THOMAS FREDERICK NEWTON

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. pmc The impact of disulfiram treatment on the reinforcing effects of cocaine: a randomized clinical trial
    Colin N Haile
    Baylor College of Medicine, Menninger Department of Psychiatry and Behavioral Sciences, Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas, United States of America
    PLoS ONE 7:e47702. 2012
  2. pmc Noradrenergic α₁ receptor antagonist treatment attenuates positive subjective effects of cocaine in humans: a randomized trial
    Thomas F Newton
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas, United States of America
    PLoS ONE 7:e30854. 2012
  3. doi request reprint A perhaps unexpected role of norepinephrine in actions of MDMA
    T F Newton
    Baylor College of Medicine, Houston, Texas, USA
    Clin Pharmacol Ther 90:215-6. 2011
  4. pmc The angiotensin-converting enzyme inhibitor perindopril treatment alters cardiovascular and subjective effects of methamphetamine in humans
    Thomas F Newton
    Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, and the Michael E DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA
    Psychiatry Res 179:96-100. 2010
  5. pmc Theories of addiction: methamphetamine users' explanations for continuing drug use and relapse
    Thomas F Newton
    Menninger Department of Psychiatry and Behavioral Sciences and the Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Addict 18:294-300. 2009
  6. pmc Evaluation of subjective effects of aripiprazole and methamphetamine in methamphetamine-dependent volunteers
    Thomas F Newton
    Baylor College of Medicine, Menninger Department of Psychiatry and Behavioral Sciences, Houston, TX, USA
    Int J Neuropsychopharmacol 11:1037-45. 2008
  7. pmc Evaluation of modafinil effects on cardiovascular, subjective, and reinforcing effects of methamphetamine in methamphetamine-dependent volunteers
    Richard De La Garza
    Baylor College of Medicine, Menninger Department of Psychiatry and Behavioral Sciences, 2002 Holcombe Boulevard, Houston, TX 77030, USA
    Drug Alcohol Depend 106:173-80. 2010
  8. pmc Influence of verbal recall of a recent stress experience on anxiety and desire for cocaine in non-treatment seeking, cocaine-addicted volunteers
    Richard De La Garza
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Addict 18:481-7. 2009
  9. pmc Relationship between gender and psychotic symptoms in cocaine-dependent and methamphetamine-dependent participants
    James J Mahoney
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas 77030, USA
    Gend Med 7:414-21. 2010
  10. pmc Acute, low-dose methamphetamine administration improves attention/information processing speed and working memory in methamphetamine-dependent individuals displaying poorer cognitive performance at baseline
    James J Mahoney
    Baylor College of Medicine, Menninger Department of Psychiatry and Behavioral Sciences, Houston, TX, United States
    Prog Neuropsychopharmacol Biol Psychiatry 35:459-65. 2011

