B-cell response, including T follicular helper (Tfh) cells, and why human LCs lack this ability...
  37. ncbi request reprint The central role of dendritic cells and interferon-alpha in SLE
    Virginia Pascual
    Baylor Institute for Immunology Research, Dallas, Texas 75204, USA
    Curr Opin Rheumatol 15:548-56. 2003
    ..This review summarizes the recently uncovered role of dendritic cell subsets and one of their products, interferon-alpha, in the pathophysiology of systemic lupus erythematosus...
  38. pmc Expansion of melanoma-specific cytolytic CD8+ T cell precursors in patients with metastatic melanoma vaccinated with CD34+ progenitor-derived dendritic cells
    Sophie Paczesny
    Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    J Exp Med 199:1503-11. 2004
    ..These results justify the design of larger follow-up studies to assess the immunological and clinical response to peptide-pulsed CD34-DC vaccines...
  39. ncbi request reprint Immune and clinical outcomes in patients with stage IV melanoma vaccinated with peptide-pulsed dendritic cells derived from CD34+ progenitors and activated with type I interferon
    Jacques Banchereau
    Baylor Institute for Immunology Research, Dallas, TX, USA
    J Immunother 28:505-16. 2005
    ..Overall, these results suggest that IFN-alpha-activated CD34-DCs are safe but elicit only limited immune responses, underscoring the need to test different DC maturation factors...
  40. ncbi request reprint Long-term outcomes in patients with metastatic melanoma vaccinated with melanoma peptide-pulsed CD34(+) progenitor-derived dendritic cells
    Joseph W Fay
    Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX 75204, USA
    Cancer Immunol Immunother 55:1209-18. 2006
    ..The present results therefore justify the design of larger follow-up studies to assess the immunological and clinical outcomes in patients with metastatic melanoma vaccinated with peptide-pulsed CD34-derived DCs...
  41. pmc A modular analysis framework for blood genomics studies: application to systemic lupus erythematosus
    Damien Chaussabel
    Baylor NIAID Cooperative Center for Translational Research on Human Immunology and Biodefense, Baylor Institute for Immunology Research and Baylor Research Institute, Dallas, TX 75204, USA
    Immunity 29:150-64. 2008
    ..Thus, this work describes the implementation and application of a methodology designed to support systems-scale analysis of the human immune system in translational research settings...
  42. ncbi request reprint Analysis of significance patterns identifies ubiquitous and disease-specific gene-expression signatures in patient peripheral blood leukocytes
    Damien Chaussabel
    The Baylor NIAID Cooperative Center for Translational Research on Human Immunology and Biodefense and Baylor Institute for Immunology Research, 3434 Live Oak Street, Suite 205, Dallas, TX 75204, USA
    Ann N Y Acad Sci 1062:146-54. 2005
    ..Conversely, a "sentinel signature" that was common to all seven diseases was characterized. These findings bring new perspectives for the application of blood leukocyte expression signatures for diagnosis and early disease detection...
  43. ncbi request reprint Dendritic cells as therapeutic vaccines against cancer
    Jacques Banchereau
    Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, Texas 75204, USA
    Nat Rev Immunol 5:296-306. 2005
    ..A better understanding of how dendritic cells regulate immune responses will allow us to better exploit these cells to induce effective antitumour immunity...
  44. ncbi request reprint Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6
    Gaetan Jego
    Baylor Institute for Immunology Research, 3434 Live Oak Street, Dallas, Texas 75204, USA
    Immunity 19:225-34. 2003
    ..These plasma cells display the high levels of CD38 found on tissue plasma cells. Thus, pDCs are critical for the generation of plasma cells and antibody responses...
  45. pmc CD2 distinguishes two subsets of human plasmacytoid dendritic cells with distinct phenotype and functions
    Toshimichi Matsui
    Baylor National Institute of Allergy and Infectious Diseases, Cooperative Center for Translational Research on Human Immunology and Biodefense, Dallas, TX 75204, USA
    J Immunol 182:6815-23. 2009
    ..Thus, human blood pDCs are composed of subsets with specific phenotype and functions...
