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Genomes and GenesSpecies | Pablo OkhuysenSummaryAffiliation: Baylor College of Medicine Country: USA Publications
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Publications
Traveler's diarrhea due to intestinal protozoaP C Okhuysen
Department of Medicine, Division of Infectious Diseases and School of Public Health, University of Texas Health Science Center in Houston, Houston, TX 77030, USA
Clin Infect Dis 33:110-4. 2001..The microbiology, epidemiology, clinical presentation, and treatment of the most common intestinal parasites found in travelers are presented in this minireview...- Current concepts in travelers' diarrhea: epidemiology, antimicrobial resistance and treatmentPablo C Okhuysen
Division of Infectious Diseases, The University of Texas Health Science Center, Houston Medical School, 6431 Fannin, Houston, TX 77030, USA
Curr Opin Infect Dis 18:522-6. 2005..The aim of this article is to review recent advances in travelers' diarrhea, which remains one of the most common health problems afflicting individuals from developed countries visiting less affluent regions of the world... - Cryptosporidium virulence determinants--are we there yet?Pablo C Okhuysen
Department of Medicine, Division of Infectious Diseases and The School of Public Health, The University of Texas Health Science Center at Houston Medical School, 6431 Fannin, 1 728 JFB, Houston, TX 77030, USA
Int J Parasitol 32:517-25. 2002..Here, we review the salient characteristics of some of these putative virulence determinants, including molecules that are involved in adhesion, protein degradation and the modulation of the host responses... - Infectivity of a Cryptosporidium parvum isolate of cervine origin for healthy adults and interferon-gamma knockout micePablo C Okhuysen
Department of Medicine, Division of Infectious Diseases, and School of Public Health, University of Texas Houston Health Science Center, Houston, TX 77030, USA
J Infect Dis 185:1320-5. 2002..The Moredun isolate was more pathogenic than the reference GCH-1 isolate. The GKO mouse model of cryptosporidiosis is useful for discerning isolate-specific differences in pathogenicity... - Cryptosporidiosis in childrenDavid B Huang
Division of Infectious Diseases The University of Texas Medical School and School of Public Health 6431 Fannin, 1 728 JFB Houston, TX 77030, USA
Semin Pediatr Infect Dis 15:253-9. 2004..Recent clinical trials in pediatric cryptosporidiosis have shown nitazoxanide to be effective therapy... - Antibody response of healthy adults to recombinant thrombospondin-related adhesive protein of cryptosporidium 1 after experimental exposure to cryptosporidium oocystsPablo C Okhuysen
Division of Infectious Diseases, The University of Texas Houston Medical School and School of Public Health, Houston, Texas 77030, USA
Clin Diagn Lab Immunol 11:235-8. 2004..These findings suggest that increases in antibody reactivity to rTRAP-C1 occur after recent exposure to C. parvum... - Treatment of travelers' diarrhea: randomized trial comparing rifaximin, rifaximin plus loperamide, and loperamide aloneHerbert L DuPont
Center for Infectious Diseases, University of Texas School of Public Health, Houston, Texas, USA
Clin Gastroenterol Hepatol 5:451-6. 2007..This study evaluated the efficacy and safety of rifaximin-loperamide in the treatment of travelers' diarrhea... - Enterotoxigenic Escherichia coli heat-labile toxin seroconversion in US travelers to MexicoJose Flores
Division of Infectious Diseases, University of Texas Medical School at Houston, Houston, TX 77030, USA
J Travel Med 15:156-61. 2008..However, the role of LT-producing ETEC (LT-ETEC) as a cause of diarrhea is controversial. We conducted a cohort study in US students traveling to Mexico to assess the ETEC-LT seroconversion rate after natural exposure... - A review of an emerging enteric pathogen: enteroaggregative Escherichia coliDavid B Huang
Infectious Diseases Section, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, 535EE, Houston, TX 77030, USA
J Med Microbiol 55:1303-11. 2006..Ciprofloxacin and rifaximin continue to be an effective treatment in persons infected with EAEC. This review is intended to provide an updated review for healthcare workers on EAEC, an emerging enteric pathogen... - A single-nucleotide polymorphism in the gene encoding osteoprotegerin, an anti-inflammatory protein produced in response to infection with diarrheagenic Escherichia coli, is associated with an increased risk of nonsecretory bacterial diarrhea in North AmeJamal A Mohamed
