Research Topics
Species | Karen NiederreitherSummaryAffiliation: Baylor College of Medicine Country: USA Publications
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Detail Information
Publications
Retinoic acid in development: towards an integrated viewKaren Niederreither
Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Nat Rev Genet 9:541-53. 2008..Some of these functions could be maintained throughout the life of an organism to regulate cell-lineage decisions and/or the differentiation of stem cell populations, highlighting possibilities for regenerative medicine...
Endogenous retinoic acid regulates cardiac progenitor differentiationSong Chang Lin
Departments of Medicine and Molecular and Cellular Biology, Center for Cardiovascular Development, Baylor College of Medicine, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 107:9234-9. 2010..Hence, although lack of RA signaling increases cardiac SP numbers, simultaneous reductions in Fgf signaling reduce cardiomyocyte differentiation, possibly accounting for long-term defects in myocardial growth...
Retinoic acid regulates morphogenesis and patterning of posterior foregut derivativesZengxin Wang
Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
Dev Biol 297:433-45. 2006..Our data implicate RA as a regulator of gene expression in the early embryonic lung and stomach region upstream of Hox, Tbx and FGF10 signaling...- Retinoic acid regulates endothelial cell proliferation during vasculogenesisLihua Lai
Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
Development 130:6465-74. 2003..Thus, these data indicate that RA plays a crucial role in mammalian vascular development; it is required to control endothelial cell proliferation and vascular remodeling during vasculogenesis... - Inhibition of Tgf beta signaling by endogenous retinoic acid is essential for primary lung bud inductionFelicia Chen
Pulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA
Development 134:2969-79. 2007..Our data support a novel mechanism of RA-Tgfbeta-Fgf10 interactions in the developing foregut, in which endogenous RA controls Tgfbeta activity in the prospective lung field to allow local expression of Fgf10 and induction of lung buds... - Rescue of morphogenetic defects and of retinoic acid signaling in retinaldehyde dehydrogenase 2 (Raldh2) mouse mutants by chimerism with wild-type cellsJulien Vermot
, UMR 7104 du CNRS, U. 596 de l'INSERM, , Cedex, CU de Strasbourg, France
Differentiation 74:661-8. 2006.... - Retinoic acid deficiency alters second heart field formationLucile Ryckebusch
Developmental Biology Institute of Marseille Luminy, Centre National de la Recherche Scientifique Unité Mixte de Recherche 6216, Campus de Luminy Case 907, 13009 Marseille, France
Proc Natl Acad Sci U S A 105:2913-8. 2008..5 and RA signaling by generating double mutant mice. Strikingly, Nkx2.5 deficiency was able to rescue molecular defects in the posterior region of the Raldh2(-/-) mutant heart, in a gene dosage-dependent manner... - Conditional (loxP-flanked) allele for the gene encoding the retinoic acid-synthesizing enzyme retinaldehyde dehydrogenase 2 (RALDH2)Julien Vermot
Institut de Genetique et de Biologie Moleculaire et Cellulaire, UMR 7104 du CNRS, U 596 de l INSERM, Universite Louis Pasteur, CU de Strasbourg, France
Genesis 44:155-8. 2006..The conditional allele described herein is a genetic tool for studying tissue-specific, RALDH2-dependent functions of retinoic acid during development and in adult life... - Distinct roles for retinoic acid receptors alpha and beta in early lung morphogenesisTushar J Desai
Pulmonary Center, Boston University School of Medicine, 80 East Concord Street R 304, Boston, MA 02118, USA
Dev Biol 291:12-24. 2006..Our data support the idea that balanced activation of RAR alpha and beta is critical for proper lung bud initiation and endodermal differentiation... - Retinaldehyde dehydrogenase 2 (RALDH2)-mediated retinoic acid synthesis regulates early mouse embryonic forebrain development by controlling FGF and sonic hedgehog signalingVanessa Ribes
, CNRS, INSERM, , BP 10142, 67404 Illkirch Cedex, CU de Strasbourg, France
