Research Topics
Genomes and GenesSpecies | Vijay NambiSummaryAffiliation: Baylor College of Medicine Country: USA Publications
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Publications
The 9p21 genetic variant is additive to carotid intima media thickness and plaque in improving coronary heart disease risk prediction in white participants of the Atherosclerosis Risk in Communities (ARIC) StudyVijay Nambi
Section of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine, Methodist DeBakey Heart and Vascular Center, The Methodist Hospital, Houston, TX, USA
Atherosclerosis 222:135-7. 2012..We evaluated whether the addition of carotid intima media thickness and plaque (CIMT-P), and a single nucleotide polymorphism on chromosome 9p21 (9p21) together improve coronary heart disease (CHD) risk prediction in the ARIC study...- Common carotid artery intima-media thickness is as good as carotid intima-media thickness of all carotid artery segments in improving prediction of coronary heart disease risk in the Atherosclerosis Risk in Communities (ARIC) studyVijay Nambi
Section of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX, USA
Eur Heart J 33:183-90. 2012..We evaluated whether CCA-IMT is comparable to A-CIMT when added to TRF and plaque information in improving CHD risk prediction in the Atherosclerosis Risk in Communities (ARIC) study... - Differences in responses of platelets to fluid shear stress in patients with peripheral artery disease (PAD) and coronary artery disease (CAD)Vijay Nambi
Section of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX, USA
Platelets 20:199-205. 2009..Although the mechanism for these observed differences are not clear, we hypothesize that in vivo platelet activation in PAD patients may contribute to the differences and will need to be further investigated... - Carotid intima-media thickness and presence or absence of plaque improves prediction of coronary heart disease risk: the ARIC (Atherosclerosis Risk In Communities) studyVijay Nambi
Section of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
J Am Coll Cardiol 55:1600-7. 2010..We evaluated whether carotid intima-media thickness (CIMT) and the presence or absence of plaque improved coronary heart disease (CHD) risk prediction when added to traditional risk factors (TRF)... 
The use of myeloperoxidase as a risk marker for atherosclerosisVijay Nambi
Section of Cardiology, Baylor College of Medicine, 6550 Fannin, SM 677, Houston, TX 77030, USA
Curr Atheroscler Rep 7:127-31. 2005..Clinical studies have suggested an association between levels of MPO and the presence of coronary artery disease and endothelial dysfunction, and have shown a possible additional role to troponin in patients with chest pain...- Lipoprotein-associated phospholipase A2: pathogenic mechanisms and clinical utility for predicting cardiovascular eventsVijay Nambi
Section of Cardiology, Baylor College of Medicine, 6550 Fannin, SM 677, Houston, TX 77030, USA
Curr Atheroscler Rep 8:374-81. 2006..Statin therapy has been shown to reduce Lp-PLA(2), and selective inhibitors of Lp-PLA(2) are under development. Additional research is needed to further determine the role of Lp-PLA(2) in atherogenesis and atherothrombotic events... 
Preoperative statin therapy decreases risk of postoperative renal insufficiencySalim S Virani
Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX, USA
Cardiovasc Ther 28:80-6. 2010..Although current guidelines recommend withholding statins in perioperative patients, little information is available on whether perioperative statin use increases risk for postoperative renal failure...- Relation of cholesterol and lipoprotein parameters with carotid artery plaque characteristics: the Atherosclerosis Risk in Communities (ARIC) carotid MRI studySalim S Virani
Michael E DeBakey Veterans Affairs Medical Center, Houston, TX 77030, United States
Atherosclerosis 219:596-602. 2011.... - Associations between lipoprotein(a) levels and cardiovascular outcomes in black and white subjects: the Atherosclerosis Risk in Communities (ARIC) StudySalim S Virani
Michael E DeBakey Veterans Affairs Medical Center Health Services Research and Development Center of Excellence, Houston, TX, USA
Circulation 125:241-9. 2012..We evaluated associations between Lp(a) and incident CVD events in blacks and whites in the Atherosclerosis Risk in Communities (ARIC) study... - Chromosome 9p21 single nucleotide polymorphisms are not associated with recurrent myocardial infarction in patients with established coronary artery diseaseSalim S Virani
Center of Excellence, Health Services Research and Development, Michael E DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA
Circ J 76:950-6. 2012.... - Carotid arterial wall characteristics are associated with incident ischemic stroke but not coronary heart disease in the Atherosclerosis Risk in Communities (ARIC) studyEric Y Yang
Section of Atherosclerosis and Vascular Medicine, Department of Internal Medicine, Baylor College of Medicine, Houston TX, USA
