David L Nelson

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. pmc The unstable repeats--three evolving faces of neurological disease
    David L Nelson
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 77:825-43. 2013
  2. ncbi request reprint NEMO, NFkappaB signaling and incontinentia pigmenti
    David L Nelson
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Curr Opin Genet Dev 16:282-8. 2006
  3. pmc RNA-binding proteins hnRNP A2/B1 and CUGBP1 suppress fragile X CGG premutation repeat-induced neurodegeneration in a Drosophila model of FXTAS
    Oyinkan A Sofola
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Neuron 55:565-71. 2007
  4. pmc The Drosophila FMRP and LARK RNA-binding proteins function together to regulate eye development and circadian behavior
    Oyinkan Sofola
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 28:10200-5. 2008
  5. pmc Fragile X-related proteins regulate mammalian circadian behavioral rhythms
    Jing Zhang
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Am J Hum Genet 83:43-52. 2008
  6. pmc Ectopic expression of CGG containing mRNA is neurotoxic in mammals
    Vera Hashem
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Mol Genet 18:2443-51. 2009
  7. pmc Interruptions in the expanded ATTCT repeat of spinocerebellar ataxia type 10: repeat purity as a disease modifier?
    Tohru Matsuura
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Hum Genet 78:125-9. 2006
  8. doi request reprint Social behavior in Fmr1 knockout mice carrying a human FMR1 transgene
    Corinne M Spencer
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Behav Neurosci 122:710-5. 2008
  9. ncbi request reprint Reversal of sensorimotor gating abnormalities in Fmr1 knockout mice carrying a human Fmr1 transgene
    Richard Paylor
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Behav Neurosci 122:1371-7. 2008
  10. pmc Altered hippocampal synaptic plasticity in the FMR1 gene family knockout mouse models
    Jing Zhang
    Baylor College of Medicine, Department of Molecular and Human Genetics, One Baylor Plaza, Houston, TX 77030, USA
    J Neurophysiol 101:2572-80. 2009

Detail Information

Publications30

  1. pmc The unstable repeats--three evolving faces of neurological disease
    David L Nelson
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 77:825-43. 2013
    ..In addition to providing insight into the mechanisms underlying these devastating neurological disorders, the study of these unstable microsatellite repeat disorders has provided insight into very basic aspects of neuroscience...
  2. ncbi request reprint NEMO, NFkappaB signaling and incontinentia pigmenti
    David L Nelson
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Curr Opin Genet Dev 16:282-8. 2006
    ..Recent advances in mouse models and in understanding the multiple roles of NEMO in the cell provide additional avenues to define the various roles of NEMO in NFkappaB signaling...
  3. pmc RNA-binding proteins hnRNP A2/B1 and CUGBP1 suppress fragile X CGG premutation repeat-induced neurodegeneration in a Drosophila model of FXTAS
    Oyinkan A Sofola
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Neuron 55:565-71. 2007
    ..Furthermore, we show that hnRNP A2/B1 directly interacts with riboCGG repeats and that the CUGBP1 protein interacts with the riboCGG repeats via hnRNP A2/B1...
  4. pmc The Drosophila FMRP and LARK RNA-binding proteins function together to regulate eye development and circadian behavior
    Oyinkan Sofola
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 28:10200-5. 2008
    ..Furthermore, we show genetic interactions between the corresponding genes indicating that dFMRP and LARK function together to regulate eye development and circadian behavior...
  5. pmc Fragile X-related proteins regulate mammalian circadian behavioral rhythms
    Jing Zhang
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Am J Hum Genet 83:43-52. 2008
    ....
  6. pmc Ectopic expression of CGG containing mRNA is neurotoxic in mammals
    Vera Hashem
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Mol Genet 18:2443-51. 2009
    ....
  7. pmc Interruptions in the expanded ATTCT repeat of spinocerebellar ataxia type 10: repeat purity as a disease modifier?
