Research Topics
| S PathakSummaryAffiliation: Baylor College of Medicine Country: USA Publications
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Detail Information
Publications
Telomere dynamics, aneuploidy, stem cells, and cancer (review)Sen Pathak
Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Int J Oncol 20:637-41. 2002....- Anvirzel, an extract of Nerium oleander, induces cell death in human but not murine cancer cellsS Pathak
Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston 77030, USA
Anticancer Drugs 11:455-63. 2000.... - Spontaneous regression of cutaneous melanoma in sinclair swine is associated with defective telomerase activity and extensive telomere erosionS Pathak
Cellular Genetics Laboratory, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Int J Oncol 17:1219-24. 2000..Such abnormal chromosome configurations are lost, following the breakage-fusion-bridge-cycles, and result in extensive DNA fragmentation, as shown by laddering experiments, and, finally, cell death... 
Can cancer cells transform normal host cells into malignant cells?S Pathak
Department of Cell Biology, The University of Texas MD Anderson Cancer Center, Houston 77030, USA
Br J Cancer 76:1134-8. 1997..These results suggest that cancer cells are capable of inducing neoplastic transformation in stromal cells of the host organ by some, as yet unknown, epigenetic mechanism(s)...- Heterochromatin and interstitial telomeric DNA homologyA S Multani
Department of Cancer Biology, The University of Texas, M.D. Anderson Cancer Center, Houston 77030, USA
Chromosoma 110:214-20. 2001.... - Integrin-mediated entry into S phase of human gastric adenocarcinoma cellsT Udagawa
Department of Immunology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
Clin Exp Metastasis 13:427-38. 1995..These studies suggest that during the metastatic process, integrin receptor interaction with the insoluble matrix may be an important step leading to proliferation of some tumors... - Human bone marrow transplant rejection is associated with telomere cleavageA S Multani
Department of Cancer Biology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
Int J Mol Med 8:607-10. 2001..We, therefore, conclude that BM rejection could be directly associated with the cleavage, clustering, and extrusion of telomeric DNA in the donor cells... - Loss of chromosomal integrity drives rat mammary tumorigenesisThea M Goepfert
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Int J Cancer 120:985-94. 2007..Collectively, these data suggest that the carcinogen MNU induces changes resulting in genetic instability detectable before hyperplasia and tumors develop in the rat mammary gland... - Ruta 6 selectively induces cell death in brain cancer cells but proliferation in normal peripheral blood lymphocytes: A novel treatment for human brain cancerSen Pathak
Department of Molecular Genetics, M D Anderson Cancer Center, Houston, TX 77030, USA
Int J Oncol 23:975-82. 2003..Cancer cell death was initiated by telomere erosion and completed through mitotic catastrophe events. We propose that Ruta in combination with Ca3(PO4)2 could be used for effective treatment of brain cancers, particularly glioma... - Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathwayPurnima R Laud
Department of Molecular Genetics, University of Texas, The M D Anderson Cancer Center, Houston, Texas 77030, USA
Genes Dev 19:2560-70. 2005.... - Telomere erosion-induced mitotic catastrophe in continuously grown chinese hamster don cellsSea H Sohn
Department of Animal Science and Biotechnology, Chinju National University, Chinju, 660-758, Republic of Korea
Exp Cell Res 279:271-6. 2002.... - Pleotropic effects of genistein on MCF-7 breast cancer cellsSreenivasa R Chinni
Department of Urology and Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
Int J Mol Med 12:29-34. 2003..From these results, we conclude that genistein-induced inhibition of cell division is partly mediated by decreased telomere length, reduced mitosis and inhibition of Akt activation, leading to induction of apoptosis... - Essential role of limiting telomeres in the pathogenesis of Werner syndromeSandy Chang
Department of Molecular Genetics, M D Anderson Cancer Center, Box 11, 1515 Holcombe Blvd, Houston, Texas 77030, USA
Nat Genet 36:877-82. 2004..These genetic data indicate that the delayed manifestation of the complex pleiotropic of Wrn deficiency relates to telomere shortening... - Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeresLing Wu
Department of Molecular Genetics, Box 1006, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Cell 126:49-62. 2006..Telomeric HR following Pot1a loss requires NBS1. Pot1a deletion also results in chromosomal instability. Our results suggest that POT1a is crucial for the maintenance of both telomere integrity and overall genomic stability... - Prostate cancer metastasis: role of the host microenvironment in promoting epithelial to mesenchymal transition and increased bone and adrenal gland metastasisJianchun Xu
Department of Urology, Molecular Urology and Therapeutics Program, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Prostate 66:1664-73. 2006..Cytogenetic analyses of parental and ARCaP subclones confirmed their clonality. CONCLUSIONS: ARCaP uniquely models the molecular basis of prostate cancer bone and adrenal metastases and epithelial to mesenchymal transition... - Molecular analysis of anoikis resistance in oral cavity squamous cell carcinomaMichael E Kupferman
Department of Head and Neck Surgery, MD Anderson Cancer Center, University of Texas, 1515 Holcombe Blvd, Unit 441, Houston, TX 77030, USA
Oral Oncol 43:440-54. 2007..Therapies targeting these potential mediators of anoikis resistance may prove to be beneficial in the treatment of metastatic squamous cell carcinoma... - POT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombinationHua He
Department of Molecular Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
EMBO J 25:5180-90. 2006..Our results indicate that POT1b plays important protective functions at telomeres and that proper maintenance of chromosomal stability requires both POT proteins... - Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescenceWilfredo Cosme-Blanco
Department of Cancer Genetics, The MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
EMBO Rep 8:497-503. 2007..These results indicate that suppression of spontaneous tumorigenesis by dysfunctional telomeres requires the activation of the p53-dependent cellular senescence pathway... - Drug-resistant breast carcinoma (MCF-7) cells are paradoxically sensitive to apoptosisJack S K Chen
Department of Bioimmunotherapy, The University of Texas, M.D. Anderson Cancer Center, Houston, Texas 77030, USA
J Cell Physiol 200:223-34. 2004.... - Tumor-specific low molecular weight forms of cyclin E induce genomic instability and resistance to p21, p27, and antiestrogens in breast cancerSaid Akli
Department of Experimental Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
Cancer Res 64:3198-208. 2004.... 
