Richard Paylor

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. pmc Genetic background modulates behavioral impairments in R6/2 mice and suggests a role for dominant genetic modifiers in Huntington’s disease pathogenesis
    Randi Michelle Cowin
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Mamm Genome 23:367-77. 2012
  2. pmc Onset and progression of behavioral and molecular phenotypes in a novel congenic R6/2 line exhibiting intergenerational CAG repeat stability
    Randi Michelle Cowin
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 6:e28409. 2011
  3. doi request reprint Reversal of sensorimotor gating abnormalities in Fmr1 knockout mice carrying a human Fmr1 transgene
    Richard Paylor
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Behav Neurosci 122:1371-7. 2008
  4. ncbi request reprint The use of behavioral test batteries, II: effect of test interval
    Richard Paylor
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Physiol Behav 87:95-102. 2006
  5. ncbi request reprint Rai1 deficiency in mice causes learning impairment and motor dysfunction, whereas Rai1 heterozygous mice display minimal behavioral phenotypes
    Weimin Bi
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030 3498, USA
    Hum Mol Genet 16:1802-13. 2007
  6. pmc Modifying behavioral phenotypes in Fmr1KO mice: genetic background differences reveal autistic-like responses
    Corinne M Spencer
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Autism Res 4:40-56. 2011
  7. ncbi request reprint Exaggerated behavioral phenotypes in Fmr1/Fxr2 double knockout mice reveal a functional genetic interaction between Fragile X-related proteins
    Corinne M Spencer
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Mol Genet 15:1984-94. 2006
  8. doi request reprint Neuronal aggregates are associated with phenotypic onset in the R6/2 Huntington's disease transgenic mouse
    Randi Michelle Cowin
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Behav Brain Res 229:308-19. 2012
  9. pmc Genetic reduction of group 1 metabotropic glutamate receptors alters select behaviors in a mouse model for fragile X syndrome
    Alexia M Thomas
    Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
    Behav Brain Res 223:310-21. 2011
  10. pmc Removal of FKBP12 enhances mTOR-Raptor interactions, LTP, memory, and perseverative/repetitive behavior
    Charles A Hoeffer
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 60:832-45. 2008

Collaborators

Detail Information

Publications47

  1. pmc Genetic background modulates behavioral impairments in R6/2 mice and suggests a role for dominant genetic modifiers in Huntington’s disease pathogenesis
    Randi Michelle Cowin
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Mamm Genome 23:367-77. 2012
    ..This identification may lead to novel targets for treatment and help elucidate the molecular mechanisms of HD pathogenesis...
  2. pmc Onset and progression of behavioral and molecular phenotypes in a novel congenic R6/2 line exhibiting intergenerational CAG repeat stability
    Randi Michelle Cowin
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 6:e28409. 2011
    ..Data from TR-FRET suggest an association of mutant protein state changes (soluble versus aggregated) in disease onset and progression...
  3. doi request reprint Reversal of sensorimotor gating abnormalities in Fmr1 knockout mice carrying a human Fmr1 transgene
    Richard Paylor
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Behav Neurosci 122:1371-7. 2008
    ....
  4. ncbi request reprint The use of behavioral test batteries, II: effect of test interval
    Richard Paylor
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Physiol Behav 87:95-102. 2006
    ..Thus, it is possible with the current test battery to reduce the inter-test interval to facilitate the rate of studying and identifying behavioral phenotypes in mice...
  5. ncbi request reprint Rai1 deficiency in mice causes learning impairment and motor dysfunction, whereas Rai1 heterozygous mice display minimal behavioral phenotypes
    Weimin Bi
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030 3498, USA
    Hum Mol Genet 16:1802-13. 2007
    ....
  6. pmc Modifying behavioral phenotypes in Fmr1KO mice: genetic background differences reveal autistic-like responses
    Corinne M Spencer
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Autism Res 4:40-56. 2011
    ..This approach has allowed us to identify improved models for different behavioral symptoms present in FXS including autistic-like traits...
  7. ncbi request reprint Exaggerated behavioral phenotypes in Fmr1/Fxr2 double knockout mice reveal a functional genetic interaction between Fragile X-related proteins
    Corinne M Spencer
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Mol Genet 15:1984-94. 2006
    ..Our findings suggest that Fmr1 and Fxr2 genes contribute in a cooperative manner to pathways controlling locomotor activity, sensorimotor gating and cognitive processes...
  8. doi request reprint Neuronal aggregates are associated with phenotypic onset in the R6/2 Huntington's disease transgenic mouse
    Randi Michelle Cowin
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Behav Brain Res 229:308-19. 2012
    ..We believe that these data suggest a role for aggregation and inclusion localization in HD pathogenesis and propose a mechanism for the age of onset delay observed in R6/2 mice...
