S Y Roth

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. ncbi Histone acetyltransferases
    S Y Roth
    Department of Biochemistry and Molecular Biology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Annu Rev Biochem 70:81-120. 2001
  2. ncbi Ssn6-Tup1 interacts with class I histone deacetylases required for repression
    A D Watson
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Genes Dev 14:2737-44. 2000
  3. ncbi Essential and redundant functions of histone acetylation revealed by mutation of target lysines and loss of the Gcn5p acetyltransferase
    W Zhang
    Department of Biochemistry and Molecular Biology, U T M D Anderson Cancer Center, Houston, TX 77030, USA
    EMBO J 17:3155-67. 1998
  4. ncbi Loss of Gcn5l2 leads to increased apoptosis and mesodermal defects during mouse development
    W Xu
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Nat Genet 26:229-32. 2000
  5. ncbi Recruitment of the yeast Tup1p-Ssn6p repressor is associated with localized decreases in histone acetylation
    J R Bone
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 276:1808-13. 2001
  6. ncbi Amino termini of histones H3 and H4 are required for a1-alpha2 repression in yeast
    L Huang
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Mol Cell Biol 17:6555-62. 1997
  7. ncbi Mammalian GCN5 and P/CAF acetyltransferases have homologous amino-terminal domains important for recognition of nucleosomal substrates
    W Xu
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Cell Biol 18:5659-69. 1998
  8. ncbi Identification of protein interactions by far Western analysis
    D G Edmondson
    M.D. Anderson Cancer Center, Houston, Texas, USA
    Curr Protoc Mol Biol . 2001
  9. ncbi Identification of protein interactions by far Western analysis
    D G Edmondson
    M.D. Anderson Cancer Center, Houston, Texas, USA
    Curr Protoc Cell Biol . 2001
  10. ncbi Repression domain of the yeast global repressor Tup1 interacts directly with histones H3 and H4
    D G Edmondson
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Genes Dev 10:1247-59. 1996

Collaborators

Detail Information

Publications13

  1. ncbi Histone acetyltransferases
    S Y Roth
    Department of Biochemistry and Molecular Biology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Annu Rev Biochem 70:81-120. 2001
    ..Although the functions of HATs and the mechanisms by which they are regulated are only beginning to be understood, these fundamental processes are likely to have far-reaching implications for human biology and disease...
  2. ncbi Ssn6-Tup1 interacts with class I histone deacetylases required for repression
    A D Watson
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Genes Dev 14:2737-44. 2000
    ..Strikingly, two of these class I HDACs interact physically with Ssn6-Tup1. These findings suggest that Ssn6-Tup1 actively recruits deacetylase activities to deacetylate adjacent nucleosomes and promote Tup1-histone interactions...
  3. ncbi Essential and redundant functions of histone acetylation revealed by mutation of target lysines and loss of the Gcn5p acetyltransferase
    W Zhang
    Department of Biochemistry and Molecular Biology, U T M D Anderson Cancer Center, Houston, TX 77030, USA
    EMBO J 17:3155-67. 1998
    ....
  4. ncbi Loss of Gcn5l2 leads to increased apoptosis and mesodermal defects during mouse development
    W Xu
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Nat Genet 26:229-32. 2000
    ..Our studies are the first to demonstrate that specific acetyltransferases are required for cell survival and mesoderm formation during mammalian development...
  5. ncbi Recruitment of the yeast Tup1p-Ssn6p repressor is associated with localized decreases in histone acetylation
    J R Bone
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 276:1808-13. 2001
    ..Taken together, our results suggest that stable decreases in histone acetylation levels are directed and/or maintained by the Tup1p-Ssn6p repressor complex...
  6. ncbi Amino termini of histones H3 and H4 are required for a1-alpha2 repression in yeast
    L Huang
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Mol Cell Biol 17:6555-62. 1997
    ..Our data indicate that chromatin is important to Ssn6-Tup1-mediated repression but that the degrees of chromatin organization directed by these proteins differ at different promoters...
  7. ncbi Mammalian GCN5 and P/CAF acetyltransferases have homologous amino-terminal domains important for recognition of nucleosomal substrates
    W Xu
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Cell Biol 18:5659-69. 1998
    ..Thus, the unique amino-terminal domains of mammalian P/CAF and GCN5 may provide additional functions important to recognition of chromatin substrates and the regulation of gene expression...
  8. ncbi Identification of protein interactions by far Western analysis
    D G Edmondson
    M.D. Anderson Cancer Center, Houston, Texas, USA
    Curr Protoc Mol Biol . 2001
    ..This method is performed totally in vitro, and the proteins of interest can be prepared in a variety of ways...
  9. ncbi Identification of protein interactions by far Western analysis
    D G Edmondson
    M.D. Anderson Cancer Center, Houston, Texas, USA
    Curr Protoc Cell Biol . 2001
    ..This technique utilizes a nonantibody protein probe to detect interacting proteins immobilized on a membrane support. Proteins to be assayed can be prepared by multiple techniques and detected by several labeling schemes...
  10. ncbi Repression domain of the yeast global repressor Tup1 interacts directly with histones H3 and H4
    D G Edmondson
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Genes Dev 10:1247-59. 1996
    ..Tup1/histone interactions are negatively influenced by high levels of histone acetylation, suggesting a mechanism whereby the organization of chromatin may be modulated in response to changing environmental signals...
  11. ncbi Conservation of histone binding and transcriptional repressor functions in a Schizosaccharomyces pombe Tup1p homolog
    Y Mukai
    Department of Biotechnology, Graduate School of Engineering, Osaka University, Suita, Osaka 565 0871, Japan
    Mol Cell Biol 19:8461-8. 1999
    ..pombe. Furthermore, Tup11p binds specifically to histones H3 and H4 in vitro, indicating that both the repression and histone binding functions of Tup1p-related proteins are conserved across species...
  12. ncbi Transcription-linked acetylation by Gcn5p of histones H3 and H4 at specific lysines
    M H Kuo
    Department of Biology, University of Rochester, New York 14627, USA
    Nature 383:269-72. 1996
    ....
  13. ncbi Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activation
    J E Brownell
    Department of Biology, University of Rochester, New York, 14627, USA
    Cell 84:843-51. 1996
    ..These findings shed light on the biochemical function of the evolutionarily conserved Gcn5p-Ada complex, directly linking histone acetylation to gene activation, and indicate that histone acetylation is a targeted phenomenon...