    Tohru Matsuura
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Hum Genet 78:125-9. 2006
    ..Our findings for SCA10 challenge this convention and suggest that the purity of the expanded repeat element may be a disease modifier...
  8. doi request reprint Social behavior in Fmr1 knockout mice carrying a human FMR1 transgene
    Corinne M Spencer
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Behav Neurosci 122:710-5. 2008
    ..This finding expands the number of murine behavioral responses caused by Fmr1 deficiency and corrected by overexpression of human FMRP...
  9. ncbi request reprint Reversal of sensorimotor gating abnormalities in Fmr1 knockout mice carrying a human Fmr1 transgene
    Richard Paylor
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Behav Neurosci 122:1371-7. 2008
    ....
  10. pmc Altered hippocampal synaptic plasticity in the FMR1 gene family knockout mouse models
    Jing Zhang
    Baylor College of Medicine, Department of Molecular and Human Genetics, One Baylor Plaza, Houston, TX 77030, USA
    J Neurophysiol 101:2572-80. 2009
    ..These results indicated that both FMRP and FXR2P function in synaptic plasticity and that they likely operate in related but independent pathways...
  11. ncbi request reprint Chromosomal microarray analysis (CMA) detects a large X chromosome deletion including FMR1, FMR2, and IDS in a female patient with mental retardation
    Frank J Probst
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Med Genet A 143:1358-65. 2007
    ..This case demonstrates the utility of CMA both for detecting a submicroscopic chromosomal deletion and for suggesting further testing that could possibly lead to therapeutic options for patients with developmental delay...
  12. ncbi request reprint Exaggerated behavioral phenotypes in Fmr1/Fxr2 double knockout mice reveal a functional genetic interaction between Fragile X-related proteins
    Corinne M Spencer
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Mol Genet 15:1984-94. 2006
    ..Our findings suggest that Fmr1 and Fxr2 genes contribute in a cooperative manner to pathways controlling locomotor activity, sensorimotor gating and cognitive processes...
  13. pmc Positive selection of a pre-expansion CAG repeat of the human SCA2 gene
    Fuli Yu
    Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, USA
    PLoS Genet 1:e41. 2005
    ..These results suggest that a recent positive selection of the pre-expansion SCA2 CAG repeat has occurred in Utah residents with European ancestry...
  14. ncbi request reprint Argonaute-2-dependent rescue of a Drosophila model of FXTAS by FRAXE premutation repeat
    Oyinkan A Sofola
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Mol Genet 16:2326-32. 2007
    ..These data support the concept that RNA toxicity is the mechanism of neuronal toxicity and suggests potential reversal of RNA-mediated phenotypes with complementary RNA molecules...
  15. ncbi request reprint Evolutionary and biomedical insights from the rhesus macaque genome
    Richard A Gibbs
    Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA
    Science 316:222-34. 2007
    ..The complete description of the macaque genome blueprint enhances the utility of this animal model for biomedical research and improves our understanding of the basic biology of the species...
  16. pmc Bmal1 and β-cell clock are required for adaptation to circadian disruption, and their loss of function leads to oxidative stress-induced β-cell failure in mice
    Jeongkyung Lee
    Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    Mol Cell Biol 33:2327-38. 2013
    ..Thus, the cell-autonomous function of Bmal1 is required for normal β-cell function by mitigating oxidative stress and serves to preserve β-cell function in the face of circadian misalignment...
  17. ncbi request reprint Instability of a premutation-sized CGG repeat in FMR1 YAC transgenic mice
    Andrea M Peier
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Genomics 80:423-32. 2002
    ..Overall, our results indicate both similarities and differences between the behavior of a premutation-sized repeat in mouse and that in human...
