F M Orson

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. ncbi Vaccines for cocaine abuse
    Frank M Orson
    Veterans Affairs Medical Center, Houston, TX 77030, USA
    Hum Vaccin 5:194-9. 2009
  2. ncbi Triple helix formation: binding avidity of acridine-conjugated AG motif third strands containing natural, modified and surrogate bases opposed to pyrimidine interruptions in a polypurine target
    F M Orson
    The Veterans Affairs Medical Center, Department of Internal Medicine, Baylor College of Medicine, Building 109, Room 226, VAMC, 2002 Holcombe, Houston, TX 77030, USA
    Nucleic Acids Res 27:810-6. 1999
  3. ncbi Protection against influenza infection by cytokine-enhanced aerosol genetic immunization
    Frank M Orson
    Veterans Affairs Medical Center, Baylor College of Medicine, Houston, TX 77030, USA
    J Gene Med 8:488-97. 2006
  4. ncbi Substance abuse vaccines
    Frank M Orson
    Veterans Affairs Medical Center, Houston, TX 77030, USA
    Ann N Y Acad Sci 1141:257-69. 2008
  5. ncbi Intravenous immunoglobulin therapy suppresses manifestations of the angioedema with hypereosinophilia syndrome
    Frank M Orson
    Veterans Affairs Medical Center, Building 109, Room 226, Baylor College of Medicine, 2002 Holcombe, Houston, TX 77030, USA
    Am J Med Sci 326:94-7. 2003
  6. ncbi The future of vaccines in the management of addictive disorders
    Frank M Orson
    Veterans Administration Medical Center, 2002 Holcombe, Houston, TX 77030, USA
    Curr Psychiatry Rep 9:381-7. 2007
  7. ncbi Genetic immunization with lung-targeting macroaggregated polyethyleneimine-albumin conjugates elicits combined systemic and mucosal immune responses
    F M Orson
    Veterans Affairs Medical Center, Baylor College of Medicine, Houston, TX 77030, USA
    J Immunol 164:6313-21. 2000
  8. ncbi Aerosol delivery of robust polyethyleneimine-DNA complexes for gene therapy and genetic immunization
    C L Densmore
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Ther 1:180-8. 2000
  9. ncbi Gene delivery to the lung using protein/polyethylenimine/plasmid complexes
    F M Orson
    Veterans Affairs Medical Center, Baylor College of Medicine, Houston, TX, USA
    Gene Ther 9:463-71. 2002
  10. ncbi Various factors (allergen nature, mouse strain, CpG/recombinant protein expressed) influence the immune response elicited by genetic immunization
    J M Chatel
    Veterans Affairs Medical Center, Baylor College of Medicine, Houston, TX, USA
    Allergy 58:641-7. 2003

