Research Topics
Genomes and Genes | Pulivarthi H RaoSummaryAffiliation: Baylor College of Medicine Country: USA Publications
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Deletion of 1p32-p36 is the most frequent genetic change and poor prognostic marker in adenoid cystic carcinoma of the salivary glandsPulivarthi H Rao
Texas Children s Cancer Center, Baylor College of Medicine, The University of Texas M D Anderson Cancer Center and Spectral Genomics, Houston, Texas, USA
Clin Cancer Res 14:5181-7. 2008..The purpose of this study is to identify prognostic factors other than tumor stage that can be used to predict the outcome of the patients with ACC...- Chromosomal amplifications, 3q gain and deletions of 2q33-q37 are the frequent genetic changes in cervical carcinomaPulivarthi H Rao
Texas Children s Cancer Center, Baylor College of Medicine, Houston, TX, USA
BMC Cancer 4:5. 2004..Therefore, genetic characterization is essential for understanding the biology and clinical heterogeneity in cervical cancer (CC)... - Cell cycle regulator gene CDC5L, a potential target for 6p12-p21 amplicon in osteosarcomaXin Yan Lu
Texas Children s Cancer Center, Baylor College of Medicine, 6621 Fannin Street, MC 3 3320, Houston, TX 77030, USA
Mol Cancer Res 6:937-46. 2008..These results indicate that CDC5L, a cell cycle regulator important for the G2-M transition, is the most likely candidate oncogene for the 6p12-p21 amplicon found in osteosarcoma... - Frequent amplification and rearrangement of chromosomal bands 6p12-p21 and 17p11.2 in osteosarcomaChing C Lau
Department of Pediatrics, Texas Children s Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA
Genes Chromosomes Cancer 39:11-21. 2004.... - Medulloblastoma outcome is adversely associated with overexpression of EEF1D, RPL30, and RPS20 on the long arm of chromosome 8Massimiliano De Bortoli
Texas Children s Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA
BMC Cancer 6:223. 2006..In the present study, we applied cytogenetic characterization to guide the identification of biologically significant genes from gene expression microarray profiles of medulloblastoma... - Clinical utility of array comparative genomic hybridization for detection of chromosomal abnormalities in pediatric acute lymphoblastic leukemiaKaren R Rabin
Department of Pediatric Hematology Oncology, Baylor College of Medicine, Houston, Texas 77030, USA
Pediatr Blood Cancer 51:171-7. 2008..Accurate detection of recurrent chromosomal abnormalities is critical to assign patients to risk-based therapeutic regimens for pediatric acute lymphoblastic leukemia (ALL)... - Genome-wide array comparative genomic hybridization analysis reveals distinct amplifications in osteosarcomaTsz Kwong Man
Texas Children s Cancer Center, Baylor College of Medicine, Houston, TX, USA
BMC Cancer 4:45. 2004..Therefore, a better understanding of the underlying molecular genetic events leading to tumor initiation and progression could result in the identification of potential diagnostic and therapeutic targets... - Novel Chromosomal Rearrangements and Break Points at the t(6;9) in Salivary Adenoid Cystic Carcinoma: Association with MYB-NFIB Chimeric Fusion, MYB Expression, and Clinical OutcomeYoshitsugu Mitani
Authors Affiliations Departments of Pathology, Head and Neck Surgery, Bioinformatics and Computational Biology, Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center Department of Pediatrics, Baylor College of Medicine, Houston, Texas and Cancer Genome Project, The Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom
Clin Cancer Res 17:7003-14. 2011..Objective: To investigate the molecular genetic heterogeneity associated with the t(6:9) in adenoid cystic carcinoma (ACC) and correlate the findings with patient clinical outcome... - Comprehensive molecular cytogenetic characterization of cervical cancer cell linesCharles P Harris
Laboratory of Molecular Cytogenetics, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA
Genes Chromosomes Cancer 36:233-41. 2003..This comprehensive cytogenetic characterization of eight CC cell lines enhances their utility in experimental studies aimed at gene discovery and functional analysis... - Overexpression of Separase induces aneuploidy and mammary tumorigenesisNenggang Zhang
Department of Pediatric Hematology Oncology, Texas Children s Cancer Center, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 105:13033-8. 2008..These results collectively suggest that Separase is an oncogene, whose overexpression alone in mammary epithelial cells is sufficient to induce aneuploidy and tumorigenesis in a p53 mutant background... - Comprehensive analysis of the MYB-NFIB gene fusion in salivary adenoid cystic carcinoma: Incidence, variability, and clinicopathologic significanceYoshitsugu Mitani
