Virginia Pascual

Summary

Affiliation: Baylor University Medical Center
Country: USA

Publications

  1. pmc Tracking interferon in autoimmunity
    Virginia Pascual
    Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    Immunity 36:7-9. 2012
  2. ncbi request reprint Systemic lupus erythematosus: all roads lead to type I interferons
    Virginia Pascual
    Baylor Institute for Immunology Research, 3434 Live Oak Street, Suite 205, Dallas, TX 75204, USA
    Curr Opin Immunol 18:676-82. 2006
  3. pmc A genomic approach to human autoimmune diseases
    Virginia Pascual
    Baylor Institute for Immunology Research, INSERM U, Dallas, Texas 75204, USA
    Annu Rev Immunol 28:535-71. 2010
  4. pmc Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade
    Virginia Pascual
    Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    J Exp Med 201:1479-86. 2005
  5. ncbi request reprint The central role of dendritic cells and interferon-alpha in SLE
    Virginia Pascual
    Baylor Institute for Immunology Research, Dallas, Texas 75204, USA
    Curr Opin Rheumatol 15:548-56. 2003
  6. doi request reprint Human plasma cells express granzyme B
    Wei Xu
    Baylor Institute for Immunology Research, Dallas, TX, USA Pharma Research and Early Development, Roche Glycart, Schlieren, Switzerland
    Eur J Immunol 44:275-84. 2014
  7. pmc Blood leukocyte microarrays to diagnose systemic onset juvenile idiopathic arthritis and follow the response to IL-1 blockade
    Florence Allantaz
    Baylor National Institute of Allergy and Infectious Diseases Cooperative Center for Translational Research on Human Immunology and Biodefense, Dallas, TX 75204, USA
    J Exp Med 204:2131-44. 2007
  8. pmc How the study of children with rheumatic diseases identified interferon-alpha and interleukin-1 as novel therapeutic targets
    Virginia Pascual
    Baylor Institute for Immunology Research and Baylor Research Institute, Dallas, TX 75204, USA
    Immunol Rev 223:39-59. 2008
  9. ncbi request reprint Dendritic cells control B cell growth and differentiation
    Gaetan Jego
    Baylor Institute for Immunology Research and Baylor NIAID Cooperative Center for Translational Research on Human Immunology and Biodefense, Dallas, TX 75204, USA
    Curr Dir Autoimmun 8:124-39. 2005
  10. ncbi request reprint Immunotherapy via dendritic cells
    A Karolina Palucka
    Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX 75204, USA
    Adv Exp Med Biol 560:105-14. 2005

Research Grants

  1. ADMINISTRATIVE CORE
    Maria Pascual; Fiscal Year: 2007
  2. Use of Microarrays to Understand Systemic Arthritis
    Maria Pascual; Fiscal Year: 2006
  3. ECTOPIC GERMINAL CENTER REACTION IN SYSTEMIC LUPUS
    Maria Pascual; Fiscal Year: 2004
  4. Education:Symposium, Training, and Website
    Maria Pascual; Fiscal Year: 2003
  5. GENES SPECIFIC TO B CELL GERMINAL CENTER REACTIONS
    Maria Pascual; Fiscal Year: 2002
  6. Use of Microarrays to Understand Systemic Arthritis
    MARIA VIRGINIA PASCUAL; Fiscal Year: 2010

