Matthew Rasband

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. doi request reprint Cytoskeleton: axons earn their stripes
    Matthew N Rasband
    Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Curr Biol 23:R197-8. 2013
  2. pmc Composition, assembly, and maintenance of excitable membrane domains in myelinated axons
    Matthew N Rasband
    Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, United States
    Semin Cell Dev Biol 22:178-84. 2011
  3. pmc Clustered K+ channel complexes in axons
    Matthew N Rasband
    Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, United States
    Neurosci Lett 486:101-6. 2010
  4. doi request reprint The axon initial segment and the maintenance of neuronal polarity
    Matthew N Rasband
    Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nat Rev Neurosci 11:552-62. 2010
  5. pmc Na+ channels get anchored...with a little help
    Matthew N Rasband
    Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
    J Cell Biol 183:975-7. 2008
  6. pmc Neurofascin assembles a specialized extracellular matrix at the axon initial segment
    Kristian L Hedstrom
    Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06032, USA
    J Cell Biol 178:875-86. 2007
  7. doi request reprint Spectrin and ankyrin-based cytoskeletons at polarized domains in myelinated axons
    Keiichiro Susuki
    Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Exp Biol Med (Maywood) 233:394-400. 2008
  8. pmc betaIV spectrin is recruited to axon initial segments and nodes of Ranvier by ankyrinG
    Yang Yang
    Department of Neuroscience, University of Connecticut Health Center, University of Connecticut, Farmington, CT 06032, USA
    J Cell Biol 176:509-19. 2007
  9. doi request reprint The functional organization and assembly of the axon initial segment
    Yasuhiro Ogawa
    Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Curr Opin Neurobiol 18:307-13. 2008
  10. pmc Disruption of the axon initial segment cytoskeleton is a new mechanism for neuronal injury
    Dorothy P Schafer
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06032, USA
    J Neurosci 29:13242-54. 2009

Research Grants

  1. Neuroglial Interactions at the Node of Ranvier
    Matthew Rasband; Fiscal Year: 2009
  2. Neuroglial Interactions at the Node of Ranvier
    Matthew N Rasband; Fiscal Year: 2010
  3. Neuroglial Interactions at the Node of Ranvier
    Matthew Rasband; Fiscal Year: 2006
  4. Mechanisms of CNS node of Ranvier formation
    Matthew N Rasband; Fiscal Year: 2010

