Research Topics
| Susan J MarriottSummaryAffiliation: Baylor College of Medicine Country: USA Publications
| Collaborators
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Detail Information
Publications
HTLV-I antisense transcripts initiating in the 3'LTR are alternatively spliced and polyadenylatedMarie Hélène Cavanagh
Centre de Recherche en Infectiologie, Centre Hospitalier Universitaire de Quebec, Pavillon CHUL, Quebec, G1V 4G2, Canada
Retrovirology 3:15. 2006..Thorough characterization is required to demonstrate the existence of these transcripts and gain insight into their role in retrovirus biology...
Ancient, independent evolution and distinct molecular features of the novel human T-lymphotropic virus type 4William M Switzer
Laboratory Branch, Division of HIV AIDS Prevention, National Center for HIV AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Retrovirology 6:9. 2009..Analysis of full-length genomes can provide basic information on the evolutionary history and replication and pathogenic potential of new viruses...
Activation of the HTLV-I long terminal repeat by the hepatitis B virus X proteinS J Marriott
Division of Molecular Virology, Baylor College of Medicine, Houston, Texas 77030, USA
Virology 224:206-13. 1996..These results raise the possibility that the HBV X protein may affect the level of HTLV-I gene expression in co-infected individuals...- Impact of HTLV-I Tax on cell cycle progression and the cellular DNA damage repair responseSusan J Marriott
Baylor College of Medicine, Department of Molecular Virology and Microbiology, One Baylor Plaza, Houston, TX 77030, USA
Oncogene 24:5986-95. 2005..The contribution of these activities to genome instability and cellular transformation will be discussed... - Augmentation of human T cell leukaemia virus type I Tax transactivation by octamer binding sitesS J Marriott
Division of Molecular Virology, Baylor College of Medicine, Houston, TX 77030, USA
J Gen Virol 78:2259-67. 1997..Taken together, these results demonstrate that the degree of Tax transactivation can be influenced by the elemental composition of the target promoter... - Damaged DNA and miscounted chromosomes: human T cell leukemia virus type I tax oncoprotein and genetic lesions in transformed cellsSusan J Marriott
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
J Biomed Sci 9:292-8. 2002..The consequences of these effects as well as the evolutionary advantage this may provide to HTLV-I are discussed... - Human T-cell leukemia virus type 1 tax attenuates the ATM-mediated cellular DNA damage responseChandtip Chandhasin
Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
J Virol 82:6952-61. 2008..Attempts to replicate in the presence of these lesions would result in gradual accumulation of mutations, leading to genome instability and cellular transformation... - Effect of transforming viruses on molecular mechanisms associated with cancerTajhal Dayaram
Interdepartmental Program in Cell and Molecular Biology, Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
J Cell Physiol 216:309-14. 2008..While the transforming properties of these viruses are probably unintended consequences of replication strategies, they provide excellent systems in which to study cancer development... - Impact of transforming viruses on cellular mutagenesis, genome stability, and cellular transformationMichael L Gatza
Interdepartmental Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Environ Mol Mutagen 45:304-25. 2005..This review discusses mechanisms utilized by these viral oncoproteins, Tax, HBx, and E6/E7, to mediate genomic instability and cellular transformation... - Human T-cell leukemia virus type 1 Tax enhances serum response factor DNA binding and alters site selectionHeather Y Winter
Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
J Virol 81:6089-98. 2007..These results suggest that Tax activates SRF-responsive transcription by enhancing its binding affinity to multiple different SRE sequences... - Ubiquitination of HTLV-I Tax in response to DNA damage regulates nuclear complex formation and nuclear exportMichael L Gatza
Department of Molecular Virology and Microbiology, Interdepartmental Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Retrovirology 4:95. 2007..Therefore, we hypothesized that post-translational modifications of Tax that occur in response to DNA damage regulate the localization of Tax and its interactions with cellular proteins... - Activation of the human T-cell leukemia virus type 1 long terminal repeat by the ternary complex factor Elk-1Heather Y Winter