Collaborators

Detail Information

Publications41

  1. pmc Tracking interferon in autoimmunity
    Virginia Pascual
    Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    Immunity 36:7-9. 2012
    ..In this issue of Immunity, Gall et al. (2012) characterize, in a murine model of autoimmunity, the origin and progression of the type I interferon response leading to disease...
  2. ncbi request reprint Systemic lupus erythematosus: all roads lead to type I interferons
    Virginia Pascual
    Baylor Institute for Immunology Research, 3434 Live Oak Street, Suite 205, Dallas, TX 75204, USA
    Curr Opin Immunol 18:676-82. 2006
    ..This novel information is leading to the development of IFN antagonists as a potential therapeutic intervention in SLE, thus bringing hope to SLE patients...
  3. pmc A genomic approach to human autoimmune diseases
    Virginia Pascual
    Baylor Institute for Immunology Research, INSERM U, Dallas, Texas 75204, USA
    Annu Rev Immunol 28:535-71. 2010
    ..We expect this to crystallize within the coming decade, as these methods become part of the personalized medicine armamentarium...
  4. pmc Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade
    Virginia Pascual
    Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    J Exp Med 201:1479-86. 2005
    ..We conclude that IL-1 is a major mediator of the inflammatory cascade that underlies SoJIA and that this cytokine represents a target for therapy in this disease...
  5. ncbi request reprint The central role of dendritic cells and interferon-alpha in SLE
    Virginia Pascual
    Baylor Institute for Immunology Research, Dallas, Texas 75204, USA
    Curr Opin Rheumatol 15:548-56. 2003
    ..This review summarizes the recently uncovered role of dendritic cell subsets and one of their products, interferon-alpha, in the pathophysiology of systemic lupus erythematosus...
  6. doi request reprint Human plasma cells express granzyme B
    Wei Xu
    Baylor Institute for Immunology Research, Dallas, TX, USA Pharma Research and Early Development, Roche Glycart, Schlieren, Switzerland
    Eur J Immunol 44:275-84. 2014
    ..The precise role of GrzB in PC biology remains to be understood and studies in mice will not help as their PCs do not express GrzB. ..
  7. pmc Blood leukocyte microarrays to diagnose systemic onset juvenile idiopathic arthritis and follow the response to IL-1 blockade
    Florence Allantaz
    Baylor National Institute of Allergy and Infectious Diseases Cooperative Center for Translational Research on Human Immunology and Biodefense, Dallas, TX 75204, USA
    J Exp Med 204:2131-44. 2007
    ..Availability of early diagnostic markers may allow prompt initiation of therapy and prevention of disabilities...
  8. pmc How the study of children with rheumatic diseases identified interferon-alpha and interleukin-1 as novel therapeutic targets
    Virginia Pascual
    Baylor Institute for Immunology Research and Baylor Research Institute, Dallas, TX 75204, USA
    Immunol Rev 223:39-59. 2008
    ..Finally, our pilot clinical trials using IL-1 blockers have shown remarkable clinical benefits in SoJIA patients refractory to other medications...
  9. ncbi request reprint Dendritic cells control B cell growth and differentiation
    Gaetan Jego
    Baylor Institute for Immunology Research and Baylor NIAID Cooperative Center for Translational Research on Human Immunology and Biodefense, Dallas, TX 75204, USA
    Curr Dir Autoimmun 8:124-39. 2005
    ..It may also provide an explanation for spreading of the autoimmune repertoire as autoimmunity develops...
  10. ncbi request reprint Immunotherapy via dendritic cells
    A Karolina Palucka
    Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX 75204, USA
    Adv Exp Med Biol 560:105-14. 2005
    ..Indeed, what we learn from studying autoimmunity will help us induce strong vaccine specific immunity, either protective, as in the case of microbes, or therapeutic, as in the case of tumors...
  11. pmc Serum from patients with SLE instructs monocytes to promote IgG and IgA plasmablast differentiation
    Hyemee Joo
    Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    J Exp Med 209:1335-48. 2012
    ..Collectively, our study suggests that a direct myeloid DC-B cell interplay might contribute to the pathogenesis of SLE...
  12. pmc Microarray-based identification of novel biomarkers in IL-1-mediated diseases
    Florence Allantaz
    Baylor Institute for Immunology Research and Baylor Research Institute, Dallas, TX, USA
    Curr Opin Immunol 19:623-32. 2007
    ..Blood gene expression profiling can be used to identify such biomarkers. This review will summarize recent studies in the field and will discuss some of the challenges raised by the use of this technology in biomarker discovery...
  13. pmc Systems scale interactive exploration reveals quantitative and qualitative differences in response to influenza and pneumococcal vaccines
    Gerlinde Obermoser
    Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, TX 75204, USA
    Immunity 38:831-44. 2013
    ..Together, these results suggest that comparing global immune responses elicited by different vaccines will be critical to our understanding of the immune mechanisms underpinning successful vaccination...
  14. pmc IL-12 receptor β1 deficiency alters in vivo T follicular helper cell response in humans
    Nathalie Schmitt
    Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    Blood 121:3375-85. 2013
    ..Thus, our study shows that the IL-12-STAT4 axis is associated with the development and the functions of Tfh cells in vivo in humans...
