Research Topics
Genomes and Genes | Joanne RichardsSummaryAffiliation: Baylor College of Medicine Country: USA Publications
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Publications
Expression of FKHR, FKHRL1, and AFX genes in the rodent ovary: evidence for regulation by IGF-I, estrogen, and the gonadotropinsJoAnne S Richards
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Mol Endocrinol 16:580-99. 2002..Thus, as a target of FSH (cAMP), E2 and IGF-I signaling in granulosa cells, FKHR likely coordinates numerous cell survival mechanisms...- New signaling pathways for hormones and cyclic adenosine 3',5'-monophosphate action in endocrine cellsJ S Richards
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 3498, USA
Mol Endocrinol 15:209-18. 2001..Thus, FSH and TSH activation of PKB and Sgk may occur via this alternative cAMP pathway that involves cAMP-GEFs and the activation of the PI3-K/PDK1 pathway... - Molecular mechanisms of ovulation and luteinizationJ S Richards
Baylor College of Medicine, Houston, TX 77030, USA
Mol Cell Endocrinol 145:47-54. 1998..The complex series of events involves specific ovarian cell types, diverse signaling pathways and temporally controlled expression of specific genes. This review will focus on several genes shown to control the ovulation process... - Graafian follicle function and luteinization in nonprimatesJ S Richards
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
J Soc Gynecol Investig 8:S21-3. 2001..The dramatic reprogramming of gene expression in granulosa cells leading to that of luteal cells is complete within 5 to 7 hours and is irreversible... - Ovulation: new dimensions and new regulators of the inflammatory-like responseJoAnne S Richards
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Annu Rev Physiol 64:69-92. 2002.... - Novel signaling pathways that control ovarian follicular development, ovulation, and luteinizationJoAnne S Richards
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Recent Prog Horm Res 57:195-220. 2002..Whereas PR appears to regulate the induction of novel proteases, COX-2 appears to regulate cumulus expansion. This review summarizes some new aspects of peptide and steroid hormone signaling in the rodent ovary... - Regulated expression of ADAMTS family members in follicles and cumulus oocyte complexes: evidence for specific and redundant patterns during ovulationJoAnne S Richards
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Biol Reprod 72:1241-55. 2005.... - Immune-like mechanisms in ovulationJoAnne S Richards
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA
Trends Endocrinol Metab 19:191-6. 2008.... - Genetics of ovulationJoAnne S Richards
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Semin Reprod Med 25:235-42. 2007..Novel signaling molecules include members of the WNT/FRIZZLED family, the BMP family, and transcription factors. Some of these novel genes may become useful predictors of ovulation success and/or embryo health and viability... - The ovary: basic biology and clinical implicationsJoAnne S Richards
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
J Clin Invest 120:963-72. 2010.... - Ovulation: new factors that prepare the oocyte for fertilizationJoAnne S Richards
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Mol Cell Endocrinol 234:75-9. 2005..Thus, HA binding proteins and associated factors appear to be essential components of the matrix that is obligatory for release of the COCs through the ovulation pore... - Hormone-induced proliferation and differentiation of granulosa cells: a coordinated balance of the cell cycle regulators cyclin D2 and p27Kip1R L Robker
Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Mol Endocrinol 12:924-40. 1998.... - Ovarian cell differentiation: a cascade of multiple hormones, cellular signals, and regulated genesJ S Richards
Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Recent Prog Horm Res 50:223-54. 1995..GnRH has been used in several studies to examine the ability of the protein kinase C pathway to mimic effects of high LH.(ABSTRACT TRUNCATED AT 250 WORDS).. - Ovulation: a multi-gene, multi-step processR L Robker
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Steroids 65:559-70. 2000..Furthermore, mRNAs encoding cathepsin L and ADAMTS-1 are reduced in the PRKO mice compared to their wild-type littermates. These novel observations indicate that these two proteases regulate some key step(s) controlling ovulation... - Hormonal regulation, localization, and functional activity of the progesterone receptor in granulosa cells of rat preovulatory folliclesU Natraj
Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030
