Nicholas Mitsiades

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. doi request reprint B-Raf Inhibition in the Clinic: Present and Future
    Warren Fiskus
    Department of Medicine Department of Molecular and Cellular Biology Dan L Duncan Cancer Center and Center for Drug Discovery, Baylor College of Medicine, Houston, Texas 77030 email
    Annu Rev Med 67:29-43. 2016
  2. pmc Clinical appraisal of abiraterone in the treatment of metastatic prostatic cancer: patient considerations, novel opportunities, and future directions
    Diego J Bedoya
    Clearview Cancer Institute, Huntsville, AL, USA
    Onco Targets Ther 6:9-18. 2013
  3. pmc Distinct patterns of dysregulated expression of enzymes involved in androgen synthesis and metabolism in metastatic prostate cancer tumors
    Nicholas Mitsiades
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 72:6142-52. 2012
  4. pmc Genotype-dependent sensitivity of uveal melanoma cell lines to inhibition of B-Raf, MEK, and Akt kinases: rationale for personalized therapy
    Nicholas Mitsiades
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Invest Ophthalmol Vis Sci 52:7248-55. 2011
  5. pmc miR-137 Targets p160 Steroid Receptor Coactivators SRC1, SRC2, and SRC3 and Inhibits Cell Proliferation
    Vijay Kumar Eedunuri
    Adrienne Helis Malvin Medical Research Foundation V K E, New Orleans, Louisiana 70130 and Departments of Molecular and Cellular Biology K R, W F, C G, S A C, C F, S S S, J S, J S M, C C, B W O, N M and Department of Medicine W F, C G, S A C, C F, S S S, J S, J S M, N M, Baylor College of Medicine, Houston, Texas 77030
    Mol Endocrinol 29:1170-83. 2015
  6. pmc Androgen receptor is the key transcriptional mediator of the tumor suppressor SPOP in prostate cancer
    Chuandong Geng
    Department of Medicine, Baylor College of Medicine, Houston, Texas Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas
    Cancer Res 74:5631-43. 2014
  7. pmc Protein kinase C inhibitors sensitize GNAQ mutant uveal melanoma cells to ionizing radiation
    Jasmina Ziva Cerne
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States
    Invest Ophthalmol Vis Sci 55:2130-9. 2014
  8. pmc Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover
    Chuandong Geng
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 110:6997-7002. 2013
  9. pmc Moving Beyond the Androgen Receptor (AR): Targeting AR-Interacting Proteins to Treat Prostate Cancer
    Christopher Foley
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Suite R407, MS BCM187, Houston, TX, 77030, USA
    Horm Cancer 7:84-103. 2016
  10. pmc HER2 Signaling Drives DNA Anabolism and Proliferation through SRC-3 Phosphorylation and E2F1-Regulated Genes
    Bryan C Nikolai
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas
    Cancer Res 76:1463-75. 2016

Collaborators

Detail Information

Publications11

  1. doi request reprint B-Raf Inhibition in the Clinic: Present and Future
    Warren Fiskus
    Department of Medicine Department of Molecular and Cellular Biology Dan L Duncan Cancer Center and Center for Drug Discovery, Baylor College of Medicine, Houston, Texas 77030 email
    Annu Rev Med 67:29-43. 2016
    ..Combinatorial approaches targeting the Raf pathway hold promise for even more substantial clinical benefits in the future. ..
  2. pmc Clinical appraisal of abiraterone in the treatment of metastatic prostatic cancer: patient considerations, novel opportunities, and future directions
    Diego J Bedoya
    Clearview Cancer Institute, Huntsville, AL, USA
    Onco Targets Ther 6:9-18. 2013
    ....
  3. pmc Distinct patterns of dysregulated expression of enzymes involved in androgen synthesis and metabolism in metastatic prostate cancer tumors
    Nicholas Mitsiades
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 72:6142-52. 2012
    ....
  4. pmc Genotype-dependent sensitivity of uveal melanoma cell lines to inhibition of B-Raf, MEK, and Akt kinases: rationale for personalized therapy
    Nicholas Mitsiades
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Invest Ophthalmol Vis Sci 52:7248-55. 2011
    ..The impact of B-Raf and MEK inhibitors on Gα-mutant UMs remains unknown...
  5. pmc miR-137 Targets p160 Steroid Receptor Coactivators SRC1, SRC2, and SRC3 and Inhibits Cell Proliferation
    Vijay Kumar Eedunuri
    Adrienne Helis Malvin Medical Research Foundation V K E, New Orleans, Louisiana 70130 and Departments of Molecular and Cellular Biology K R, W F, C G, S A C, C F, S S S, J S, J S M, C C, B W O, N M and Department of Medicine W F, C G, S A C, C F, S S S, J S, J S M, N M, Baylor College of Medicine, Houston, Texas 77030
    Mol Endocrinol 29:1170-83. 2015
    ..These results support the development and testing of microRNA-based therapies (in particular based on restoring miR-137 levels) for targeting the oncogenic family of p160 SRCs in cancer. ..
  6. pmc Androgen receptor is the key transcriptional mediator of the tumor suppressor SPOP in prostate cancer
    Chuandong Geng
    Department of Medicine, Baylor College of Medicine, Houston, Texas Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas
    Cancer Res 74:5631-43. 2014
    ..Overall, our studies highlight the AR axis as the key transcriptional output of SPOP in prostate adenocarcinoma and provide an explanation for the prostate-specific tumor suppressor role of wt-SPOP...
  7. pmc Protein kinase C inhibitors sensitize GNAQ mutant uveal melanoma cells to ionizing radiation
    Jasmina Ziva Cerne
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States
    Invest Ophthalmol Vis Sci 55:2130-9. 2014
    ..In this study, we investigated the impact of small-molecule PKC inhibitors bisindolylmaleimide I (BIM) and sotrastaurin (AEB071), combined with ionizing radiation (IR), on survival in melanoma cell lines...
  8. pmc Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover
    Chuandong Geng
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 110:6997-7002. 2013
    ..This tumor suppressor effect is abrogated by the PC-associated SPOP mutations. These studies provide a possible explanation for the role of SPOP mutations in PC, and highlight the potential of SRC-3 as a therapeutic target in PC...
  9. pmc Moving Beyond the Androgen Receptor (AR): Targeting AR-Interacting Proteins to Treat Prostate Cancer
    Christopher Foley
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Suite R407, MS BCM187, Houston, TX, 77030, USA
    Horm Cancer 7:84-103. 2016
    ....
  10. pmc HER2 Signaling Drives DNA Anabolism and Proliferation through SRC-3 Phosphorylation and E2F1-Regulated Genes
    Bryan C Nikolai
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas
    Cancer Res 76:1463-75. 2016
    ..These results have implications for rational discovery of pharmacologic combinations in preclinical models of adjuvant treatment and therapeutic resistance...
  11. pmc The essential role of GATA transcription factors in adult murine prostate
    Lijuan Xiao
    Department of Medicine, Section of Hematology and Oncology, Baylor College of Medicine, Houston, TX, USA
    Oncotarget 7:47891-47903. 2016
    ....