Research Topics
| Yasuhiro NishiyamaSummaryAffiliation: Baylor College of Medicine Country: USA Publications
Research Grants
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Detail Information
Publications
An efficient synthesis of N-tert-butoxycarbonyl-O-cyclohexyl-L-tyrosineY Nishiyama
Department of Industrial Chemistry, Faculty of Engineering, Seikei University, Tokyo, Japan
Chem Pharm Bull (Tokyo) 49:233-5. 2001..The new synthetic method described here is convenient for practical use, and would facilitate the widespread use of the Chx group for the hydroxy-protection of Tyr...- Toward selective covalent inactivation of pathogenic antibodies: a phosphate diester analog of vasoactive intestinal peptide that inactivates catalytic autoantibodiesYasuhiro Nishiyama
Chemical Immunology and Therapeutics Research Center, Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, Houston, Texas 77030, USA
J Biol Chem 279:7877-83. 2004..These results suggest a novel route to antigen-specific covalent targeting of pathogenic Abs... - Towards covalent vaccination: improved polyclonal HIV neutralizing antibody response induced by an electrophilic gp120 V3 peptide analogYasuhiro Nishiyama
Chemical Immunology Research Center, Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, Houston, Texas 77030, USA
J Biol Chem 282:31250-6. 2007..These results suggest that electrophilic immunization induces a sufficiently robust nucleophilic Ab response to enhance the anti-microbial efficacy of candidate polypeptide vaccines... - Covalent reactivity of phosphonate monophenyl esters with serine proteinases: an overlooked feature of presumed transition state analogsYasuhiro Nishiyama
Chemical Immunology and Therapeutics Research Center, Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, 6431 Fannin, Houston, TX 77030, USA
Arch Biochem Biophys 402:281-8. 2002..47 vs 2.0 min(-1)). These observations suggest that the covalent reactivity of phosphonate monoesters contributes to their interactions with serine proteinases, including certain proteolytic antibodies... - Anti-HIV-1 peptides derived from partial amino acid sequences of CC-chemokine RANTES. Regulated upon activation, normal T-cell expressed and secretedYasuhiro Nishiyama
Chemical Immunology and Therapeutics Research Center, Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, 77030, USA
Bioorg Med Chem 10:4113-7. 2002..The results indicate that multiple regions, including the N-terminal part responsible for chemotactic activity, are involved in anti-HIV-1 activity of RANTES, yielding possible lead compounds for anti-HIV-1 agents... - VIPase autoantibodies in Fas-defective mice and patients with autoimmune diseaseYogesh Bangale
Chemical Immunology Research Center, Department of Pathology, University of Texas Medical School, 6431 Fannin, Houston, TX 77030, USA
FASEB J 17:628-35. 2003..These observations show that VIP is a target for specific catalytic autoantibodies in autoimmune disease... - Exceptional amyloid beta peptide hydrolyzing activity of nonphysiological immunoglobulin variable domain scaffoldsHiroaki Taguchi
Chemical Immunology Research Center, Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, Houston, Texas 77030, USA
J Biol Chem 283:36724-33. 2008..In view of their superior catalytic activity, the VL domain IgVs may help attain clearance of medically important antigens more efficiently than natural Igs... - Characterization of gp120 hydrolysis by IgA antibodies from humans without HIV infectionStephanie Planque
Chemical Immunology Research Center, Department of Pathology and Laboratory Medicine and Hemophilia and Thrombophilia Center, University of Texas Houston Medical School, Houston, Texas 77030, USA
AIDS Res Hum Retroviruses 23:1541-54. 2007..The neutralizing activity was specifically inhibited by an electrophilic inhibitor of the catalytic activity. The existence of catalytic IgAs to gp120 in uninfected humans suggests their role in resistance to HIV... - Catalytic antibodies to amyloid beta peptide in defense against Alzheimer diseaseHiroaki Taguchi
Chemical Immunology Research Center, University of Texas Houston Medical School, Houston, TX 77030, USA
Autoimmun Rev 7:391-7. 2008..Reduced Abeta aggregation and neurotoxicity attributable to the catalytic function were evident. These findings provide a foundation for development of catalytic Igs for AD immunotherapy... - Toward effective HIV vaccination: induction of binary epitope reactive antibodies with broad HIV neutralizing activityYasuhiro Nishiyama
Department of Pathology and Laboratory Medicine, Chemical Immunology Research Center, University of Texas Houston Medical School, Houston, Texas 77030, USA