Endocrinology 133:761-9. 1993.... - Progesterone-regulated genes in the ovulation process: ADAMTS-1 and cathepsin L proteasesR L Robker
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 97:4689-94. 2000.... - Regulation of AP1 (Jun/Fos) factor expression and activation in ovarian granulosa cells. Relation of JunD and Fra2 to terminal differentiationS C Sharma
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
J Biol Chem 275:33718-28. 2000.... - Cyclic AMP-dependent and -independent regulation of cholesterol side chain cleavage cytochrome P-450 (P-450scc) in rat ovarian granulosa cells and corpora lutea. cDNA and deduced amino acid sequence of rat P-450sccR B Oonk
Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030
J Biol Chem 264:21934-42. 1989..These data suggest that expression of the P-450scc gene in rat ovarian follicular cells is regulated in a sequential manner by cAMP-dependent and cAMP-independent mechanisms associated with granulosa cells and luteal cells, respectively... - Differentiation-dependent prolactin responsiveness and stat (signal transducers and activators of transcription) signaling in rat ovarian cellsD L Russell
Baylor College of Medicine, Department of Cell Biology, Houston, Texas 77030, USA
Mol Endocrinol 13:2049-64. 1999..luteinization... - An E-box region within the prostaglandin endoperoxide synthase-2 (PGS-2) promoter is required for transcription in rat ovarian granulosa cellsJ K Morris
Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
J Biol Chem 271:16633-43. 1996.... - Identification and characterization of the GC-rich and cyclic adenosine 3',5'-monophosphate (cAMP)-inducible promoter of the type II beta cAMP-dependent protein kinase regulatory subunit geneR C Kurten
Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030
Mol Endocrinol 6:536-50. 1992.... - Aromatase cytochrome P450 in rat ovarian granulosa cells before and after luteinization: adenosine 3',5'-monophosphate-dependent and independent regulation. Cloning and sequencing of rat aromatase cDNA and 5' genomic DNAG J Hickey
Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030
Mol Endocrinol 4:3-12. 1990..Thus, rapid cellular and molecular events occur in granulosa cells within 5-7 h after an ovulatory LH/hCG surge that alter the hormonal regulation of the aromatase gene... - Identification of a cyclic adenosine 3',5'-monophosphate-response element in the rat aromatase promoter that is required for transcriptional activation in rat granulosa cells and R2C leydig cellsS L Fitzpatrick
Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030
Mol Endocrinol 8:1309-19. 1994..The presence of identical SF-1 and CRE-like sequences in the human ovarian aromatase promoter II suggests that the human promoter may also be regulated in a similar manner... - Steroidogenic factor-1 binding and transcriptional activity of the cholesterol side-chain cleavage promoter in rat granulosa cellsJ W Clemens
Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030
Endocrinology 134:1499-508. 1994.... - Purification and characterization of a novel, distinct isoform of prostaglandin endoperoxide synthase induced by human chorionic gonadotropin in granulosa cells of rat preovulatory folliclesJ Sirois
Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030
J Biol Chem 267:6382-8. 1992.... - Expression of Drosophila neoplastic tumor suppressor genes discslarge, scribble, and lethal giant larvae in the mammalian ovaryJulie H Y Huang
Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Gene Expr Patterns 3:3-11. 2003..Our data suggests that as in Drosophila, these tumor suppressors may cooperate during mammalian folliculogenesis, but also have distinct functions... - Transcriptional regulation of p21/CIP1 cell cycle inhibitor by PDEF controls cell proliferation and mammary tumor progressionJeremy S Schaefer
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
J Biol Chem 285:11258-69. 2010..This study conclusively proves that PDEF is a breast tumor suppressor for the first time using both in vitro and in vivo systems. PDEF can be further developed as a target for designing therapeutic intervention of breast cancer... - Rat cholesterol side-chain cleavage cytochrome P-450 (P-450scc) gene. Structure and regulation by cAMP in vitroR B Oonk
Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030
J Biol Chem 265:22392-401. 1990..Thus, the cAMP domains specific to this and other steroidogenic genes remain to be clearly identified... - Hyaluronan fragments generated by sperm-secreted hyaluronidase stimulate cytokine/chemokine production via the TLR2 and TLR4 pathway in cumulus cells of ovulated COCs, which may enhance fertilizationMasayuki Shimada