  9. pmc Genetic reduction of group 1 metabotropic glutamate receptors alters select behaviors in a mouse model for fragile X syndrome
    Alexia M Thomas
    Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
    Behav Brain Res 223:310-21. 2011
    ..Therefore, the goals for this study were to extend our understanding of the effects of modulating Gp1 mGluR activity on Fmr1 KO behavioral responses...
  10. pmc Removal of FKBP12 enhances mTOR-Raptor interactions, LTP, memory, and perseverative/repetitive behavior
    Charles A Hoeffer
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 60:832-45. 2008
    ..Our results indicate that FKBP12 plays a critical role in the regulation of mTOR-Raptor interactions, LTP, memory, and perseverative behaviors...
  11. pmc Ectopic expression of CGG containing mRNA is neurotoxic in mammals
    Vera Hashem
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Mol Genet 18:2443-51. 2009
    ....
  12. pmc Rai1 duplication causes physical and behavioral phenotypes in a mouse model of dup(17)(p11.2p11.2)
    Katherina Walz
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Clin Invest 116:3035-41. 2006
    ..These data provide a model for variation in copy number of single genes that could influence common traits such as obesity and behavior...
  13. doi request reprint Social behavior in Fmr1 knockout mice carrying a human FMR1 transgene
    Corinne M Spencer
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Behav Neurosci 122:710-5. 2008
    ..This finding expands the number of murine behavioral responses caused by Fmr1 deficiency and corrected by overexpression of human FMRP...
  14. pmc Marble burying reflects a repetitive and perseverative behavior more than novelty-induced anxiety
    Alexia Thomas
    Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
    Psychopharmacology (Berl) 204:361-73. 2009
    ..An increasing number of investigators utilize the marble-burying assay despite the paucity of information available regarding what underlies the behavior...
  15. pmc Genetic reduction of muscarinic M4 receptor modulates analgesic response and acoustic startle response in a mouse model of fragile X syndrome (FXS)
    Surabi Veeraragavan
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Behav Brain Res 228:1-8. 2012
    ..Since the pharmacological antagonists were not highly specific, we investigated the specific role of M4 receptors in the Fmr1KO mouse model, using a genetic approach...
  16. ncbi request reprint Abnormalities of social interactions and home-cage behavior in a mouse model of Rett syndrome
    Paolo Moretti
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Mol Genet 14:205-20. 2005
    ..The study of Mecp2(308/Y) mice will allow the identification of the molecular basis of social impairment in RTT and related autistic spectrum disorders...
  17. ncbi request reprint Mice lacking Tropomodulin-2 show enhanced long-term potentiation, hyperactivity, and deficits in learning and memory
    Patrick R Cox
    Division of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cell Neurosci 23:1-12. 2003
    ..Electrophysiological analysis revealed enhanced LTP in Tmod2(lacZ-/-) mice. These studies suggest that Tmod2 plays a role in behavior, learning, memory, and synaptic plasticity...
  18. ncbi request reprint Mice with truncated MeCP2 recapitulate many Rett syndrome features and display hyperacetylation of histone H3
    Mona Shahbazian
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 35:243-54. 2002
    ....
  19. doi request reprint Group I metabotropic glutamate receptor antagonists alter select behaviors in a mouse model for fragile X syndrome
    Alexia M Thomas
    Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Psychopharmacology (Berl) 219:47-58. 2012
    ..Currently, no studies have assessed the effect of mGluR1 modulation on Fmr1 KO behavior, and there has not been an extensive behavioral analysis of mGluR5 manipulation in Fmr1 KO mice...
  20. pmc Tbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: implications for 22q11 deletion syndrome
    Richard Paylor
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:7729-34. 2006
    ..Thus, Tbx1 and Gnb1l are strong candidates for psychiatric disease in 22q11DS patients and candidate susceptibility genes for psychiatric disease in the wider population...
  21. ncbi request reprint The nicotinic acetylcholine receptor subunit alpha 5 mediates short-term effects of nicotine in vivo
    Ramiro Salas
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Pharmacol 63:1059-66. 2003
    ..In addition, (125)I-epibatidine and [(125)I]alpha-bungarotoxin binding in the brains of alpha 5-deficient mice is normal. Together, these results suggest a direct involvement of the alpha 5 subunit in the observed phenotypes...
  22. ncbi request reprint A long CAG repeat in the mouse Sca1 locus replicates SCA1 features and reveals the impact of protein solubility on selective neurodegeneration
    Kei Watase
    Department of Molecular and Human Genetics, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 34:905-19. 2002
    ..It appears that those neurons that cannot sequester the mutant protein efficiently and thereby curb its toxicity suffer the worst damage from polyglutamine-induced toxicity...