Stroke 43:103-8. 2012..We evaluated the association of carotid ultrasound-derived arterial stiffness measures with incident coronary heart disease (CHD) and ischemic stroke in the Atherosclerosis Risk in Communities (ARIC) study... - Lipoprotein-associated phospholipase A2 and high-sensitivity C-reactive protein improve the stratification of ischemic stroke risk in the Atherosclerosis Risk in Communities (ARIC) studyVijay Nambi
Department of Medicine, Section of Atherosclerosis and Vascular Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
Stroke 40:376-81. 2009.... - Cardiac troponin T measured by a highly sensitive assay predicts coronary heart disease, heart failure, and mortality in the Atherosclerosis Risk in Communities StudyJustin T Saunders
6565 Fannin, MS A 601, Houston, TX 77030, USA
Circulation 123:1367-76. 2011.... - Outcomes of preoperative angiotensin-converting enzyme inhibitor therapy in patients undergoing isolated coronary artery bypass graftingSalman J Bandeali
Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
Am J Cardiol 110:919-23. 2012..In conclusion, preoperative ACE inhibitor use was associated with an increased risk of MAEs after CABG, in particular postoperative renal dysfunction and atrial fibrillation... - Isolated coronary artery bypass grafting in obese individuals: a propensity matched analysis of outcomesMahboob Alam
Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
Circ J 75:1378-85. 2011..There is conflicting data regarding the impact of obesity on morbidity and mortality in patients undergoing isolated coronary artery bypass grafting (CABG)... - Variability and persistence of aspirin response in lower extremity peripheral arterial disease patientsJustin Saunders
Section of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine, Houston, Tex, USA
J Vasc Surg 53:668-75. 2011.... - Usefulness of single nucleotide polymorphism in chromosome 4q25 to predict in-hospital and long-term development of atrial fibrillation and survival in patients undergoing coronary artery bypass graftingSalim S Virani
Michael E DeBakey Veterans Affairs Medical Center Health Services Research and Development Center of Excellence, Houston, Texas, USA
Am J Cardiol 107:1504-9. 2011.... - Association between traditional cholesterol parameters, lipoprotein particle concentration, novel biomarkers and carotid plaques in retired National Football League playersSalim S Virani
Health Services Research and Development, Michael E DeBakey VA Medical Center Health Services Research and Development Center of Excellence, Houston, TX 77030, USA
Atherosclerosis 222:551-6. 2012.... - Obesity: an independent predictor of in-hospital postoperative renal insufficiency among patients undergoing cardiac surgery?Salim S Virani
Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
Tex Heart Inst J 36:540-5. 2009.... - Novel markers of inflammation in atherosclerosisSalim S Virani
Department of Medicine, Baylor College of Medicine, 6565 Fannin, M S A 601, Houston, TX 77030, USA
Curr Atheroscler Rep 10:164-70. 2008..It also discusses the limitations of current risk stratification models and characteristics of a good biomarker... - Impact of adding a single allele in the 9p21 locus to traditional risk factors on reclassification of coronary heart disease risk and implications for lipid-modifying therapy in the Atherosclerosis Risk in Communities studyAriel Brautbar
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
Circ Cardiovasc Genet 2:279-85. 2009.... - Clinical implications of JUPITER (Justification for the Use of statins in Prevention: an Intervention Trial Evaluating Rosuvastatin) in a U.S. population insights from the ARIC (Atherosclerosis Risk in Communities) studyEric Y Yang
Section of Atherosclerosis and Vascular Medicine, Baylor College of Medicine, Houston, Texas, USA
J Am Coll Cardiol 54:2388-95. 2009.... - Non-high-density lipoprotein cholesterol calculation and goal awareness among physicians-in-trainingSmita I Negi
Section of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX, USA
J Clin Lipidol 6:50-7. 2012..Non-high density lipoprotein cholesterol (non-HDL-C) goal attainment per Adult Treatment Panel III (ATP III) guidelines remains low... - Does preoperative statin therapy improve outcomes in patients undergoing isolated cardiac valve surgery?Salim S Virani
Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
Am J Cardiol 102:1235-9. 2008..In conclusion, preoperative statin therapy was not associated with a decrease in morbidity or mortality in patients undergoing isolated cardiac valve surgery... - The role of lipoprotein-associated phospholipase A2 as a marker for atherosclerosisSalim S Virani
Department of Medicine, Baylor College of Medicine, 6565 Fannin, M S A 601, Houston, TX 77030, USA
Curr Atheroscler Rep 9:97-103. 2007..This article reviews the potential mechanisms by which Lp-PLA2 may participate in the pathogenesis of atherosclerosis and its clinical manifestations, namely, coronary artery disease and stroke... - Utility of statin therapy using high-sensitivity C-reactive protein as an indicator of coronary heart disease riskVijay Nambi
Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
Curr Atheroscler Rep 7:22-8. 2005..The utility of CRP as a target of therapy remains to be proved, and these ongoing studies will likely provide us with guidance... - Markers of inflammation and their clinical significanceChristie M Ballantyne
