D L Mann

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. ncbi Recent insights into the role of tumor necrosis factor in the failing heart
    D L Mann
    Winters Center for Heart Failure Research, Cardiology Section, Department of Medicine, Veterans Administration Medical Center and Baylor College of Medicine, 2002 Holcombe Blvd, Houston TX 77030, USA
    Heart Fail Rev 6:71-80. 2001
  2. ncbi Mechanisms and models in heart failure: the biomechanical model and beyond
    Douglas L Mann
    Winters Center for Heart Failure Research, Department of Medicine, Baylor College of Medicine, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA
    Circulation 111:2837-49. 2005
  3. ncbi Heart failure: beyond practice guidelines
    Douglas L Mann
    Section of Cardiology, Baylor College of Medicine and the Texas Heart Institute, 1709 Dryden Road, 9th Fl, BCM620--FC 9.83, Houston, TX 77030, USA
    Tex Heart Inst J 33:201-3. 2006
  4. ncbi Targeted anticytokine therapy and the failing heart
    Douglas L Mann
    Winters Center for Heart Failure Research, Cardiology Section, Department of Medicine, Michael E DeBakey Veterans Administration Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Cardiol 95:9C-16C; discussion 38C-40C. 2005
  5. ncbi Stress-activated cytokines and the heart: from adaptation to maladaptation
    Douglas L Mann
    Winters Center for Heart Failure Research, Department of Medicine, Baylor College of Medicine and Houston Veterans Administration Medical Center, Houston, Texas 77030, USA
    Annu Rev Physiol 65:81-101. 2003
  6. ncbi Targeted anticytokine therapy in patients with chronic heart failure: results of the Randomized Etanercept Worldwide Evaluation (RENEWAL)
    Douglas L Mann
    Winters Center for Heart Failure Research, Baylor College of Medicine and the Houston VA, Houston, Tex 77030, USA
    Circulation 109:1594-602. 2004
  7. ncbi Inflammatory mediators and the failing heart: past, present, and the foreseeable future
    Douglas L Mann
    Winters Center for Heart Failure Research, The Cardiology Section, Department of Medicine, Veterans Administration Medical Center, Methodist Hospital, and Baylor College of Medicine, Houston, Tex 77030, USA
    Circ Res 91:988-98. 2002
  8. ncbi Clinical evaluation of the CorCap Cardiac Support Device in patients with dilated cardiomyopathy
    Douglas L Mann
    Baylor College of Medicine, Houston, Texas, USA
    Ann Thorac Surg 84:1226-35. 2007
  9. ncbi Effects of vesnarinone on peripheral circulating levels of cytokines and cytokine receptors in patients with heart failure: a report from the Vesnarinone Trial
    A Deswal
    Winters Center for Heart Failure Research, Houston VA Medical Center, Cardiology Section, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Chest 120:453-9. 2001
  10. ncbi Group B Streptococcus induces TNF-alpha gene expression and activation of the transcription factors NF-kappa B and activator protein-1 in human cord blood monocytes
    J G Vallejo
    Infectious Diseases Section, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    J Immunol 165:419-25. 2000

Research Grants

  1. The Texas Medical Center Regional Coordinating Center for Heart Failure
    Douglas Mann; Fiscal Year: 2007
  2. GENES THAT CONTROL CELL NUMBER--CARDIAC TNF & APOPTOSIS
    Douglas Mann; Fiscal Year: 2002

Detail Information

Publications97

  1. ncbi Recent insights into the role of tumor necrosis factor in the failing heart
    D L Mann
    Winters Center for Heart Failure Research, Cardiology Section, Department of Medicine, Veterans Administration Medical Center and Baylor College of Medicine, 2002 Holcombe Blvd, Houston TX 77030, USA
    Heart Fail Rev 6:71-80. 2001
    ....
  2. ncbi Mechanisms and models in heart failure: the biomechanical model and beyond
    Douglas L Mann
    Winters Center for Heart Failure Research, Department of Medicine, Baylor College of Medicine, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA
    Circulation 111:2837-49. 2005
  3. ncbi Heart failure: beyond practice guidelines
    Douglas L Mann
    Section of Cardiology, Baylor College of Medicine and the Texas Heart Institute, 1709 Dryden Road, 9th Fl, BCM620--FC 9.83, Houston, TX 77030, USA
    Tex Heart Inst J 33:201-3. 2006
  4. ncbi Targeted anticytokine therapy and the failing heart
    Douglas L Mann
    Winters Center for Heart Failure Research, Cardiology Section, Department of Medicine, Michael E DeBakey Veterans Administration Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Cardiol 95:9C-16C; discussion 38C-40C. 2005
    ..This review summarizes what has been learned from the negative clinical trials, as well as the potential direction of future research in this area...
  5. ncbi Stress-activated cytokines and the heart: from adaptation to maladaptation
    Douglas L Mann
    Winters Center for Heart Failure Research, Department of Medicine, Baylor College of Medicine and Houston Veterans Administration Medical Center, Houston, Texas 77030, USA
    Annu Rev Physiol 65:81-101. 2003
    ....