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, 77030 4009, USA
Clin Cancer Res 16:4722-31. 2010.... - Medulloblastomas overexpress the p53-inactivating oncogene WIP1/PPM1DRobert C Castellino
Department of Pediatrics, Texas Children s Cancer Center, Baylor College of Medicine, 6621 Fannin Street, MC 3 3320, Houston, TX 77030, USA
J Neurooncol 86:245-56. 2008..These results indicate that medulloblastoma express significant levels of WIP1 that modulate genotoxic responsiveness by negatively regulating p53... - A handcuff model for the cohesin complexNenggang Zhang
Department of Pediatric Hematology Oncology, Texas Children s Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA
J Cell Biol 183:1019-31. 2008..These data support a two-ring handcuff model for the cohesin complex, which is flexible enough to establish and maintain sister chromatid cohesion as well as ensure the fidelity of chromosome segregation in higher eukaryotes... - Molecular cytogenetic applications in analysis of the cancer genomePulivarthi H Rao
Baylor College of Medicine, Texas Children s Cancer Center, Houston, USA
Methods Mol Biol 383:165-85. 2007..The opportunities to detect genetic alterations in cancer cells continue to evolve with the use of these methodologies both in diagnosis and research... - Amplification of MGC2177, PLAG1, PSMC6P, and LYN in a malignant mixed tumor of salivary gland detected by cDNA microarray with tyramide signal amplificationYvonne T M Tsang
Texas Children s Cancer Center, Cancer Genomics Group, MC3 3320, Department of Pediatrics, Baylor College of Medicine, 6621 Fannin Street, Houston, TX 77030, USA
Cancer Genet Cytogenet 152:124-8. 2004..2 approximately q13: MGC2177, PLAG1, PSMC6P, and LYN. The amplification was further validated with real-time quantitative polymerase chain reaction... - A systems biology approach reveals common metastatic pathways in osteosarcomaRicardo J Flores
Texas Children s Cancer Center, Texas Children s Hospital, Houston, TX, USA
BMC Syst Biol 6:50. 2012..In this study, we used a systems biology approach to identify common metastatic pathways that are jointly supported by both mRNA and protein expression data in two distinct human metastatic OS models... - Comparative genomic hybridization for analysis of changes in DNA copy number in multiple myelomaPulivarthi H Rao
Texas Childrens Cancer Centre, Baylor College of Medicine, Houston TX, USA
Methods Mol Med 113:71-83. 2005..The detailed procedures for CGH, including DNA labeling, hybridization, fluorescence microscopy, digital image analysis, and data interpretation, as well as the limitations of CGH are discussed in this chapter... - Translocation t(6;14) as the sole chromosomal abnormality in adenoid cystic carcinoma of the base of tongueDiana Bell
Department of Pathology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Head Neck Pathol 1:165-8. 2007..This finding supports a critical role for this event in the development of this tumor. The implications of chromosome 6q translocation in this case and in previously reported adenoid cystic carcinomas are highlighted and discussed... - Genomic segmental polymorphisms in inbred mouse strainsJiangzhen Li
Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Nat Genet 36:952-4. 2004..The identification of these apparently common segmental polymorphisms suggests that these differences can contribute to genetic variability and pathologic susceptibility... - Disruption of scaffold attachment factor B1 leads to TBX2 up-regulation, lack of p19ARF induction, lack of senescence, and cell immortalizationKlaudia M Dobrzycka
Department of Medicine, The Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
Cancer Res 66:7859-63. 2006..SAFB1 loss also caused lack of contact inhibition, increased foci formation, and increased oncogene-induced anchorage-independent growth. These findings suggest that SAFB1 is a novel player in cellular immortalization and transformation... - piggyBac transposon/transposase system to generate CD19-specific T cells for the treatment of B-lineage malignanciesPallavi V Raja Manuri
Division of Pediatrics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Hum Gene Ther 21:427-37. 2010..PB transposition for generating human T cells with redirected specificity to a desired target such as CD19 is a new genetic approach with therapeutic implications... - A clinically relevant orthotopic xenograft model of ependymoma that maintains the genomic signature of the primary tumor and preserves cancer stem cells in vivoLitian Yu
Laboratory of Molecular Neuro Oncology, Texas Children s Cancer Center, Texas Children s Hospital, Baylor College of Medicine, 6621 Fannin Street, MC 3 3320, Houston, TX 77030, USA