J Biol Chem 284:30627-42. 2009..We present models accounting for improved CD4-binding site recognition and broad HIV neutralizing activity of the mAbs, long sought goals in HIV vaccine development... - Towards irreversible HIV inactivation: stable gp120 binding by nucleophilic antibodiesYasuhiro Nishiyama
Chemical Immunology and Therapeutics Research Center, Department of Pathology and Laboratory Medicine, University of Texas-Houston Medical School, Houston, Texas 77030, USA
J Mol Recognit 19:423-31. 2006..These findings suggest the feasibility of raising antibodies capable of long-lasting inactivation of antigens by electrophilic immunization... - Naturally occurring proteolytic antibodies: selective immunoglobulin M-catalyzed hydrolysis of HIV gp120Sudhir Paul
Chemical Immunology and Therapeutics Research Center, Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, Houston, Texas 77030, USA
J Biol Chem 279:39611-9. 2004..These observations suggest that IgMs can selectively cleave gp120 by a nucleophilic mechanism and raise the possibility of their role as defense enzymes... - Autoantibody-catalyzed hydrolysis of amyloid beta peptideHiroaki Taguchi
Chemical Immunology Research Center, Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, Houston, Texas 77030, USA
J Biol Chem 283:4714-22. 2008..Our results suggest that catalytic IgM autoantibodies can help clear Abeta, and they open the possibility of using catalytic Abs for AD immunotherapy... - Neutralization of genetically diverse HIV-1 strains by IgA antibodies to the gp120-CD4-binding site from long-term survivors of HIV infectionStephanie Planque
Chemical Immunology Research Center and Gulf States Hemophilia and Thrombophilia Center, Departments of Pathology and Pediatrics, University of Texas Houston Medical School, Houston, Texas, USA
AIDS 24:875-84. 2010..To identify an HIV epitope suitable for vaccine development... - Naturally occurring catalytic antibodies: evidence for preferred development of the catalytic function in IgA class antibodiesYukie Mitsuda
Department of Pathology and Laboratory Medicine, Chemical Immunology Research Center, University of Texas Houston Medical School, 6431 Fannin, Houston, TX 77030, USA
Mol Biotechnol 36:113-22. 2007..These observations suggest that mechanisms underlying B cell clonal selection favor the retention and improvement of catalytic activity in the IgA, but not the IgG compartment of the immune response... - Back to the future: covalent epitope-based HIV vaccine developmentSudhir Paul
Department of Pathology and Laboratory Medicine, Chemical Immunology Research Center, University of Texas Houston Medical School, 6431 Fannin, MSB 2 230A, Houston, TX 77030, USA
Expert Rev Vaccines 9:1027-43. 2010..We summarize evidence supporting development of covalent immunization as the first vaccine strategy with the potential to induce an antibody response to a conserved HIV epitope that neutralizes genetically divergent HIV strains... - Cross-clade HIV-1 neutralization by an antibody fragment from a lupus phage display librarySangeeta Karle
Chemical Immunology Research Center, Department of Pathology, University of Texas, Houston Medical School, USA
AIDS 18:329-31. 2004..The scFv neutralized R5 and X4-dependent HIV-1 strains from clades B, C, and D. The lupus repertoire may be useful as a source of neutralizing antibodies to HIV... - Broadly distributed chemical reactivity of natural antibodies expressed in coordination with specific antigen binding activityStephanie Planque
Chemical Immunology and Therapeutics Research Center, Department of Pathology and Laboratory Medicine, University of Texas-Houston Medical School, 77030, USA
J Biol Chem 278:20436-43. 2003.... - Specific HIV gp120-cleaving antibodies induced by covalently reactive analog of gp120Sudhir Paul
Chemical Immunology Research Center, Department of Pathology, University of Texas, Houston Medical School, 77030, USA
J Biol Chem 278:20429-35. 2003..These findings suggest the feasibility of raising antigen-specific proteolytic antibodies on demand by covalent immunization... - A mechanism-based probe for gp120-Hydrolyzing antibodiesHiroaki Taguchi
Chemical Immunology and Therapeutics Research Center, Department of Pathology and Laboratory Medicine, University of Texas-Houston Medical School, 6431 Fannin, Houston, TX 77030, USA
Bioorg Med Chem Lett 12:3167-70. 2002..These results reveal that the peptidyl phosphonate ester can serve as a probe for the antigen recognition and catalytic subsites of proteolytic antibodies... - Antibodies to the superantigenic site of HIV-1 gp120: hydrolytic and binding activities of the light chain subunitYasuhiro Nishiyama
Chemical Immunology and Therapeutics Research Center, Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, 6431 Fannin, Houston, TX 77030, USA