Department of Applied Animal Science, Graduate School of Biosphere Science, Hiroshima University, Higashi Hiroshima, Hiroshima, 739 8528, Japan
Development 135:2001-11. 2008.... - TAF4b, a TBP associated factor, is required for oocyte development and functionAllison E Falender
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Dev Biol 288:405-19. 2005..Thus, infertility in Taf4b null female mice is associated with defects in early follicle formation, oocyte maturation, and zygotic cleavage following ovulation and fertilization... - Dominant-stable beta-catenin expression causes cell fate alterations and Wnt signaling antagonist expression in a murine granulosa cell tumor modelDerek Boerboom
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Cancer Res 66:1964-73. 2006..Together, these results suggest that misregulated Wnt/beta-catenin signaling alters the fate of granulosa cells and that the GCT that arise in Catnb(flox(ex3)/+);Amhr2(cre/+) mice result from the clonal expansion of metaplastic cells... - Gene expression profiles of cumulus cell oocyte complexes during ovulation reveal cumulus cells express neuronal and immune-related genes: does this expand their role in the ovulation process?Inmaculada Hernandez-Gonzalez
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Mol Endocrinol 20:1300-21. 2006.... - Paracrine and autocrine regulation of epidermal growth factor-like factors in cumulus oocyte complexes and granulosa cells: key roles for prostaglandin synthase 2 and progesterone receptorMasayuki Shimada
Department of Molecular Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Mol Endocrinol 20:1352-65. 2006.... - Induced expression of pattern recognition receptors in cumulus oocyte complexes: novel evidence for innate immune-like functions during ovulationMasayuki Shimada
Department of Molecular Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Mol Endocrinol 20:3228-39. 2006..Collectively, these results provide novel evidence that cumulus cells as well as granulosa cells express innate immune related genes that may play critical roles in surveillance and cell survival during the ovulation process... - Follicle-stimulating hormone induces multiple signaling cascades: evidence that activation of Rous sarcoma oncogene, RAS, and the epidermal growth factor receptor are critical for granulosa cell differentiationChad M Wayne
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Mol Endocrinol 21:1940-57. 2007.... - Synaptosomal-associated protein 25 gene expression is hormonally regulated during ovulation and is involved in cytokine/chemokine exocytosis from granulosa cellsMasayuki Shimada
Department of Applied Animal Science, Graduate School of Biosphere Science, Hiroshima University, 1 4 4, Kagamiyama, Higashi Hiroshima, Hiroshima 739 8528, Japan
Mol Endocrinol 21:2487-502. 2007..From these results, we conclude that progesterone-progesterone receptor-mediated SNAP25 expression in cumulus oocyte complexes and granulosa cells regulates cytokine and chemokine secretion via an exocytosis system... - Hormone-induced expression of tumor necrosis factor alpha-converting enzyme/A disintegrin and metalloprotease-17 impacts porcine cumulus cell oocyte complex expansion and meiotic maturation via ligand activation of the epidermal growth factor receptorYasuhisa Yamashita
Department of Applied Animal Science, Graduate School of Biosphere Science, Hiroshima University, 1 4 4 Kagamiyama, Higashi Hiroshima, Japan
Endocrinology 148:6164-75. 2007..Thus, TACE/ADAM17 is induced and the activity is involved in porcine COC expansion as well as oocyte meiotic maturation through the activation of EGF receptor in cumulus cells... - Regulated expression of ADAM8 (a disintegrin and metalloprotease domain 8) in the mouse ovary: evidence for a regulatory role of luteinizing hormone, progesterone receptor, and epidermal growth factor-like growth factorsVenkataraman Sriraman
Institute of Genetechnology Microbiology, University of Bielefeld, D 33501 Bielefeld, Germany
Biol Reprod 78:1038-48. 2008..To our knowledge, ADAM8 is the first member of the ADAM family shown to be hormonally regulated... - Targeted disruption of Pten in ovarian granulosa cells enhances ovulation and extends the life span of luteal cellsHeng Yu Fan
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Mol Endocrinol 22:2128-40. 2008.... - Selective expression of KrasG12D in granulosa cells of the mouse ovary causes defects in follicle development and ovulationHeng Yu Fan