Neuro Oncol 12:580-94. 2010..This cell line and model will facilitate the biological studies and preclinical drug screenings for pediatric ependymomas... - Follicular variant of papillary thyroid carcinoma: genome-wide appraisal of a controversial entityVolkert B Wreesmann
Laboratory of Epithelial Cancer Biology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
Genes Chromosomes Cancer 40:355-64. 2004..Our findings suggest a stronger relationship between the FVPTC and FTA/FTC than previously appreciated and support further consideration of the current classification of thyroid neoplasms... - Chromosomal aberrations in patients with head and neck squamous cell carcinoma do not vary based on severity of tobacco/alcohol exposureBhuvanesh Singh
Laboratory of Epithelial Cancer Biology, Biology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York, USA
BMC Genet 3:22. 2002..We used comparative genomic hybridization (CGH) to screen for the genetic aberrations in 71 patients with head and neck squamous cell carcinoma and stratified the findings by the status of tobacco/alcohol exposure... - Amplification of the 3q26.3 locus is associated with progression to invasive cancer and is a negative prognostic factor in head and neck squamous cell carcinomasBhuvanesh Singh
Laboratory of Epithelial Cancer Biology, The Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Am J Pathol 161:365-71. 2002..6; 95% confidence interval = 1.9 to 29.6). The findings suggest that the 3q copy number status is an important marker for tumor progression and prognostication in patients with head and neck squamous cell carcinoma... - Genomic and expression analysis of the 12p11-p12 amplicon using EST arrays identifies two novel amplified and overexpressed genesVeronique Bourdon
Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Cancer Res 62:6218-23. 2002..Combined array comparative genomic hybridization and array expression analysis is a valid approach for gene discovery in large chromosomal amplicons... - Genetic abnormalities associated with chemoradiation resistance of head and neck squamous cell carcinomaGuido B van den Broek
Department of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
Clin Cancer Res 13:4386-91. 2007..To identify reliable predictors of chemoradiation resistance of advanced head and neck squamous cell carcinoma (HNSCC)... - Gene dosage alterations revealed by cDNA microarray analysis in cervical cancer: identification of candidate amplified and overexpressed genesGopeshwar Narayan
Department of Pathology, Columbia University Medical Center, NY 10032, USA
Genes Chromosomes Cancer 46:373-84. 2007..These data, thus, form an important step toward the identification of biologically relevant genes in CC pathogenesis. This article contains Supplementary Material available at http://www.interscience.wiley.com/jpages/1045-2257/suppmat... - Squamous cell carcinoma related oncogene/DCUN1D1 is highly conserved and activated by amplification in squamous cell carcinomasInderpal Sarkaria
Laboratory of Epithelial Cancer Biology, Thoracic Surgery Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Cancer Res 66:9437-44. 2006..Collectively, these data suggest that SCCRO is a novel component of the HH signaling pathway involved in the malignant transformation of squamous cell lineage... - Genome-wide profiling of papillary thyroid cancer identifies MUC1 as an independent prognostic markerVolkert B Wreesmann
Laboratory of Epithelial Cancer Biology, Head and Neck Service, Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
Cancer Res 64:3780-9. 2004..3; 95% confidence interval, 1.1-5.5; P = 0.03). Our data suggest that MUC1 dysregulation is associated with aggressive behavior of PTC and may serve as a prognostic marker and potential therapeutic target in this disease... - Spectral karyotyping identifies new rearrangements, translocations, and clinical associations in diffuse large B-cell lymphomaGouri Nanjangud
Cell Biology Program, Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Blood 99:2554-61. 2002..These studies emphasize the value of SKY analysis for redefinition of chromosomal instability in DLBCL to enhance gene discovery as well as clinical correlation analysis... - p53 regulates cell survival by inhibiting PIK3CA in squamous cell carcinomasBhuvanesh Singh
Laboratory of Epithelial Cancer Biology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Genes Dev 16:984-93. 2002..Thus, p53 regulates cell survival by inhibiting the PI3K/AKT prosurvival signal independent of PTEN in epithelial tumors. This inhibition is required for p53-mediated apoptosis in malignant cells... - Genome-wide appraisal of thyroid cancer progressionVolkert B Wreesmann
Laboratory of Epithelial Cancer Biology, Head and Neck Service, New York, New York 10021, USA
