Aksam Merched

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. ncbi Nutrigenetics and nutrigenomics of atherosclerosis
    Aksam J Merched
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA
    Curr Atheroscler Rep 15:328. 2013
  2. ncbi Atherosclerosis: evidence for impairment of resolution of vascular inflammation governed by specific lipid mediators
    Aksam J Merched
    Department of Molecular and Cellular Biology, Baylor College of Medicine and St Luke s Episcopal Hospital, Houston, TX 77030, USA
    FASEB J 22:3595-606. 2008
  3. ncbi Beta2 integrins modulate the initiation and progression of atherosclerosis in low-density lipoprotein receptor knockout mice
    Aksam Merched
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, R630, Houston, TX 77030, USA
    Cardiovasc Res 85:853-63. 2010
  4. ncbi Nutrigenetic disruption of inflammation-resolution homeostasis and atherogenesis
    Aksam J Merched
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    J Nutrigenet Nutrigenomics 4:12-24. 2011
  5. ncbi Absence of p21Waf1/Cip1/Sdi1 modulates macrophage differentiation and inflammatory response and protects against atherosclerosis
    Aksam J Merched
    Department of Molecular, Division of Diabetes, Endocrinology, and Metabolism, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Circulation 110:3830-41. 2004
  6. ncbi Mechanical stretch inhibits oxidized low density lipoprotein-induced apoptosis in vascular smooth muscle cells by up-regulating integrin alphavbeta3 and stablization of PINCH-1
    Jizhong Cheng
    Department of Internal Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Biol Chem 282:34268-75. 2007
  7. ncbi Macrophage-specific p53 expression plays a crucial role in atherosclerosis development and plaque remodeling
    Aksam J Merched
    Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Arterioscler Thromb Vasc Biol 23:1608-14. 2003

Detail Information

Publications7

  1. ncbi Nutrigenetics and nutrigenomics of atherosclerosis
    Aksam J Merched
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA
    Curr Atheroscler Rep 15:328. 2013
    ....
  2. ncbi Atherosclerosis: evidence for impairment of resolution of vascular inflammation governed by specific lipid mediators
    Aksam J Merched
    Department of Molecular and Cellular Biology, Baylor College of Medicine and St Luke s Episcopal Hospital, Houston, TX 77030, USA
    FASEB J 22:3595-606. 2008
    ..Taken together, these findings suggest that a failure of local endogenous resolution mechanisms may underlie the unremitting inflammation that fuels atherosclerosis...
  3. ncbi Beta2 integrins modulate the initiation and progression of atherosclerosis in low-density lipoprotein receptor knockout mice
    Aksam Merched
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, R630, Houston, TX 77030, USA
    Cardiovasc Res 85:853-63. 2010
    ..Here, we investigated the effect of inactivation of beta2 integrins at different stages of atherosclerosis by timed bone marrow transplantation (BMT) of CD18(-/-) cells in low-density lipoprotein receptor knockout (LDLR(-/-)) mice...
  4. ncbi Nutrigenetic disruption of inflammation-resolution homeostasis and atherogenesis
    Aksam J Merched
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    J Nutrigenet Nutrigenomics 4:12-24. 2011
    ..The present study was designed to determine whether augmenting dietary lipids modulates the body's endogenous anti-inflammatory pro-resolving mechanisms and promotes atherosclerosis...
  5. ncbi Absence of p21Waf1/Cip1/Sdi1 modulates macrophage differentiation and inflammatory response and protects against atherosclerosis
    Aksam J Merched
    Department of Molecular, Division of Diabetes, Endocrinology, and Metabolism, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Circulation 110:3830-41. 2004
    ..p21 is also involved in the maturation and differentiation of monocytes into macrophages...
  6. ncbi Mechanical stretch inhibits oxidized low density lipoprotein-induced apoptosis in vascular smooth muscle cells by up-regulating integrin alphavbeta3 and stablization of PINCH-1
    Jizhong Cheng
    Department of Internal Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Biol Chem 282:34268-75. 2007
    ..Furthermore, mechanical stretch prevented VSMC from apoptosis via a mechanism that involves alphaVbeta3 integrin expression, stabilization of PINCH-1, and remodeling of the cytoskeleton...
  7. ncbi Macrophage-specific p53 expression plays a crucial role in atherosclerosis development and plaque remodeling
    Aksam J Merched
    Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Arterioscler Thromb Vasc Biol 23:1608-14. 2003
    ..In this study, we investigated how macrophage-specific loss of p53 function might modulate atherosclerosis development in LDL receptor-deficient mice, a model for familial hypercholesterolemia...