  15. pmc Harnessing human dendritic cell subsets for medicine
    Hideki Ueno
    Baylor Institute for Immunology Research and INSERM U899, Dallas, TX 75204, USA
    Immunol Rev 234:199-212. 2010
    ..In this article, we summarize our recent studies aimed at a better understanding of the DC system to unravel the pathophysiology of human diseases and design novel human vaccines...
  16. pmc Macrophages induce differentiation of plasma cells through CXCL10/IP-10
    Wei Xu
    Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    J Exp Med 209:1813-23, S1-2. 2012
    ..Thus, our results reveal a novel dialog between Ms and B cells, in which IP-10 acts as a PC differentiation factor...
  17. ncbi request reprint Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6
    Gaetan Jego
    Baylor Institute for Immunology Research, 3434 Live Oak Street, Dallas, Texas 75204, USA
    Immunity 19:225-34. 2003
    ..These plasma cells display the high levels of CD38 found on tissue plasma cells. Thus, pDCs are critical for the generation of plasma cells and antibody responses...
  18. ncbi request reprint Analysis of significance patterns identifies ubiquitous and disease-specific gene-expression signatures in patient peripheral blood leukocytes
    Damien Chaussabel
    The Baylor NIAID Cooperative Center for Translational Research on Human Immunology and Biodefense and Baylor Institute for Immunology Research, 3434 Live Oak Street, Suite 205, Dallas, TX 75204, USA
    Ann N Y Acad Sci 1062:146-54. 2005
    ..Conversely, a "sentinel signature" that was common to all seven diseases was characterized. These findings bring new perspectives for the application of blood leukocyte expression signatures for diagnosis and early disease detection...
  19. pmc Human CD1c+ dendritic cells drive the differentiation of CD103+ CD8+ mucosal effector T cells via the cytokine TGF-β
    Chun I Yu
    Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    Immunity 38:818-30. 2013
    ..Thus, CD1c(+) and CD141(+) DCs generate CD8(+) T cells with different properties, and CD1c(+) DCs specialize in the regulation of mucosal CD8(+) T cells...
  20. pmc Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus
    Gina S Garcia-Romo
    Baylor Institute for Immunology Research, Dallas, TX 752014, USA
    Sci Transl Med 3:73ra20. 2011
    ..Our results reveal an unsuspected role for neutrophils in SLE pathogenesis and identify a novel link between nucleic acid-recognizing antibodies and type I IFN production in this disease...
  21. pmc Cross-regulation of TNF and IFN-alpha in autoimmune diseases
    A Karolina Palucka
    Baylor Institute for Immunology Research, 3434 Live Oak Street, Dallas, TX 75214, USA
    Proc Natl Acad Sci U S A 102:3372-7. 2005
    ..These results, therefore, might provide a mechanistic explanation for the development of anti-dsDNA antibodies and lupus-like syndrome in patients undergoing anti-TNF therapy...
  22. ncbi request reprint Gene expression in peripheral blood mononuclear cells from children with diabetes
    Ellen C Kaizer
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9063, USA
    J Clin Endocrinol Metab 92:3705-11. 2007
    ....
  23. pmc Interferon and granulopoiesis signatures in systemic lupus erythematosus blood
    Lynda Bennett
    Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    J Exp Med 197:711-23. 2003
    ..Therefore, while the IFN signature confirms the central role of this cytokine in SLE, microarray analysis of blood cells reveals that immature granulocytes may be involved in SLE pathogenesis...
  24. pmc Induction of ICOS+CXCR3+CXCR5+ TH cells correlates with antibody responses to influenza vaccination
    Salah Eddine Bentebibel
    Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, TX 75204, USA
    Sci Transl Med 5:176ra32. 2013
    ..Thus, the emergence of blood ICOS+CXCR3+CXCR5+CD4+ T cells correlates with the development of protective antibody responses generated by memory B cells upon seasonal influenza vaccination...
  25. pmc Neutrophils come of age in chronic inflammation
    Simone Caielli
    Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    Curr Opin Immunol 24:671-7. 2012
    ..Understanding the mechanisms that underlie neutrophil activation, migration, survival and their various forms of death in health and disease might provide us with new approaches to treat chronic inflammatory conditions...
  26. pmc A modular analysis framework for blood genomics studies: application to systemic lupus erythematosus
    Damien Chaussabel
    Baylor NIAID Cooperative Center for Translational Research on Human Immunology and Biodefense, Baylor Institute for Immunology Research and Baylor Research Institute, Dallas, TX 75204, USA
    Immunity 29:150-64. 2008
    ..Thus, this work describes the implementation and application of a methodology designed to support systems-scale analysis of the human immune system in translational research settings...
  27. ncbi request reprint Autoimmunity through cytokine-induced dendritic cell activation
    Jacques Banchereau
    Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX 75204 USA
    Immunity 20:539-50. 2004
    ..This model complements the Type 1/Type 2 paradigm. Therefore, immunity can be viewed as a dynamic system driven by two sets of opposite vectors: IFN-alpha/beta/TNF and IFN-gamma/IL-4...
  28. pmc Assessing the human immune system through blood transcriptomics
    Damien Chaussabel
