Genomes and Genes
Affiliation: University of Texas School of Public Health
- Adiponectin/leptin ratio and metabolic syndrome in a Mexican American populationShaper Mirza
University of Texas Health Science Center atHouston, School of Public Health, Brownsville Campus, USA
Clin Invest Med 34:E290. 2011..Adiponectin and leptin play critical roles in the development of Metabolic Syndrome (MetS). This study was designed to assess the feasibility of using circulating levels of adiponectin and leptin for the early diagnosis of MetS...
- Identification of susceptibility genes for complex diseases using pooling-based genome-wide association scansYohan Bosse
Laval Hospital Research Center, Laval University, Pavillon Margeritte d Youville, Chemin Sainte Foy, Quebec, QC, Canada
Hum Genet 125:305-18. 2009..The low cost associated with a pooling-based GWAS clearly justifies its use in screening for genetic determinants of complex diseases...
- The effect of the MHC locus on autoantibodies in type 1 diabetesH Q Qu
J Med Genet 46:469-71. 2009..To investigate whether the presence of autoantibodies specific for type 1 diabetes (T1D) is determined by the major genetic susceptibility locus for the disease at the HLA genes, using the T1D Genetics Consortium data...
- Association of RASGRP1 with type 1 diabetes is revealed by combined follow-up of two genome-wide studiesH Q Qu
J Med Genet 46:553-4. 2009....
- A cis-acting regulatory variant in the IL2RA locusHui Qi Qu
Endocrine Genetics Lab, The McGill University Health Center and Montreal Children s Hospital, Montreal, Quebec, Canada
J Immunol 183:5158-62. 2009....
- From disease association to risk assessment: an optimistic view from genome-wide association studies on type 1 diabetesZhi Wei
Department of Computer Science, New Jersey Institute of Technology, Newark, New Jersey, United States of America
PLoS Genet 5:e1000678. 2009..We are optimistic that genotype-based disease risk assessment may be feasible for diseases where a notable proportion of the risk has already been captured by SNP arrays...
- Remapping the type I diabetes association of the CTLA4 locusH Q Qu
Department of Pediatrics, McGill University, Montreal, Quebec, Canada
Genes Immun 10:S27-32. 2009..Comprehensive resequencing and fine mapping of the CTLA4 region are still needed to clarify the causal variants...
- The type I diabetes association of the IL2RA locusH Q Qu
Endocrine Genetics Laboratory, The McGill University Health Center Montreal Children s Hospital, 2300 Tupper, Montreal, Quebec, Canada
Genes Immun 10:S42-8. 2009..Instead, the most significant independent effect was detected from the 5' flanking IL2RA SNP rs4749955, which remained significant after regression for H5. Thus, we confirm independent effects at the IL2RA locus...
- Reassessment of the type I diabetes association of the OAS1 locusH Q Qu
Department of Pediatrics, McGill University, 23 Tupper, Montreal, Quebec, Canada
Genes Immun 10:S69-73. 2009..Extended LD in populations earlier examined may account for the prior observation of an association of T1D with OAS1 variants. This possibility needs to be addressed further by fine mapping of the T1D association represented in 12q24...
- Rfx6 directs islet formation and insulin production in mice and humansStuart B Smith
Diabetes Center, University of California San Francisco, San Francisco, California 94143, USA
Nature 463:775-80. 2010..These studies demonstrate a unique position for Rfx6 in the hierarchy of factors that coordinate pancreatic islet development in both mice and humans. Rfx6 could prove useful in efforts to generate beta-cells for patients with diabetes...
- Genome-wide profiling using single-nucleotide polymorphism arrays identifies novel chromosomal imbalances in pediatric glioblastomasHui Qi Qu
Montreal Children s Hospital, 2300 Tupper, Montreal, Que, Canada, H3H 1P3
Neuro Oncol 12:153-63. 2010..It further shows that, despite commonalities in a few CNAs, pGBM and aGBMs are two different diseases...
- Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effectsKai Wang
Center for Applied Genomics, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Hum Mol Genet 19:2059-67. 2010....
- In silico replication of the genome-wide association results of the Type 1 Diabetes Genetics ConsortiumHui Qi Qu
Department of Pediatrics, McGill University, Montreal, QC, Canada H4H 2P4
Hum Mol Genet 19:2534-8. 2010..This study replicated T1D association with at least as many of these novel loci as expected from the power of our sample size, thus supporting the validity of the new discoveries...
- Statistical significance in genetic association studiesHui Qi Qu
Clin Invest Med 33:E266-70. 2010
- Knowledge gaining by human genetic studies on tuberculosis susceptibilityHui Qi Qu
Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas Health Science Center at Houston, School of Public Health, Brownsville, Texas 78520, USA
J Hum Genet 56:177-82. 2011....