  46. pmc Interferon and granulopoiesis signatures in systemic lupus erythematosus blood
    Lynda Bennett
    Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    J Exp Med 197:711-23. 2003
    ..Therefore, while the IFN signature confirms the central role of this cytokine in SLE, microarray analysis of blood cells reveals that immature granulocytes may be involved in SLE pathogenesis...
  47. ncbi request reprint Blood dendritic cells and DC-poietins in systemic lupus erythematosus
    Michelle A Gill
    Baylor Institute for Immunology Research, Dallas, Texas, USA
    Hum Immunol 63:1172-80. 2002
    ..Although IFN-alpha remains at the center of immunologic aberrations in SLE, it remains to be determined whether increased shedding of soluble TNF receptors could also be ascribed to IFN-alpha...
  48. pmc Gene expression patterns in blood leukocytes discriminate patients with acute infections
    Octavio Ramilo
    Baylor National Institute of Allergy and Infections Diseases NIAID Cooperative Center for Translational Research on Human Immunology and Biodefense and Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    Blood 109:2066-77. 2007
    ..Thus, microarray analyses of patient peripheral blood leukocytes might assist in the differential diagnosis of infectious diseases...
  49. ncbi request reprint Dendritic cells control B cell growth and differentiation
    Gaetan Jego
    Baylor Institute for Immunology Research and Baylor NIAID Cooperative Center for Translational Research on Human Immunology and Biodefense, Dallas, TX 75204, USA
    Curr Dir Autoimmun 8:124-39. 2005
    ..It may also provide an explanation for spreading of the autoimmune repertoire as autoimmunity develops...
  50. pmc Functional specializations of human epidermal Langerhans cells and CD14+ dermal dendritic cells
    Eynav Klechevsky
    Baylor Institute for Immunology Research and Baylor Research Institute, Dallas, TX 75204, USA
    Immunity 29:497-510. 2008
    ..Thus, the human skin displays three DC subsets, two of which, i.e., CD14(+) DCs and LCs, display functional specializations, the preferential activation of humoral and cellular immunity, respectively...
  51. ncbi request reprint Dendritic cell subsets generated from CD34+ hematopoietic progenitors can be transfected with mRNA and induce antigen-specific cytotoxic T cell responses
    Hideki Ueno
    Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX 75204, USA
    J Immunol Methods 285:171-80. 2004
    ..Thus, RNA can be used to deliver antigens to two distinct myeloid DC subsets in CD34-DC cultures...
  52. pmc How the study of children with rheumatic diseases identified interferon-alpha and interleukin-1 as novel therapeutic targets
    Virginia Pascual
    Baylor Institute for Immunology Research and Baylor Research Institute, Dallas, TX 75204, USA
    Immunol Rev 223:39-59. 2008
    ..Finally, our pilot clinical trials using IL-1 blockers have shown remarkable clinical benefits in SoJIA patients refractory to other medications...
  53. ncbi request reprint Dendritic cell subsets in health and disease
    Hideki Ueno
    Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    Immunol Rev 219:118-42. 2007
    ..Alterations of the DC system result in diseases such as autoimmunity, allergy, and cancer. Conversely, DCs can be exploited for vaccination, and novel vaccines that directly target DCs in vivo are being designed...
  54. ncbi request reprint Autoimmunity through cytokine-induced dendritic cell activation
    Jacques Banchereau
    Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX 75204 USA
    Immunity 20:539-50. 2004
    ..This model complements the Type 1/Type 2 paradigm. Therefore, immunity can be viewed as a dynamic system driven by two sets of opposite vectors: IFN-alpha/beta/TNF and IFN-gamma/IL-4...
  55. ncbi request reprint Dendritic cells: controllers of the immune system and a new promise for immunotherapy
    Jacques Banchereau
    Baylor Institute for Immunology Research, Dallas, Texas 75204, USA
    Ann N Y Acad Sci 987:180-7. 2003
    ..Another pathway includes plasmacytoid DCs, which promptly secrete large amounts of IFN-alpha/beta viral encounter. Thus, insights into in vivo DC functions are important to understand the launching and modulation of immunity...