  6. ncbi Targeted anticytokine therapy in patients with chronic heart failure: results of the Randomized Etanercept Worldwide Evaluation (RENEWAL)
    Douglas L Mann
    Winters Center for Heart Failure Research, Baylor College of Medicine and the Houston VA, Houston, Tex 77030, USA
    Circulation 109:1594-602. 2004
    ..Studies in experimental models and preliminary clinical experience suggested a possible therapeutic role for the soluble tumor necrosis factor antagonist etanercept in heart failure...
  7. ncbi Inflammatory mediators and the failing heart: past, present, and the foreseeable future
    Douglas L Mann
    Winters Center for Heart Failure Research, The Cardiology Section, Department of Medicine, Veterans Administration Medical Center, Methodist Hospital, and Baylor College of Medicine, Houston, Tex 77030, USA
    Circ Res 91:988-98. 2002
    ..This review will summarize the tremendous growth of knowledge that has taken place in this field, with a focus on what we have learned from the negative clinical trials, as well as the potential direction of future research in this area...
  8. ncbi Clinical evaluation of the CorCap Cardiac Support Device in patients with dilated cardiomyopathy
    Douglas L Mann
    Baylor College of Medicine, Houston, Texas, USA
    Ann Thorac Surg 84:1226-35. 2007
    ..Left ventricular (LV) remodeling is related to adverse outcomes in heart failure. The CorCap Cardiac Support Device (CSD; Acorn Cardiovascular, Inc, St. Paul, MN) is an implantable device that attenuates LV remodeling...
  9. ncbi Effects of vesnarinone on peripheral circulating levels of cytokines and cytokine receptors in patients with heart failure: a report from the Vesnarinone Trial
    A Deswal
    Winters Center for Heart Failure Research, Houston VA Medical Center, Cardiology Section, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Chest 120:453-9. 2001
    ....
  10. ncbi Group B Streptococcus induces TNF-alpha gene expression and activation of the transcription factors NF-kappa B and activator protein-1 in human cord blood monocytes
    J G Vallejo
    Infectious Diseases Section, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    J Immunol 165:419-25. 2000
    ..Therefore, disrupting the signal transduction pathways induced by GBS has the potential to attenuate the production of immune response mediators, thereby halting or possibly reversing the course of this potentially fatal disease...
  11. ncbi Results of targeted anti-tumor necrosis factor therapy with etanercept (ENBREL) in patients with advanced heart failure
    B Bozkurt
    Winters Center for Heart Failure Research, Department of Medicine, Veterans Administration Medical Center, Houston, TX 77030, USA
    Circulation 103:1044-7. 2001
    ....
  12. ncbi Is inflammation good for the ischemic heart--perspectives beyond the ordinary
    M L Entman
    Department of Medicine and Pediatrics, De Bakey Heart Center, Baylor College of Medicine and Methodist Hospital, Houston, Texas 77030, USA
    Z Kardiol 89:IX/82-7. 2000
    ..In this presentation, we will discuss our approach and data designed to evaluate potential protective roles of the inflammatory reaction after reperfusion...
  13. ncbi Inflammatory mediators and the failing heart: a translational approach
    Abhinav Diwan
    Winters Center for Heart Failure Research, The Cardiology Section, Department of Medicine, Veterans Administration Medical Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Curr Mol Med 3:161-82. 2003
    ..This review will summarize the tremendous growth of knowledge that has taken place in this field, with a focus on what we have learned from the negative clinical trials, as well as the potential direction of future research in this area...
  14. ncbi Brief murine myocardial I/R induces chemokines in a TNF-alpha-independent manner: role of oxygen radicals
    T O Nossuli
    Section of Cardiovascular Sciences and Cardiology, Department of Medicine, The DeBakey Heart Center, Baylor College of Medicine, and The Methodist Hospital, Texas 77030, USA
    Am J Physiol Heart Circ Physiol 281:H2549-58. 2001
    ..The results suggest that ROI generation in the reperfused myocardium rapidly induces C-C and C-X-C chemokines in the venular endothelium in the absence of infarction or irreversible cellular injury...
  15. ncbi Left ventricular remodeling in transgenic mice with cardiac restricted overexpression of tumor necrosis factor
    N Sivasubramanian
    Winters Center for Heart Failure Research, Cardiology Section, Department of Medicine, Veterans Affairs Medical Center, Houston, TX 77030, USA
    Circulation 104:826-31. 2001
    ..The mechanisms responsible for tumor necrosis factor (TNF)-induced LV structural remodeling in the adult heart are not known...
  16. ncbi Functional significance of hemodynamic overload-induced expression of leukemia-inhibitory factor in the adult mammalian heart
    F Wang
    Winters Center for Heart Failure Research, Department of Medicine, Houston VA Medical Center, Baylor College of Medicine, Houston, TX 77030, USA
    Circulation 103:1296-302. 2001
    ....
  17. ncbi Cytokines and cytokine receptors in advanced heart failure: an analysis of the cytokine database from the Vesnarinone trial (VEST)
    A Deswal
    Winters Center for Heart Failure Research, Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
    Circulation 103:2055-9. 2001
    ..CONCLUSIONS: Cytokines and cytokine receptors are independent predictors of mortality in patients with advanced heart failure. Moreover, circulating levels of cytokines are modified by age, sex, and cause of heart failure...