Mol Immunol 44:2707-18. 2007..The pairing of such light chains with heavy chains capable of gp120(SAg) recognition represents a potential mechanism for generating protective Abs with enhanced HIV binding strength and anti-viral proteolytic activity... - Ontogeny of proteolytic immunity: IgM serine proteasesStephanie Planque
Department of Pathology and Laboratory Medicine, University of Texas, Houston Medical School, Houston, Texas 77030, USA
J Biol Chem 279:14024-32. 2004..These observations indicate the existence of serine protease-like BCRs and secreted IgM Abs as innate immunity components with potential roles in B cell development and Ab effector functions... - Catalytic antibodies to HIV: physiological role and potential clinical utilityStephanie Planque
Department of Pathology, University of Texas Houston Medical School, Houston, TX, USA
Autoimmun Rev 7:473-9. 2008..Further study of the properties of the naturally occurring anti-SAg catalytic Igs should provide valuable guidance in designing a prophylactic vaccine that amplifies protective catalytic immunity to HIV... - Immunological origin and functional properties of catalytic autoantibodies to amyloid beta peptideSudhir Paul
Department of Pathology and Laboratory Medicine, Chemical Immunology Research Center, University of Texas Houston Medical School, Houston, TX 77030, USA
J Clin Immunol 30:S43-9. 2010..Criteria appropriate for developing a CIVIG formulation with potential therapeutic utility are discussed, including isolation of the Abeta-specific catalytic subsets present in IgM and IgG from human blood... - Nature and nurture of catalytic antibodiesSudhir Paul
Chemical Immunology Research Center, Department of Pathology, University of Texas Houston Medical School, Texas, USA
Adv Exp Med Biol 750:56-75. 2012..These concepts may be useful for developing novel vaccines that capitalize and improve on constitutive antibody functions for protection against microbes... - Broadly distributed nucleophilic reactivity of proteins coordinated with specific ligand binding activityYasuhiro Nishiyama
Chemical Immunology and Therapeutics Research Center, Department of Pathology and Laboratory Medicine, University of Texas-Houston Medical School, 6431 Fannin, Houston, TX 77030, USA
J Mol Recognit 18:295-306. 2005..These observations suggest the potential of EPs for specific and covalent targeting of proteins, and raise the possibility of nucleophile-electrophile pairing as a novel mechanism stabilizing protein-protein complexes... - Antibodies as defensive enzymesSudhir Paul
Chemical Immunology and Therapeutics Research Center, Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, MSB 2 250, 6431 Fannin, Houston, TX 77030, USA
Springer Semin Immunopathol 26:485-503. 2005.... - Autoantibodies to the epidermal growth factor receptor in systemic sclerosis, lupus, and autoimmune miceStephanie Planque
Chemical Immunology and Therapeutics Research Center, Department of Pathology and Internal Medicine, University of Texas-Houston Medical School, Houston, Texas 77030, USA
FASEB J 17:136-43. 2003..Short-lived but strong inhibition of cellular DNA synthesis was observed in the presence of the autoantibodies. We concluded that autoantibody responses to EGFR hold the potential of fulfilling a pathogenic role in autoimmune disease... - Antibodies to a Superantigenic Glycoprotein 120 Epitope as the Basis for Developing an HIV VaccineStephanie A Planque
Department of Pathology and Laboratory Medicine, Chemical Immunology Research Center, University of Texas Medical School at Houston, Houston, TX 77030
J Immunol 189:5367-81. 2012..The studies indicate broad and potent HIV neutralization by constitutive Abs as an innate, germline-encoded activity directed to the superantigenic CD4BD(core) epitope that is available for amplification for vaccination against HIV... - Vasoactive intestinal peptide binding autoantibodies in autoimmune humans and miceYogesh Bangale
Department of Pathology and Medicine, Chemical Immunology Research Center, University of Texas Medical School, Houston, TX, USA
Peptides 23:2251-7. 2002..The depletion of VIP by specific antibodies in autoimmune disease may interfere with VIP regulation of T cells and inflammatory cells and result in further amplification of autoreactive immunological responses... - Prospects for immunotherapeutic proteolytic antibodiesYong-Xin Zhou
Chemical Immunology and Therapeutics Research Center, Department of Pathology and Laboratory Medicine, University of Texas-Houston Medical School, 6431 Fannin, Houston, TX 77030, USA
J Immunol Methods 269:257-68. 2002..In reference to therapy of HIV infection, assurance is required that the Abs recognize the native conformation of gp120 expressed as a trimer on the virus surface... - Antibody light chain-catalyzed hydrolysis of a hepatitis C virus peptideHiroaki Taguchi
