Karen Niederreither

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. doi request reprint Retinoic acid in development: towards an integrated view
    Karen Niederreither
    Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nat Rev Genet 9:541-53. 2008
  2. pmc Endogenous retinoic acid regulates cardiac progenitor differentiation
    Song Chang Lin
    Departments of Medicine and Molecular and Cellular Biology, Center for Cardiovascular Development, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 107:9234-9. 2010
  3. ncbi request reprint Retinoic acid regulates morphogenesis and patterning of posterior foregut derivatives
    Zengxin Wang
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Dev Biol 297:433-45. 2006
  4. ncbi request reprint Retinoic acid regulates endothelial cell proliferation during vasculogenesis
    Lihua Lai
    Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Development 130:6465-74. 2003
  5. ncbi request reprint Inhibition of Tgf beta signaling by endogenous retinoic acid is essential for primary lung bud induction
    Felicia Chen
    Pulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA
    Development 134:2969-79. 2007
  6. ncbi request reprint Rescue of morphogenetic defects and of retinoic acid signaling in retinaldehyde dehydrogenase 2 (Raldh2) mouse mutants by chimerism with wild-type cells
    Julien Vermot
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, UMR 7104 du CNRS, U 596 de l INSERM, Universite Louis Pasteur, Cedex, CU de Strasbourg, France
    Differentiation 74:661-8. 2006
  7. pmc Retinoic acid deficiency alters second heart field formation
    Lucile Ryckebusch
    Developmental Biology Institute of Marseille Luminy, Centre National de la Recherche Scientifique Unité Mixte de Recherche 6216, Campus de Luminy Case 907, 13009 Marseille, France
    Proc Natl Acad Sci U S A 105:2913-8. 2008
  8. ncbi request reprint Conditional (loxP-flanked) allele for the gene encoding the retinoic acid-synthesizing enzyme retinaldehyde dehydrogenase 2 (RALDH2)
    Julien Vermot
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, UMR 7104 du CNRS, U 596 de l INSERM, Universite Louis Pasteur, CU de Strasbourg, France
    Genesis 44:155-8. 2006
  9. ncbi request reprint Distinct roles for retinoic acid receptors alpha and beta in early lung morphogenesis
    Tushar J Desai
    Pulmonary Center, Boston University School of Medicine, 80 East Concord Street R 304, Boston, MA 02118, USA
    Dev Biol 291:12-24. 2006
  10. ncbi request reprint Retinaldehyde dehydrogenase 2 (RALDH2)-mediated retinoic acid synthesis regulates early mouse embryonic forebrain development by controlling FGF and sonic hedgehog signaling
    Vanessa Ribes
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS, INSERM, Universite Louis Pasteur, BP 10142, 67404 Illkirch Cedex, CU de Strasbourg, France
    Development 133:351-61. 2006

Collaborators

  • Pascal Dolle
  • Michael D Schneider
  • Wellington V Cardoso
  • KAREN K contact HIRSCHI
  • Richard P Harvey
  • Eri Hashino
  • Raymond Romand
  • Julien Vermot
  • Pierre Chambon
  • Zengxin Wang
  • Song Chang Lin
  • Lucile Ryckebusch
  • Felicia Chen
  • Tushar J Desai
  • Vanessa Ribes
  • Stephane Zaffran
  • JINING LU
  • Jun Qian
  • Andree Dierich
  • Patricia Serpente
  • Merce Martin
  • Jean Marie Garnier
  • Lihua Lai
  • Michela Noseda
  • Xuan Chi
  • Nicolas Bertrand
  • Robert Schwartz
  • Nadia Messaddeq
  • Alex P Gould
  • Leanne M Wiedemann
  • Michele Kedinger
  • Jabier Gallego-Llamas
  • Valerie Fraulob
  • Norbert B Ghyselinck
  • Gerard Gradwohl
  • Stefan Tümpel
  • Robb Krumlauf
  • Jabier Gallego Llamas
  • Brenda L Bohnsack

