Martin M Matzuk

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. doi request reprint Genetics of mammalian reproduction: modeling the end of the germline
    Martin M Matzuk
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Annu Rev Physiol 74:503-28. 2012
  2. pmc Transforming growth factor β receptor type 1 is essential for female reproductive tract integrity and function
    Qinglei Li
    Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA
    PLoS Genet 7:e1002320. 2011
  3. pmc Small-molecule inhibition of BRDT for male contraception
    Martin M Matzuk
    Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA
    Cell 150:673-84. 2012
  4. pmc Appetite for reproduction: dietary restriction, aging and the mammalian gonad
    Roopa L Nalam
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    J Biol 7:23. 2008
  5. doi request reprint LIN28 lets BLIMP1 take the right course
    Martin M Matzuk
    Departments of Pathology, Molecular and Cellular Biology, and Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Dev Cell 17:160-1. 2009
  6. pmc The biology of infertility: research advances and clinical challenges
    Martin M Matzuk
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, USA
    Nat Med 14:1197-213. 2008
  7. ncbi request reprint Interrelationship of growth differentiation factor 9 and inhibin in early folliculogenesis and ovarian tumorigenesis in mice
    Xuemei Wu
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 18:1509-19. 2004
  8. ncbi request reprint Expression profiling analyses of gonadotropin responses and tumor development in the absence of inhibins
    Kathleen H Burns
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Endocrinology 144:4492-507. 2003
  9. ncbi request reprint Identification and characterization of evolutionarily conserved pufferfish, zebrafish, and frog orthologs of GASZ
    Wei Yan
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Biol Reprod 70:1619-25. 2004
  10. pmc Mouse TEX14 is required for embryonic germ cell intercellular bridges but not female fertility
    Michael P Greenbaum
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Biol Reprod 80:449-57. 2009

Detail Information

Publications99

  1. doi request reprint Genetics of mammalian reproduction: modeling the end of the germline
    Martin M Matzuk
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Annu Rev Physiol 74:503-28. 2012
    ....
  2. pmc Transforming growth factor β receptor type 1 is essential for female reproductive tract integrity and function
    Qinglei Li
    Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA
    PLoS Genet 7:e1002320. 2011
    ..Thus, TGFBR1 is required for female reproductive tract integrity and function, and disruption of TGFBR1-mediated signaling leads to catastrophic structural and functional consequences in the oviduct and uterus...
  3. pmc Small-molecule inhibition of BRDT for male contraception
    Martin M Matzuk
    Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA
    Cell 150:673-84. 2012
    ..These data establish a new contraceptive that can cross the blood:testis boundary and inhibit bromodomain activity during spermatogenesis, providing a lead compound targeting the male germ cell for contraception...
  4. pmc Appetite for reproduction: dietary restriction, aging and the mammalian gonad
    Roopa L Nalam
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    J Biol 7:23. 2008
    ..A recent study in BMC Biology profiling the effects of aging and DR on gonadal gene expression provides novel molecular evidence that has a significant impact on this theory of aging...
  5. doi request reprint LIN28 lets BLIMP1 take the right course
    Martin M Matzuk
    Departments of Pathology, Molecular and Cellular Biology, and Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Dev Cell 17:160-1. 2009
    ....
  6. pmc The biology of infertility: research advances and clinical challenges
    Martin M Matzuk
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, USA
    Nat Med 14:1197-213. 2008
    ..Additionally, new approaches to contraception remain elusive. Nevertheless, the basic and clinical advances in the understanding of the molecular controls of reproduction are impressive and will ultimately improve patient care...
  7. ncbi request reprint Interrelationship of growth differentiation factor 9 and inhibin in early folliculogenesis and ovarian tumorigenesis in mice
    Xuemei Wu
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 18:1509-19. 2004
    ..Thus, GDF9 appears to function indirectly to regulate early granulosa cell proliferation and theca recruitment in vivo...