Research Grants

Detail Information

Publications13

  1. pmc The impact of disulfiram treatment on the reinforcing effects of cocaine: a randomized clinical trial
    Colin N Haile
    Baylor College of Medicine, Menninger Department of Psychiatry and Behavioral Sciences, Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas, United States of America
    PLoS ONE 7:e47702. 2012
    ..5 and 125 mg/d) increased cocaine use. We conducted the present study to better understand how disulfiram alters the reinforcing effects of cocaine in cocaine users...
  2. pmc Noradrenergic α₁ receptor antagonist treatment attenuates positive subjective effects of cocaine in humans: a randomized trial
    Thomas F Newton
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas, United States of America
    PLoS ONE 7:e30854. 2012
    ..The objective of this study was to evaluate the impact of treatment with the noradrenergic α(1) receptor antagonist doxazosin on the positive subjective effects of cocaine...
  3. doi request reprint A perhaps unexpected role of norepinephrine in actions of MDMA
    T F Newton
    Baylor College of Medicine, Houston, Texas, USA
    Clin Pharmacol Ther 90:215-6. 2011
    ..Building on earlier work, their new data provide new insights into the pharmacodynamics of MDMA and other monoamine-releasing agents...
  4. pmc The angiotensin-converting enzyme inhibitor perindopril treatment alters cardiovascular and subjective effects of methamphetamine in humans
    Thomas F Newton
    Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, and the Michael E DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA
    Psychiatry Res 179:96-100. 2010
    ..There were significant perindoprilmethamphetamine interactions for diastolic blood pressure and for ratings of "Any Drug Effect", indicating inverted U dose-effect functions for these indices...
  5. pmc Theories of addiction: methamphetamine users' explanations for continuing drug use and relapse
    Thomas F Newton
    Menninger Department of Psychiatry and Behavioral Sciences and the Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Addict 18:294-300. 2009
    ....
  6. pmc Evaluation of subjective effects of aripiprazole and methamphetamine in methamphetamine-dependent volunteers
    Thomas F Newton
    Baylor College of Medicine, Menninger Department of Psychiatry and Behavioral Sciences, Houston, TX, USA
    Int J Neuropsychopharmacol 11:1037-45. 2008
    ..Further research with lower doses of aripiprazole, possibly using study designs aimed at evaluating efficacy for relapse prevention, are needed before ruling out aripiprazole as a treatment for Meth dependence...
  7. pmc Evaluation of modafinil effects on cardiovascular, subjective, and reinforcing effects of methamphetamine in methamphetamine-dependent volunteers
    Richard De La Garza
    Baylor College of Medicine, Menninger Department of Psychiatry and Behavioral Sciences, 2002 Holcombe Boulevard, Houston, TX 77030, USA
    Drug Alcohol Depend 106:173-80. 2010
    ..Given these encouraging, though non-significant trends, the primary conclusion is that it appears safe to proceed with modafinil in further clinical evaluations of therapeutic efficacy...
  8. pmc Influence of verbal recall of a recent stress experience on anxiety and desire for cocaine in non-treatment seeking, cocaine-addicted volunteers
    Richard De La Garza
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Addict 18:481-7. 2009
    ..These data suggest that simply recalling a stressful event may not be a sufficient enough stimulus to contribute to craving or relapse in cocaine-addicted individuals...
  9. pmc Relationship between gender and psychotic symptoms in cocaine-dependent and methamphetamine-dependent participants
    James J Mahoney
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas 77030, USA
    Gend Med 7:414-21. 2010
    ..However, the research and literature on gender differences and stimulant-induced psychosis have been mixed...
  10. pmc Acute, low-dose methamphetamine administration improves attention/information processing speed and working memory in methamphetamine-dependent individuals displaying poorer cognitive performance at baseline
    James J Mahoney
    Baylor College of Medicine, Menninger Department of Psychiatry and Behavioral Sciences, Houston, TX, United States
    Prog Neuropsychopharmacol Biol Psychiatry 35:459-65. 2011
    ..As a result, stimulants may serve as a successful treatment for improving cognitive functioning in those Meth-dependent individuals experiencing neurocognitive impairment...
  11. pmc The cardiovascular and subjective effects of methamphetamine combined with gamma-vinyl-gamma-aminobutyric acid (GVG) in non-treatment seeking methamphetamine-dependent volunteers
    Richard De La Garza
    Baylor College of Medicine, Menninger Department of Psychiatry and Behavioral Sciences, Houston, TX, USA
    Pharmacol Biochem Behav 94:186-93. 2009
    ..Taken together, the data indicate that GVG treatment is generally well tolerated but not efficacious in attenuating the positive subjective effects of methamphetamine in the laboratory...
  12. pmc Modafinil administration improves working memory in methamphetamine-dependent individuals who demonstrate baseline impairment
    Ari D Kalechstein
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Addict 19:340-4. 2010
    ..The findings provide an initial indication that modafinil can reverse methamphetamine-associated impairments in working memory...
  13. pmc Quantitative EEG abnormalities are associated with memory impairment in recently abstinent methamphetamine-dependent individuals
    Ari D Kalechstein
    Baylor College of Medicine, Menninger Department of Psychiatry and Behavioral Sciences, Houston, TX 77030, USA
    J Neuropsychiatry Clin Neurosci 21:254-8. 2009
    ..e., memory deficits) when users are not intoxicated...

Research Grants7

  1. Laboratory Models of Cocaine Self-Administration
    Thomas Newton; Fiscal Year: 2005
    ..abstract_text> ..
  2. Laboratory Models of Cocaine Self-Administration
    Thomas Newton; Fiscal Year: 2006
    ..abstract_text> ..
  3. Laboratory Models of Cocaine Self-Administration
    Thomas Newton; Fiscal Year: 2007
    ..abstract_text> ..
  4. An ACE Inhibitor as a Treatment for Methamphetamine Dependence
    Thomas Newton; Fiscal Year: 2009
    ..A separate human laboratory study will examine the dose-dependent effects of perindopril on MA- induced craving, though these participants will not take part in the clinical trial. ..
  5. An ACE Inhibitor as a Treatment for Methamphetamine Dependence
    THOMAS FREDERICK NEWTON; Fiscal Year: 2010
    ..A separate human laboratory study will examine the dose-dependent effects of perindopril on MA- induced craving, though these participants will not take part in the clinical trial. ..