  18. ncbi request reprint Genetics. The critical region in trisomy 21
    David L Nelson
    Department of Molecular and Human Genetics and the Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA
    Science 306:619-21. 2004
  19. pmc Somatic and germline instability of the ATTCT repeat in spinocerebellar ataxia type 10
    Tohru Matsuura
    Department of Neurology, Baylor College of Medicine, Houston, TX, USA
    Am J Hum Genet 74:1216-24. 2004
    ....
  20. ncbi request reprint Human genetics. Primate shadow play
    Richard A Gibbs
    Department of Molecular and Human Genetics, Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA
    Science 299:1331-3. 2003
  21. ncbi request reprint Impaired conditioned fear and enhanced long-term potentiation in Fmr2 knock-out mice
    Yanghong Gu
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 22:2753-63. 2002
    ..Thus, although a number of studies have suggested that diminished LTP is associated with memory impairment, our data suggest that increased LTP may be a mechanism that leads to impaired cognitive processing as well...
  22. ncbi request reprint The human secretin gene: fine structure in 11p15.5 and sequence variation in patients with autism
    Takanori Yamagata
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Genomics 80:185-94. 2002
    ..Although imprinting is a characteristic of some genes in the vicinity, we could find no evidence for methylation of SCT in lymphoblast cells from patients or control individuals...
  23. pmc Haplotype and linkage disequilibrium architecture for human cancer-associated genes
    Penelope E Bonnen
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Genome Res 12:1846-53. 2002
    ..As a result, a low marker density should be adequate to identify haplotypes that represent the common variation at a locus, thereby decreasing costs and increasing efficacy of association studies...
  24. ncbi request reprint Physical and genetic characterization reveals a pseudogene, an evolutionary junction, and unstable loci in distal Xq28
    Swaroop Aradhya
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza 902E, Houston, TX 77030, USA
    Genomics 79:31-40. 2002
    ..Collectively, these data highlight some interesting features of the genomic sequence in Xq28 and will be useful for positional cloning efforts, mouse mutagenesis studies, and further evolutionary analyses...
  25. pmc Complex SNP-based haplotypes in three human helicases: implications for cancer association studies
    Dimitra Trikka
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Genome Res 12:627-39. 2002
    ....
  26. ncbi request reprint Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway
    Peng Jin
    Department of Human Genetics, Emory University, 615 Michael Street, Atlanta, Georgia 30322, USA
    Nat Neurosci 7:113-7. 2004
    ..Our results suggest that FMRP may regulate neuronal translation via microRNAs and links microRNAs with human disease...
  27. pmc The DNA sequence of the human X chromosome
    Mark T Ross
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Nature 434:325-37. 2005
    ..Of this number, 168 have been explained by mutations in 113 X-linked genes, which in many cases were characterized with the aid of the DNA sequence...
  28. ncbi request reprint [3H]LY334370, a novel radioligand for the 5-HT1F receptor. II. Autoradiographic localization in rat, guinea pig, monkey and human brain
    Virginia L Lucaites
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Naunyn Schmiedebergs Arch Pharmacol 371:178-84. 2005
    ....
  29. ncbi request reprint Pharmacologic characterization of the cloned human trace amine-associated receptor1 (TAAR1) and evidence for species differences with the rat TAAR1
    David B Wainscott
    Eli Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Mail Drop 0510, Indianapolis, IN 46285, USA
    J Pharmacol Exp Ther 320:475-85. 2007
    ..This unique pharmacologic profile suggests the potential for development of TAAR-selective agonists and antagonists to study their physiologic roles...
  30. ncbi request reprint Audiogenic seizure susceptibility is reduced in fragile X knockout mice after introduction of FMR1 transgenes
    Sebastiano A Musumeci
    Department of Neurology, Oasi Institute for Research on Mental Retardation and Brain Aging IRCCS, Troina, Italy
    Exp Neurol 203:233-40. 2007
    ..We found that AGS susceptibility rescue is complete in the G6 mice and partial in YAC mice. Our data indicate that the introduction of the human FMR1 gene in Fmr1 KO mice is able to revert the Fmr1 KO epileptic phenotype...