N-methyl-N'-nitro-N-nitrosoguanidine-induced senescence-like growth arrest in colon cancer cells is associated with loss of adenomatous polyposis coli protein, microtubule organization, and telomeric DNAAruna S Jaiswal
UF Shands Cancer Center and Anatomy and Cell Biology, College of Medicine, Academic Research Building, Room R4 216, PO Box 100232, University of Florida, Gainesville, FL 32610, USA
Mol Cancer 3:3. 2004..In the present study we report that the DNA-damaging agent N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) is able to induce senescence in the HCT-116 colon cancer cell line...- Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNAJiang Shou
Department of Neurosurgery, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Road, Houston, TX 77030, USA
Oncogene 21:878-89. 2002..These results show that hDkk-1 is a pro-apoptotic gene and suggest that it may play important roles in linking the oncogenic Wnt and p53 tumor suppressor pathways... - Human breast cancer MCF-7 cell line contains inherently drug-resistant subclones with distinct genotypic and phenotypic featuresEswaran Devarajan
Department of Bioimmunotherapy, The University of Texas, M.D. Anderson Cancer Center, Houston, TX 77030, USA
Int J Oncol 20:913-20. 2002..These results suggest that drug resistance is an inherent property of some cancer cells that are present in the initial tumor burden and exhibit distinct phenotypic/genotypic alterations... - Characterization of a renal cell carcinoma cell line derived from a human bone metastasis and establishment of an experimental nude mouse modelKristy L Weber
Department of Cancer Biology, University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA
J Urol 168:774-9. 2002..CONCLUSIONS: This cell line and animal model may allow further study of the biology and mechanism of renal cell carcinoma bone metastasis... - Organ- and tissue-specific stem cells and carcinogenesisSen Pathak
Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
Anticancer Res 22:1353-6. 2002..I, therefore, suggest that drug development for cancer treatment be directed towards tissue-specific stem cells... - Targeted therapy against human lung cancer in nude mice by high-affinity recombinant antimesothelin single-chain Fv immunotoxinDominic Fan
Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Mol Cancer Ther 1:595-600. 2002..Our data indicate that mesothelin-producing squamous cell carcinoma of the lung may be a good target for this immunotoxin... - Adenoviral-mediated retinoblastoma 94 produces rapid telomere erosion, chromosomal crisis, and caspase-dependent apoptosis in bladder cancer and immortalized human urothelial cells but not in normal urothelial cellsXinqiao Zhang
Department of Genitourinary Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA
Cancer Res 63:760-5. 2003..The lack of cytotoxicity to normal cells should also provide a high therapeutic index when used in gene therapy protocols for the treatment of bladder and other cancers... - Molecular characterization of new melanoma cell lines from C3H mice induced by ethanol plus ultraviolet radiationFaith M Strickland
Department of Immunology-178, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
Cancer Res 63:3503-10. 2003..These reagents will provide opportunities to search for new tumor suppressor genes that may contribute to the growth and metastasis of primary melanoma... - In vivo opossum xenograft model for cancer researchZhiqiang Wang
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA
Cancer Res 63:6121-4. 2003..These results establish Monodelphis as a natural mammalian model to study the cascade of interactions between xenografted cells and the host system... - Evidence that senescent human prostate epithelial cells enhance tumorigenicity: cell fusion as a potential mechanism and inhibition by p16INK4a and hTERTBobby Bhatia
Department of Carcinogenesis, University of Texas MD Anderson Cancer Center, Science Park Research Division, Smithville, TX 78957, USA
Int J Cancer 122:1483-95. 2008..These results suggest that senescent NHP cells, like senescent fibroblasts, may promote tumor development and that one of the mechanisms underlying the senescent NHP cell-enhanced tumorigenicity could be through cell fusion...