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Development 135:2127-37. 2008..Transient but not sustained activation of RAS in granulosa cells is therefore crucial for directing normal follicle development and initiating the ovulation process... - Cyclic guanosine 5'-monophosphate-dependent protein kinase II is induced by luteinizing hormone and progesterone receptor-dependent mechanisms in granulosa cells and cumulus oocyte complexes of ovulating folliclesVenkataraman Sriraman
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Mol Endocrinol 20:348-61. 2006.... - Mice null for Frizzled4 (Fzd4-/-) are infertile and exhibit impaired corpora lutea formation and functionMinnie Hsieh
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Biol Reprod 73:1135-46. 2005..Thus, Fzd4 appears to impact the formation of the corpus luteum by mechanisms that more closely phenocopy Prlr null mice... - Egr-1 induction in rat granulosa cells by follicle-stimulating hormone and luteinizing hormone: combinatorial regulation by transcription factors cyclic adenosine 3',5'-monophosphate regulatory element binding protein, serum response factor, sp1, and earlDarryl L Russell
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Mol Endocrinol 17:520-33. 2003..These observations indicate that the Egr-1 gene is a target of both FSH and LH action that may mediate molecular programs of proliferation and/or differentiation during follicle growth, ovulation, and luteinization... - Transactivation of the progesterone receptor gene in granulosa cells: evidence that Sp1/Sp3 binding sites in the proximal promoter play a key role in luteinizing hormone inducibilityVenkataraman Sriraman
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Mol Endocrinol 17:436-49. 2003..Rather, Sp1/Sp3 appear to recruit other factors to the promoter... - Decreased expression of tumor necrosis factor-alpha-stimulated gene 6 in cumulus cells of the cyclooxygenase-2 and EP2 null miceScott A Ochsner
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Endocrinology 144:1008-19. 2003..These observations identify TSG-6 as a target of PG action and show that its production in ovulatory follicles is associated with proper formation of the cumulus-derived extracellular matrix... - Hormone-regulated expression and localization of versican in the rodent ovaryDarryl L Russell
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Endocrinology 144:1020-31. 2003..These observations suggest that versican (V0, V1, and V3) is a matrix component of the granulosa layer throughout folliculogenesis and is enriched in remodeling matrices during ovulation and neovascularization of the corpora lutea... - Differential expression of steroidogenic factor-1 and FTF/LRH-1 in the rodent ovaryAllison E Falender
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Endocrinology 144:3598-610. 2003..Collectively these data indicate that granulosa cells of small and preovulatory follicles express both SF-1 and FTF/LRH-1 and that each orphan receptor may regulate target gene expression in these cells... - Processing and localization of ADAMTS-1 and proteolytic cleavage of versican during cumulus matrix expansion and ovulationDarryl L Russell
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
J Biol Chem 278:42330-9. 2003..These observations suggest that one function of ADAMTS-1 in ovulation is to cleave versican in the expanded COC matrix and that the anovulatory phenotype of PRKO mice is at least partially due to loss of this function... - Disrupted function of tumor necrosis factor-alpha-stimulated gene 6 blocks cumulus cell-oocyte complex expansionScott A Ochsner
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Endocrinology 144:4376-84. 2003..Collectively, these results indicate that TSG-6 mRNA is induced in cumulus cells in culture by cAMP and that the secreted TSG-6 protein is a key structural component of the mouse COC matrix... - Expression and localization of secreted frizzled-related protein-4 in the rodent ovary: evidence for selective up-regulation in luteinized granulosa cellsMinnie Hsieh
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Endocrinology 144:4597-606. 2003..Therefore, regulation of sFRP-4 by LH and PRL may be important for modulating Fz-1, which is known to be expressed in periovulatory follicles, and Wnt-4/Fz-4, which are expressed in corpora lutea... - Cathepsin L gene expression and promoter activation in rodent granulosa cellsVenkataraman Sriraman
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Place, Houston, TX 77030, USA
Endocrinology 145:582-91. 2004.... - Small nuclear RING finger protein expression during gonad development: regulation by gonadotropins and estrogen in the postnatal ovarySirpa J Hirvonen-Santti
Biomedicum Helsinki, Institute of Biomedicine Physiology, University of Helsinki, P O Box 63, FIN 00014 Helsinki, Finland