  18. ncbi In vivo expression of proinflammatory mediators in the adult heart after endotoxin administration: the role of toll-like receptor-4
    G Baumgarten
    Department of Medicine, Cardiology Section, Winters Center for Heart Failure Research, and Veterans Affairs Medical Center, Baylor College of Medicine, Houston, Texas, USA
    J Infect Dis 183:1617-24. 2001
    ..Activation of myocardial NF-kappaB was observed within 30 min in C3HeB/FeJ mice but not in C3H/HeJ mice. These findings suggest that myocardial TLR-4 is involved in signaling cytokine production within the heart during endotoxic shock...
  19. ncbi The yin/yang of innate stress responses in the heart
    D L Mann
    Winters Center for Heart Failure Research, Department of Medicine, Baylor College of Medicine, Houston Veterans Administration Medical Center, Houston, Texas 77030, USA
    Cold Spring Harb Symp Quant Biol 67:363-70. 2002
  20. ncbi The role of innate immune responses in the heart in health and disease
    Pascal Knuefermann
    Winters Center for Heart Failure Research, MS 524, 6565 Fannin, Houston, TX 77030, USA
    Trends Cardiovasc Med 14:1-7. 2004
    ..Nonetheless, as will be discussed further herein, these inflammatory mediators all have the potential to produce cardiac decompensation when expressed at sufficiently high concentrations...
  21. ncbi An overview of tumor necrosis factor alpha and the failing human heart
    G Torre-Amione
    Winters Center for Heart Failure Research, Department of Medicine, Veterans Administration Medical Center, Houston, Texas, USA
    Curr Opin Cardiol 14:206-10. 1999
    ..g., tumor necrosis factor alpha), much like the neurohormones, may represent another class of biologically active molecules that are responsible for the development and progression of heart failure...
  22. ncbi Blocking the endogenous increase in HSP 72 increases susceptibility to hypoxia and reoxygenation in isolated adult feline cardiocytes
    M Nakano
    VA Medical Center, Houston, Tex 77030, USA
    Circulation 95:1523-31. 1997
    ....
  23. ncbi Functional significance of inflammatory mediators in a murine model of resuscitated hemorrhagic shock
    Jesus G Vallejo
    Winters Center for Heart Failure Research, Houston, Texas 77030, USA
    Am J Physiol Heart Circ Physiol 288:H1272-7. 2005
    ....
  24. ncbi Differential regulation of mitogen-activated protein kinases in the failing human heart in response to mechanical unloading
    M Flesch
    Winters Center for Heart Failure Research, Baylor College of Medicine, VA Medical Center, Houston, Texas, USA
    Circulation 104:2273-6. 2001
    ..These changes in MAPK activity are associated with changes in myocyte hypertrophy and viability, suggesting a potential mechanistic basis for some of the observed salutary changes after LVAD support...
  25. ncbi Hemodynamic effects of tezosentan, an intravenous dual endothelin receptor antagonist, in patients with class III to IV congestive heart failure
    G Torre-Amione
    Winters Center for Heart Failure Research, the Eugene and Judith Campbell Laboratories for Cardiac Transplantation Research, Houston, Texas, USA
    Circulation 103:973-80. 2001
    ..We assessed the hemodynamic effects and safety of tezosentan, an intravenous dual endothelin receptor antagonist, in patients with moderate to severe heart failure...
  26. ncbi Experimental options in the treatment of heart failure: the role of cytokine antagonism
    D Kalra
    Winters Center for Heart Failure Research, Veterans Administration Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
    Heart Fail Monit 1:114-21. 2001
    ..In addition, this article reviews the existing clinical literature, which suggests that cytokine antagonism is safe and potentially effective in patients with heart failure...
  27. ncbi Cyclooxygenase-2 inhibitor treatment improves left ventricular function and mortality in a murine model of doxorubicin-induced heart failure
    Reynolds M Delgado
    Department of Adult Cardiology, Texas Heart Institute at St Luke s Episcopal Hospital, Houston, Tex 77030, USA
    Circulation 109:1428-33. 2004
    ..Because COX-2 inhibitors are useful in treating many inflammation-mediated diseases, we asked whether COX-2 inhibition can attenuate heart failure progression...
  28. ncbi TNF-alpha acts via p38 MAPK to stimulate expression of the ubiquitin ligase atrogin1/MAFbx in skeletal muscle
    Yi Ping Li
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    FASEB J 19:362-70. 2005
    ..These data suggest that TNF-alpha acts via p38 to increase atrogin1/MAFbx gene expression in skeletal muscle...
  29. ncbi Targeted overexpression of transmembrane tumor necrosis factor provokes a concentric cardiac hypertrophic phenotype
    Ziad I Dibbs
    Winters Center for Heart Failure Research, Houston, TX 77030, USA
    Circulation 108:1002-8. 2003
    ..Whereas the effects of secreted TNF in the heart have been characterized extensively, the effects of transmembrane TNF in the heart are unknown...
  30. ncbi Cardiology patient page. Shortness of breath
    Biykem Bozkurt
    Houston VA Medical Center and the Winters Center for Heart Failure Research, Baylor College of Medicine, Houston, Tex 77030, USA
    Circulation 108:e11-3. 2003
  31. ncbi Role of the innate immune system in acute viral myocarditis
    Chien Hua Huang
    Winters Center for Heart Failure Research, Houston, TX 77030, USA
    Basic Res Cardiol 104:228-37. 2009
    ..Viewed together, these data suggest that the duration and degree of activation of the innate immune system plays a critical role in determining host outcomes in experimental viral myocarditis...