Division of Infectious Diseases, The University of Texas Medical School, Center for Infectious Diseases, Baylor College of Medicine, Houston, TX, USA
J Infect Dis 199:477-85. 2009.... - Epidemiology of cryptosporidiosis in North American travelers to MexicoParvathy Nair
The University of Texas Health Science Center at Houston Medical School and School of Public Health, Houston, Texas, USA
Am J Trop Med Hyg 79:210-4. 2008..Speciation by 18SrRNA sequencing showed that 13 cases were caused by C. parvum and only 1 case was caused by C. hominis. ELISA showed a sensitivity of 50% and specificity of 100% compared with PCR... - Post-diarrhea chronic intestinal symptoms and irritable bowel syndrome in North American travelers to MexicoPablo C Okhuysen
Division of Infectious Diseases, Medical School, The University of Texas Health Science Center at Houston, 6431 Fannin, JFB 1.728, Houston, TX 77096, USA
Am J Gastroenterol 99:1774-8. 2004..Postinfectious complications of traveler's diarrhea require further study for etiology and strategy for prevention... - A novel single-nucleotide polymorphism in the lactoferrin gene is associated with susceptibility to diarrhea in North American travelers to MexicoJamal A Mohamed
Division of Infectious Diseases, The University of Texas Medical School, Houston, TX 77030, USA
Clin Infect Dis 44:945-52. 2007..We investigated the impact that selected single-nucleotide polymorphisms (SNPs) in the human lactoferrin gene have on susceptibility to traveler's diarrhea... - Seroprevalence of the enteroaggregative Escherichia coli virulence factor dispersin among USA travellers to Cuernavaca, Mexico: a pilot studyDavid B Huang
Department of Medicine, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
J Med Microbiol 57:476-9. 2008..Further studies are needed to characterize in more detail the host clinical and immunological responses to the dispersin protein... - A randomized, double-blind, placebo-controlled trial of rifaximin to prevent travelers' diarrheaHerbert L DuPont
University of Texas Houston, Baylor College of Medicine, St Luke s Episcopal Hospital, and M D Anderson Cancer Center, Houston, Texas 77030, USA
Ann Intern Med 142:805-12. 2005..Travelers' diarrhea causes substantial morbidity and postinfectious irritable bowel syndrome... - Antibacterial chemoprophylaxis in the prevention of traveler's diarrhea: evaluation of poorly absorbed oral rifaximinHerbert L DuPont
Houston School of Public Health, Houston, TX, USA
Clin Infect Dis 41:S571-6. 2005.... - Virulence characteristics and the molecular epidemiology of enteroaggregative Escherichia coli isolates from travellers to developing countriesDavid B Huang
Baylor College of Medicine, Division of Infectious Diseases, Houston, TX, USA
J Med Microbiol 56:1386-92. 2007.... - Association of putative enteroaggregative Escherichia coli virulence genes and biofilm production in isolates from travelers to developing countriesJamal A Mohamed
Division of Infectious Diseases, Department of Internal Medicine, University of Texas Medical School, Houston, TX 77030, USA
J Clin Microbiol 45:121-6. 2007..This study suggests that biofilm formation is a common phenomenon among EAEC isolates derived from travelers with or without diarrhea and that multiple genes associated with biofilm formation are regulated by aggR... - Evaluation of recombinant oocyst protein CP41 for detection of cryptosporidium-specific antibodiesSonia A Kjos
Center for Infectious Diseases, The University of Texas Health Science Center School of Public Health, Houston, TX 77030, USA
Clin Diagn Lab Immunol 12:268-72. 2005..These results indicate that the use of the recombinant CP41 antigen in a standardized serodiagnostic assay could provide a reliable and cost-effective method for assessing human exposure to Cryptosporidium... - Cryptosporidium hominis: experimental challenge of healthy adultsCynthia L Chappell
The University of Texas Health Science Center at Houston, School of Public Health and Medical School, Houston, Texas 77030, USA
