Research Topics
Genomes and Genes | Joseph F PetrosinoSummaryAffiliation: Baylor College of Medicine Country: USA Publications
| Collaborators
|
Detail Information
Publications
Subtle genetic changes enhance virulence of methicillin resistant and sensitive Staphylococcus aureusSarah K Highlander
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA
BMC Microbiol 7:99. 2007..Epidemiological studies suggest that USA300 is more virulent than other CA-MRSA. The genetic determinants that render virulence and dominance to USA300 remain unclear...- Chromosome rearrangement and diversification of Francisella tularensis revealed by the type B (OSU18) genome sequenceJoseph F Petrosino
Department of Molecular Virology and Microbiology, Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, BCM280, Houston, TX 77030, USA
J Bacteriol 188:6977-85. 2006..Nonconservative differences between the two strains likely include the LVS attenuating mutation(s)... - Genome sequence of Fusobacterium nucleatum subspecies polymorphum - a genetically tractable fusobacteriumSandor E Karpathy
Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America Department of Microbiology and Molecular Genetics, University of Texas Medical School, Houston, Texas, United States of America
PLoS ONE 2:e659. 2007..These findings indicate that F. nucleatum subsp. polymorphum is proficient at horizontal gene transfer and that exchange with the Firmicutes, particularly the Clostridia, is common... - Paradoxical DNA repair and peroxide resistance gene conservation in Bacillus pumilus SAFR-032Jason Gioia
Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, USA
PLoS ONE 2:e928. 2007.... 
Identification of novel and cross-species seroreactive proteins from Bacillus anthracis using a ligation-independent cloning-based, SOS-inducible expression systemBrian D McWilliams
Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Microb Pathog 53:250-8. 2012..These results will contribute to the future selection of targets in antigenicity and protection studies as one or more of these proteins may prove to be worthy of inclusion in future vaccine preparations...- Metagenomic pyrosequencing and microbial identificationJoseph F Petrosino
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA
Clin Chem 55:856-66. 2009..The Human Microbiome Project has ushered in a new era for human metagenomics and high-throughput next-generation sequencing strategies... - Complete genome sequence of Treponema pallidum ssp. pallidum strain SS14 determined with oligonucleotide arraysPetra Matejková
Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Alkek N1619, Houston, TX 77030, USA
BMC Microbiol 8:76. 2008..pallidum remains the enigmatic pathogen, since no virulence factors have been identified and the pathogenesis of the disease is poorly understood. Increasing rates of new syphilis cases per year have been observed recently... - Stress-induced beta-lactam antibiotic resistance mutation and sequences of stationary-phase mutations in the Escherichia coli chromosomeJoseph F Petrosino
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030 3411, USA
J Bacteriol 191:5881-9. 2009..The important evolutionary implication is that not only loss-of-function mutations but also change-of-function mutations can be generated by this mechanism... - Adaptive amplification and point mutation are independent mechanisms: evidence for various stress-inducible mutation mechanismsP J Hastings
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
PLoS Biol 2:e399. 2004..We suggest that the availability of alternative pathways for genetic/evolutionary adaptation and clonal expansion under stress may be exploited during processes ranging from the evolution of drug resistance to cancer progression... - Chromosomal system for studying AmpC-mediated beta-lactam resistance mutation in Escherichia coliJoseph F Petrosino
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030 3411, USA
Antimicrob Agents Chemother 46:1535-9. 2002..coli chromosome. These cells acquire spontaneous recombination- and SOS response-independent beta-lactam resistance mutations in ampD. This chromosomal system is useful for studying mutation mechanisms that promote antibiotic resistance... 
Francisella tularensis genomics and proteomicsRichard W Titball
Defence Science and Technology Laboratory, Porton Down, Salisbury, SP4 0JQ, UK
Ann N Y Acad Sci 1105:98-121. 2007..These proteins might be exploited as components of vaccines or diagnostic systems...- The complete genome sequence of Escherichia coli DH10B: insights into the biology of a laboratory workhorseTim Durfee
DNASTAR, Inc, Madison, Wisconsin 53705, USA
J Bacteriol 190:2597-606. 2008..Finally, while the sequence confirms most of the reported alleles, the sequence of deoR is wild type, necessitating reexamination of the assumed basis for the high transformability of DH10B...