  32. ncbi Treatment of the metabolic syndrome: the impact of lifestyle modification
    Allison M Pritchett
    Winters Center for Heart Failure Research, Baylor College of Medicine, One Baylor Plaza, MC 523D, Houston, TX 77030, USA
    Curr Atheroscler Rep 7:95-102. 2005
    ..However, the remaining challenge is how to promote long-term adherence to a healthier, more active lifestyle and avoid reversion to old habits...
  33. ncbi Biomarkers of inflammation in heart failure
    Biykem Bozkurt
    Section of Cardiology, 3C 306A, Michael E DeBakey V A Medical Center, Houston, TX, 77030, USA
    Heart Fail Rev 15:331-41. 2010
    ..This review will focus on the emerging role of inflammatory biomarkers, including pro-inflammatory cytokines, C-reactive protein, and erythrocyte sedimentation rate in patients with HF...
  34. ncbi Inhibition of PPAR-alpha activity in mice with cardiac-restricted expression of tumor necrosis factor: potential role of TGF-beta/Smad3
    Kenichi Sekiguchi
    Winters Center for Heart Failure Research, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Physiol Heart Circ Physiol 292:H1443-51. 2007
    ..Although speculative, TGF-beta-driven repair mechanisms may also include the additional benefit of limiting FAO in injured myocardium...
  35. ncbi Load-dependent and -independent regulation of proinflammatory cytokine and cytokine receptor gene expression in the adult mammalian heart
    Georg Baumgarten
    Winters Center for Heart Failure Research, Department of Medicine, Houston VAMC and Baylor College of Medicine, Houston, Tex 77030, USA
    Circulation 105:2192-7. 2002
    ....
  36. ncbi Endogenous tumor necrosis factor protects the adult cardiac myocyte against ischemic-induced apoptosis in a murine model of acute myocardial infarction
    K M Kurrelmeyer
    Winters Center for Heart Failure Research, Cardiology Section, Veterans Affairs Medical Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 97:5456-61. 2000
    ..These data suggest that TNF signaling gives rise to one or more cytoprotective signals that prevent and/or delay the development of cardiac myocyte apoptosis after acute ischemic injury...
  37. ncbi Increased myocardial gene expression of tumor necrosis factor-alpha and nitric oxide synthase-2: a potential mechanism for depressed myocardial function in hibernating myocardium in humans
    Dinesh K Kalra
    Section of Cardiology, Baylor College of Medicine, Houston, TX 77030, USA
    Circulation 105:1537-40. 2002
    ....
  38. ncbi Cross-regulation between the renin-angiotensin system and inflammatory mediators in cardiac hypertrophy and failure
    Kenichi Sekiguchi
    Cardiology Section of the Department of Medicine, Winters Center for Heart Failure Research, Houston VAMC and Baylor College of Medicine, 6565 Fannin, MS 524, Houston, TX 77030, USA
    Cardiovasc Res 63:433-42. 2004
    ..Accordingly, in the present review, we will discuss the evidence which suggests that there is a functionally significant cross-talk between neurohormonal and inflammatory cytokine signaling in cardiac hypertrophy and failure...
  39. ncbi Preclinical and clinical assessment of the safety and potential efficacy of thalidomide in heart failure
    Ildiko Agoston
    Winters Center for Heart Failure Research, Cardiology Section, Department of Medicine, Veterans Affairs Medical Center, Baylor College of Medicine, Houston, Texas 77030, USA
    J Card Fail 8:306-14. 2002
    ..CONCLUSIONS: Taken together these results suggest that thalidomide or its derivatives may be useful in selected patients with HF. This potential needs to be studied in larger clinical trials...
  40. ncbi Experimental and clinical basis for the use of statins in patients with ischemic and nonischemic cardiomyopathy
    Kumudha Ramasubbu
    Winters Center for Heart Failure Research, Department of Medicine, Baylor College of Medicine and the Texas Heart Institute at St Luke s Episcopal Hospital, Houston, Texas 77030, USA
    J Am Coll Cardiol 51:415-26. 2008
    ..This review will examine the potential benefits of statins in HF patients with ischemic and nonischemic cardiomyopathy as well as potential concerns regarding the use of statins in these patients...
  41. ncbi Activation and functional significance of the renin-angiotensin system in mice with cardiac restricted overexpression of tumor necrosis factor
    Markus Flesch
    Winters Center for Heart Failure Research, Cardiology Section of Department of Medicine, Houston VAMC and Baylor College of Medicine, Houston, Tex 77030, USA
    Circulation 108:598-604. 2003
    ....
  42. ncbi Rationale, design, and methods for a pivotal randomized clinical trial for the assessment of a cardiac support device in patients with New York health association class III-IV heart failure
    Douglas L Mann
    Center for Heart Failure, Baylor College of Medicine, Houston, Texas 77030, USA
    J Card Fail 10:185-92. 2004
    ....
  43. ncbi TNF provokes cardiomyocyte apoptosis and cardiac remodeling through activation of multiple cell death pathways
    Sandra B Haudek
    Winters Center for Heart Failure Research, Baylor College of Medicine, Houston, Texas, USA
    J Clin Invest 117:2692-701. 2007
    ....
