Research Topics
Genomes and GenesSpecies | Alanna MorrisonSummaryAffiliation: Baylor College of Medicine Country: USA Publications
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Publications
Sodium intake and cardiovascular diseaseAlanna C Morrison
School of Public Health, University of Texas Health Science Center at Houston, Texas 77030, USA
Annu Rev Public Health 32:71-90. 2011..Public health policy to reduce sodium intake in the United States would have significant cost-savings, far greater than the cost of intervention, and would also result in a significant gain in quality-adjusted life years...- Evaluating the context-dependent effect of family history of stroke in a genome scan for hypertensionAlanna C Morrison
Human Genetics Center, University of Texas, Houston Health Science Center, 1200 Herman Pressler, Ste 453 E, Houston, TX 77030, USA
Stroke 34:1170-5. 2003..Hypertension is an important risk factor for stroke, and the 2 diseases may share susceptibility genes in common. We sought to identify genomic regions influencing susceptibility to both hypertension and stroke... - Genome scan for hypertension in nonobese African Americans: the National Heart, Lung, and Blood Institute Family Blood Pressure ProgramAlanna C Morrison
Human Genetics Center, University of Texas Houston Health Science Center, Houston, Texas 77030, USA
Am J Hypertens 17:834-8. 2004..For this reason, we sought to identify genomic regions influencing susceptibility to hypertension in a nonobese sample of hypertensive African American families... - Genome-wide linkage study of erythrocyte sodium-lithium countertransportAlanna C Morrison
Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
Am J Hypertens 18:653-6. 2005..Thus, in this study, genome-wide linkage scans for SLC were performed in two independent samples of pedigrees from the Rochester Family Heart Study (RFHS)... - Genomic variation associated with mortality among adults of European and African ancestry with heart failure: the cohorts for heart and aging research in genomic epidemiology consortiumAlanna C Morrison
Atherosclerosis Risk in Communities Study University of Texas Health Science Center at Houston, Human Genetics Center, Houston, TX 77030, USA
Circ Cardiovasc Genet 3:248-55. 2010.... - Single nucleotide polymorphisms associated with coronary heart disease predict incident ischemic stroke in the atherosclerosis risk in communities studyAlanna C Morrison
Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Cerebrovasc Dis 26:420-4. 2008..The idea that ischemic stroke and CHD may share some common genetic factors, such as variation in SERPINA9, should be investigated in other studies... - Regional association-based fine-mapping for sodium-lithium countertransport on chromosome 10Alanna C Morrison
Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, USA
Am J Hypertens 21:117-21. 2008..Consistent evidence of genetic linkage was shown for SLC on chromosome 10, and a region of interest was localized between 26 and 56 Mb... - ADD1 460W allele associated with cardiovascular disease in hypertensive individualsAlanna C Morrison
Human Genetics Center, University of Texas Houston Health Science Center, Houston, Tex 77030, USA
Hypertension 39:1053-7. 2002..An interaction with hypertension in the association between the ADD1 G460W polymorphism and cardiovascular disease merits further testing in additional populations... - LPL polymorphism predicts stroke risk in menAlanna C Morrison
Human Genetics Center, University of Texas Houston Health Science Center, Houston, Texas 77030, USA
Genet Epidemiol 22:233-42. 2002..This association does not appear to be mediated by triglyceride, high-density lipoprotein (HDL)- and low-density lipoprotein (LDL)-cholesterol levels, or additional stroke risk factors... - Prediction of coronary heart disease risk using a genetic risk score: the Atherosclerosis Risk in Communities StudyAlanna C Morrison
Human Genetics Center and Division of Epidemiology, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Am J Epidemiol 166:28-35. 2007..This study demonstrates the concept of aggregating information from multiple single nucleotide polymorphisms into a risk score and indicates that it can improve prediction of incident CHD in the ARIC study... - ESR1 polymorphism is associated with plasma lipid and apolipoprotein levels in Caucasians of the Rochester Family Heart StudyKathy L E Klos
Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA
J Lipid Res 49:1701-6. 2008..0030 and P = 0.0024) than in males (P > 0.05). These findings suggest that ESR1 variation plays an age- and sex-dependent role in determining plasma lipid and apolipoprotein levels... - Genetic variation in solute carrier genes is associated with preeclampsiaAlanna C Morrison
Human Genetics Center and the Division of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA
Am J Obstet Gynecol 203:491.e1-491.e13. 2010..The objective of the study was to evaluate allelic variation in 26 members of the solute carrier (SLC) gene family for an association with preeclampsia... - GOSR2 Lys67Arg is associated with hypertension in whitesTamra E Meyer
Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, USA
Am J Hypertens 22:163-8. 2009..We chose this SNP because it was nominally associated with CHD in earlier studies. Further, GOSR2 is located in a linkage region for hypertension and BP in human and animal studies... - Diabetes genes and prostate cancer in the Atherosclerosis Risk in Communities studyTamra E Meyer
Human Genetics Center and Division of Epidemiology, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Cancer Epidemiol Biomarkers Prev 19:558-65. 2010..02; blacks only). The TCF7L2 rs7903146 T allele was inversely associated with PrCa using a dominant genetic model (HR, 0.79; 95% CI, 0.65-0.97). Further knowledge of T2D gene-PrCa mechanisms may improve understanding of PrCa etiology... - Plasma MCP-1 level and risk for peripheral arterial disease and incident coronary heart disease: Atherosclerosis Risk in Communities studyRon C Hoogeveen
Section of Atherosclerosis and Lipoprotein Research, Department of Medicine, Baylor College of Medicine and Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart Center, 6565 Fannin, M S F 701, Houston, TX 77030, USA
Atherosclerosis 183:301-7. 2005..These data show that MCP-1 is associated with atherosclerotic disease in two vascular beds and suggest that MCP-1 may be a novel target for atherosclerosis therapy... - Association of folate receptor (FOLR1, FOLR2, FOLR3) and reduced folate carrier (SLC19A1) genes with meningomyeloceleMichelle R O'Byrne
Department of Pediatrics, The University of Texas Medical School at Houston, Houston, Texas 77030, USA
Birth Defects Res A Clin Mol Teratol 88:689-94. 2010..Periconceptional folic acid supplementation is a modifier of MM risk in humans, leading toan interest in the folate transport genes as potential candidates for association to MM... - Genetic association study of putative functional single nucleotide polymorphisms of genes in folate metabolism and spina bifidaCarla A Martinez
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Texas Health Science Center, Houston, TX, USA
Am J Obstet Gynecol 201:394.e1-11. 2009..We tested putative functional single nucleotide polymorphisms (SNPs) in genes that regulate the folate/homocysteine metabolism pathway for their contribution to spina bifida (SB) susceptibility... - Use of wrapper algorithms coupled with a random forests classifier for variable selection in large-scale genomic association studiesAndrei S Rodin
Human Genetics Center, School of Public Health, University of Texas Health Science Center, Houston, Texas, USA
J Comput Biol 16:1705-18. 2009.... - Matrix metalloproteinase-1 and tissue inhibitors do not predict incident coronary artery disease in the atherosclerosis risk in communities (ARIC) studyVijay Nambi
Section of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
Tex Heart Inst J 35:388-94. 2008.... - Characteristics of a spina bifida population including North American Caucasian and Hispanic individualsKit Sing Au
Department of Pediatrics, The University of Texas Medical School at Houston, Houston, Texas 77030, USA
Birth Defects Res A Clin Mol Teratol 82:692-700. 2008..MM is a disorder of neural development caused by contributions from genes and environmental factors that result in the NTD and lead to a spectrum of physical and neurocognitive phenotypes... - Comprehensive linkage and linkage heterogeneity analysis of 4344 sibling pairs affected with hypertension from the Family Blood Pressure ProgramTiffany A Greenwood
Polymorphism Research Laboratory, Department of Psychiatry, University of California, San Diego, La Jolla, California 92093 0603, USA
Genet Epidemiol 31:195-210. 2007..Ultimately our results suggest that evidence for linkage heterogeneity can only be detected with large sample sizes, such as the FBPP, which is consistent with theoretical sample size calculations... - A whole-genome scan for stroke or myocardial infarction in family blood pressure program familiesRichard Sherva
Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, USA
Stroke 39:1115-20. 2008..Using data from the Family Blood Pressure Program, we tested for chromosomal regions linked to the composite phenotype of stroke or myocardial infarction in a large set of hypertensive families... - Five common gene variants identify elevated genetic risk for coronary heart diseaseLance A Bare
Celera, Alameda, California 94502, USA
Genet Med 9:682-9. 2007....
Research Grants
- Genetic Etiology of Sodium-Lithium CountertransportAlanna Morrison; Fiscal Year: 2007..e. sodium-lithium countertransport and hypertension, respectively). The goal of the project is the identification of allelic variation influencing sodium-lithium countertransport as well as risk of developing essential hypertension. ..
- Role of the Solute Carrier Gene Family in HypertensionAlanna C Morrison; Fiscal Year: 2010....