Collaborators

Detail Information

Publications28

  1. doi request reprint Cytoskeleton: axons earn their stripes
    Matthew N Rasband
    Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Curr Biol 23:R197-8. 2013
    ..New 'super-resolution' imaging of the submembranous axonal cytoskeleton reveals that it is organized in a periodic, ladder-like structure with alternating rings of actin linked together by intervening complexes of spectrin...
  2. pmc Composition, assembly, and maintenance of excitable membrane domains in myelinated axons
    Matthew N Rasband
    Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, United States
    Semin Cell Dev Biol 22:178-84. 2011
    ..Proper assembly and maintenance of these domains is necessary for action potential generation and propagation, and the overall function of the neuron...
  3. pmc Clustered K+ channel complexes in axons
    Matthew N Rasband
    Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, United States
    Neurosci Lett 486:101-6. 2010
    ..These interacting proteins play important roles in recruiting K+ channels to distinct axonal domains. Here, I review the composition, functions, and mechanism of localization of these K+ channel complexes in axons...
  4. doi request reprint The axon initial segment and the maintenance of neuronal polarity
    Matthew N Rasband
    Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nat Rev Neurosci 11:552-62. 2010
    ..Here, I review the role of the AIS in the development and maintenance of neuronal polarity and discuss how disrupted polarity may be a common component of many diseases and injuries that affect the nervous system...
  5. pmc Na+ channels get anchored...with a little help
    Matthew N Rasband
    Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
    J Cell Biol 183:975-7. 2008
    ..The presence of CK2 at the axon initial segment and nodes of Ranvier provides a mechanism to regulate the specific accumulation and retention of Na(+) channels within these important domains...
  6. pmc Neurofascin assembles a specialized extracellular matrix at the axon initial segment
    Kristian L Hedstrom
    Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06032, USA
    J Cell Biol 178:875-86. 2007
    ..Thus, NF-186 assembles and links the specialized brevican-containing AIS extracellular matrix to the intracellular cytoskeleton...
  7. doi request reprint Spectrin and ankyrin-based cytoskeletons at polarized domains in myelinated axons
    Keiichiro Susuki
    Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Exp Biol Med (Maywood) 233:394-400. 2008
    ..Increased insights into the role of the cytoskeleton could provide important clues about the pathophysiology of various neurological disorders...
  8. pmc betaIV spectrin is recruited to axon initial segments and nodes of Ranvier by ankyrinG
    Yang Yang
    Department of Neuroscience, University of Connecticut Health Center, University of Connecticut, Farmington, CT 06032, USA
    J Cell Biol 176:509-19. 2007
    ..Finally, using adenovirus for transgene delivery into myelinated neurons, we demonstrate that betaIV spectrin recruitment to nodes of Ranvier also depends on binding to ankG...
  9. doi request reprint The functional organization and assembly of the axon initial segment
    Yasuhiro Ogawa
    Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Curr Opin Neurobiol 18:307-13. 2008
    ....
  10. pmc Disruption of the axon initial segment cytoskeleton is a new mechanism for neuronal injury
    Dorothy P Schafer
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06032, USA
    J Neurosci 29:13242-54. 2009
    ..We conclude that loss of AIS ion channel clusters and neuronal polarity are important contributors to neuronal dysfunction after injury, and that strategies to facilitate recovery must preserve or repair the AIS cytoskeleton...
  11. ncbi request reprint Neuron-glia interactions at the node of Ranvier
    Matthew N Rasband
    Department of Neuroscience, University of Connecticut Health Center, Farmington 06030 3401, USA
    Results Probl Cell Differ 43:129-49. 2006
    ..This review will discuss several examples illustrating how myelinating glia actively regulate the excitable properties of axons including the kinds of channels expressed and their subcellular localization...
  12. pmc Where is the spike generator of the cochlear nerve? Voltage-gated sodium channels in the mouse cochlea
    Waheeda A Hossain
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Neurosci 25:6857-68. 2005
    ....
  13. ncbi request reprint BetaIV spectrins are essential for membrane stability and the molecular organization of nodes of Ranvier
    Yang Yang
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030 3401, USA
    J Neurosci 24:7230-40. 2004
    ..These results show that quivering mutations disrupt betaIV spectrin retention and stability at nodes and that distinct protein domains regulate nodal structural integrity and molecular organization...
  14. pmc AnkyrinG is required for maintenance of the axon initial segment and neuronal polarity
    Kristian L Hedstrom
    Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06032, USA
    J Cell Biol 183:635-40. 2008
    ..Our results demonstrate that the loss of ankG causes axons to acquire the molecular characteristics of dendrites; thus, ankG is required for the maintenance of neuronal polarity and molecular organization of the AIS...
  15. ncbi request reprint Intrinsic and extrinsic determinants of ion channel localization in neurons
    Kristian L Hedstrom
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Neurochem 98:1345-52. 2006
    ....
  16. pmc Electrical excitability of early neurons in the human cerebral cortex during the second trimester of gestation
    Anna R Moore
    Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030, USA
    Cereb Cortex 19:1795-805. 2009
    ..These results yield the first physiological characterization of developing human fetal cortical neurons with preserved morphologies in intact surrounding brain tissue...