  44. ncbi New therapeutics for chronic heart failure
    Douglas L Mann
    Winters Center for Heart Failure Research, Department of Medicine, Baylor College of Medicine, 6565 Fannin Street, Houston, Texas 77030, USA
    Annu Rev Med 53:59-74. 2002
    ..We review the rationale for existing heart failure therapies and discuss the reasoning behind the development of some emerging therapies...
  45. ncbi Circulating levels of tumor necrosis factor correlate with indexes of depressed heart rate variability: a study in patients with mild-to-moderate heart failure
    Hector A Malave
    Winters Center for Heart Failure Research, Houston, TX 77030, USA
    Chest 123:716-24. 2003
    ....
  46. ncbi Expression and functional significance of tumor necrosis factor receptors in human myocardium
    G Torre-Amione
    Cardiology Section, Veterans Administration Medical Center, Houston, TX 77030, USA
    Circulation 92:1487-93. 1995
    ..TNF-alpha acts by binding to two specific receptors: TNFR1 and TNFR2. However, neither the presence nor the significance of TNF receptors has been studied in the adult mammalian heart...
  47. ncbi Veterans Affairs Quality Enhancement Research Initiative in chronic heart failure
    C M Ashton
    Houston Center for Quality of Care and Utilization Studies, Veterans Affairs Medical Center of Houston, Texas 77030, USA
    Med Care 38:I26-37. 2000
    ..Lessons learned about CHF in the course of the CHF QUERI will be applicable to all people with heart failure and to all health care systems--VA as well as non-VA--that care for them...
  48. ncbi Acute decompensated heart failure: contemporary medical management
    Susan M Joseph
    Division of Cardiology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Tex Heart Inst J 36:510-20. 2009
    ..This review summarizes the contemporary management of patients with acute decompensated heart failure...
  49. ncbi Treatment of heart failure beyond practice guidelines. Role of cardiac remodeling
    Arunima Misra
    Winters Center for Heart Failure Research, Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
    Circ J 72:A1-7. 2008
    ....
  50. ncbi Comparison of patients with heart failure and preserved left ventricular ejection fraction among those with versus without diabetes mellitus
    David Aguilar
    Winters Center for Heart Failure Research and Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
    Am J Cardiol 105:373-7. 2010
    ..68, 95% confidence interval 1.26 to 2.25, p <0.001). In conclusion, in patients with HF and preserved LVEF, diabetes is associated with significantly increased risk of developing adverse HF outcomes...
  51. ncbi Cardiac myocyte apoptosis provokes adverse cardiac remodeling in transgenic mice with targeted TNF overexpression
    David Engel
    Winters Center for Heart Failure Research, Baylor College of Medicine, and Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas 77030, USA
    Am J Physiol Heart Circ Physiol 287:H1303-11. 2004
    ..These studies show that progressive cardiac myocyte apoptosis is sufficient to contribute to adverse cardiac remodeling in the adult mammalian heart through progressive LV wall thinning...
  52. ncbi Adaptive and maladptive effects of SMAD3 signaling in the adult heart after hemodynamic pressure overloading
    Vijay Divakaran
    Sections of Cardiology and Cardiovascular Sciences, and Departments of Medicine and Molecular Physiology and Biophysics, Winters Center for Heart Failure Research, Baylor College of Medicine, Houston, Tex, USA
    Circ Heart Fail 2:633-42. 2009
    ....
  53. ncbi Transforming growth factor-beta receptor antagonism attenuates myocardial fibrosis in mice with cardiac-restricted overexpression of tumor necrosis factor
    Yasushi Sakata
    Section of Cardiology, Department of Medicine, Winters Center for Heart Failure Research, Houston, TX, USA
    Basic Res Cardiol 103:60-8. 2008
    ....
  54. ncbi Targeted overexpression of noncleavable and secreted forms of tumor necrosis factor provokes disparate cardiac phenotypes
    Abhinav Diwan
    Winters Center for Heart Failure Research, Houston VAMC, Baylor College of Medicine and The Methodist Hospital, Houston, Tex 77030, USA
    Circulation 109:262-8. 2004
    ..CONCLUSIONS: These findings suggest that posttranslational processing of TNF, as opposed to TNF expression per se, is responsible for the adverse cardiac remodeling that occurs after sustained TNF overexpression...
  55. ncbi Tumor necrosis factor-induced signal transduction and left ventricular remodeling
    Douglas L Mann
    Department of Medicine, Cardiology Section, Winters Center for Heart Failure Research, Houston Veterans Administration Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    J Card Fail 8:S379-86. 2002
    ..This article will review the role of tumor necrosis factor-induced signal transduction and the process of left ventricular remodeling...
  56. ncbi Angiotensin II induces tumor necrosis factor biosynthesis in the adult mammalian heart through a protein kinase C-dependent pathway
    Dinesh Kalra
    Winters Center for Heart Failure Research, Cardiology Section, Department of Medicine, Veterans Administration Medical Center, and Baylor College of Medicine, Houston, Tex 77030, USA
    Circulation 105:2198-205. 2002
    ..CONCLUSIONS: These studies suggest that Ang II provokes TNF biosynthesis in the adult mammalian heart through a PKC-dependent pathway...