    Baylor Institute for Immunology Research and Baylor Research Institute, 3434 Live Oak, Dallas, TX 75204, USA
    BMC Biol 8:84. 2010
    ..Recent technological and methodological advances that will carry the blood transcriptome research field forward are also discussed...
  29. ncbi request reprint Dendritic cells: controllers of the immune system and a new promise for immunotherapy
    Jacques Banchereau
    Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX 75204, USA
    Novartis Found Symp 252:226-35; discussion 235-8, 257-67. 2003
    ..50% of SLE patients have high serum levels of IFNalpha, which could explain T/B lymphopenia. Yet, plasmacytoid DCs, a major IFNalpha source, are 80% decreased. pDCs and IFNalpha may play a role in SLE pathogenesis and therapy...
  30. ncbi request reprint Dendritic cells: controllers of the immune system and a new promise for immunotherapy
    Jacques Banchereau
    Baylor Institute for Immunology Research, Dallas, Texas 75204, USA
    Ann N Y Acad Sci 987:180-7. 2003
    ..Another pathway includes plasmacytoid DCs, which promptly secrete large amounts of IFN-alpha/beta viral encounter. Thus, insights into in vivo DC functions are important to understand the launching and modulation of immunity...
  31. ncbi request reprint Dendritic cell subsets in health and disease
    Hideki Ueno
    Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    Immunol Rev 219:118-42. 2007
    ..Alterations of the DC system result in diseases such as autoimmunity, allergy, and cancer. Conversely, DCs can be exploited for vaccination, and novel vaccines that directly target DCs in vivo are being designed...
  32. pmc Interferon-α induces unabated production of short-lived plasma cells in pre-autoimmune lupus-prone (NZB×NZW)F1 mice but not in BALB/c mice
    Alexis Mathian
    Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    Eur J Immunol 41:863-72. 2011
    ..Thus, our work provides new insights into effectiveness and limitations of the current SLE therapies...
  33. pmc Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion
    Rimpei Morita
    Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, TX 75204, USA
    Immunity 34:108-21. 2011
    ..Importantly, the skewing of subsets correlated with disease activity and frequency of blood plasmablasts. Collectively, our study suggests that an altered balance of Tfh cell subsets contributes to human autoimmunity...
  34. ncbi request reprint Autoimmune mechanisms in children with systemic lupus erythematosus
    Dorothee Stichweh
    Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    Curr Rheumatol Rep 7:421-6. 2005
    ..Clinical trials to test several of these novel therapies are currently underway...
  35. ncbi request reprint Blood dendritic cells and DC-poietins in systemic lupus erythematosus
    Michelle A Gill
    Baylor Institute for Immunology Research, Dallas, Texas, USA
    Hum Immunol 63:1172-80. 2002
    ..Although IFN-alpha remains at the center of immunologic aberrations in SLE, it remains to be determined whether increased shedding of soluble TNF receptors could also be ascribed to IFN-alpha...
  36. pmc From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines
    Jacques Banchereau
    Baylor Institute for Immunology Research, Dallas, Texas, USA
    Nat Immunol 13:925-31. 2012
    ..We also emphasize how information accumulated through in vitro as well as in vivo studies of genetically engineered mice can help in the understanding and treatment of human diseases...
  37. ncbi request reprint Type I interferon in systemic lupus erythematosus and other autoimmune diseases
    Jacques Banchereau
    Baylor Institute for Immmunology Research, 3434 Live Oak, Dallas, Texas 75204, USA
    Immunity 25:383-92. 2006
    ..Genetic alterations in lineages other than B cells might explain other autoimmune syndromes where type I IFNs appear to be involved...
  38. ncbi request reprint Update on pediatric systemic lupus erythematosus
    Dorothee Stichweh
    Baylor Institute for Immunology Research, Dallas, Texas, and the UT Southwestern Medical Center, Dallas, Texas, USA
    Curr Opin Rheumatol 16:577-87. 2004
    ..Emerging clues on the pathogenesis of the disease based on recent human studies conducted both in children and adults, will also be summarized...
  39. ncbi request reprint Human germinal center B cells differ from naive and memory B cells by their aggregated MHC class II-rich compartments lacking HLA-DO
    Cecile Chalouni
    Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    Int Immunol 15:457-66. 2003
    ..Taken together, our results show that human GC B cells differ from naive and memory B cells by their aggregated MIIC that lack HLA-DO...
  40. ncbi request reprint Dramatic improvement of pyoderma gangrenosum with infliximab in a patient with PAPA syndrome
    Dorothee S Stichweh
    UT Southwestern Medical Center at Dallas and Texas Scottish Rite Hospital for Children, Dallas, Texas, USA
    Pediatr Dermatol 22:262-5. 2005
    ..A dramatic improvement in his pyoderma gangrenosum was observed after one infusion of infliximab, and a second infusion led to its resolution. Our observation extends the therapeutic use of infliximab to this component of PAPA syndrome...
  41. ncbi request reprint Autoantibody activity in Waldenstrom's macroglobulinemia
    Marvin J Stone
    Baylor Charles A Sammons Cancer Center, 3535 Worth Street, Dallas, TX 75246, USA
    Clin Lymphoma 5:225-9. 2005
    ..Study of the antigens reacting with monoclonal IgMs may provide further insight into the pathogenesis of WM...