  8. ncbi request reprint Expression profiling analyses of gonadotropin responses and tumor development in the absence of inhibins
    Kathleen H Burns
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Endocrinology 144:4492-507. 2003
    ..These 10 genes have expression patterns and postulated functions suggesting that they mediate important processes in the physiology and pathology of ovarian and adrenal tissue...
  9. ncbi request reprint Identification and characterization of evolutionarily conserved pufferfish, zebrafish, and frog orthologs of GASZ
    Wei Yan
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Biol Reprod 70:1619-25. 2004
    ..The data presented here are important for future studies of the physiological roles of GASZ using fish and amphibians as animal models...
  10. pmc Mouse TEX14 is required for embryonic germ cell intercellular bridges but not female fertility
    Michael P Greenbaum
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Biol Reprod 80:449-57. 2009
    ..Thus, while TEX14 and intercellular bridges have an essential role in postnatal spermatogenesis, they are not required in the embryo...
  11. pmc Defective gonadotropin-dependent ovarian folliculogenesis and granulosa cell gene expression in inhibin-deficient mice
    Ankur K Nagaraja
    Department of Pathology and Immunology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Endocrinology 151:4994-5006. 2010
    ..These data indicate the gonadotropins initiate an improper program of cell differentiation prior to tumor formation in the absence of inhibins...
  12. ncbi request reprint Intraovarian activins are required for female fertility
    Stephanie A Pangas
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 21:2458-71. 2007
    ..Thus, in contrast to the known tumor suppressor role of activins in some tissues, our data indicate that activin betaA and betaB function redundantly in a growth stimulatory pathway in the mammalian ovary...
  13. pmc Luteinizing hormone promotes gonadal tumorigenesis in inhibin-deficient mice
    Ankur K Nagaraja
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cell Endocrinol 294:19-28. 2008
    ..We conclude that LH is not required for tumor formation in the absence of inhibins but promotes tumor progression, likely through alterations in serum hormone levels and cell cycle regulators...
  14. pmc Deletion of Dicer in somatic cells of the female reproductive tract causes sterility
    Ankur K Nagaraja
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 22:2336-52. 2008
    ..Thus, our findings reveal diverse and critical roles for Dicer and its miRNA products in the development and function of the female reproductive tract...
  15. ncbi request reprint NOBOX deficiency disrupts early folliculogenesis and oocyte-specific gene expression
    Aleksandar Rajkovic
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 77030, USA
    Science 305:1157-9. 2004
    ..Therefore, Nobox is critical for specifying an oocyte-restricted gene expression pattern essential for postnatal follicle development...
  16. pmc GASZ is essential for male meiosis and suppression of retrotransposon expression in the male germline
    Lang Ma
    Department of Pathology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS Genet 5:e1000635. 2009
    ..These studies provide the first evidence for an essential structural role for GASZ in male fertility and epigenetic and post-transcriptional silencing of retrotransposons by stabilizing MILI in nuage...
  17. pmc A link between mir-100 and FRAP1/mTOR in clear cell ovarian cancer
    Ankur K Nagaraja
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 24:447-63. 2010
    ....
  18. ncbi request reprint Restricted germ cell expression of a gene encoding a novel mammalian HORMA domain-containing protein
    Stephanie A Pangas
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Gene Expr Patterns 5:257-63. 2004
    ..The mouse Nohma gene is comprised of 15 exons and maps to chromosome 3. A human ortholog was also identified. The expression pattern of Nohma suggests that it may be a critical regulatory protein in germ cell meiosis...
  19. pmc Loss of inhibin alpha uncouples oocyte-granulosa cell dynamics and disrupts postnatal folliculogenesis
    Michelle Myers
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Dev Biol 334:458-67. 2009
    ..Together, these data provide key evidence to suggest that regulation of the inhibin/activin system is essential for early folliculogenesis in the prepubertal mouse ovary...
  20. pmc Conditional deletion of the retinoblastoma (Rb) gene in ovarian granulosa cells leads to premature ovarian failure
    Claudia Andreu-Vieyra
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 22:2141-61. 2008
    ..Taken together, our results suggest that RB is required for the temporal-specific pattern of expression of key genes involved in follicular development...