  57. ncbi Escherichia coli LPS-induced LV dysfunction: role of toll-like receptor-4 in the adult heart
    Shintaro Nemoto
    Department of Medicine, Houston Veterans Affairs Medical Center, Houston, Texas 77030, USA
    Am J Physiol Heart Circ Physiol 282:H2316-23. 2002
    ..This study suggests that TLR-4 mediates the LV dysfunction that occurs in LPS-induced shock. Therefore, TLR-4 might be a therapeutic target for attenuating the effects of LPS on the heart...
  58. ncbi CD14-deficient mice are protected against lipopolysaccharide-induced cardiac inflammation and left ventricular dysfunction
    Pascal Knuefermann
    Department of Medicine, Baylor College of Medicine, Houston, Tex, USA
    Circulation 106:2608-15. 2002
    ..CD14 mediates the inflammatory response to lipopolysaccharide (LPS) in various organs including the heart. In this study we investigated the role of CD14 in LPS-induced myocardial dysfunction in vivo...
  59. ncbi Mitochondrial tolerance to stress impaired in failing heart
    Cevher Ozcan
    Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic and Foundation, Guggenheim 7F, Rochester, MN 55905, USA
    J Mol Cell Cardiol 35:1161-6. 2003
    ..This abnormal vulnerability to stress underscores the impact of mitochondrial dysfunction in the pathobiology of heart failure...
  60. ncbi Desmin mutation responsible for idiopathic dilated cardiomyopathy
    D Li
    Section of Cardiology, Molecular Biology Computational Resource, Baylor College of Medicine, Houston, TX, USA
    Circulation 100:461-4. 1999
    ..Considerable evidence suggests desmin, a muscle-specific intermediate filament, plays a significant role in cardiac growth and development...
  61. ncbi Heterogeneous effects of tissue inhibitors of matrix metalloproteinases on cardiac fibroblasts
    Joshua D Lovelock
    Winters Center for Heart Failure Research, Michael E. DeBakey Department of Veterans Affairs Medical Center, Houston, Texas 77030, USA
    Am J Physiol Heart Circ Physiol 288:H461-8. 2005
    ....
  62. ncbi Effects of changes in left ventricular contractility on indexes of contractility in mice
    Shintaro Nemoto
    Department of Medicine, Houston Veterans Affairs Medical Center, Texas 77030, USA
    Am J Physiol Heart Circ Physiol 283:H2504-10. 2002
    ..Heart rate has a modest but significant effect on P-V relationship-derived indexes and must be considered in the evaluation of murine cardiac physiology...
  63. ncbi A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway
    Min Xie
    Center for Cardiovascular Development, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:17378-83. 2006
    ..Thus, by disrupting the endogenous TAK1 locus, we prove a pivotal role for TAK1 in the LKB1/AMPK signaling axis, an essential governor of cell metabolism...
  64. ncbi Downregulation of connexin40 and increased prevalence of atrial arrhythmias in transgenic mice with cardiac-restricted overexpression of tumor necrosis factor
    Sam E Sawaya
    Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    Am J Physiol Heart Circ Physiol 292:H1561-7. 2007
    ..In conclusion, sustained inflammatory signaling contributed to atrial structural remodeling and downregulation of connexin40 that was associated with an increased prevalence of atrial arrhythmias...
  65. ncbi The metabolic syndrome and mortality in an ethnically diverse heart failure population
    Saamir A Hassan
    Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
    J Card Fail 14:590-5. 2008
    ..Similar data are not available for a heart failure (HF) population. This study sought to determine the prevalence of the MetS and its effect on mortality in a HF population...
  66. ncbi The emerging role of microRNAs in cardiac remodeling and heart failure
    Vijay Divakaran
    Winters Center for Heart Failure Research, Section of Cardiology, Department of Medicine, Baylor College of Medicine, and Texas Heart Institute at St Luke s Episcopal Hospital, Houston, Tex, USA
    Circ Res 103:1072-83. 2008
    ..Here, we review the biology of miRNAs in relation to their role in modulating various aspects of the process of cardiac remodeling, as well as discuss the potential application of miRNA biology to the field of heart failure...
  67. ncbi Cellular remodeling in heart failure disrupts K(ATP) channel-dependent stress tolerance
    Denice M Hodgson
    Department of Medicine, Mayo Clinic, Mayo Foundation, Rochester, MN 55905, USA
    EMBO J 22:1732-42. 2003
    ..Thus, disease-induced K(ATP) channel metabolic dysregulation is a contributor to the pathobiology of heart failure, illustrating a mechanism for acquired channelopathy...
  68. ncbi Comparison of outcomes of white versus black patients hospitalized with heart failure and preserved ejection fraction
    Ildiko Agoston
    Division of Cardiology, University of Texas Medical Branch, Galveston, Texas, USA
    Am J Cardiol 94:1003-7. 2004
    ..This underscores the importance of evaluating other agents for the treatment of patients who have HF-PEF...
  69. ncbi Left ventricular size and shape: determinants of mechanical signal transduction pathways
    Douglas L Mann
    Winters Center for Heart Failure Research, Baylor College of Medicine, St. Luke's Episcopal Hospital, USA
    Heart Fail Rev 10:95-100. 2005
    ....