Am J Trop Med Hyg 75:851-7. 2006..Cryptosporidium hominis 10 oocysts) and is clinically is infectious for healthy adults (ID(50) = similar to C. parvum-induced illness. In contrast to C. parvum, C. hominis elicted a serum IgG response in most infected persons... - Cryptosporidium muris in a Texas canine populationPhilip J Lupo
Center for Infectious Disease, The University of Texas School of Public Health, Houston, Texas 77030, USA
Am J Trop Med Hyg 78:917-21. 2008..To our knowledge, this is the first report of a naturally occurring C. muris infection in a canine host. The finding of C. muris in asymptomatic canines supports the notion of dogs as potential sources of human infection... - Rifaximin treatment of pathogen-negative travelers' diarrheaHerbert L DuPont
Center for Infectious Diseases, Houston School of Public Health, The University of Texas, Houston, TX, USA
J Travel Med 14:16-9. 2007..Antibacterial drugs appear to be effective in shortening the illness of a majority of cases of travelers' diarrhea... - Influence of host interleukin-10 polymorphisms on development of traveler's diarrhea due to heat-labile enterotoxin-producing Escherichia coli in travelers from the United States who are visiting MexicoJose Flores
Division of Infectious Diseases, The University of Texas Medical School, 6431 Fannin Street, Houston, TX 77030, USA
Clin Vaccine Immunol 15:1194-8. 2008..002). Travelers genetically predisposed to produce high levels of IL-10 were more likely to experience symptomatic ETEC TD... - Loperamide plus azithromycin more effectively treats travelers' diarrhea in Mexico than azithromycin aloneCharles D Ericsson
Department of Medicine, Division of Infectious Diseases, University of Texas Medical School at Houston, and St Luke s Episcopal Hospital, Houston, TX 77030, USA
J Travel Med 14:312-9. 2007.... - PCR-based assay using occult blood detection cards for detection of diarrheagenic Escherichia coli in specimens from U.S. travelers to Mexico with acute diarrheaKevin A Grimes
Division of Infectious Diseases, The University of Texas Medical School, Houston, Texas, USA
J Clin Microbiol 46:2227-30. 2008..DNA extracted from fecal cards that was used for the detection of occult blood is of use in identifying diarrheagenic E. coli... - Noroviruses as a cause of diarrhea in travelers to Guatemala, India, and MexicoHoonmo L Koo
Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
J Clin Microbiol 48:1673-6. 2010..Significant variation in the prevalence of NoV diarrhea and in the predominant genogroup infecting travelers was demonstrated, dependent upon the specific geographic location and over time... - Genetic susceptibility to enteroaggregative Escherichia coli diarrhea: polymorphism in the interleukin-8 promotor regionZhi Dong Jiang
University of Texas School of Public Health, Houston, Texas, USA
J Infect Dis 188:506-11. 2003..0053). In the present study, the AA genotype at the -251 position was associated with the occurrence of EAEC-associated diarrhea and increased levels of fecal IL-8... - Substance P expression correlates with severity of diarrhea in cryptosporidiosisPrema Robinson
Infectious Diseases Section, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
J Infect Dis 188:290-6. 2003..This study demonstrates a direct correlation between SP levels and disease severity and may imply that SP plays a role in diarrhea mediation... - CryptosporidiosisCynthia L Chappell
Center for Infectious Diseases, School of Public Health, The University of Texas Health Science Center at Houston, 77030, USA
Curr Opin Infect Dis 15:523-7. 2002..Cryptosporidium research has increased dramatically since the human disease was first recognized in 1976. The present review summarizes recent work in three of the several areas of active Cryptosporidium investigation... - A retrospective, comparative evaluation of dysglycemias in hospitalized patients receiving gatifloxacin, levofloxacin, ciprofloxacin, or ceftriaxoneJohn F Mohr
Division of Infectious Diseases, Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
Pharmacotherapy 25:1303-9. 2005..To compare rates of blood glucose abnormalities in hospitalized patients receiving fluoroquinolones or ceftriaxone, and to describe the characteristics of patients who develop blood glucose abnormalities while receiving these agents... - Association of interleukin-8 polymorphism and immunoglobulin G anti-toxin A in patients with Clostridium difficile-associated diarrheaZhi Dong Jiang