Detail Information

Publications20

  1. doi request reprint Retinoic acid in development: towards an integrated view
    Karen Niederreither
    Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nat Rev Genet 9:541-53. 2008
    ..Some of these functions could be maintained throughout the life of an organism to regulate cell-lineage decisions and/or the differentiation of stem cell populations, highlighting possibilities for regenerative medicine...
  2. pmc Endogenous retinoic acid regulates cardiac progenitor differentiation
    Song Chang Lin
    Departments of Medicine and Molecular and Cellular Biology, Center for Cardiovascular Development, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 107:9234-9. 2010
    ..Hence, although lack of RA signaling increases cardiac SP numbers, simultaneous reductions in Fgf signaling reduce cardiomyocyte differentiation, possibly accounting for long-term defects in myocardial growth...
  3. ncbi request reprint Retinoic acid regulates morphogenesis and patterning of posterior foregut derivatives
    Zengxin Wang
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Dev Biol 297:433-45. 2006
    ..Our data implicate RA as a regulator of gene expression in the early embryonic lung and stomach region upstream of Hox, Tbx and FGF10 signaling...
  4. ncbi request reprint Retinoic acid regulates endothelial cell proliferation during vasculogenesis
    Lihua Lai
    Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Development 130:6465-74. 2003
    ..Thus, these data indicate that RA plays a crucial role in mammalian vascular development; it is required to control endothelial cell proliferation and vascular remodeling during vasculogenesis...
  5. ncbi request reprint Inhibition of Tgf beta signaling by endogenous retinoic acid is essential for primary lung bud induction
    Felicia Chen
    Pulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA
    Development 134:2969-79. 2007
    ..Our data support a novel mechanism of RA-Tgfbeta-Fgf10 interactions in the developing foregut, in which endogenous RA controls Tgfbeta activity in the prospective lung field to allow local expression of Fgf10 and induction of lung buds...
  6. ncbi request reprint Rescue of morphogenetic defects and of retinoic acid signaling in retinaldehyde dehydrogenase 2 (Raldh2) mouse mutants by chimerism with wild-type cells
    Julien Vermot
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, UMR 7104 du CNRS, U 596 de l INSERM, Universite Louis Pasteur, Cedex, CU de Strasbourg, France
    Differentiation 74:661-8. 2006
    ....
  7. pmc Retinoic acid deficiency alters second heart field formation
    Lucile Ryckebusch
    Developmental Biology Institute of Marseille Luminy, Centre National de la Recherche Scientifique Unité Mixte de Recherche 6216, Campus de Luminy Case 907, 13009 Marseille, France
    Proc Natl Acad Sci U S A 105:2913-8. 2008
    ..5 and RA signaling by generating double mutant mice. Strikingly, Nkx2.5 deficiency was able to rescue molecular defects in the posterior region of the Raldh2(-/-) mutant heart, in a gene dosage-dependent manner...
  8. ncbi request reprint Conditional (loxP-flanked) allele for the gene encoding the retinoic acid-synthesizing enzyme retinaldehyde dehydrogenase 2 (RALDH2)
    Julien Vermot
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, UMR 7104 du CNRS, U 596 de l INSERM, Universite Louis Pasteur, CU de Strasbourg, France
    Genesis 44:155-8. 2006
    ..The conditional allele described herein is a genetic tool for studying tissue-specific, RALDH2-dependent functions of retinoic acid during development and in adult life...
  9. ncbi request reprint Distinct roles for retinoic acid receptors alpha and beta in early lung morphogenesis
    Tushar J Desai
    Pulmonary Center, Boston University School of Medicine, 80 East Concord Street R 304, Boston, MA 02118, USA
    Dev Biol 291:12-24. 2006
    ..Our data support the idea that balanced activation of RAR alpha and beta is critical for proper lung bud initiation and endodermal differentiation...
  10. ncbi request reprint Retinaldehyde dehydrogenase 2 (RALDH2)-mediated retinoic acid synthesis regulates early mouse embryonic forebrain development by controlling FGF and sonic hedgehog signaling
    Vanessa Ribes
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS, INSERM, Universite Louis Pasteur, BP 10142, 67404 Illkirch Cedex, CU de Strasbourg, France
    Development 133:351-61. 2006