Section of Atherosclerosis and Lipoprotein Research, Baylor College of Medicine, 6565 Fannin, M S A 601, Houston, TX 77030 3498, USA
Atheroscler Suppl 6:21-9. 2005.... - Role of biomarkers in developing new therapies for vascular diseaseVijay Nambi
Section of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine, and Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart Center, 6565 Fannin, M S A 601, Houston, Texas 77030, USA
World J Surg 31:676-81. 2007..These biomarkers may be used to identify specific populations that may benefit from therapies, as surrogate markers of clinical efficacy, or as targets of therapy... - Barriers to non-HDL cholesterol goal attainment by providersSalim S Virani
Health Policy and Quality Program, Michael E DeBakey VA Medical Center, Health Services Research and Development Center of Excellence and Section of Health Services Research, Baylor College of Medicine, Houston, TX 77030, USA
Am J Med 124:876-80.e2. 2011..This study assessed providers' knowledge of, attitude toward, and practice regarding non-HDL-C... - Relationship between circulating levels of RANTES (regulated on activation, normal T-cell expressed, and secreted) and carotid plaque characteristics: the Atherosclerosis Risk in Communities (ARIC) Carotid MRI StudySalim S Virani
Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, Methodist DeBakey Heart and Vascular Center, Houston, TX 77030, USA
Eur Heart J 32:459-68. 2011..To assess the relationship between regulated on activation, normal T-cell expressed and secreted (RANTES) and carotid atherosclerotic plaque burden and plaque characteristics... - Preoperative statin therapy is not associated with a decrease in the incidence of postoperative atrial fibrillation in patients undergoing cardiac surgerySalim S Virani
Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
Am Heart J 155:541-6. 2008..We investigated whether preoperative statin therapy was associated with decreased incidence of postoperative AF in patients undergoing cardiac surgery, including isolated valve surgery and patients with low ejection fraction (EF)... - Automatic quantification of muscle volumes in magnetic resonance imaging scans of the lower extremitiesGerd Brunner
Division of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
Magn Reson Imaging 29:1065-75. 2011..Experiments for the fully automatic detection of muscle volume in MRI scans demonstrated an averaged accuracy, sensitivity and specificity for leave-one-out cross-validation of 88.3%, 93.6% and 87.2%, respectively... - Lipid management: considerations in acute coronary syndromeVenkateshwar R Polsani
Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
Curr Cardiol Rep 10:334-41. 2008..A growing body of literature supports the concept that early and intensive treatment with statins after an ACS event decreases recurrent adverse cardiovascular events. We review available evidence pertaining to lipid alterations in ACS... - Peripheral arterial occlusive disease: magnetic resonance imaging and the role of aggressive medical managementAlan B Lumsden
Methodist DeBakey Heart Center, Baylor College of Medicine, 1709 Dryden Street, Suite 1500, Houston, Texas 77030, USA
World J Surg 31:695-704. 2007..These studies will advance our understanding of the molecular mechanisms of inflammation and thrombosis associated with aggressive lipid modification... - Matrix metalloproteinase-1 and tissue inhibitors do not predict incident coronary artery disease in the atherosclerosis risk in communities (ARIC) studyVijay Nambi
Section of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
Tex Heart Inst J 35:388-94. 2008.... - Ultrasound imaging of carotid intima-media thickness: an office-based tool to assist physicians in cardiovascular risk assessmentEric Y Yang
Section of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine and Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart and Vascular Center, Houston, TX, USA
Curr Atheroscler Rep 13:431-6. 2011.... - A genetic risk score based on direct associations with coronary heart disease improves coronary heart disease risk prediction in the Atherosclerosis Risk in Communities (ARIC), but not in the Rotterdam and Framingham Offspring, StudiesAriel Brautbar
Department of Medical Genetics, Marshfield Clinic, Marshfield, WI, USA
Atherosclerosis 223:421-6. 2012..We examined whether SNPs selected based on predefined criteria will improve CHD risk prediction when added to traditional risk factors (TRFs)... - The role of carotid intimal thickness and plaque imaging in risk stratification for coronary heart diseaseSmita I Negi
Section of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
Curr Atheroscler Rep 14:115-23. 2012..Recent guidelines have given CIMT and plaque-based risk prediction a class II A recommendation. This article reviews the available data related to the use of CIMT and plaque information in CHD risk prediction... - Efficacy and tolerability of multidrug therapy for hypertriglyceridemiaVenkateshwar R Polsani