Center for Infectious Diseases, 1200 Herman Pressler, Room 739, University of Texas School of Public Health, Houston, Texas 77030, USA
Clin Gastroenterol Hepatol 5:964-8. 2007..This study examined the relationship between serum immunoglobulin G antibodies to CD toxin A and the presence of IL-8 AA genotype in hospitalized patients with CDAD... - Interleukin-8 response in an intestinal HCT-8 cell line infected with enteroaggregative and enterotoxigenic Escherichia coliDavid B Huang
University of Texas Health Science Center, Houston Medical School, 6431 Fannin, JFB 1.728, Houston, TX 77030, USA
Clin Diagn Lab Immunol 11:548-51. 2004.... - Enteroaggregative Escherichia coli infectionJose Flores
Division of Infectious Diseases, The University of Texas Medical School at Houston, Texas, USA
Curr Opin Gastroenterol 25:8-11. 2009..To review studies that improve the current knowledge on the epidemiology, virulence factors, detection, and chronic complications of enteroaggregative Escherichia coli (EAEC) infection... - Pilot study of whole-blood gamma interferon response to the Vibrio cholerae toxin B subunit and resistance to enterotoxigenic Escherichia coli-associated diarrheaJose Flores
Center for Infectious Diseases, School of Public Health, University of Texas at Houston, Houston, Texas, USA
Clin Vaccine Immunol 17:879-81. 2010..Markers of the cellular immune response to ETEC LT could help in identifying individuals immune to ETEC LT, and these markers deserve additional study... - Enteroaggregative Escherichia coli: an emerging enteric pathogenDavid B Huang
Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
Am J Gastroenterol 99:383-9. 2004..The objective of this review is to increase awareness of this important emerging pathogen and to discuss the epidemiology, pathogenesis, and host-pathogen factors associated with EAEC infection... - Characterization of gp120 hydrolysis by IgA antibodies from humans without HIV infectionStephanie Planque
Chemical Immunology Research Center, Department of Pathology and Laboratory Medicine and Hemophilia and Thrombophilia Center, University of Texas Houston Medical School, Houston, Texas 77030, USA
AIDS Res Hum Retroviruses 23:1541-54. 2007..The neutralizing activity was specifically inhibited by an electrophilic inhibitor of the catalytic activity. The existence of catalytic IgAs to gp120 in uninfected humans suggests their role in resistance to HIV... - Interleukin-8, tumor necrosis factor-alpha, and lactoferrin in immunocompetent hosts with experimental and Brazilian children with acquired cryptosporidiosisCirle S Alcantara
Division of Geographic and International Medicine, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
Am J Trop Med Hyg 68:325-8. 2003..Although considered relatively non-inflammatory. cryptosporidiosis is often associated with mild inflammation, especially in children in an endemic area... - A functional collagen adhesin gene, acm, in clinical isolates of Enterococcus faecium correlates with the recent success of this emerging nosocomial pathogenSreedhar R Nallapareddy
Department of Internal Medicine, Division of Infectious Diseases, Center for the Study of Emerging and Re Emerging Pathogens, University of Texas Medical School, Houston, Texas 77030, USA
Infect Immun 76:4110-9. 2008..faecium genogroup referred to as clonal complex 17 (CC17), which has emerged globally. Taken together, our findings support the hypothesis that Acm has contributed to the emergence of E. faecium and CC17 in nosocomial infections... - HIV1 and the gut in the era of highly active antiretroviral therapyEsteban C Nannini
Division of Infectious Diseases, The University of Texas, Houston Medical School, 6431 Fannin Street, Room 1 728 JFB, Houston, TX 77030, USA
Curr Gastroenterol Rep 4:392-8. 2002.... - High levels of CXCL10 are produced by intestinal epithelial cells in AIDS patients with active cryptosporidiosis but not after reconstitution of immunityHeuy Ching Wang
Infectious Disease Section, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, 525D, Houston, TX 77030, USA
Infect Immun 75:481-7. 2007..By contrast, in AIDS patients lacking effector cells, CXCL10 may contribute to the immunopathogenesis by recruiting inflammatory cells... - Molecular epidemiology of the fsr locus and of gelatinase production among different subsets of Enterococcus faecalis isolatesJill C Roberts