  21. ncbi request reprint Effects of granulosa cell-specific deletion of Rb in Inha-alpha null female mice
    Claudia Andreu-Vieyra
    Baylor College of Medicine, Department of Pathology, One Baylor Plaza, Smith Building S217, Houston, Texas 77030, USA
    Endocrinology 148:3837-49. 2007
    ..These findings confirm the importance of P27 as a cell cycle regulator in granulosa cells and suggest functional compensation between RB-like proteins in ovarian tumorigenesis...
  22. ncbi request reprint Roles of NPM2 in chromatin and nucleolar organization in oocytes and embryos
    Kathleen H Burns
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Science 300:633-6. 2003
    ..Thus, Npm2 is a maternal effect gene critical for nuclear and nucleolar organization and embryonic development...
  23. ncbi request reprint Identification of Zfp393, a germ cell-specific gene encoding a novel zinc finger protein
    Wei Yan
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mech Dev 118:233-9. 2002
    ..We hypothesize that ZFP393 functions as a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development...
  24. pmc TEX14 interacts with CEP55 to block cell abscission
    Tokuko Iwamori
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, S217, Houston, TX 77030, USA
    Mol Cell Biol 30:2280-92. 2010
    ..Thus, TEX14 prevents the completion of cytokinesis by altering the destiny of CEP55 from a nidus for abscission to an integral component of the intercellular bridge...
  25. pmc Granulosa cell-expressed BMPR1A and BMPR1B have unique functions in regulating fertility but act redundantly to suppress ovarian tumor development
    Mark A Edson
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 24:1251-66. 2010
    ..These studies support a role for a functional BMP signaling axis as a tumor suppressor pathway in the ovary, with BMPR1A and BMPR1B acting downstream of BMP ligands and upstream of BMP receptor SMADs...
  26. ncbi request reprint Growth differentiation factor 9 regulates expression of the bone morphogenetic protein antagonist gremlin
    Stephanie A Pangas
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 279:32281-6. 2004
    ..We propose that gremlin modulates the cross-talk between GDF9 and BMP signaling that is necessary during follicle development because both ligands use components of the same signaling pathway...
  27. pmc Oogenesis requires germ cell-specific transcriptional regulators Sohlh1 and Lhx8
    Stephanie A Pangas
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:8090-5. 2006
    ..In addition, we show that Lhx8 is downstream of Sohlh1 and critical in fertility. Thus, Sohlh1 and Lhx8 are two germ cell-specific, critical regulators of oogenesis...
  28. ncbi request reprint Regulation of growth differentiation factor 9 expression in oocytes in vivo: a key role of the E-box
    Changning Yan
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Biol Reprod 74:999-1006. 2006
    ..3MUT-mGdf9-Luc) abolished expression in the ovary but not in the testis. These observations indicate that the E-box is a key regulatory sequence for Gdf9 expression in the ovary...
  29. pmc Tektin 3 is required for progressive sperm motility in mice
    Angshumoy Roy
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Reprod Dev 76:453-9. 2009
    ..Our results suggest that tektins are potential candidate genes for nonsyndromic asthenozoospermia in humans...
  30. ncbi request reprint Cyclin D2 and p27 are tissue-specific regulators of tumorigenesis in inhibin alpha knockout mice
    Kathleen H Burns
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 17:2053-69. 2003
    ....
  31. pmc Association of mutations in the zona pellucida binding protein 1 (ZPBP1) gene with abnormal sperm head morphology in infertile men
    Alexander N Yatsenko
    Departments of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Hum Reprod 18:14-21. 2012
    ..We hypothesize that missense mutations exert a dominant-negative effect due to altered ZPBP1 protein folding and protein:protein interactions in the acrosome...
  32. pmc High-grade serous ovarian cancer arises from fallopian tube in a mouse model
    Jaeyeon Kim
    Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 109:3921-6. 2012
    ..Thus, this mouse model demonstrates a paradigm for the origin and initiation of high-grade serous ovarian carcinomas, the most common and deadliest ovarian cancer...