    ..These results unveil crucial roles of RA during early mouse forebrain development, which may involve the regulation of the expansion of neural progenitor cells through a crosstalk with FGF and sonic hedgehog signaling pathways...
  11. ncbi request reprint Dorsal pancreas agenesis in retinoic acid-deficient Raldh2 mutant mice
    Merce Martin
    INSERM, U682, Strasbourg, France
    Dev Biol 284:399-411. 2005
    ..We conclude that RA synthesized in the mesenchyme is specifically required for the normal development of the dorsal pancreatic endoderm at a stage preceding Pdx 1 function...
  12. ncbi request reprint Retinoic acid controls the bilateral symmetry of somite formation in the mouse embryo
    Julien Vermot
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, BP 10142, 67404 Illkirch Cedex, Strasbourg, France
    Science 308:563-6. 2005
    ..These data implicate retinoic acid as an endogenous signal that maintains the bilateral synchrony of mesoderm segmentation, and therefore controls bilateral symmetry, in vertebrate embryos...
  13. ncbi request reprint Direct crossregulation between retinoic acid receptor {beta} and Hox genes during hindbrain segmentation
    Patricia Serpente
    Medical Research Council, National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK
    Development 132:503-13. 2005
    ..We propose that the function of this circuit is to align the initially incongruent expression of multiple RA-induced genes at a single segment boundary...
  14. ncbi request reprint Complementary expression patterns of retinoid acid-synthesizing and -metabolizing enzymes in pre-natal mouse inner ear structures
    Raymond Romand
    Institut Clinique de la Souris, 1, rue Laurent Fries, B P 10142, 67404 Illkirch, France
    Gene Expr Patterns 4:123-33. 2004
    ....
  15. ncbi request reprint The regional pattern of retinoic acid synthesis by RALDH2 is essential for the development of posterior pharyngeal arches and the enteric nervous system
    Karen Niederreither
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, BP 10142, 67404 Illkirch Cedex, CU de Strasbourg, France
    Development 130:2525-34. 2003
    ..Thus, RALDH2 plays a crucial role in producing RA required for pharyngeal development, and RA is one of the diffusible mesodermal signals that pattern the pharyngeal endoderm...
  16. pmc Decreased embryonic retinoic acid synthesis results in a DiGeorge syndrome phenotype in newborn mice
    Julien Vermot
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche, Médicale Université Louis Pasteur, College de France, BP 10142, 67404 Illkirch Cedex, France
    Proc Natl Acad Sci U S A 100:1763-8. 2003
    ....
  17. pmc Retinaldehyde dehydrogenase 2 (RALDH2)- independent patterns of retinoic acid synthesis in the mouse embryo
    Karen Niederreither
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche ScientifiqueInstitut National de la Santé et de la Recherche MédicaleUniversité Louis PasteurCollège de France, Strasbourg, France
    Proc Natl Acad Sci U S A 99:16111-6. 2002
    ....
  18. ncbi request reprint Embryonic retinoic acid synthesis is required for forelimb growth and anteroposterior patterning in the mouse
    Karen Niederreither
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, BP 10142, 67404 Illkirch Cedex, CU de Strasbourg, France
    Development 129:3563-74. 2002
    ..We suggest that RA signaling cooperates with a posteriorly restricted factor such as dHand, to generate a functional zone of polarizing activity (ZPA)...
  19. ncbi request reprint Genetic evidence that oxidative derivatives of retinoic acid are not involved in retinoid signaling during mouse development
    Karen Niederreither
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France
    Nat Genet 31:84-8. 2002
    ..We provide genetic evidence that ALDH1A2 and CYP26A1 activities concurrently establish local embryonic retinoic acid levels that must be finely tuned to allow posterior organ development and to prevent spina bifida...
  20. ncbi request reprint Differential expression of retinoic acid-synthesizing (RALDH) enzymes during fetal development and organ differentiation in the mouse
    Karen Niederreither
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, B P 163, 67404 Illkirch Cedex, C U de Strasbourg, France
    Mech Dev 110:165-71. 2002
    ..Only Raldh1 expression is seen after birth in specific brain structures. These data indicate a requirement for regulated RA synthesis in various differentiating organs...