Research Grants18

  1. ADMINISTRATIVE CORE
    Maria Pascual; Fiscal Year: 2007
    ..This component will also maintain a website with video files from the Symposia and Workshops. A five person external Advisory Committee is in place to serve the program. ..
  2. Use of Microarrays to Understand Systemic Arthritis
    Maria Pascual; Fiscal Year: 2006
    ..Our ultimate goal is to design novel therapies to antagonize the causative agent and/or the genetic pathways responsible for the establishment of this intriguing disease. ..
  3. ECTOPIC GERMINAL CENTER REACTION IN SYSTEMIC LUPUS
    Maria Pascual; Fiscal Year: 2004
    ..3. To identify the + _ nature and function of the SLE-restricted CD19- CD20- cell populations that co-purify with B cells. 4. To determine the clinical relevance of the + _ accumulation f IgD+ CD38+ B cells and/or CD19- CD20- cells. ..
  4. Education:Symposium, Training, and Website
    Maria Pascual; Fiscal Year: 2003
    ..humanimmunologybiodefense.com?) will be created. Three components will be proposed on the Website: Standard Operating Procedures, Human Immunology and Infectious Diseases Reviews, and Symposium recording. ..
  5. GENES SPECIFIC TO B CELL GERMINAL CENTER REACTIONS
    Maria Pascual; Fiscal Year: 2002
    ..These studies may help reaching a better understanding of the connections between the processes of normal B cell differentiation and the development of germinal center malignancies. ..
  6. Use of Microarrays to Understand Systemic Arthritis
    MARIA VIRGINIA PASCUAL; Fiscal Year: 2010
    ..Understanding the basis of IL-1 dysregulation might shed light on very basic aspects of cytokine biology and help finding novel therapeutic targets for this disease. ..