  33. pmc Mice deficient in oocyte-specific oligoadenylate synthetase-like protein OAS1D display reduced fertility
    Wei Yan
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Biol 25:4615-24. 2005
    ..We propose that OAS1D suppresses the interferon/OAS/RNase L-mediated cellular destruction by interacting with OAS1A during oogenesis and early embryonic development...
  34. pmc Genetic evidence that SMAD2 is not required for gonadal tumor development in inhibin-deficient mice
    Saneal Rajanahally
    Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas 77030, USA
    Reprod Biol Endocrinol 8:69. 2010
    ....
  35. pmc Conditional deletion of Smad1 and Smad5 in somatic cells of male and female gonads leads to metastatic tumor development in mice
    Stephanie A Pangas
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Biol 28:248-57. 2008
    ..These data strongly implicate the BR-SMADs as part of a critical developmental pathway in ovaries and testis that, when disrupted, leads to malignant transformation...
  36. pmc Loss of zona pellucida binding proteins in the acrosomal matrix disrupts acrosome biogenesis and sperm morphogenesis
    Yi Nan Lin
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Biol 27:6794-805. 2007
    ..Whereas ZPBP1 was discovered for an in vitro role in sperm-egg interactions, we have shown that both ZPBP proteins play an earlier structural role during spermiogenesis...
  37. pmc BMPR2 is required for postimplantation uterine function and pregnancy maintenance
    Takashi Nagashima
    Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Clin Invest 123:2539-50. 2013
    ....
  38. ncbi request reprint Prevention of cachexia-like syndrome development and reduction of tumor progression in inhibin-deficient mice following administration of a chimeric activin receptor type II-murine Fc protein
    Qinglei Li
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Hum Reprod 13:675-83. 2007
    ..The current findings have potential implications in the design of new drugs or strategies for the treatment of ovarian and testicular tumors and other conditions where ligands signal through ActRII...
  39. pmc TEX14 is essential for intercellular bridges and fertility in male mice
    Michael P Greenbaum
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:4982-7. 2006
    ..Thus, TEX14 is required for intercellular bridges in vertebrate germ cells, and these studies provide evidence that the intercellular bridge is essential for spermatogenesis and fertility...
  40. ncbi request reprint Regulation of FSHbeta and GnRH receptor gene expression in activin receptor II knockout male mice
    T Rajendra Kumar
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Endocrinol 212:19-27. 2003
    ..Our studies confirm the importance of using in vivo genetic models for studying regulation of the hypothalamic-pituitary-gonadal axis...
  41. ncbi request reprint Sexually dimorphic roles of steroid hormone receptor signaling in gonadal tumorigenesis
    Kathleen H Burns
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 17:2039-52. 2003
    ....
  42. ncbi request reprint Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization
    Alexander N Yatsenko
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Mol Genet 15:3411-9. 2006
    ..The development of non-invasive techniques to analyze genetic defects of human spermatogenesis, previously possible only with invasive testis biopsies, provides important diagnostic and therapeutic implications for reproductive medicine...
  43. pmc Testicular cell adhesion molecule 1 (TCAM1) is not essential for fertility
    Roopa L Nalam
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cell Endocrinol 315:246-53. 2010
    ..However, Tcam1 knockout mice that we generated are fertile, and testis weights and sperm counts were not significantly altered. Therefore, we conclude that TCAM1 is not essential for male fertility or germ cell function in Mus musculus...
  44. ncbi request reprint SMAD3 regulates gonadal tumorigenesis
    Qinglei Li
    Department of Pathology, One Baylor Plaza, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 21:2472-86. 2007
    ..Moreover, the activin-induced cachexia syndrome is potentially mediated through both SMAD2 and SMAD3 or only through SMAD2 in the liver and stomach. These studies identify sexually dimorphic functions of SMAD3 in gonadal tumorigenesis...
  45. pmc Identification and characterization of RBM44 as a novel intercellular bridge protein
    Tokuko Iwamori
    Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 6:e17066. 2011
    ..Rbm44 null male mice produce somewhat increased sperm, and show enhanced fertility of unknown etiology. Thus, although RBM44 localizes to intercellular bridges during meiosis, RBM44 is not required for fertility in contrast to TEX14...