Department of Molecular Virology and Microbiology, Baylor College of Medicine, MS 385, One Baylor Plaza, Houston, Texas 77030, USA
J Virol 81:13075-81. 2007..These results identify a functional SRE within the HTLV-1 LTR and suggest that both Elk-1 and SRF play important roles in regulating basal HTLV-1 gene expression... - Cellular transformation by the HTLV-I Tax protein, a jack-of-all-tradesMichael L Gatza
Interdepartmental Program in Cell and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Oncogene 22:5141-9. 2003..This review will concentrate on the effects of Tax on the dysregulation of the G(1)/S and G(2)/M checkpoints as well as the suppression of DNA damage repair leading to cellular transformation... - The HTLV-I Tax oncoprotein: hyper-tasking at the molecular levelDiane R Wycuff
Dept Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
Front Biosci 10:620-42. 2005..Whereas for the virus these functions of Tax provide a means for successful completion of its life cycle, for the cell, they result at best in anarchy, and at worst in death of both the cell and the organism of which that cell is a part... - Genotoxic stress and cellular stress alter the subcellular distribution of human T-cell leukemia virus type 1 tax through a CRM1-dependent mechanismMichael L Gatza
Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza MS-385, Houston, TX 77030, USA
J Virol 80:6657-68. 2006..Changes in Tax distribution and interacting partners are likely to affect cellular processes that regulate cellular transformation... - The HTLV-1 Tax oncoprotein represses Ku80 gene expressionRazvan I Ducu
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
Virology 416:1-8. 2011..The reduction of Ku80 transcription by Tax may deplete the cell of an essential DNA break binding protein, resulting in reduced repair of DNA double strand breaks and accumulation genomic mutations... - Human T-cell leukemia virus type 1 Tax relieves repression of proliferating cell nuclear antigen gene expressionDustin C Edwards
Department of Molecular Virology and Microbiology, Baylor College of Medicine, MS 385, One Baylor Plaza, Houston, TX 77030, USA
J Virol 82:11714-22. 2008.... - Genomic instability driven by the human T-cell leukemia virus type I (HTLV-I) oncoprotein, TaxFrancene J Lemoine
Interdepartmental Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, Texas, TX 77030, USA
Oncogene 21:7230-4. 2002..These data suggest that HTLV-I Tax alters the genomic stability of cells, an effect that may play an important role in Tax-mediated, HTLV-I associated cellular transformation... - Identification of a functional serum response element in the HTLV-I LTRDiane R Wycuff
Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Virology 324:540-53. 2004..These data identify a functional serum response element in the HTLV-I LTR and suggest that SRF may play an important role in regulating basal HTLV-I gene expression in early infection and reactivation from latency... - High throughput method to quantify anterior-posterior polarity of T-cells and epithelial cellsCharletha V Irvin-Wilson
Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA Email C V I W K K R T J
Viruses 3:2396-411. 2011..This general approach represents a significant advancement over manual cell polarity scoring, which is subject to experimenter bias and requires more time and effort to evaluate large numbers of cells... - Meeting report on the 13th International Conference on Human Retrovirology: human T-cell leukemia virus research 30 years after adult T-cell leukemiaMasao Matsuoka
Institute for Virus Research, Kyoto University, Kyoto, Japan
Cancer Res 67:10638-41. 2007 - A new sensitive and quantitative HTLV-I-mediated cell fusion assay in T cellsMarie Ève Paré
Centre de Recherche en Infectiologie, Centre Hospitalier Universitaire de Quebec, Pavillon CHUL, Canada
Virology 338:309-22. 2005.... - Activation of HTLV-I gene transcription by protein tyrosine phosphatase inhibitorsMélanie Langlois
Centre de Recherche en Infectiologie, Centre Hospitalier Universitaire de Quebec, Pavillon CHUL, Ste Foy Québec, Canada G1V 4G2
Virology 329:395-411. 2004..These results demonstrate for the first time a powerful effect of PTP inhibitors on HTLV-I LTR activity and suggest participation of both CREB-dependent and -independent pathways in this activation...