Development 133:351-61. 2006..These results unveil crucial roles of RA during early mouse forebrain development, which may involve the regulation of the expansion of neural progenitor cells through a crosstalk with FGF and sonic hedgehog signaling pathways... - Dorsal pancreas agenesis in retinoic acid-deficient Raldh2 mutant miceMerce Martin
INSERM, U682, Strasbourg, France
Dev Biol 284:399-411. 2005..We conclude that RA synthesized in the mesenchyme is specifically required for the normal development of the dorsal pancreatic endoderm at a stage preceding Pdx 1 function... - Retinoic acid controls the bilateral symmetry of somite formation in the mouse embryoJulien Vermot
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, BP 10142, 67404 Illkirch Cedex, Strasbourg, France
Science 308:563-6. 2005..These data implicate retinoic acid as an endogenous signal that maintains the bilateral synchrony of mesoderm segmentation, and therefore controls bilateral symmetry, in vertebrate embryos... - Direct crossregulation between retinoic acid receptor {beta} and Hox genes during hindbrain segmentationPatricia Serpente
Medical Research Council, National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK
Development 132:503-13. 2005..We propose that the function of this circuit is to align the initially incongruent expression of multiple RA-induced genes at a single segment boundary... - Complementary expression patterns of retinoid acid-synthesizing and -metabolizing enzymes in pre-natal mouse inner ear structuresRaymond Romand
Institut Clinique de la Souris, 1, rue Laurent Fries, B P 10142, 67404 Illkirch, France
Gene Expr Patterns 4:123-33. 2004.... - The regional pattern of retinoic acid synthesis by RALDH2 is essential for the development of posterior pharyngeal arches and the enteric nervous systemKaren Niederreither
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, BP 10142, 67404 Illkirch Cedex, CU de Strasbourg, France
Development 130:2525-34. 2003..Thus, RALDH2 plays a crucial role in producing RA required for pharyngeal development, and RA is one of the diffusible mesodermal signals that pattern the pharyngeal endoderm... - Decreased embryonic retinoic acid synthesis results in a DiGeorge syndrome phenotype in newborn miceJulien Vermot
Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche, Médicale Université Louis Pasteur, College de France, BP 10142, 67404 Illkirch Cedex, France
Proc Natl Acad Sci U S A 100:1763-8. 2003.... - Retinaldehyde dehydrogenase 2 (RALDH2)- independent patterns of retinoic acid synthesis in the mouse embryoKaren Niederreither
Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche ScientifiqueInstitut National de la Santé et de la Recherche MédicaleUniversité Louis PasteurCollège de France, Strasbourg, France
Proc Natl Acad Sci U S A 99:16111-6. 2002.... - Embryonic retinoic acid synthesis is required for forelimb growth and anteroposterior patterning in the mouseKaren Niederreither
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, BP 10142, 67404 Illkirch Cedex, CU de Strasbourg, France
Development 129:3563-74. 2002..We suggest that RA signaling cooperates with a posteriorly restricted factor such as dHand, to generate a functional zone of polarizing activity (ZPA)... - Genetic evidence that oxidative derivatives of retinoic acid are not involved in retinoid signaling during mouse developmentKaren Niederreither
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France
Nat Genet 31:84-8. 2002..We provide genetic evidence that ALDH1A2 and CYP26A1 activities concurrently establish local embryonic retinoic acid levels that must be finely tuned to allow posterior organ development and to prevent spina bifida... - Differential expression of retinoic acid-synthesizing (RALDH) enzymes during fetal development and organ differentiation in the mouseKaren Niederreither
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, B P 163, 67404 Illkirch Cedex, C U de Strasbourg, France
Mech Dev 110:165-71. 2002..Only Raldh1 expression is seen after birth in specific brain structures. These data indicate a requirement for regulated RA synthesis in various differentiating organs...