  46. pmc Absence of inhibin alpha and retinoblastoma protein leads to early sertoli cell dysfunction
    Roopa L Nalam
    Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 5:e11797. 2010
    ..These results demonstrate that RB is not essential for Sertoli cell tumorigenesis in Inha KO mice but that loss of Inha accelerates the infertility phenotype of Rb cKO mice...
  47. ncbi request reprint Zygote arrest 1 (Zar1) is a novel maternal-effect gene critical for the oocyte-to-embryo transition
    Xuemei Wu
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nat Genet 33:187-91. 2003
    ..Thus, Zar1 is the first identified oocyte-specific maternal-effect gene that functions at the oocyte-to-embryo transition and, as such, offers new insights into the initiation of embryonic development and fertility control in mammals...
  48. pmc Haploinsufficiency of kelch-like protein homolog 10 causes infertility in male mice
    Wei Yan
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:7793-8. 2004
    ....
  49. pmc HILS1 is a spermatid-specific linker histone H1-like protein implicated in chromatin remodeling during mammalian spermiogenesis
    Wei Yan
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:10546-51. 2003
    ..Because HILS1 also belongs to the large winged helix/forkhead protein superfamily, HILS1 may also regulate gene transcription, DNA repair, and/or other chromosome processes during mammalian spermiogenesis...
  50. pmc Discovery of novel microRNAs in female reproductive tract using next generation sequencing
    Chad J Creighton
    The Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 5:e9637. 2010
    ..Our novel miRNAs were detectable in multiple samples, but expressed at low levels and not specific to any one tissue or cell type. To date, this study represents the largest set of samples analyzed together to identify novel miRNAs...
  51. pmc Redundant roles of SMAD2 and SMAD3 in ovarian granulosa cells in vivo
    Qinglei Li
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Cell Biol 28:7001-11. 2008
    ....
  52. pmc Functional microRNA involved in endometriosis
    Shannon M Hawkins
    Department of Obstetrics and Gynecology, Baylor College of Medicine, 1709 Dryden Drive, Suite 1100, Houston, Texas 77030, USA
    Mol Endocrinol 25:821-32. 2011
    ..Thus, miR-29c and other abnormally regulated microRNA appear to play important roles in the pathophysiology of uterine function and dysfunction...
  53. ncbi request reprint Inhibin alpha-iCre mice: Cre deleter lines for the gonads, pituitary, and adrenal
    Carolina J Jorgez
    Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Genesis 44:183-8. 2006
    ..These lines could be useful to understand reproduction and other processes by establishing conditional knockout mouse models...
  54. pmc Activin-like kinase 2 functions in peri-implantation uterine signaling in mice and humans
    Caterina Clementi
    Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, United States of America Departments of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, United States of America Center for Reproductive Medicine, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS Genet 9:e1003863. 2013
    ....
  55. pmc Dysregulation of uterine signaling pathways in progesterone receptor-Cre knockout of dicer
    Shannon M Hawkins
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 26:1552-66. 2012
    ..These data implicate Dicer and appropriate miRNA expression as essential players in the regulation of multiple uterine signaling pathways required for uterine development and appropriate function...
  56. pmc Retinoblastoma protein plays multiple essential roles in the terminal differentiation of Sertoli cells
    Roopa L Nalam
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 23:1900-13. 2009
    ..Our results demonstrate that RB is essential for proper terminal differentiation of Sertoli cells...
  57. ncbi request reprint Premature luteinization and cumulus cell defects in ovarian-specific Smad4 knockout mice
    Stephanie A Pangas
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 20:1406-22. 2006
    ....
  58. ncbi request reprint Mining the oocyte transcriptome
    Claudia Andreu-Vieyra
    Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Trends Endocrinol Metab 17:136-43. 2006
    ..These technological improvements will help to expand our understanding of folliculogenesis and oocyte physiology and improve human reproductive health...
