JEFFREY contact ROSEN

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. pmc Stem cell antigen-1 (sca-1) regulates mammary tumor development and cell migration
    Torey D Batts
    Interdepartmental Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 6:e27841. 2011
  2. pmc Pregnancy-induced noncoding RNA (PINC) associates with polycomb repressive complex 2 and regulates mammary epithelial differentiation
    Amy N Shore
    Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS Genet 8:e1002840. 2012
  3. pmc P190B RhoGAP has pro-tumorigenic functions during MMTV-Neu mammary tumorigenesis and metastasis
    Peter R McHenry
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, South Bend, 46617, USA
    Breast Cancer Res 12:R73. 2010
  4. pmc Prospective isolation and characterization of committed and multipotent progenitors from immortalized mouse mammary epithelial cells with morphogenic potential
    Frances S Kittrell
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Breast Cancer Res 13:R41. 2011
  5. pmc Keratin 6 is not essential for mammary gland development
    Sandra L Grimm
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Breast Cancer Res 8:R29. 2006
  6. pmc Stop! In the name of transforming growth factor-beta: keeping estrogen receptor-alpha-positive mammary epithelial cells from proliferating
    Sandra L Grimm
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Breast Cancer Res 8:106. 2006
  7. pmc Estrogen regulation of mammary gland development and breast cancer: amphiregulin takes center stage
    Heather L LaMarca
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Baylor Plaza, Houston, TX 77030, USA
    Breast Cancer Res 9:304. 2007
  8. pmc Haploinsufficiency for p190B RhoGAP inhibits MMTV-Neu tumor progression
    Brandy M Heckman-Stoddard
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Breast Cancer Res 11:R61. 2009
  9. pmc An intraductal human-in-mouse transplantation model mimics the subtypes of ductal carcinoma in situ
    Fariba Behbod
    Department of Pathology and Laboratory Medicine, The University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Breast Cancer Res 11:R66. 2009

Research Grants

  1. HORMONAL REGULATION OF BREAST CANCER
    Jeffrey Rosen; Fiscal Year: 2000
  2. HORMONAL REGULATION OF BREAST CANCER
    Jeffrey Rosen; Fiscal Year: 2001
  3. HORMONAL REGULATION OF BREAST CANCER
    Jeffrey Rosen; Fiscal Year: 2001
  4. HORMONAL REGULATION OF BREAST CANCER
    Jeffrey Rosen; Fiscal Year: 2001
  5. Therapeutic Targeting of Breast Cancer Tumor Initiating Cells
    JEFFREY contact ROSEN; Fiscal Year: 2010
  6. HORMONAL REGULATION OF BREAST CANCER
    Jeffrey Rosen; Fiscal Year: 1999
  7. HORMONAL REGULATION OF BREAST CANCER
    Jeffrey Rosen; Fiscal Year: 1980

Collaborators

  • Chad J Creighton
  • Kevin Roarty
  • Sandra L Grimm
  • Frances S Kittrell
  • Fariba Behbod
  • Peter R McHenry
  • Brandy M Heckman-Stoddard
  • Heather L LaMarca
  • Amy N Shore
  • Yiqun Zhang
  • Torey D Batts
  • Sofia Kerbawy
  • Daniel Medina
  • Tracy Vargo-Gogola
  • Susan G Hilsenbeck
  • Matthew P Herrick
  • Marcel E Dinger
  • Martin A Smith
  • Elena B Kabotyanski
  • Wa Xian
  • Arnoud Sonnenberg
  • Mei Zhang
  • Heather L Machado
  • Martha Z Carletti
  • Yi Li
  • Jessica Heestand
  • James C Sears
  • Peggy Chang
  • Lewis A Chodosh
  • Megan Rybarczyk
  • Edward J Gunther
  • Jeffrey Settleman
  • Vivian Jiang
  • D Craig Allred
  • Min Hu
  • Hung Wen Yeh
  • Jessica C Heestand
  • Heather LaMarca
  • Evelin Young
  • David Edwards
  • Purna Mukhopadhyay
  • Kornelia Polyak

