Matthew N Rasband

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. Zollinger D, Baalman K, Rasband M. The ins and outs of polarized axonal domains. Annu Rev Cell Dev Biol. 2015;31:647-67 pubmed publisher
    ..Here, we discuss the various polarized domains of myelinated axons, how they are established by both intrinsic and extrinsic interactions, and the polarity of myelinating glia. ..
  2. Normand E, Rasband M. Subcellular patterning: axonal domains with specialized structure and function. Dev Cell. 2015;32:459-68 pubmed publisher
    ..In this review, we introduce the concept of subcellular patterning as applied to axons and discuss how these patterning events depend on both intrinsic, cytoskeletal mechanisms and extrinsic, myelinating glia-dependent mechanisms. ..
  3. Rasband M. Glial Contributions to Neural Function and Disease. Mol Cell Proteomics. 2016;15:355-61 pubmed publisher
    ..I describe proteomic approaches that have been used to investigate glial cell function and composition and the experimental limitations faced by investigators working with glia. ..
  4. Wang C, Ortiz Gonzalez X, Yum S, Gill S, White A, Kelter E, et al. βIV Spectrinopathies Cause Profound Intellectual Disability, Congenital Hypotonia, and Motor Axonal Neuropathy. Am J Hum Genet. 2018;102:1158-1168 pubmed publisher
    ..Our findings define a class of spectrinopathies and reveal the molecular pathologies causing nervous-system dysfunction. ..
  5. Rasband M. The axon initial segment and the maintenance of neuronal polarity. Nat Rev Neurosci. 2010;11:552-62 pubmed publisher
    ..Here, I review the role of the AIS in the development and maintenance of neuronal polarity and discuss how disrupted polarity may be a common component of many diseases and injuries that affect the nervous system. ..
  6. Rasband M. Clustered K+ channel complexes in axons. Neurosci Lett. 2010;486:101-6 pubmed publisher
    ..These interacting proteins play important roles in recruiting K+ channels to distinct axonal domains. Here, I review the composition, functions, and mechanism of localization of these K+ channel complexes in axons. ..
  7. Zhang C, Rasband M. Cytoskeletal control of axon domain assembly and function. Curr Opin Neurobiol. 2016;39:116-21 pubmed publisher
    ..Here, we review recent studies that provide significant additional insight into the cytoskeleton-dependent mechanisms controlling the functional organization of axons. ..
  8. Huang Y, Rasband M. Organization of the axon initial segment: Actin like a fence. J Cell Biol. 2016;215:9-11 pubmed
    ..201603108) demonstrate via high-speed single-particle tracking and superresolution microscopy that lipid-anchored molecules in the axon initial segment are confined to membrane domains separated by periodically spaced actin rings. ..
  9. Susuki K, Otani Y, Rasband M. Submembranous cytoskeletons stabilize nodes of Ranvier. Exp Neurol. 2016;283:446-51 pubmed publisher
    ..Glial ankyrins enriched at paranodes facilitate node formation. Finally, disruption of spectrins or ankyrins by genetic mutations or proteolysis is involved in the pathophysiology of various neurological or psychiatric disorders. ..

More Information

Publications16

  1. Marin M, Ziburkus J, JANKOWSKY J, Rasband M. Amyloid-β plaques disrupt axon initial segments. Exp Neurol. 2016;281:93-8 pubmed publisher
    ..This paper demonstrates that neurons near Aβ plaques have disrupted axon initial segments. Loss or disruption of AIS is predicted to have detrimental consequences for brain function. ..
  2. Marin M, de Lima S, Gilbert H, Giger R, Benowitz L, Rasband M. Reassembly of Excitable Domains after CNS Axon Regeneration. J Neurosci. 2016;36:9148-60 pubmed publisher
    ..We show, for the first time, that regenerated CNS axons have the capacity to both remyelinate and reassemble the axon initial segments and nodes of Ranvier necessary for rapid and efficient action potential propagation. ..
  3. Rasband M. Cytoskeleton: axons earn their stripes. Curr Biol. 2013;23:R197-8 pubmed publisher
    ..New 'super-resolution' imaging of the submembranous axonal cytoskeleton reveals that it is organized in a periodic, ladder-like structure with alternating rings of actin linked together by intervening complexes of spectrin...
  4. Baalman K, Marin M, Ho T, Godoy M, Cherian L, Robertson C, et al. Axon initial segment-associated microglia. J Neurosci. 2015;35:2283-92 pubmed publisher
    ..These results reveal a unique population of microglia that specifically interact with the AIS in the adult cortex. ..
  5. Zollinger D, Chang K, Baalman K, Kim S, Rasband M. The Polarity Protein Pals1 Regulates Radial Sorting of Axons. J Neurosci. 2015;35:10474-84 pubmed publisher
    ..Radial sorting is essential for efficient and proper myelination and is disrupted in some types of congenital muscular dystrophy. ..
  6. Huang C, Zhang C, Ho T, Oses Prieto J, Burlingame A, Lalonde J, et al. ?II Spectrin Forms a Periodic Cytoskeleton at the Axon Initial Segment and Is Required for Nervous System Function. J Neurosci. 2017;37:11311-11322 pubmed publisher
  7. Huang C, Zhang C, Zollinger D, Leterrier C, Rasband M. An ?II Spectrin-Based Cytoskeleton Protects Large-Diameter Myelinated Axons from Degeneration. J Neurosci. 2017;37:11323-11334 pubmed publisher
    ..We show that nodal ?II spectrin is found at greater densities in large-diameter myelinated axons, suggesting that nodes are particularly vulnerable domains requiring a specialized cytoskeleton to protect against axon degeneration. ..