  59. pmc Connective tissue growth factor is required for normal follicle development and ovulation
    Takashi Nagashima
    Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 25:1740-59. 2011
    ..These findings demonstrate that CTGF is a downstream mediator in TGF-β and progesterone signaling cascades and is necessary for normal follicle development and ovulation...
  60. pmc Deletion of the novel oocyte-enriched gene, Gpr149, leads to increased fertility in mice
    Mark A Edson
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Endocrinology 151:358-68. 2010
    ..Thus, Gpr149 null mice are one of the few models with enhanced fertility, and GPR149 could be a target for small molecules to enhance fertility in the assisted reproductive technology clinic...
  61. ncbi request reprint Absence of tektin 4 causes asthenozoospermia and subfertility in male mice
    Angshumoy Roy
    Department of Pathology, One Baylor Plaza, Baylor College of Medicine, Houston, Texas 77030, USA
    FASEB J 21:1013-25. 2007
    ..5 h. Our studies demonstrate that TEKT4 is necessary for the proper coordinated beating of the sperm flagellum and male reproductive physiology...
  62. pmc Characterization of spermatogonial stem cells lacking intercellular bridges and genetic replacement of a mutation in spermatogonial stem cells
    Naoki Iwamori
    Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 7:e38914. 2012
    ..Our study provides a therapeutic potential of spermatogonial stem cells for reproductive medicine if they can be cultured long-term...
  63. pmc Molecular profiling uncovers a p53-associated role for microRNA-31 in inhibiting the proliferation of serous ovarian carcinomas and other cancers
    Chad J Creighton
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 70:1906-15. 2010
    ....
  64. pmc Analysis of microRNA expression in the prepubertal testis
    Gregory M Buchold
    Department of Pathology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 5:e15317. 2010
    ..These studies provide a foundation for interpretation of miRNA changes associated with testicular pathology and identification of novel components of the miRNA editing machinery in the testis...
  65. pmc Inhibitory phosphorylation of separase is essential for genome stability and viability of murine embryonic germ cells
    Xingxu Huang
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS Biol 6:e15. 2008
    ..Our results indicate that inhibitory phosphorylation of separase plays a critical role in the maintenance of sister chromatid cohesion and genome stability in proliferating postmigratory primordial germ cells...
  66. ncbi request reprint Zygote arrest 1 (Zar1) is an evolutionarily conserved gene expressed in vertebrate ovaries
    Xuemei Wu
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Biol Reprod 69:861-7. 2003
    ....
  67. ncbi request reprint Sequence and expression of testis-expressed gene 14 (Tex14): a gene encoding a protein kinase preferentially expressed during spermatogenesis
    Meng Hsing Wu
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Gene Expr Patterns 3:231-6. 2003
    ..TEX14 is predicted to be localized to the nucleus, suggesting that it may play a key role in regulating gene expression or modulating nuclear events during mammalian spermatogenesis...
  68. pmc Germ cell intercellular bridges
    Michael P Greenbaum
    Department of Radiation Oncology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cold Spring Harb Perspect Biol 3:a005850. 2011
    ....
  69. ncbi request reprint Society for Reproductive Biology Founders' Lecture 2007. Insights into germ cell biology: from the bench to the clinic
    Angshumoy Roy
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX, USA
    Reprod Fertil Dev 19:783-91. 2007
    ..These models have helped us identify novel and unexplored areas of germ cell biology and translate this work into the fertility clinic...
  70. pmc Targeted disruption of luteinizing hormone beta-subunit leads to hypogonadism, defects in gonadal steroidogenesis, and infertility
    Xiaoping Ma
    Departments of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:17294-9. 2004
    ..Thus, LHbeta null mice represent a model to study the consequences of an isolated deficiency of LH ligand in reproduction, while retaining normal LH-responsiveness in target cells...
  71. ncbi request reprint Genetic models for transforming growth factor beta superfamily signaling in ovarian follicle development
    Stephanie A Pangas
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Endocrinol 225:83-91. 2004
    ..These new models may reveal the in vivo genetic interactions of TGFbeta superfamily ligands, receptors, binding proteins, and downstream signaling pathways...