- Molecular immunity to mycobacteria: knowledge from the mutation and phenotype spectrum analysis of Mendelian susceptibility to mycobacterial diseasesHui Qi Qu
University of Texas Health Science Center at Houston, School of Public Health, Brownsville Campus, 80 Fort Brown, SPH Bldg, Brownsville, Texas 78520, USA
Int J Infect Dis 15:e305-13. 2011..Mutations in the interleukin-12 (IL-12) signaling genes have phenotypes with non-specificity. Current studies highlight a complex molecular network in antimycobacterial immunity, centered on IFN-γ signaling...
- Prevalence of metabolic syndrome and risks of abnormal serum alanine aminotransferase in Hispanics: a population-based studyJen Jung Pan
Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas, United States of America
PLoS ONE 6:e21515. 2011..Study the prevalence of metabolic syndrome (MS) and risk factors for and association with elevated alanine aminotransferase (ALT) as markers of hepatic injury in a large Hispanic health disparity cohort with high rates of obesity...
- Decreased expression of ATP6V1H in type 2 diabetes: a pilot report on the diabetes risk study in Mexican AmericansMelanie F Molina
Division of Epidemiology, Human Genetics and Environmental Sciences, Brownsville Regional Campus, The University of Texas School of Public Health, Brownsville, TX, USA
Biochem Biophys Res Commun 412:728-31. 2011..Previous studies in mice and humans observed down-regulation of the gene expression of ATP6V1H associated with type 2 diabetes. This study identified prospectively changes in ATP6V1H expression before and after overt diabetes...
- Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetesStruan F A Grant
Center for Applied Genomics, Abramson Research Center, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Diabetes 58:290-5. 2009....
- Association analysis of type 2 diabetes Loci in type 1 diabetesHui Qi Qu
Departments of Pediatrics and Human Genetics, McGill University, Montreal, Quebec, Canada
Diabetes 57:1983-6. 2008..To search for a possible association of type 1 diabetes with 10 validated type 2 diabetes loci, i.e., PPARG, KCNJ11, WFS1, HNF1B, IDE/HHEX, SLC30A8, CDKAL1, CDKN2A/B, IGF2BP2, and FTO/RPGRIP1L...
- Strand bias in complementary single-nucleotide polymorphisms of transcribed human sequences: evidence for functional effects of synonymous polymorphismsHui Qi Qu
Endocrine Genetics Laboratory, The McGill University Health Center, Montreal Children s Hospital, Montreal, Quebec, Canada
BMC Genomics 7:213. 2006..Here we studied asymmetry of human synonymous SNPs (sSNPs) in the fourfold degenerate (FFD) sites as compared to intronic SNPs (iSNPs)...
- Lack of association of type 1 diabetes with the IL4R geneH Q Qu
Endocrine Genetics Laboratory, The McGill University Health Center, Montreal Children s Hospital, Montreal, QC, Canada
Diabetologia 49:958-61. 2006..The aim of this study was to re-evaluate the genetic association in type 1 diabetic nuclear families of mixed European background...
- Type 1 diabetes and the OAS gene cluster: association with splicing polymorphism or haplotype?M C Tessier
Endocrine Genetics Laboratory, The McGill University Health Center, Montreal Children s Hospital, Montreal, Quebec, Canada
J Med Genet 43:129-32. 2006..Recently, the minor allele of an OAS1 single nucleotide polymorphism (SNP) that alters splicing (rs10774671) was found to be associated with increased enzymatic activity and, in a case-sibling control study, with type 1 diabetes (T1D)...
- Confirmation of the association of the R620W polymorphism in the protein tyrosine phosphatase PTPN22 with type 1 diabetes in a family based studyH Qu
J Med Genet 42:266-70. 2005
- Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetesHuiqi Qu
Nat Genet 37:111-2; author reply 112-3. 2005
- Allele A in intron 4 of ecNOS gene will not increase the risk of diabetic nephropathy in type 2 diabetes of Chinese populationShan Lin
Nephron 91:768. 2002
- [Meta-analysis on the association of ACE/ID polymorphism and essential hypertension in Chinese population]H Qu
Department of Internal Medicine, General Hospital of Tianjin Medical University, Tianjin 300052, China
Zhonghua Yu Fang Yi Xue Za Zhi 35:408-11. 2001..To study on the association of the insertion(I)/deletion(D) polymorphism of the angiotensin-converting enzyme gene intron 16 (ACE/ID) and essential hypertension(EH) in Chinese population by the means of meta-analysis...
- Restless legs syndrome (RLS) in uremic patients is related to the frequency of hemodialysis sessionsQ Huiqi
Nephron 86:540. 2000
- No association of type 1 diabetes with a functional polymorphism of the LRAP geneHui Qi Qu
Endocrine Genetics Laboratory, The McGill University Health Center, Montreal Children s Hospital, 2300 Tupper, Montreal, Que H3H 1P3, Canada
Mol Immunol 44:2135-8. 2007..This study was designed to confirm that LRAP expression in B-cell derived lines is controlled by a haplotype marked by rs2762 and to see whether this would be the basis of an association with type 1 diabetes (T1D)...