  70. ncbi Asymptomatic left ventricular dysfunction: an overlooked part of the continuum of heart failure
    Arunima Misra
    Winters Center for Heart Failure Research, Department of Medicine, Baylor College of Medicine, VA Medical Center, Houston, TX 77030, USA
    Heart Fail Monit 3:42-8. 2002
    ..This review highlights the currently available data on the epidemiology, pathophysiology, diagnosis, and treatment of asymptomatic LV systolic dysfunction...
  71. ncbi Basic mechanisms of left ventricular remodeling: the contribution of wall stress
    Douglas L Mann
    Winters Center for Heart Failure Research, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Card Fail 10:S202-6. 2004
    ....
  72. ncbi Cardiac remodeling as therapeutic target: treating heart failure with Cardiac Support Devices
    Douglas L Mann
    Winters Center for Heart Failure Research, Baylor College of Medicine, St. Luke's Episcopal Hospital, USA
    Heart Fail Rev 10:93-4. 2005
  73. ncbi Proapoptotic effects of caspase-1/interleukin-converting enzyme dominate in myocardial ischemia
    Faisal M Syed
    Department of Medicine, University of Cincinnati, Cincinnati, Ohio, USA
    Circ Res 96:1103-9. 2005
    ....
  74. ncbi The cytoprotective effects of tumor necrosis factor are conveyed through tumor necrosis factor receptor-associated factor 2 in the heart
    Jana S Burchfield
    Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Heart Fail 3:157-64. 2010
    ..Noting that the scaffolding protein TNF receptor-associated factor 2 (TRAF2) is common to both TNF receptors, we hypothesized that the cytoprotective responses of TNF were mediated through TRAF2...
  75. ncbi Antiinflammatory therapy in myocarditis
    Jesus Vallejo
    Winters Center for Heart Failure Research, Cardiology Section, Medical Care Line, Veterans Affairs Medical Center, and Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Curr Opin Cardiol 18:189-93. 2003
    ....
  76. ncbi Apoptosis and the heart: a decade of progress
    Richard N Kitsis
    Department of Medicine, Cardiovascular Research Center, and Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Mol Cell Cardiol 38:1-2. 2005
    ..Seven articles written by leading investigators in the field should provide a timely review of our current understanding of the role of apoptosis in the adult mammalian heart...
  77. ncbi Innate immunity mediates myocardial preconditioning through Toll-like receptor 2 and TIRAP-dependent signaling pathways
    Jian Wen Dong
    Department of Medicine, Winters Center for Heart Failure Research, Baylor College of Medicine and Texas Children s Hospital, Houston, USA
    Am J Physiol Heart Circ Physiol 298:H1079-87. 2010
    ....
  78. ncbi Negative inotropic effects of high-mobility group box 1 protein in isolated contracting cardiac myocytes
    Huei Ping Tzeng
    Department of Medicine, Winters Center for Heart Failure Research, Houston, TX 77030, USA
    Am J Physiol Heart Circ Physiol 294:H1490-6. 2008
    ....
  79. ncbi Spectrum of pleiotropic effects of statins in heart failure
    Nitin Mathur
    Baylor College of Medicine, Houston, TX, USA
    Heart Fail Clin 4:153-61. 2008
    ..This article focuses on the non-lipid lowering effects of statins, with an emphasis on the anti-inflammatory properties of these agents...
  80. ncbi MicroRNAs and the failing heart
    Douglas L Mann
    Winters Center for Heart Failure Research, Baylor College of Medicine, Houston, USA
    N Engl J Med 356:2644-5. 2007
  81. ncbi Oxidative stress promotes ligand-independent and enhanced ligand-dependent tumor necrosis factor receptor signaling
    Hatice Z Ozsoy
    Department of Medicine and Molecular Physiology and Biophysics, Winters Center for Heart Failure Research, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 283:23419-28. 2008
    ..Taken together, these results suggest that oxidative stress promotes TNFR receptor self-interaction and ligand-independent and enhanced ligand-dependent TNF signaling...
  82. ncbi Toll-like receptor 2 modulates left ventricular function following ischemia-reperfusion injury
    Yasushi Sakata
    Winters Center for Heart Failure Research, 1709 Dryden BCM, 620 Rm 9 83, Houston, TX 77030, USA
    Am J Physiol Heart Circ Physiol 292:H503-9. 2007
    ..Thus disruption of TLR2-mediated signaling may be helpful to induce immediate or delayed myocardial protection from ischemia-reperfusion injury...
  83. ncbi Plasma matrix metalloproteinase and inhibitor profiles in patients with heart failure
    Eric M Wilson
    Cardiothoracic Surgery, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Card Fail 8:390-8. 2002
    ..These changes in MMP/TIMP levels likely reflect the progression and/or acceleration of the LV remodeling process in CHF. Thus serial measurements of plasma MMP/TIMP levels may hold diagnostic/prognostic significance in CHF patients...
  84. ncbi Duality of innate stress responses in cardiac injury, repair, and remodeling
    Eric M Wilson
    Department of Surgery, Cardiothoracic Research, Medical University of South Carolina, Charleston, SC 29425, USA
    J Mol Cell Cardiol 37:801-11. 2004
    ..Nonetheless, as will be discussed further herein, these inflammatory mediators all have the potential to produce cardiac decompensation when expressed at sufficiently high concentrations...
