Research Topics
Genomes and Genes
| Richard PaylorSummaryAffiliation: Baylor College of Medicine Country: USA Publications
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Detail Information
Publications
Reversal of sensorimotor gating abnormalities in Fmr1 knockout mice carrying a human Fmr1 transgeneRichard Paylor
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Behav Neurosci 122:1371-7. 2008....
The use of behavioral test batteries, II: effect of test intervalRichard Paylor
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
Physiol Behav 87:95-102. 2006..Thus, it is possible with the current test battery to reduce the inter-test interval to facilitate the rate of studying and identifying behavioral phenotypes in mice...- Rai1 deficiency in mice causes learning impairment and motor dysfunction, whereas Rai1 heterozygous mice display minimal behavioral phenotypesWeimin Bi
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030 3498, USA
Hum Mol Genet 16:1802-13. 2007.... 
Modifying behavioral phenotypes in Fmr1KO mice: genetic background differences reveal autistic-like responsesCorinne M Spencer
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Autism Res 4:40-56. 2011..This approach has allowed us to identify improved models for different behavioral symptoms present in FXS including autistic-like traits...- Exaggerated behavioral phenotypes in Fmr1/Fxr2 double knockout mice reveal a functional genetic interaction between Fragile X-related proteinsCorinne M Spencer
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
Hum Mol Genet 15:1984-94. 2006..Our findings suggest that Fmr1 and Fxr2 genes contribute in a cooperative manner to pathways controlling locomotor activity, sensorimotor gating and cognitive processes... - Neuronal aggregates are associated with phenotypic onset in the R6/2 Huntington's disease transgenic mouseRandi Michelle Cowin
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
Behav Brain Res 229:308-19. 2012..We believe that these data suggest a role for aggregation and inclusion localization in HD pathogenesis and propose a mechanism for the age of onset delay observed in R6/2 mice... - Genetic reduction of group 1 metabotropic glutamate receptors alters select behaviors in a mouse model for fragile X syndromeAlexia M Thomas
Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
Behav Brain Res 223:310-21. 2011..Therefore, the goals for this study were to extend our understanding of the effects of modulating Gp1 mGluR activity on Fmr1 KO behavioral responses... - Removal of FKBP12 enhances mTOR-Raptor interactions, LTP, memory, and perseverative/repetitive behaviorCharles A Hoeffer
Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
Neuron 60:832-45. 2008..Our results indicate that FKBP12 plays a critical role in the regulation of mTOR-Raptor interactions, LTP, memory, and perseverative behaviors... - Social behavior in Fmr1 knockout mice carrying a human FMR1 transgeneCorinne M Spencer
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
Behav Neurosci 122:710-5. 2008..This finding expands the number of murine behavioral responses caused by Fmr1 deficiency and corrected by overexpression of human FMRP... - Rai1 duplication causes physical and behavioral phenotypes in a mouse model of dup(17)(p11.2p11.2)Katherina Walz
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
J Clin Invest 116:3035-41. 2006..These data provide a model for variation in copy number of single genes that could influence common traits such as obesity and behavior... - Genetic reduction of muscarinic M4 receptor modulates analgesic response and acoustic startle response in a mouse model of fragile X syndrome (FXS)Surabi Veeraragavan
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
Behav Brain Res 228:1-8. 2012..Since the pharmacological antagonists were not highly specific, we investigated the specific role of M4 receptors in the Fmr1KO mouse model, using a genetic approach... - Ectopic expression of CGG containing mRNA is neurotoxic in mammalsVera Hashem
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
Hum Mol Genet 18:2443-51. 2009.... - Abnormalities of social interactions and home-cage behavior in a mouse model of Rett syndromePaolo Moretti
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
Hum Mol Genet 14:205-20. 2005..The study of Mecp2(308/Y) mice will allow the identification of the molecular basis of social impairment in RTT and related autistic spectrum disorders... - Genetic background modulates behavioral impairments in R6/2 mice and suggests a role for dominant genetic modifiers in Huntington’s disease pathogenesisRandi Michelle Cowin
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
Mamm Genome 23:367-77. 2012..This identification may lead to novel targets for treatment and help elucidate the molecular mechanisms of HD pathogenesis... - Mice with truncated MeCP2 recapitulate many Rett syndrome features and display hyperacetylation of histone H3Mona Shahbazian
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
Neuron 35:243-54. 2002.... - Mice lacking Tropomodulin-2 show enhanced long-term potentiation, hyperactivity, and deficits in learning and memoryPatrick R Cox
Division of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
Mol Cell Neurosci 23:1-12. 2003..Electrophysiological analysis revealed enhanced LTP in Tmod2(lacZ-/-) mice. These studies suggest that Tmod2 plays a role in behavior, learning, memory, and synaptic plasticity... - Marble burying reflects a repetitive and perseverative behavior more than novelty-induced anxietyAlexia Thomas
Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
Psychopharmacology (Berl) 204:361-73. 2009..An increasing number of investigators utilize the marble-burying assay despite the paucity of information available regarding what underlies the behavior... - Group I metabotropic glutamate receptor antagonists alter select behaviors in a mouse model for fragile X syndromeAlexia M Thomas
Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Psychopharmacology (Berl) 219:47-58. 2012..Currently, no studies have assessed the effect of mGluR1 modulation on Fmr1 KO behavior, and there has not been an extensive behavioral analysis of mGluR5 manipulation in Fmr1 KO mice... - Onset and progression of behavioral and molecular phenotypes in a novel congenic R6/2 line exhibiting intergenerational CAG repeat stabilityRandi Michelle Cowin
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
PLoS ONE 6:e28409. 2011..Data from TR-FRET suggest an association of mutant protein state changes (soluble versus aggregated) in disease onset and progression... - The nicotinic acetylcholine receptor subunit alpha 5 mediates short-term effects of nicotine in vivoRamiro Salas
Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
Mol Pharmacol 63:1059-66. 2003..In addition, (125)I-epibatidine and [(125)I]alpha-bungarotoxin binding in the brains of alpha 5-deficient mice is normal. Together, these results suggest a direct involvement of the alpha 5 subunit in the observed phenotypes... - Tbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: implications for 22q11 deletion syndromeRichard Paylor
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 103:7729-34. 2006..Thus, Tbx1 and Gnb1l are strong candidates for psychiatric disease in 22q11DS patients and candidate susceptibility genes for psychiatric disease in the wider population... - The modulation of fragile X behaviors by the muscarinic M4 antagonist, tropicamideSurabi Veeraragavan
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
Behav Neurosci 125:783-90. 2011..These results suggest that pharmacological antagonism of the M4 receptor modulates select behavioral responses in the Fmr1KO mice... - Modulation of behavioral phenotypes by a muscarinic M1 antagonist in a mouse model of fragile X syndromeSurabi Veeraragavan
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
Psychopharmacology (Berl) 217:143-51. 2011..Overactive signaling through the M1 receptor has been hypothesized to contribute to the phenotypes seen in fragile X mice... - Behavioral and physiological mouse assays for anxiety: a survey in nine mouse strainsJ Adriaan Bouwknecht
Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Behav Brain Res 136:489-501. 2002..We conclude that a combination of behavioral and physiological responses might lead to a better understanding in anxiety-related processes... - Enriched rearing improves behavioral responses of an animal model for CNV-based autistic-like traitsMelanie Lacaria
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
Hum Mol Genet 21:3083-96. 2012.... - A long CAG repeat in the mouse Sca1 locus replicates SCA1 features and reveals the impact of protein solubility on selective neurodegenerationKei Watase
Department of Molecular and Human Genetics, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA
Neuron 34:905-19. 2002..It appears that those neurons that cannot sequester the mutant protein efficiently and thereby curb its toxicity suffer the worst damage from polyglutamine-induced toxicity... - Multiple autism-like behaviors in a novel transgenic mouse modelShannon M Hamilton
Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
Behav Brain Res 218:29-41. 2011..The MALTT line provides a unique genetic model for examining the underlying biological mechanisms involved in ASD-related behaviors... - Phenotypic characterization of Bbs4 null mice reveals age-dependent penetrance and variable expressivityErica R Eichers
Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza Room 604B, Houston, TX 77030, USA
Hum Genet 120:211-26. 2006..Evaluations of these null mice have uncovered phenotypic features with age-dependent penetrance and variable expressivity, partially recapitulating the human BBS phenotype... - Dynamic translational and proteasomal regulation of fragile X mental retardation protein controls mGluR-dependent long-term depressionLingfei Hou
Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
Neuron 51:441-54. 2006..These findings indicate that the translation, ubiquitination, and proteolysis of FMRP functions as a dynamic regulatory system for controlling synaptic plasticity... - Behavioral characterization of mouse models for Smith-Magenis syndrome and dup(17)(p11.2p11.2)Katherina Walz
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
Hum Mol Genet 13:367-78. 2004..Our findings suggest that there is a gene(s) present in this defined genomic interval that is responsible for behavioral abnormalities in the mouse, as has been shown for the human syntenic region... - Urocortin-deficient mice display normal stress-induced anxiety behavior and autonomic control but an impaired acoustic startle responseXiaozhong Wang
Department of Molecular and Human Genetics, Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
Mol Cell Biol 22:6605-10. 2002..Ucn may modulate the acoustic startle response through the Ucn-expressing neuron projections from the region of the Edinger-Westphal nucleus... - Mouse Dach2 mutants do not exhibit gross defects in eye development or brain functionRichard J Davis
Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
Genesis 44:84-92. 2006.... - Impaired conditioned fear and enhanced long-term potentiation in Fmr2 knock-out miceYanghong Gu
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
J Neurosci 22:2753-63. 2002..Thus, although a number of studies have suggested that diminished LTP is associated with memory impairment, our data suggest that increased LTP may be a mechanism that leads to impaired cognitive processing as well... - Pitfalls in the interpretation of genetic and pharmacological effects on anxiety-like behaviour in rodentsJan Adriaan Bouwknecht
Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, USA
Behav Pharmacol 19:385-402. 2008..We believe that considering the pitfalls presented here will help researchers to design optimized experiments that can be more readily interpreted and replicated across laboratories... - Early changes in the apparent diffusion coefficient (ADC) in a mouse model of Sandhoff's disease occur prior to disease symptoms and behavioral deficitsLingyun Hu
Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, USA
Magn Reson Med 62:1175-84. 2009..5 to 4 months of age) and behavioral deficits (3 months of age). The magnitude of the decrease ranged from 4-18%... - Mouse models of 22q11 deletion syndromeRichard Paylor
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Biol Psychiatry 59:1172-9. 2006..Significant progress has already been made, and recent studies in the mouse suggest that several genes from the deleted region affect behavior and might contribute to disease burden in patients... - R-flurbiprofen improves axonal transport in the Tg2576 mouse model of Alzheimer's disease as determined by MEMRIKaren D B Smith
Dept Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, USA
Magn Reson Med 65:1423-9. 2011..0329). We then determined that R-F treatment reduced tau hyper-phosphorylation in the older animals. These data indicate that both Aβ42 and tau comprise a role in axonal transport rate deficits in the Tg2576 model of Alzheimer's Disease... - Increased sensitivity to nicotine-induced seizures in mice expressing the L250T alpha 7 nicotinic acetylcholine receptor mutationRon S Broide
Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
Mol Pharmacol 61:695-705. 2002..Hence, these present findings suggest that alterations in the properties rather than absence of alpha 7 nAChRs might affect the mechanisms underlying the convulsive properties of nicotine... - Absence of alpha7-containing neuronal nicotinic acetylcholine receptors does not prevent nicotine-induced seizuresDavide Franceschini
Division of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Brain Res Mol Brain Res 98:29-40. 2002..These findings indicate that alpha7 may not be necessary for the mechanisms underlying nicotine-induced seizures... - Deletion of the alpha7 nicotinic receptor subunit gene results in increased sensitivity to several behavioral effects produced by alcoholBarbara J Bowers
Institute for Behavioral Genetics, University of Colorado at Boulder, 447 UCB, Boulder, CO 80309, USA
Alcohol Clin Exp Res 29:295-302. 2005..The studies outlined here used alpha7 gene knockout (null mutant) mice to evaluate the potential role of alpha7 nAChRs in modulating selected behavioral and physiological effects produced by ethanol... - Knockout mouse model for Fxr2: a model for mental retardationCarola J M Bontekoe
CBG Department of Clinical Genetics, Erasmus University, Rotterdam, The Netherlands
Hum Mol Genet 11:487-98. 2002..The findings implicate a role for Fxr2 in central nervous system function... - Secretin receptor-deficient mice exhibit impaired synaptic plasticity and social behaviorIchiko Nishijima
Center for Molecular and Human Genetics, Columbus Children s Research Institute, The Ohio State University, Columbus, OH 43205, USA
Hum Mol Genet 15:3241-50. 2006..Furthermore, secretin receptor-deficient mice show abnormal social and cognitive behaviors. These findings suggest that the secretin receptor system has an important role in the central nervous system relating to social behavior... - Null mutant analysis of responses to nicotine: deletion of beta2 nicotinic acetylcholine receptor subunit but not alpha7 subunit reduces sensitivity to nicotine-induced locomotor depression and hypothermiaTheresa Tritto
Institute for Behavioral Genetics, University of Colorado, Boulder, USA
Nicotine Tob Res 6:145-58. 2004..0 mg/kg) blocked all responses following 1.0 mg/kg nicotine. This finding suggests receptors that include the beta2 nAChR subunit partially mediate nicotine's effects on locomotor activity and body temperature... - Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synucleinDeborah E Cabin
Genetic Diseases Research Branch, National Human Genome Research Institute, Bethesda, Maryland 20892 4472, USA
J Neurosci 22:8797-807. 2002..These results reveal, for the first time, the normal function of endogenous alpha-synuclein in regulating synaptic vesicle mobilization at nerve terminals... - Deletion of the beta 2 nicotinic acetylcholine receptor subunit alters development of tolerance to nicotine and eliminates receptor upregulationSarah E McCallum
Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309, USA
Psychopharmacology (Berl) 184:314-27. 2006..However, the mechanism for chronic tolerance is unclear because a direct relationship between tolerance and receptor upregulation is not consistently observed...