- Genetic control of alternative splicing in the TAP2 gene: possible implication in the genetics of type 1 diabetesHui Qi Qu
Endocrine Genetics Laboratory, The McGill University Health Center Montreal Children s Hospital, QC, Canada
Diabetes 56:270-5. 2007....
- The association between type 1 diabetes and the ITPR3 gene polymorphism due to linkage disequilibrium with HLA class IIH Q Qu
Endocrine Genetics Lab, The McGill University Health Center Montreal Children s Hospital, Montreal, Quebec, Canada
Genes Immun 9:264-6. 2008..Conditional regression showed that all of the ITPR3 SNP T1D association could be accounted for by the DQB1 effect. Therefore, our findings do not support an obvious role of genetic variation of the ITPR3 gene in T1D risk...
- A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association studyHakon Hakonarson
Center for Applied Genomics, Abramson Research Center, The Children s Hospital of Philadelphia, PA 19104 4318, USA
Diabetes 57:1143-6. 2008..03 x 10(-10)) and confirmed in two additional cohorts. Here we describe the results of testing, in these additional cohorts, 23 loci that were next in rank of statistical significance...
- The association between the IFIH1 locus and type 1 diabetesH Q Qu
Endocrine Genetics Lab, The McGill University Health Center Montreal Children s Hospital, 2300 Tupper, Montreal, QC, Canada, H3H 1P3
Diabetologia 51:473-5. 2008..We set out to validate a recently reported type 1 diabetes association from the IFIH1 gene variation in an independent cohort from a population of mixed European descent...
- The TCF7L2 locus and type 1 diabetesHui Qi Qu
Endocrine Genetics Lab, The McGill University Health Center, Montreal Children s Hospital, Montreal, Quebec, Canada
BMC Med Genet 8:51. 2007..This study aimed to investigate the possibility of genetic association between TCF7L2 and type 1 diabetes (T1D)...
- A genome-wide association study identifies KIAA0350 as a type 1 diabetes geneHakon Hakonarson
Center for Applied Genomics, Abramson Research Center, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
Nature 448:591-4. 2007..These results indicate that KIAA0350 might be involved in the pathogenesis of T1D and demonstrate the utility of the genome-wide association approach in the identification of previously unsuspected genetic determinants of complex traits...
- The IRF5 polymorphism in type 1 diabetesHui-Qi Qu
J Med Genet 44:670-2. 2007..Our results suggest that the functional IRF5 variations do not confer an obvious risk for T1D...
- A common variant of the PAX2 gene is associated with reduced newborn kidney sizeJacklyn Quinlan
Montreal Children s Hospital Research Institute, 4060 Saint Catherine West, PT 413, Montreal, Quebec, Canada
J Am Soc Nephrol 18:1915-21. 2007..Subtle renal hypoplasia in normal newborns may be partially due to a common variant of the PAX2 gene that reduces mRNA expression during kidney development...
- Toward further mapping of the association between the IL2RA locus and type 1 diabetesHui Qi Qu
Endocrine Genetics Laboratory, McGill University Health Center Montreal Children s Hospital, Montreal, Quebec, Canada
Diabetes 56:1174-6. 2007....
- Ancestral Effect on HOMA-IR Levels Quantitated in an American Population of Mexican OriginHui Qi Qu
Corresponding author Hui Qi Qu
Diabetes Care 35:2591-3. 2012..079, P = 0.019). CONCLUSIONS This unique study design demonstrates how genomic markers for quantitative ancestral information can be used in admixed populations to predict phenotypic traits such as insulin resistance...
- Population-based Risk Factors for Elevated Alanine Aminotransferase in a South Texas Mexican-American PopulationHui Qi Qu
University of Texas School of Public Health, Brownsville, Texas Electronic address
Arch Med Res 43:482-8. 2012..We aimed to identify and stratify risk factors associated with elevated ALT in a randomly selected population with a high prevalence of elevated ALT (39%), obesity (49%) and diabetes (30%)...
- PNPLA3 polymorphisms and liver aminotransferase levels in a Mexican American populationQuan Li
The University of Texas School of Public Health, Brownsville, TX 78520, USA
Clin Invest Med 35:E237-45. 2012....
- Host susceptibility to tuberculosis: insights from a longitudinal study of gene expression in diabetesH Q Qu
Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Brownsville Regional Campus, Brownsville, Texas, USA
Int J Tuberc Lung Dis 16:370-2. 2012..To examine this rationale, we investigated the expression of reported TB candidate genes in a longitudinal diabetes study. Two genes, HK2 and CD28, emerged as potential culprits in diabetes-increased TB susceptibility...