Research Grants

  1. Oral Delivery of DNA Vaccines
    FRANK ORSON; Fiscal Year: 2003

Collaborators

Detail Information

Publications17

  1. ncbi Vaccines for cocaine abuse
    Frank M Orson
    Veterans Affairs Medical Center, Houston, TX 77030, USA
    Hum Vaccin 5:194-9. 2009
    ..This review will discuss these issues and present the current developmental status of cocaine conjugate vaccines...
  2. ncbi Triple helix formation: binding avidity of acridine-conjugated AG motif third strands containing natural, modified and surrogate bases opposed to pyrimidine interruptions in a polypurine target
    F M Orson
    The Veterans Affairs Medical Center, Department of Internal Medicine, Baylor College of Medicine, Building 109, Room 226, VAMC, 2002 Holcombe, Houston, TX 77030, USA
    Nucleic Acids Res 27:810-6. 1999
    ..Molecular modeling showed that the 3-nitropyrrole.T:A triad is isomorphous with the A.A:T triad, and suggests novel parameters for evaluating new base triad designs...
  3. ncbi Protection against influenza infection by cytokine-enhanced aerosol genetic immunization
    Frank M Orson
    Veterans Affairs Medical Center, Baylor College of Medicine, Houston, TX 77030, USA
    J Gene Med 8:488-97. 2006
    ....
  4. ncbi Substance abuse vaccines
    Frank M Orson
    Veterans Affairs Medical Center, Houston, TX 77030, USA
    Ann N Y Acad Sci 1141:257-69. 2008
    ..This review will discuss these issues and present the current status of vaccine development for nicotine, cocaine, methamphetamine, phencyclidine, and morphine...
  5. ncbi Intravenous immunoglobulin therapy suppresses manifestations of the angioedema with hypereosinophilia syndrome
    Frank M Orson
    Veterans Affairs Medical Center, Building 109, Room 226, Baylor College of Medicine, 2002 Holcombe, Houston, TX 77030, USA
    Am J Med Sci 326:94-7. 2003
    ..We conclude that some cases of angioedema with hypereosinophilia syndrome may be highly responsive to IVIG therapy and, furthermore, that specific sources and/or lots of IVIG may have significantly different immunoregulatory properties...
  6. ncbi The future of vaccines in the management of addictive disorders
    Frank M Orson
    Veterans Administration Medical Center, 2002 Holcombe, Houston, TX 77030, USA
    Curr Psychiatry Rep 9:381-7. 2007
    ..The theoretical parameters that would influence vaccine-induced drug pharmacodynamics are presented in this review, along with the current status on vaccine development for nicotine, cocaine, methamphetamine, and phencyclidine...
  7. ncbi Genetic immunization with lung-targeting macroaggregated polyethyleneimine-albumin conjugates elicits combined systemic and mucosal immune responses
    F M Orson
    Veterans Affairs Medical Center, Baylor College of Medicine, Houston, TX 77030, USA
    J Immunol 164:6313-21. 2000
    ..v. or i.m. elicited only systemic responses. Thus, particle-bound plasmid DNA may have utility for genetic immunization by intravascular delivery to the lung and potentially to other organs and tissues...
  8. ncbi Aerosol delivery of robust polyethyleneimine-DNA complexes for gene therapy and genetic immunization
    C L Densmore
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Ther 1:180-8. 2000
    ..Potential applications of this technology, including the use of aerosolized PEI-DNA for genetic immunization, are discussed...
  9. ncbi Gene delivery to the lung using protein/polyethylenimine/plasmid complexes
    F M Orson
    Veterans Affairs Medical Center, Baylor College of Medicine, Houston, TX, USA
    Gene Ther 9:463-71. 2002
    ..As a result, this method may have useful applications in diseases that could benefit from recurrent therapeutic gene delivery...
  10. ncbi Various factors (allergen nature, mouse strain, CpG/recombinant protein expressed) influence the immune response elicited by genetic immunization
    J M Chatel
    Veterans Affairs Medical Center, Baylor College of Medicine, Houston, TX, USA
    Allergy 58:641-7. 2003
    ..CONCLUSIONS: Immune responses after genetic immunization are strongly influenced by the nature of the allergen, the mouse strain, and the ratio of CpG to recombinant protein expressed...
  11. ncbi Anti-drug vaccines to treat substance abuse
    Berma M Kinsey
    Research Service, Michael E DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA
    Immunol Cell Biol 87:309-14. 2009
    ..This review will discuss what has been done to bring such vaccines to human use, and what the challenges are for the future of this promising intervention...
  12. ncbi Monocyte CD49e and 110-120 kDa fibronectin fragments: HIV prognostic indicators independent of viral load and CD4 T-cell counts
    Roger D Rossen
    Michael E DeBakey Veterans Affairs Medical Center, 2002 Holcombe Boulevard, Houston, TX 77030, USA
    AIDS 23:2247-53. 2009
    ....
  13. ncbi Enhancement of both cellular and humoral responses to genetic immunization by co-administration of an antigen-expressing plasmid and a plasmid encoding the pro-apoptotic protein Bax
    Berma M Kinsey
    Veterans Affairs Medical Center, Center for AIDS Research, and Department of Internal Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    J Gene Med 6:445-54. 2004
    ..Published in 2004 by John Wiley & Sons, Ltd...
  14. ncbi Anti-cocaine vaccine development
    Berma M Kinsey
    Veterans Affairs Medical Center, TX, USA
    Expert Rev Vaccines 9:1109-14. 2010
    ....
  15. ncbi Targeted delivery of expression plasmids to the lung via macroaggregated polyethylenimine-albumin conjugates
    Frank M Orson
    Center for AIDS Research, Veterans Affairs Medical Center, Departments of Internal Medicine and Microbiology and Immunology, Baylor College of Medicine, Houston, TX, USA
    Methods Mol Med 75:575-90. 2003
  16. ncbi Vaccines against drug abuse
    X Y Shen
    Immunology Allergy and Rheumatology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
    Clin Pharmacol Ther 91:60-70. 2012
    ..We also outline the challenges and ethical concerns associated with the development of anti-addiction vaccines and their use as future therapeutics...
  17. ncbi Hepatocyte growth factor gene transfer to alveolar septa for effective suppression of lung fibrosis
    Masaki Watanabe
    Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, 4-1 Seiryo, Aoba-ku, Sendai 980-8575, Japan
    Mol Ther 12:58-67. 2005
    ..This novel HGF gene transfer method to alveolar septa with nonstimulatory MAA-PEI conjugates may have promising clinical applications...

Research Grants1

  1. Oral Delivery of DNA Vaccines
    FRANK ORSON; Fiscal Year: 2003
    ....