Endocrinology 145:2433-44. 2004..These results suggest a role for SNURF in fetal germ cell development as well as in oocyte and granulosa cell maturation in an estrogen- and gonadotropin-regulated fashion... - Down-regulated expression of A disintegrin and metalloproteinase with thrombospondin-like repeats-1 by progesterone receptor antagonist is associated with impaired expansion of porcine cumulus-oocyte complexesMasayuki Shimada
Department of Applied Animal Science, Graduate School of Biosphere Science, Hiroshima University, Higashi Hiroshima, Hiroshima 739 8528, Japan
Endocrinology 145:4603-14. 2004..These results suggest that the expression and induction of ADAMTS-1 through receptor-mediated action of progesterone in cumulus cells is one of the essential requirements for gonadotropin-regulated cumulus expansion of porcine COCs... - Coordinate transcription of the ADAMTS-1 gene by luteinizing hormone and progesterone receptorKari M H Doyle
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Mol Endocrinol 18:2463-78. 2004..In summary, LH and PRA/B exert distinct but coordinate effects on transactivation of the ADAMTS-1 gene in granulosa cells in vivo and in vitro with PR acting as an inducible coregulator of the ADAMTS-1 gene... - Temporal and spatial patterns of ovarian gene transcription following an ovulatory dose of gonadotropin in the ratLawrence L Espey
Department of Biology, Trinity University, San Antonio, Texas 78212, USA
Biol Reprod 67:1662-70. 2002..The overwhelming impression is that the molecular events of ovulation are far more complex, and therefore more highly ordered, than originally imagined... - Maintenance of spermatogenesis requires TAF4b, a gonad-specific subunit of TFIIDAllison E Falender
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Genes Dev 19:794-803. 2005.... - Regulation of the Rhox5 homeobox gene in primary granulosa cells: preovulatory expression and dependence on SP1/SP3 and GABPJames A Maclean
Department of Immunology, The University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
Biol Reprod 73:1126-34. 2005.... - Regulated expression of Wnts and Frizzleds at specific stages of follicular development in the rodent ovaryMinnie Hsieh
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Endocrinology 143:898-908. 2002..Thus, specific Wnt/Fz are expressed at distinct stages of follicular development, suggesting multiple functions for this signaling pathway in the ovary... - The involvement of the Toll-like receptor family in ovulationZhilin Liu
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA
J Assist Reprod Genet 25:223-8. 2008..However, the expression and function of innate immune cell-related genes in non-immune cells within the ovary has been reported recently and provides a novel and important regulatory system during ovulation...
Research Grants
- OVARIAN FOLLICULAR DEVELOPMENT AND HORMONE ACTIONJoanne Richards; Fiscal Year: 2002....
- LH ACTION IN OVARIAN CELL DIFFERENTIATIONJoanne Richards; Fiscal Year: 2007..A related and longer term goal of the research is to identify and characterize the genes regulated by LH, prostaglandins (PGs), and C/EBPs that control key steps in the ovulatory process. ..
- Ovarian Follicular Developmental and Hormone ActionJoanne Richards; Fiscal Year: 2007..3) Determine the molecular, cellular and hormonal basis of the altered ovarian phenotype of the TAFII105 null mice. 4) Determine the function of Wnt-4 in the adult ovary. ..
- LH ACTION IN OVARIAN CELL DIFFERENTIATIONJoanne Richards; Fiscal Year: 2009..This information should help us understand the basis for infertility in women who have abnormal menstrual cycles, reduced ovarian function and are anovulatory. ..
- LH ACTION IN OVARIAN CELL DIFFERENTIATIONJoAnne S Richards; Fiscal Year: 2010..This information should help us understand the basis for infertility in women who have abnormal menstrual cycles, reduced ovarian function and are anovulatory. ..
- OVARIAN FOLLICULAR DEVELOPMENT AND HORMONE ACTIONJoanne Richards; Fiscal Year: 1993..Using these approaches we hope to determine the molecular events that mediate cAMP and estradiol action during granulosa cell differentiation...
- LH ACTION IN OVARIAN CELL DIFFERENTIATIONJoanne Richards; Fiscal Year: 1993..Understanding the regulation of these genes should provide greater insight into the events controlling ovulation and luteinization, and perhaps the broader areas of inflammation and terminal cell differentiation, respectively...
- LH ACTION IN OVARIAN CELL DIFFERENTIATIONJoAnne S Richards; Fiscal Year: 2010..This information should help us understand the basis for infertility in women who have abnormal menstrual cycles, reduced ovarian function and are anovulatory. ..