Section of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine, 6565 Fannin, M S A 601, Houston, TX 77030, USA and Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart and Vascular Center, Houston, TX
J Clin Lipidol 3:341-4. 2009..Although there is clinical evidence for the safety and efficacy of single-drug therapy and some two-drug combinations for the treatment of hypertriglyceridemia, information is limited on the use of more than 2 drugs... - Coronary heart disease risk stratification: pitfalls and possibilitiesSmita Negi
Baylor College of Medicine, Methodist DeBakey Heart and Vascular Center, Houston, Texas, USA
Methodist Debakey Cardiovasc J 6:26-32. 2010..In this article we review the currently available risk stratification tools for predicting CHD risk and discuss potential ways to improve risk prediction... - Large-scale genomic studies reveal central role of ABO in sP-selectin and sICAM-1 levelsMaja Barbalic
Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA
Hum Mol Genet 19:1863-72. 2010..These results provide new insights into adhesion molecule biology... - Developing and assessing cardiovascular biomarkersRazvan T Dadu
Baylor College of Medicine and Methodist DeBakey Heart and Vascular Center, 6565 Fannin Street, Houston, TX 77030, USA
Transl Res 159:265-76. 2012..In this article, we will review 2 of these new biomarkers: cardiac troponin T measured by a highly sensitive assay and brain natriuretic peptide... - Segmental analysis of carotid arterial strain using speckle-trackingEric Y Yang
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
J Am Soc Echocardiogr 24:1276-1284.e5. 2011..The aims of this study were to evaluate whether speckle-tracking could be used to measure carotid arterial strain (CAS) reproducibly in healthy volunteers and to determine if CAS was lesser in individuals with diabetes... - Real-time co-registration using novel ultrasound technology: ex vivo validation and in vivo applicationsEric Y Yang
Baylor College of Medicine, 6565 Fannin Street, Houston, TX 77030, USA
J Am Soc Echocardiogr 24:720-8. 2011..We then evaluated in vivo US-US and US-MRI co-registration... - Combination therapy with statins and omega-3 fatty acidsVijay Nambi
Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
Am J Cardiol 98:34i-38i. 2006.... - Lipid management: considerations in acute coronary syndromeVenkateshwar R Polsani
Department of Medicine, Baylor College of Medicine, 6565 Fannin, Houston, TX 77030, USA
Curr Atheroscler Rep 11:149-56. 2009..A growing body of literature supports the concept that early and intensive treatment with statins after an ACS event decreases recurrent adverse cardiovascular events. We review available evidence pertaining to lipid alterations in ACS... - ASCOT-LLA and the primary prevention of coronary artery disease in hypertensive patientsVijay Nambi
Department of Medicine, Baylor College of Medicine, 6565 Fannin, MS A-601, Houston, TX 77030, USA
Curr Atheroscler Rep 6:353-8. 2004..These results suggest that all hypertensive patients with additional risk factors should receive lipid-regulating statin therapy to prevent CAD events... - Biomarkers of cardiac diseaseA J Marian
Baylor College of Medicine, One Baylor Plaza, 519D, Houston, TX 77030, USA
Expert Rev Mol Diagn 4:805-20. 2004..Selected biomarkers for coronary atherosclerosis, acute coronary syndromes and heart failure are discussed in this review... - Effectiveness of percutaneous intervention for patients with obstructive hypertrophic cardiomyopathy and coronary artery diseaseVijay Nambi
Section of Cardiology, Baylor College of Medicine, Methodist DeBakey Heart Center, Department of Medicine, Baylor College of Medicine, Houston, Texas. USA
Am J Cardiol 96:580-1. 2005..One year later, there was a significant reduction of dynamic left ventricular outflow tract obstruction and no clinical evidence of restenosis... - Prognostic value of myeloperoxidase in patients with chest painMarie-Luise Brennan
Department of Cell Biology, Cleveland Clinic Foundation, Cleveland 44195, USA
N Engl J Med 349:1595-604. 2003.... - Statins do not meet expectations for lowering low-density lipoprotein cholesterol levels when used in clinical practiceJoseph P Frolkis
Department of Preventive Cardiology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Am J Med 113:625-9. 2002..Physicians should be aware of this disparity when using statins in the clinical setting... - QRS duration and prediction of mortality in patients undergoing risk stratification for ventricular arrhythmiasVidyasagar Kalahasti
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Am J Cardiol 92:798-803. 2003..Whether QRS duration represents only a marker for mortality or if modification of this factor using resynchronization therapies will impact mortality merits further study... - A truly deadly quartet: obesity, hypertension, hypertriglyceridemia, and hyperinsulinemiaVijay Nambi
Department of Internal Medicine, The Cleveland Clinic Foundation, OH 44195, USA
Cleve Clin J Med 69:985-9. 2002..Thiazolidinedione drugs increase insulin sensitivity, but their use in the metabolic syndrome is only speculative at present. We recommend they be used only as indicated to treat diabetes mellitus...