  72. pmc Previously uncharacterized roles of platelet-activating factor acetylhydrolase 1b complex in mouse spermatogenesis
    Wei Yan
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:7189-94. 2003
    ..e., alpha2-/-Lis1+/- or alpha1-/-alpha2-/-Lis1+/- mice) restored spermatogenesis and male fertility. Our data provide evidence for unique roles of the PAFAH1B complex and, particularly, the lissencephaly protein Lis1 in spermatogenesis...
  73. pmc The mammalian ovary from genesis to revelation
    Mark A Edson
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Endocr Rev 30:624-712. 2009
    ..Clearly, we have learned much about the mammalian ovary and manipulating its most important cargo, the oocyte, since the birth of Louise Brown over 30 yr ago...
  74. ncbi request reprint Tektin3 encodes an evolutionarily conserved putative testicular microtubules-related protein expressed preferentially in male germ cells
    Angshumoy Roy
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Reprod Dev 67:295-302. 2004
    ..Our studies demonstrate that TEKTIN3 is a novel evolutionarily conserved male germ cell-enriched protein and suggest that it might perform important roles in male reproductive development and physiology...
  75. ncbi request reprint Genetic manipulations to study reproduction
    Carolina J Jorgez
    Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cell Endocrinol 234:127-35. 2005
    ....
  76. pmc Revisiting oocyte-somatic cell interactions: in search of novel intrafollicular predictors and regulators of oocyte developmental competence
    Qinglei Li
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Hum Reprod 14:673-8. 2008
    ....
  77. pmc A bioinformatics tool for linking gene expression profiling results with public databases of microRNA target predictions
    Chad J Creighton
    The Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA
    RNA 14:2290-6. 2008
    ..The software and Excel VBA source code are freely available at http://sigterms.sourceforge.net...
  78. ncbi request reprint The art and artifact of GDF9 activity: cumulus expansion and the cumulus expansion-enabling factor
    Stephanie A Pangas
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Biol Reprod 73:582-5. 2005
    ..Standardization in preparation for recombinant GDF9, as well as a more biochemical analysis of the oocyte-secreted forms of GDF9, may help to resolve the conflicts currently seen in the literature...
  79. pmc Conversion of midbodies into germ cell intercellular bridges
    Michael P Greenbaum
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Dev Biol 305:389-96. 2007
    ....
  80. ncbi request reprint Genetic engineering to study testicular tumorigenesis
    Wei Yan
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    APMIS 111:174-81; discussion 182-3. 2003
    ..Genetic engineering in mouse models provides a powerful tool to study the mechanisms of testicular tumorigenesis and define the important genetic modifiers in vivo...
  81. pmc Minireview: The roles of small RNA pathways in reproductive medicine
    Shannon M Hawkins
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 25:1257-79. 2011
    ..Biologically plausible mRNA targets for these microRNA are aggressively being discovered. The next phase of research will focus on elucidating the clinical utility of small RNA-selective agonists and antagonists...
  82. pmc The menstrual cycle: basic biology
    Shannon M Hawkins
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA
    Ann N Y Acad Sci 1135:10-8. 2008
    ..Although not perfect, mouse models have helped to identify and confirm additional components and pathways in menstrual cycle function and dysfunction in humans...
  83. ncbi request reprint The ret finger protein-like 4 gene, Rfpl4, encodes a putative E3 ubiquitin-protein ligase expressed in adult germ cells
    Aleksandar Rajkovic
    Department of Obstetrics and Gynecology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mech Dev 112:173-7. 2002
    ..We have identified the human ortholog, which maps to 19q13.4. These studies suggest that RFPL4 mediates protein degradation pathways important for gametogenesis or early embryonic development...
  84. pmc Germ-line immortality
    Martin M Matzuk
    Departments of Pathology, Molecular and Cellular Biology, and Molecular and Human Genetics, and Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:16395-6. 2004
  85. ncbi request reprint Overexpression of human chorionic gonadotropin causes multiple reproductive defects in transgenic mice
    Martin M Matzuk
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Biol Reprod 69:338-46. 2003
    ....