Chemical Immunology and Therapeutics Research Center, Department of Pathology and Laboratory Medicine, University of Texas-Houston Medical School, 6431 Fannin, 77030, USA
Bioorg Med Chem Lett 14:4529-32. 2004..One of the 39 light chains studied hydrolyzed the Val197-Ser198 bond of the peptide with Km and kcat values of 223 +/- 7 microM and 0.087 +/- 0.001 min(-1)... - Covalent inactivation of factor VIII antibodies from hemophilia A patients by an electrophilic FVIII AnalogStephanie Planque
Chemical Immunology Research Center, Department of Pathology, University of Texas Houston Medical School, Houston, Texas 77030, USA
J Biol Chem 283:11876-86. 2008..E-FVIII is a prototype reagent able to attain irreversible and specific inactivation of pathogenic Abs... - Antigen-specific proteolysis by hybrid antibodies containing promiscuous proteolytic light chains paired with an antigen-binding heavy chainGopal Sapparapu
Chemical Immunology Research Center, Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, Houston, Texas 77030, USA
J Biol Chem 284:24622-33. 2009..These studies provide proof-of-principle that the catalytic activity of a light chain can be rendered antigen-specific by pairing with a noncovalently binding heavy chain subunit... - Beneficial catalytic immunity to abeta peptideSudhir Paul
Chemical Immunology Research Center, University of Texas Houston Medical School, Houston, Texas 77030, USA
Rejuvenation Res 13:179-87. 2010..We present our view that catalytic antibodies are likely to emerge as more efficacious and safer immunotherapy reagents compared to traditional Abeta-binding antibodies... - Theory of proteolytic antibody occurrenceSudhir Paul
Chemical Immunology and Therapeutics Research Center, Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, 6431 Fannin, 77030, USA
Immunol Lett 103:8-16. 2006..This article attempts to provide a rational basis for natural Ab catalysis, in the hope that understanding this phenomenon will stimulate medical and basic science advances in the field... - Constant Domain-regulated Antibody CatalysisGopal Sapparapu
From the Chemical Immunology Research Center, Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, Houston, Texas 77030
J Biol Chem 287:36096-104. 2012.... - Phosphonate ester probes for proteolytic antibodiesS Paul
Department of Pathology and Laboratory Medicine, Chemical Immunology and Therapeutics Research Center, University of Texas Houston Medical School, Houston, Texas 77030, USA
J Biol Chem 276:28314-20. 2001..The covalent reactivity of Abs with phosphonate esters suggests their ability to recapitulate the catalytic mechanism utilized by classical serine proteases... - Constitutive production of catalytic antibodies to a Staphylococcus aureus virulence factor and effect of infectionEric L Brown
Center for Infectious Diseases, University of Texas School of Public Health, Houston, Texas 77030, USA
J Biol Chem 287:9940-51. 2012..These data suggest a potential defense function for constitutively produced catalytic antibodies to a putative superantigenic site of Efb, but an adaptive catalytic response appears to be proscribed... - Homeostatic regulation of intestinal villous epithelia by B lymphocytesYasuhiro Nishiyama
Department of Microbiology, Keio University School of Medicine, Nippon Medical School, Tokyo, Japan
J Immunol 168:2626-33. 2002.... - Identification of multiple isolated lymphoid follicles on the antimesenteric wall of the mouse small intestineHiromasa Hamada
Department of Microbiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
J Immunol 168:57-64. 2002..These findings indicate that ILF, PP, and CP constitute three distinct organized gut-associated lymphoid tissues that reside in the lamina propria of the mouse small intestine... - Onset of hepatic erythropoiesis after malarial infection in miceRamesh C Halder
Department of Immunology, Niigata University School of Medicine, Niigata 951-8510, Japan
Parasitol Int 52:259-68. 2003..Many clusters of red blood cells appeared de novo in the parenchymal space of the liver. These results revealed that malarial infection had a potential to induce the onset of hepatic erythropoiesis in mice... - Catalytic antibodies and their applicationsCarl Veith Hanson
Viral and Rickettsial Disease Laboratory, California Department of Health Services, Richmond, 94804, USA
Curr Opin Biotechnol 16:631-6. 2005..Artificial CAbs are likely to find increasing applications in research, clinical medicine, diagnostics and manufacturing...
Research Grants
- Neutralizing antibodies raised by covalent immunizationYasuhiro Nishiyama; Fiscal Year: 2007..The studies are likely to strengthen the foundation for further development of neutralizing antibodies capable of permanent virus inactivation. ..