Am J Pathol 161:1549-56. 2002..Our data suggests that the development of chromosomal instability underlies the progression to more aggressive phenotypes of thyroid cancer and sheds light on the possible genomic aberrations that may be selected for during this process... - Relationship of XIST expression and responses of ovarian cancer to chemotherapyKuan-Chun Huang
Laboratory of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Mol Cancer Ther 1:769-76. 2002..Our data suggest that XIST expression may be a potential marker for chemotherapeutic responses in ovarian cancer... - Dyskeratosis congenita and cancer in mice deficient in ribosomal RNA modificationDavide Ruggero
Molecular Biology Program, Department of Pathology, Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
Science 299:259-62. 2003..These results suggest that deregulated ribosome function is important in the initiation of DC, whereas telomere shortening may modify and/or exacerbate DC... - Molecular determinants of tumor differentiation in papillary serous ovarian carcinomaAmir A Jazaeri
Center for Cancer Research of the National Cancer Institute, Gaithersburg, Maryland, USA
Mol Carcinog 36:53-9. 2003..Dysregulation of centrosome function is one potential mechanistic link between genetic/epigenetic changes and the poorly differentiated phenotype in ovarian cancer... - Genetic analysis identifies putative tumor suppressor sites at 2q35-q36.1 and 2q36.3-q37.1 involved in cervical cancer progressionGopeshwar Narayan
Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
Oncogene 22:3489-99. 2003..Thus, these data identify frequent chromosomal amplifications in CC, and sites of TSGs at 2q35-q36.1 and 2q36.3-q37.1 that are critical in CC development... - The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instabilityMichael Overholtzer
Laboratory of Cancer Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Proc Natl Acad Sci U S A 100:11547-52. 2003..These results demonstrate that the inactivation of p53 in osteosarcomas directly by mutation versus indirectly by HDM2 amplification may have different cellular consequences with respect to the stability of the genome... - Osteosarcoma in a patient with McCune-Albright syndrome and Mazabraud's syndrome: a case report emphasizing the cytological and cytogenetic findingsDarshana N Jhala
Department of Pathology, University of Alabama, Birmingham 35233, USA
Hum Pathol 34:1354-7. 2003..We are unaware of any previous reports of the cytogenetic findings in the tissue of this rare condition, and argue for the value of FNA in the evaluation of such patients under selected conditions... - Overexpression of E2F-1 in lung and liver metastases of human colon cancer is associated with gene amplificationMarian Iwamoto
Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA
Cancer Biol Ther 3:395-9. 2004..In as much as TS is transcriptionally regulated by E2F-1, these results provide an explanation for the high levels of TS mRNA noted in some tumor samples... - Identification of novel prognosticators of outcome in squamous cell carcinoma of the head and neckVolkert B Wreesmann
Laboratory of Epithelial Cancer Biology, Head and Neck Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
J Clin Oncol 22:3965-72. 2004..A sequential approach to control for multiple comparisons and effect of confounding variables allows the identification of clinically relevant aberrations. The significance of each individual abnormality merits further consideration... - The p73 locus is commonly deleted in non-Hodgkin's lymphomasArchontoula Stoffel
Laboratory for Cancer Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Leuk Res 28:1341-5. 2004..Our results demonstrate a high proportion of p73 locus specific deletions in NHL and suggest that deletion of this locus may play a role in the progression of NHL... - Identification of DNA copy number changes in microdissected serous ovarian cancer tissue using a cDNA microarray platformHiroshi Tsuda
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Laboratory of Gynecologic Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, BLI-447, 221 Longwood Avenue, Boston, MA 02115, USA
Cancer Genet Cytogenet 155:97-107. 2004..These results show the feasibility of using the cDNA array platform to identify changes in DNA and mRNA copy number simultaneously in microdissected tumor tissues... - Similar patterns of genomic alterations characterize primary mediastinal large-B-cell lymphoma and diffuse large-B-cell lymphomaNallasivam Palanisamy
Laboratory of Cancer Genetics, Cell Biology Program, Sloan-Kettering Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
Genes Chromosomes Cancer 33:114-22. 2002..Based on these data, we conclude that PMLBCL is a distinct entity among GC-derived high-grade DLBCLs...