  17. pmc Molecular mechanisms of node of Ranvier formation
    Keiichiro Susuki
    Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston TX 77030, USA
    Curr Opin Cell Biol 20:616-23. 2008
    ..In the central nervous system, both glial soluble factors and paranodal axoglial junctions may function in a complementary manner to contribute to node formation...
  18. ncbi request reprint Paranodal transverse bands are required for maintenance but not initiation of Nav1.6 sodium channel clustering in CNS optic nerve axons
    Matthew N Rasband
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Glia 44:173-82. 2003
    ..6 clusters. Thus, transverse bands are not required for Nav1.6 clustering and localization at nodes or for exclusion of Nav1.2 from myelinated nerve fibers, but are required for the maintenance of nodal Nav1.6 cluster size and density...
  19. ncbi request reprint Spectrins and ankyrinB constitute a specialized paranodal cytoskeleton
    Yasuhiro Ogawa
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Neurosci 26:5230-9. 2006
    ..Our results demonstrate that the paranodal junction contains specialized cytoskeletal components that may be important to stabilize axon-glia interactions and contribute to the membrane protein diffusion barrier found at paranodes...
  20. ncbi request reprint It's "juxta" potassium channel!
    Matthew N Rasband
    Department of Neuroscience, University of Connecticut Health Center, Farmington, 06032, USA
    J Neurosci Res 76:749-57. 2004
    ..Recent advances in our understanding of the composition of juxtaparanodal Kv1 channel protein complexes as well as the cellular and molecular mechanisms underlying their localization at juxtaparanodes are discussed...
  21. ncbi request reprint CNP is required for maintenance of axon-glia interactions at nodes of Ranvier in the CNS
    Matthew N Rasband
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06032, USA
    Glia 50:86-90. 2005
    ..We suggest that CNP is a glial protein required for maintaining the integrity of paranodes and that disrupted axoglial signaling at this site underlies progressive axonal degeneration, observed later in the CNS of Cnp1-null mice...
  22. pmc Proteomic mapping provides powerful insights into functional myelin biology
    Christopher M Taylor
    Department of Neuroscience, MC 3401, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 3401, USA
    Proc Natl Acad Sci U S A 101:4643-8. 2004
    ..This proteomic map has been applied to analyses of the localization and function of selected proteins, providing a powerful tool to investigate the diverse functions of myelin...
  23. pmc Oligodendrocyte myelin glycoprotein does not influence node of ranvier structure or assembly
    Kae Jiun Chang
    Program in Developmental Biology and Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 30:14476-81. 2010
    ..Together, our results strongly argue against the nodal localization of OMgp and its proposed functions at nodes, and reveal OMgp's authentic localization relative to nodes and myelin...
  24. ncbi request reprint Does paranode formation and maintenance require partitioning of neurofascin 155 into lipid rafts?
    Dorothy P Schafer
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06032, USA
    J Neurosci 24:3176-85. 2004
    ..Together, these results suggest that trans interactions between oligodendroglial NF-155 and axonal ligands result in cross-linking, stabilization, and formation of paranodal lipid raft assemblies...
  25. pmc ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons
    Yasuhiro Ogawa
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 30:1038-48. 2010
    ..2 and Caspr2 clustering is normal in ADAM22-null mice. Thus, ADAM22 is an axonal component of the Kv1 K(+) channel complex that recruits MAGUKs to juxtaparanodes...
  26. pmc Postsynaptic density-93 clusters Kv1 channels at axon initial segments independently of Caspr2
    Yasuhiro Ogawa
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 28:5731-9. 2008
    ..In contrast, Caspr2, which mediates Kv1 channel clustering at the juxtaparanode, is not required for localization of Kv1 channels at the AIS. These results show PSD-93 mediates AIS accumulation of Kv1 channels independently of Caspr2...
  27. pmc Proteomic analysis of optic nerve lipid rafts reveals new paranodal proteins
    Yasuhiro Ogawa
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas, USA
    J Neurosci Res 87:3502-10. 2009
    ..Finally, we describe their distribution in dysmyelinating TremblerJ mice, a model for the peripheral neuropathy Charcot-Marie-Tooth disease...
  28. ncbi request reprint Glial regulation of the axonal membrane at nodes of Ranvier
    Dorothy P Schafer
    Department of Neuroscience, University of Connecticut Health Center, 263 Farmington Avenue, Farmington CT 06032, USA
    Curr Opin Neurobiol 16:508-14. 2006
    ..Subsequently, within each domain, axonal cell adhesion molecules are stabilized and retained through interactions with cytoskeletal and scaffolding proteins, including ankyrins and spectrins...

Research Grants11

  1. Neuroglial Interactions at the Node of Ranvier
    Matthew Rasband; Fiscal Year: 2009
    ..Identification of the mechanisms underlying neuron-glia interactions may contribute to better therapeutic treatments designed to preserve these interactions and their contribution to neuronal health and function. ..
  2. Neuroglial Interactions at the Node of Ranvier
    Matthew N Rasband; Fiscal Year: 2010
    ..Identification of the mechanisms underlying neuron-glia interactions may contribute to better therapeutic treatments designed to preserve these interactions and their contribution to neuronal health and function. ..
  3. Neuroglial Interactions at the Node of Ranvier
    Matthew Rasband; Fiscal Year: 2006
    ..abstract_text> ..
  4. Mechanisms of CNS node of Ranvier formation
    Matthew N Rasband; Fiscal Year: 2010
    ....