  85. ncbi Exercise training and skeletal muscle inflammation in chronic heart failure: feeling better about fatigue
    Douglas L Mann
    J Am Coll Cardiol 42:869-72. 2003
  86. ncbi Extracellular matrix remodeling following myocardial injury
    Merry L Lindsey
    Cardiothoracic Surgery, Medical University of South Carolina, Charleston, SC 29425, USA
    Ann Med 35:316-26. 2003
    ..MMP inhibition is a particular focus of recent studies designed to understand the underlying mechanisms of LV remodeling and to evaluate pharmacologic strategies that target the ECM to affect adverse LV remodeling following MI...
  87. ncbi The Seattle Heart Failure Model: prediction of survival in heart failure
    Wayne C Levy
    University of Washington, Seattle, WA 98177, USA
    Circulation 113:1424-33. 2006
    ....
  88. ncbi Sustained benefits of the CorCap Cardiac Support Device on left ventricular remodeling: three year follow-up results from the Acorn clinical trial
    Randall C Starling
    The Cleveland Clinic, Kaufman Center for Heart Failure, Cleveland, Ohio 44195, USA
    Ann Thorac Surg 84:1236-42. 2007
    ..However, long-term effects in patients with heart failure have not been reported...
  89. ncbi Failure of benefit and early hazard of bucindolol for Class IV heart failure
    Jeffrey L Anderson
    Division of Cardiology, LDS Hospital, University of Utah, Salt Lake City 84143, USA
    J Card Fail 9:266-77. 2003
    ..CONCLUSIONS: Class IV HF patients in BEST were at high risk. Bucindolol did not reduce death or HF hospitalization and was associated with early hazard...
  90. ncbi Myocardial proinflammatory cytokine expression and left ventricular remodeling in patients with chronic mitral regurgitation
    Hakan Oral
    Division of Cardiology, University of Michigan and Veterans Affairs Medical Centers, Ann Arbor, USA
    Circulation 107:831-7. 2003
    ....
  91. ncbi Desmin mediates TNF-alpha-induced aggregate formation and intercalated disk reorganization in heart failure
    Panagiota Panagopoulou
    Cell Biology Division, Center of Basic Research, and 2Cardiovascular Research Division, Center of Clinical Research, Biomedical Research Foundation, Academy of Athens, Athens 11527, Greece
    J Cell Biol 181:761-75. 2008
    ..Importantly, D263E desmin expression attenuated cardiomyocyte apoptosis, prevented left ventricular wall thinning, and improved the function of MHCsTNF hearts...
  92. ncbi Designs for mechanical circulatory support device studies
    James D Neaton
    University of Minnesota School of Public Health, Minneapolis, Minnesota 55415, USA
    J Card Fail 13:63-74. 2007
    ..Because patient availability to evaluate these devices is limited and randomized trials have been slow in enrolling patients, a workshop was convened to consider designs for MCSD development including alternatives to randomized trials...
  93. ncbi Angiotensin II as an inflammatory mediator: evolving concepts in the role of the renin angiotensin system in the failing heart
    Douglas L Mann
    Cardiovasc Drugs Ther 16:7-9. 2002
  94. ncbi TNFalpha decreases alphaMHC expression by a NO mediated pathway: role of E-box transcription factors for cardiomyocyte specific gene regulation
    Denise Hilfiker-Kleiner
    Department of Cardiology and Angiology, Medizinische Hochschule Hannover, Carl-Neuberg Strasse 1, 30625 Hannover, Germany
    Cardiovasc Res 53:460-9. 2002
    ..Our data obtained in cultured CM and in TNFalpha transgenic mice support the notion that TNFalpha exerts these effects by NO and E-box dependent mechanisms in vitro and possibly in vivo...
  95. ncbi Prediction of mode of death in heart failure: the Seattle Heart Failure Model
    Dariush Mozaffarian
    Harvard Medical School and Harvard School of Public Health, Boston, Mass, USA
    Circulation 116:392-8. 2007
    ..Prediction of mode of death may facilitate decisions about specific medications or devices...
  96. ncbi Targeted cancer therapeutics: the heartbreak of success
    Douglas L Mann
    Nat Med 12:881-2. 2006
  97. ncbi Plasma concentrations of tumor necrosis factor-alpha in cats with congestive heart failure
    Kathryn M Meurs
    Department of Small Animal Medicine and Surgery and the Michael E. DeBakey Institute, College of Veterinary Medicine, Texas A and M University, College Station 77843, USA
    Am J Vet Res 63:640-2. 2002
    ..Increased plasma concentrations of TNF-alpha in cats with CHF may offer insights into the pathophysiologic mechanisms of heart failure and provide targets for therapeutic interventions...

Research Grants4

  1. The Texas Medical Center Regional Coordinating Center for Heart Failure
    Douglas Mann; Fiscal Year: 2007
    ..Douglas Mann, who has experience with phase I - IV clinical trials, and who has close working relationship with of the investigators in the proposed TMC RCC by virtue of his 14 year tenure in the Texas Medical Center. (End of Abstract) ..
  2. GENES THAT CONTROL CELL NUMBER--CARDIAC TNF & APOPTOSIS
    Douglas Mann; Fiscal Year: 2002
    ..Mechanisms and countermeasures for cardiac apoptosis will be tested by Dr. Doug Mann, with emphasis on dilated cardiomyopathy triggered by overexpression of tumor necrosis factor alpha, and on investigations of human myocardium. ..