  23. pmc The modulation of fragile X behaviors by the muscarinic M4 antagonist, tropicamide
    Surabi Veeraragavan
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Behav Neurosci 125:783-90. 2011
    ..These results suggest that pharmacological antagonism of the M4 receptor modulates select behavioral responses in the Fmr1KO mice...
  24. ncbi request reprint Behavioral and physiological mouse assays for anxiety: a survey in nine mouse strains
    J Adriaan Bouwknecht
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Behav Brain Res 136:489-501. 2002
    ..We conclude that a combination of behavioral and physiological responses might lead to a better understanding in anxiety-related processes...
  25. doi request reprint Modulation of behavioral phenotypes by a muscarinic M1 antagonist in a mouse model of fragile X syndrome
    Surabi Veeraragavan
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Psychopharmacology (Berl) 217:143-51. 2011
    ..Overactive signaling through the M1 receptor has been hypothesized to contribute to the phenotypes seen in fragile X mice...
  26. pmc Enriched rearing improves behavioral responses of an animal model for CNV-based autistic-like traits
    Melanie Lacaria
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Mol Genet 21:3083-96. 2012
    ....
  27. ncbi request reprint Phenotypic characterization of Bbs4 null mice reveals age-dependent penetrance and variable expressivity
    Erica R Eichers
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza Room 604B, Houston, TX 77030, USA
    Hum Genet 120:211-26. 2006
    ..Evaluations of these null mice have uncovered phenotypic features with age-dependent penetrance and variable expressivity, partially recapitulating the human BBS phenotype...
  28. pmc Multiple autism-like behaviors in a novel transgenic mouse model
    Shannon M Hamilton
    Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
    Behav Brain Res 218:29-41. 2011
    ..The MALTT line provides a unique genetic model for examining the underlying biological mechanisms involved in ASD-related behaviors...
  29. pmc Deficits in adult neurogenesis, contextual fear conditioning, and spatial learning in a Gfap mutant mouse model of Alexander disease
    Tracy L Hagemann
    Waisman Center and Department of Comparative Biosciences, University of Wisconsin Madison, Madison, Wisconsin 53705, and Department of Molecular and Human Genetics and Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030
    J Neurosci 33:18698-706. 2013
    ..In addition, they display impairments in contextual learning and spatial memory. This is the first demonstration of cognitive phenotypes in a model of primary astrocyte disease. ..
  30. pmc Urocortin-deficient mice display normal stress-induced anxiety behavior and autonomic control but an impaired acoustic startle response
    Xiaozhong Wang
    Department of Molecular and Human Genetics, Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cell Biol 22:6605-10. 2002
    ..Ucn may modulate the acoustic startle response through the Ucn-expressing neuron projections from the region of the Edinger-Westphal nucleus...
  31. ncbi request reprint Behavioral characterization of mouse models for Smith-Magenis syndrome and dup(17)(p11.2p11.2)
    Katherina Walz
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Mol Genet 13:367-78. 2004
    ..Our findings suggest that there is a gene(s) present in this defined genomic interval that is responsible for behavioral abnormalities in the mouse, as has been shown for the human syntenic region...
  32. ncbi request reprint Dynamic translational and proteasomal regulation of fragile X mental retardation protein controls mGluR-dependent long-term depression
    Lingfei Hou
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    Neuron 51:441-54. 2006
    ..These findings indicate that the translation, ubiquitination, and proteolysis of FMRP functions as a dynamic regulatory system for controlling synaptic plasticity...
  33. ncbi request reprint Mouse Dach2 mutants do not exhibit gross defects in eye development or brain function
    Richard J Davis
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Genesis 44:84-92. 2006
    ....
  34. doi request reprint Pitfalls in the interpretation of genetic and pharmacological effects on anxiety-like behaviour in rodents
    Jan Adriaan Bouwknecht
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, USA
    Behav Pharmacol 19:385-402. 2008
    ..We believe that considering the pitfalls presented here will help researchers to design optimized experiments that can be more readily interpreted and replicated across laboratories...
  35. ncbi request reprint Impaired conditioned fear and enhanced long-term potentiation in Fmr2 knock-out mice
    Yanghong Gu
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 22:2753-63. 2002
    ..Thus, although a number of studies have suggested that diminished LTP is associated with memory impairment, our data suggest that increased LTP may be a mechanism that leads to impaired cognitive processing as well...
  36. pmc Early changes in the apparent diffusion coefficient (ADC) in a mouse model of Sandhoff's disease occur prior to disease symptoms and behavioral deficits
    Lingyun Hu
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, USA
    Magn Reson Med 62:1175-84. 2009
    ..5 to 4 months of age) and behavioral deficits (3 months of age). The magnitude of the decrease ranged from 4-18%...