Center for the Study of Emerging and Re-emerging Pathogens and Department of Microbiology and Molecular Genetics, The University of Texas Medical School at Houston, Houston, Texas 77030, USA
J Clin Microbiol 42:2317-20. 2004..While these findings indicate that neither fsr nor gelatinase is required for E. faecalis to cause infection, this study did not address whether fsr or gelatinase affects the severity of disease, as it does in animal models... - Enteroaggregative Escherichia coli is a cause of acute diarrheal illness: a meta-analysisDavid B Huang
Division of Infectious Diseases, Baylor College of Medicine, University of Texas at Houston, USA
Clin Infect Dis 43:556-63. 2006.... - Genetics of susceptibility to infection with enteric pathogensJose Flores
Division of Infectious Diseases, The University of Texas at Houston Medical School, Houston, Texas 77030, USA
Curr Opin Infect Dis 22:471-6. 2009..This review examines recent developments in human genetic susceptibility to enteropathogens that cause infectious diarrhea... - Molecular cloning and analysis of the Cryptosporidium parvum aminopeptidase N geneRanjit S Padda
Department of Medicine, Division of Infectious Diseases, The University of Texas Health Science Center in Houston, Houston, TX 77030, USA
Int J Parasitol 32:187-97. 2002..The aminopeptidase N mRNA was expressed in infective sporozoites and during the infection of human HCT-8 enterocytes as revealed by reverse transcription PCR... - Human studies provide insight into the pathogenesis, immunology, and treatment of cryptosporidiosisA Clinton White
Clin Infect Dis 37:989; author reply 989-90. 2003 - Noroviruses as a cause of traveler's diarrhea among students from the United States visiting MexicoGwangpyo Ko
Department of Environmental Health, School of Public Health, Seoul National University, 28 Yunkeun dong, ChongRo Ku, Seoul 110 799, South Korea
J Clin Microbiol 43:6126-9. 2005..This study indicates that NoV is an underappreciated cause of traveler's diarrhea... - Cryptosporidium dose response studies: variation between isolatesPeter F M Teunis
National Institute for Public Health and the Environment, Bilthoven, The Netherlands
Risk Anal 22:175-83. 2002..This finding is of great importance for quantitative risk assessment as it provides strong evidence for heterogeneity in infectivity among isolates of the same species... - Treatment of chronic cryptosporidiosis in AIDS with rIL-12 induces an immune response associated with improvement but severe side-effectsPablo C Okhuysen
AIDS 19:1333-4. 2005 - Cryptosporidium dose-response studies: variation between hostsPeter F M Teunis
National Institute for Public Health and the Environment, BA Bilthoven, The Netherlands
Risk Anal 22:475-85. 2002..Using such an approach provides first insights into the variation of susceptibility to infection in the general population... - Use of a patch containing heat-labile toxin from Escherichia coli against travellers' diarrhoea: a phase II, randomised, double-blind, placebo-controlled field trialSarah A Frech
IOMAI Corporation, Gaithersburg, MD, USA
Lancet 371:2019-25. 2008..We investigated the rate of diarrhoea attacks, safety, and feasibility of a vaccine containing heat-labile enterotoxin (LT) from ETEC delivered to the skin by patch in travellers to Mexico and Guatemala... - Fecal cytokines and markers of intestinal inflammation in international travelers with diarrhea due to NorovirusesGwangpyo Ko
Seoul National University, School of Public Health, Institute of Health and Environment, Seoul, Korea
J Med Virol 78:825-8. 2006..Intestinal inflammation associated with increased fecal lactoferrin, important in bacterial enteric infection, was not found in NoV-associated gastroenteritis... - Cryptosporidium parvum: identification and characterization of an acid phosphataseMaría Magdalena Aguirre-García
Department of Experimental Medicine, School of Medicine, UNAM, Dr Balmis 148, Colonia Doctores, Mexico City, DF 06726, Mexico
Parasitol Res 101:85-9. 2007..This is the first demonstration of acid phosphatase activity in Cryptosporidium...
Research Grants
- Gene Polymorphisms Predisposing to Infectious DiarrheaPablo Okhuysen; Fiscal Year: 2006..abstract_text> ..
- Gene Polymorphisms Predisposing to Infectious DiarrheaPablo Okhuysen; Fiscal Year: 2007..abstract_text> ..