  56. ncbi request reprint Hyperthermia enhances CTL cross-priming
    Hongzhen Shi
    Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    J Immunol 176:2134-41. 2006
    ..Thus, heat treatment of tumor cells permits enhanced cross-priming, possibly via up-regulation of both HSPs and tumor Ag expression...
  57. ncbi request reprint Increased blood myeloid dendritic cells and dendritic cell-poietins in Langerhans cell histiocytosis
    Alexandre Rolland
    Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    J Immunol 174:3067-71. 2005
    ..Thus, early hemopoietic cytokines such as FLT3-L, stem cell factor, and M-CSF maybe relevant in LCH pathogenesis and might be considered as novel therapeutic targets...
  58. pmc Cross-regulation of TNF and IFN-alpha in autoimmune diseases
    A Karolina Palucka
    Baylor Institute for Immunology Research, 3434 Live Oak Street, Dallas, TX 75214, USA
    Proc Natl Acad Sci U S A 102:3372-7. 2005
    ..These results, therefore, might provide a mechanistic explanation for the development of anti-dsDNA antibodies and lupus-like syndrome in patients undergoing anti-TNF therapy...
  59. ncbi request reprint TNF skews monocyte differentiation from macrophages to dendritic cells
    Pascale Chomarat
    Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX 75204, USA
    J Immunol 171:2262-9. 2003
    ..Thus, TNF facilitates the induction of adaptive immunity by promoting DC differentiation not only from CD34+ progenitors but also from CD14+ blood precursors...
  60. ncbi request reprint Mobilization of plasmacytoid and myeloid dendritic cells to mucosal sites in children with respiratory syncytial virus and other viral respiratory infections
    Michelle A Gill
    Baylor Institute for Immunology Research, and Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas and Children s Medical Center Dallas, Dallas, Texas 75204, USA
    J Infect Dis 191:1105-15. 2005
    ..Respiratory syncytial virus (RSV) is the principal etiologic agent of bronchiolitis and viral pneumonia in infants and young children. Yet, many aspects of its immunopathogenesis are not well understood...
  61. pmc Dendritic cells and cytokines in human inflammatory and autoimmune diseases
    Patrick Blanco
    CHU Bordeaux, 33076 Bordeaux, France
    Cytokine Growth Factor Rev 19:41-52. 2008
    ....
  62. ncbi request reprint Langerhans cells: daughters of monocytes
    A Karolina Palucka
    Nat Immunol 7:223-4. 2006
  63. doi request reprint Tumour immunity: effector response to tumour and role of the microenvironment
    Alberto Mantovani
    Istituto Clinico Humanitas and Institute of Pathology, University of Milan, Milan, Italy
    Lancet 371:771-83. 2008
    ....
  64. pmc Humanized mice: are we there yet?
    Francesca Macchiarini
    Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Exp Med 202:1307-11. 2005
    ....

Research Grants9

  1. Dendritic Cells and Breast Cancer Immunity
    A Palucka; Fiscal Year: 2004
    ..Overall, this proposal will permit us to demonstrate that efficient breast cancer immunity can be generated and used to reject the tumor thus permitting development of novel treatment modalities in breast cancer. ..
  2. Mice with Human Dendritic Cells to Test Vaccine Potency
    A Palucka; Fiscal Year: 2004
    ..The experiments proposed here would lay ground for further use of SCID-hu/DCs mice to study other vaccines and demonstrate development of protective immunity upon in vivo rechallenge. ..
  3. Diversification of Cytotoxic Effector Cells Via LPS-activated DCs
    Anna Karolina Palucka; Fiscal Year: 2010
    ..Vaccination with DCs could become an option for patients with earlier disease stages. ..
  4. Vaccination with IL-15 DC to Generate Melanoma-specific Protective Memory T Cells
    Anna Karolina Palucka; Fiscal Year: 2010
    ..Current therapies have the potential to improve outcome in a fraction of patients but are associated with considerable toxicity. Vaccination with melanoma antigen-loaded dendritic cells (DCs) could improve outcomes without toxicity. ..