  37. doi request reprint Fmr1 and Nlgn3 knockout rats: Novel tools for investigating autism spectrum disorders
    Shannon M Hamilton
    Department of Molecular and Human Genetics, Baylor College of Medicine
    Behav Neurosci 128:103-9. 2014
    ..These data provide important first evidence regarding the utility of rats as genetic models for investigating ASD-relevant genes. (PsycINFO Database Record (c) 2014 APA, all rights reserved). ..
  38. ncbi request reprint Mouse models of 22q11 deletion syndrome
    Richard Paylor
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Biol Psychiatry 59:1172-9. 2006
    ..Significant progress has already been made, and recent studies in the mouse suggest that several genes from the deleted region affect behavior and might contribute to disease burden in patients...
  39. ncbi request reprint Increased sensitivity to nicotine-induced seizures in mice expressing the L250T alpha 7 nicotinic acetylcholine receptor mutation
    Ron S Broide
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Pharmacol 61:695-705. 2002
    ..Hence, these present findings suggest that alterations in the properties rather than absence of alpha 7 nAChRs might affect the mechanisms underlying the convulsive properties of nicotine...
  40. pmc R-flurbiprofen improves axonal transport in the Tg2576 mouse model of Alzheimer's disease as determined by MEMRI
    Karen D B Smith
    Dept Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, USA
    Magn Reson Med 65:1423-9. 2011
    ..0329). We then determined that R-F treatment reduced tau hyper-phosphorylation in the older animals. These data indicate that both Aβ42 and tau comprise a role in axonal transport rate deficits in the Tg2576 model of Alzheimer's Disease...
  41. ncbi request reprint Absence of alpha7-containing neuronal nicotinic acetylcholine receptors does not prevent nicotine-induced seizures
    Davide Franceschini
    Division of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Brain Res Mol Brain Res 98:29-40. 2002
    ..These findings indicate that alpha7 may not be necessary for the mechanisms underlying nicotine-induced seizures...
  42. ncbi request reprint Deletion of the alpha7 nicotinic receptor subunit gene results in increased sensitivity to several behavioral effects produced by alcohol
    Barbara J Bowers
    Institute for Behavioral Genetics, University of Colorado at Boulder, 447 UCB, Boulder, CO 80309, USA
    Alcohol Clin Exp Res 29:295-302. 2005
    ..The studies outlined here used alpha7 gene knockout (null mutant) mice to evaluate the potential role of alpha7 nAChRs in modulating selected behavioral and physiological effects produced by ethanol...
  43. ncbi request reprint Null mutant analysis of responses to nicotine: deletion of beta2 nicotinic acetylcholine receptor subunit but not alpha7 subunit reduces sensitivity to nicotine-induced locomotor depression and hypothermia
    Theresa Tritto
    Institute for Behavioral Genetics, University of Colorado, Boulder, USA
    Nicotine Tob Res 6:145-58. 2004
    ..0 mg/kg) blocked all responses following 1.0 mg/kg nicotine. This finding suggests receptors that include the beta2 nAChR subunit partially mediate nicotine's effects on locomotor activity and body temperature...
  44. ncbi request reprint Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein
    Deborah E Cabin
    Genetic Diseases Research Branch, National Human Genome Research Institute, Bethesda, Maryland 20892 4472, USA
    J Neurosci 22:8797-807. 2002
    ..These results reveal, for the first time, the normal function of endogenous alpha-synuclein in regulating synaptic vesicle mobilization at nerve terminals...
  45. ncbi request reprint Knockout mouse model for Fxr2: a model for mental retardation
    Carola J M Bontekoe
    CBG Department of Clinical Genetics, Erasmus University, Rotterdam, The Netherlands
    Hum Mol Genet 11:487-98. 2002
    ..The findings implicate a role for Fxr2 in central nervous system function...
  46. ncbi request reprint Deletion of the beta 2 nicotinic acetylcholine receptor subunit alters development of tolerance to nicotine and eliminates receptor upregulation
    Sarah E McCallum
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309, USA
    Psychopharmacology (Berl) 184:314-27. 2006
    ..However, the mechanism for chronic tolerance is unclear because a direct relationship between tolerance and receptor upregulation is not consistently observed...
  47. pmc Secretin receptor-deficient mice exhibit impaired synaptic plasticity and social behavior
    Ichiko Nishijima
    Center for Molecular and Human Genetics, Columbus Children s Research Institute, The Ohio State University, Columbus, OH 43205, USA
    Hum Mol Genet 15:3241-50. 2006
    ..Furthermore, secretin receptor-deficient mice show abnormal social and cognitive behaviors. These findings suggest that the secretin receptor system has an important role in the central nervous system relating to social behavior...