  86. ncbi request reprint Deconstructing mammalian reproduction: using knockouts to define fertility pathways
    Angshumoy Roy
    Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Reproduction 131:207-19. 2006
    ..This review focuses on the merits, utility, and the variations of the knockout technology in studies of reproduction in mammals...
  87. pmc Local signalling environments and human male infertility: what we can learn from mouse models
    Roopa L Nalam
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Expert Rev Mol Med 12:e15. 2010
    ..Analysis of these signalling processes in spermatogenesis using mouse models has provided investigators with an invaluable tool to effectively translate basic science research to the research of human disease and infertility...
  88. ncbi request reprint GDF-9 and BMP-15: oocyte organizers
    Xuemei Wu
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Rev Endocr Metab Disord 3:27-32. 2002
  89. ncbi request reprint Functional analysis of oocyte-expressed genes using transgenic models
    Aleksandar Rajkovic
    Department of Obstetrics and Gynecology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Endocrinol 187:5-9. 2002
    ..The combination of these identification approaches, coupled with the use of knockout mice, will lead to many future functional studies of genes uniquely devoted to oogenesis and folliculogenesis...
  90. ncbi request reprint Knockout of pentraxin 3, a downstream target of growth differentiation factor-9, causes female subfertility
    Simona Varani
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 16:1154-67. 2002
    ..These studies demonstrate that PTX3 plays important roles in cumulus cell-oocyte interaction in the periovulatory period as a downstream protein in the GDF-9 signal transduction cascade...
  91. ncbi request reprint Identification of Gasz, an evolutionarily conserved gene expressed exclusively in germ cells and encoding a protein with four ankyrin repeats, a sterile-alpha motif, and a basic leucine zipper
    Wei Yan
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 16:1168-84. 2002
    ....
  92. ncbi request reprint Intercellular communication in the mammalian ovary: oocytes carry the conversation
    Martin M Matzuk
    Department of Pathology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
    Science 296:2178-80. 2002
    ..The challenge for the future is to identify the factors that participate in this communication and their mechanisms of action...
  93. ncbi request reprint Nobox is a homeobox-encoding gene preferentially expressed in primordial and growing oocytes
    Nobuhiro Suzumori
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mech Dev 111:137-41. 2002
    ..In situ hybridization analysis demonstrates that Nobox mRNA is present in primordial and growing oocytes. Nobox is one of the first homeobox-encoding genes preferentially expressed during mammalian folliculogenesis...
  94. ncbi request reprint Granulosa cell-specific inactivation of follistatin causes female fertility defects
    Carolina J Jorgez
    Program in Developmental Biology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mol Endocrinol 18:953-67. 2004
    ..These studies are the first report of a granulosa cell-specific deletion of a gene in the postnatal ovary and have important implications for future endeavors to generate ovary-specific knockout mouse models...
  95. pmc RFPL4 interacts with oocyte proteins of the ubiquitin-proteasome degradation pathway
    Nobuhiro Suzumori
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:550-5. 2003
    ..The specificity of its expression and these interactions suggest that RFPL4 targets cyclin B1 for proteasomal degradation, a key aspect of oocyte cell cycle control during meiosis and the crucial oocyte-to-embryo transition to mitosis...
  96. ncbi request reprint Altered excitation-contraction coupling with skeletal muscle specific FKBP12 deficiency
    Wei Tang
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    FASEB J 18:1597-9. 2004
    ..In highly used muscles such as the diaphragm, adaptation to the loss of FKBP12 occurs, possibly due to the increased Ca2+ influx...
  97. ncbi request reprint Characterization of integrin expression in the mouse ovary
    Kathleen H Burns
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Biol Reprod 67:743-51. 2002
    ..Specific integrins are associated with ovarian cellular phenotypes in mice, which raises intriguing possibilities as to integrin functions in oocyte competence, follicular development, luteinization, and granulosa cell proliferation...
  98. ncbi request reprint Genetic dissection of mammalian fertility pathways
    Martin M Matzuk
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Nat Cell Biol 4:s41-9. 2002
    ....