Detail Information

Publications9

  1. pmc Stem cell antigen-1 (sca-1) regulates mammary tumor development and cell migration
    Torey D Batts
    Interdepartmental Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 6:e27841. 2011
    ..However, at present the functional role for Sca-1 is poorly defined...
  2. pmc Pregnancy-induced noncoding RNA (PINC) associates with polycomb repressive complex 2 and regulates mammary epithelial differentiation
    Amy N Shore
    Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS Genet 8:e1002840. 2012
    ..Additionally, a PRC2 complex that includes mPINC and RbAp46 may confer epigenetic modifications that maintain a population of mammary epithelial cells committed to the alveolar fate in the involuted gland...
  3. pmc P190B RhoGAP has pro-tumorigenic functions during MMTV-Neu mammary tumorigenesis and metastasis
    Peter R McHenry
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, South Bend, 46617, USA
    Breast Cancer Res 12:R73. 2010
    ..To further investigate the potential pro-tumorigenic actions of p190B, we examined the effects of exogenous p190B expression within the mammary epithelium on MMTV-Neu tumor formation and progression...
  4. pmc Prospective isolation and characterization of committed and multipotent progenitors from immortalized mouse mammary epithelial cells with morphogenic potential
    Frances S Kittrell
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Breast Cancer Res 13:R41. 2011
    ....
  5. pmc Keratin 6 is not essential for mammary gland development
    Sandra L Grimm
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Breast Cancer Res 8:R29. 2006
    ....
  6. pmc Stop! In the name of transforming growth factor-beta: keeping estrogen receptor-alpha-positive mammary epithelial cells from proliferating
    Sandra L Grimm
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Breast Cancer Res 8:106. 2006
    ....
  7. pmc Estrogen regulation of mammary gland development and breast cancer: amphiregulin takes center stage
    Heather L LaMarca
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Baylor Plaza, Houston, TX 77030, USA
    Breast Cancer Res 9:304. 2007
    ..These studies implicate a critical role for amphiregulin in mammary stem cell differentiation as well as breast cancer initiation and progression...
  8. pmc Haploinsufficiency for p190B RhoGAP inhibits MMTV-Neu tumor progression
    Brandy M Heckman-Stoddard
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Breast Cancer Res 11:R61. 2009
    ..P190B is required for mammary gland morphogenesis, and overexpression of p190B in the mammary gland induces hyperplastic lesions. Hence, we hypothesized that p190B may play a pivotal role in mammary tumorigenesis...
  9. pmc An intraductal human-in-mouse transplantation model mimics the subtypes of ductal carcinoma in situ
    Fariba Behbod
    Department of Pathology and Laboratory Medicine, The University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Breast Cancer Res 11:R66. 2009
    ..The resulting models, which mimicked some of the diversity of human noninvasive breast cancers in vivo, were used to show whether subtypes of human DCIS might contain distinct subpopulations of tumor-initiating cells...

Research Grants24

  1. HORMONAL REGULATION OF BREAST CANCER
    Jeffrey Rosen; Fiscal Year: 2000
    ..In Aim 5, the role of p53 and apoptosis in mammary carcinogenesis induced by chemical carcinogens and by the overexpression of IGF1 will be studied. ..
  2. HORMONAL REGULATION OF BREAST CANCER
    Jeffrey Rosen; Fiscal Year: 2001
    ..In Aim 5, the role of p53 and apoptosis in mammary carcinogenesis induced by chemical carcinogens and by the overexpression of IGF1 will be studied. ..
  3. HORMONAL REGULATION OF BREAST CANCER
    Jeffrey Rosen; Fiscal Year: 2001
    ..In Aim 5, the role of p53 and apoptosis in mammary carcinogenesis induced by chemical carcinogens and by the overexpression of IGF1 will be studied. ..
  4. HORMONAL REGULATION OF BREAST CANCER
    Jeffrey Rosen; Fiscal Year: 2001
    ..In Aim 5, the role of p53 and apoptosis in mammary carcinogenesis induced by chemical carcinogens and by the overexpression of IGF1 will be studied. ..
  5. Therapeutic Targeting of Breast Cancer Tumor Initiating Cells
    JEFFREY contact ROSEN; Fiscal Year: 2010
    ..These now provide novel models for the elucidation of critical signaling pathways and therapeutics required to eliminate these cells. ..
  6. HORMONAL REGULATION OF BREAST CANCER
    Jeffrey Rosen; Fiscal Year: 1999
    ..In Aim 5, the role of p53 and apoptosis in mammary carcinogenesis induced by chemical carcinogens and by the overexpression of IGF1 will be studied. ..
  7. HORMONAL REGULATION OF BREAST CANCER
    Jeffrey Rosen; Fiscal Year: 1980
    ..No unique tumor-specific sequences were identified and the primary differences appeared to be in the different abundancies of certain RNAs, especially the milk protein mRNAs...