Research Topics
Genomes and Genes
| Dan LiuSummaryAffiliation: Baylor College of Medicine Country: USA Publications
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Detail Information
Publications
Human NUF2 interacts with centromere-associated protein E and is essential for a stable spindle microtubule-kinetochore attachmentDan Liu
Laboratory of Cellular Dynamics, University of Science and Technology of China and the National Laboratory for Physical Sciences, Hefei 230027, China
J Biol Chem 282:21415-24. 2007..Our results indicate that HsNUF2 and CENP-E are required for organization of stable microtubule-kinetochore attachment that is essential for faithful chromosome segregation in mitosis...- Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteinsDan Liu
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
J Biol Chem 279:51338-42. 2004..These results help to unify previous observations and suggest that telomere maintenance depends on the multi-subunit telosome... - The human Rap1 protein complex and modulation of telomere lengthMatthew S O'Connor
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
J Biol Chem 279:28585-91. 2004..These results indicate that hRap1 negatively regulates telomere length in vivo and suggest that the linker region of hRap1 may modulate the recruitment of negative regulators of telomere length... - PTOP interacts with POT1 and regulates its localization to telomeresDan Liu
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
Nat Cell Biol 6:673-80. 2004..Furthermore, expression of the respective interaction domains on PTOP and POT1 alone extended telomere length in human cells. Therefore, PTOP heterodimerizes with POT1 and regulates POT1 telomeric recruitment and telomere length... - A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assemblyMatthew S O'Connor
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 103:11874-9. 2006..Our results suggest that coordinated interactions among TPP1, TIN2, TRF1, and TRF2 may ensure robust assembly of the telosome, telomere targeting of its subunits, and, ultimately, regulated telomere maintenance... - TRF2 functions as a protein hub and regulates telomere maintenance by recognizing specific peptide motifsHyeung Kim
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Nat Struct Mol Biol 16:372-9. 2009..Our findings indicate that an array of TRF2 molecules functions as a protein hub and regulates telomeres by recruiting different signaling molecules via a linear sequence code... - OB fold-containing protein 1 (OBFC1), a human homolog of yeast Stn1, associates with TPP1 and is implicated in telomere length regulationMa Wan
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
J Biol Chem 284:26725-31. 2009..Taken together, our studies suggest that OBFC1/AAF44 represents a new player in the telomere interactome for telomere maintenance... - TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomeraseHuawei Xin
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Nature 445:559-62. 2007.... - Telomere maintenance through spatial control of telomeric proteinsLiuh Yow Chen
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Mol Cell Biol 27:5898-909. 2007.... - Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cellsJiancong Liang
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Nat Cell Biol 10:731-9. 2008..Our data collectively suggest that Nanog and Oct4 associate with unique repressor complexes on their target genes to control ES cell fate... - Identification of Flightless-I as a substrate of the cytokine-independent survival kinase CISKJun Xu
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA
J Biol Chem 284:14377-85. 2009..These findings support the model that CISK phosphorylates FLII and activates nuclear receptor transcription and suggest a new cell survival signaling pathway mediated by PI 3-kinase and CISK... - Inside the mammalian telomere interactome: regulation and regulatory activities of telomeresZhou Songyang
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Crit Rev Eukaryot Gene Expr 16:103-18. 2006..The establishment of the Telomere Interactome will also enable the integration of the intricate circuitries that regulate telomeres with other cellular interactomes in vertebrates... - The telosome/shelterin complex and its functionsHuawei Xin
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Baylor Plaza, Houston, TX 77030, USA
Genome Biol 9:232. 2008..A complex of six telomere-associated proteins has been identified--the telosome or shelterin complex--that is crucial for both the maintenance of telomere structure and its signaling functions... - Irgm1 protects hematopoietic stem cells by negative regulation of IFN signalingKatherine Y King
Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA
Blood 118:1525-33. 2011..The deleterious effects of excessive IFN signaling may explain how hematologic abnormalities arise in patients with inflammatory conditions... - ERM-mediated genetic screens in mammalian cellsDan Liu
Cell based Assay Screening Service Core, Baylor College of Medicine, Houston, Texas, USA
Methods Enzymol 446:409-19. 2008..This chapter will discuss general design, procedures, and applications of the ERM strategy... - Analysis of average telomere length in cultured human cellsDan Liu
Department of Biochemistry and Molecular Biology, Cell based Assay Screening Service Core, Baylor College of Medicine, Houston, TX, USA
Methods Mol Biol 735:13-9. 2011..Tremendous heterogeneity can be observed both between species and within a single cell line population. Here, we describe the assay that analyzes the average length of telomeres in cultured cells (TRF analysis)... - Genetic mapping of anti-apoptosis pathways in myeloid progenitor cellsDan Liu
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, USA
Methods Mol Biol 559:283-91. 2009..The advantages of the ERM method include regulatable expression, flexible design, and efficiency... - Tie2/TEK modulates the interaction of glioma and brain tumor stem cells with endothelial cells and promotes an invasive phenotypeDan Liu
Department of Neuro Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
Oncotarget 1:700-9. 2010.... - Genetic screening reveals an essential role of p27kip1 in restriction of breast cancer progressionYuhui Yuan
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Cancer Res 67:8032-42. 2007..These findings suggest that p27 plays an essential role in restriction of breast cancer progression... - Structural basis of membrane targeting by the Phox homology domain of cytokine-independent survival kinase (CISK-PX)Yi Xing
Department of Biological Structure, University of Washington, Seattle, Washington 98195 7420, USA
J Biol Chem 279:30662-9. 2004..Furthermore, biochemical studies reveal that CISK-PX dimerizes in the presence of the linker between the PX domain and kinase domain, suggesting a multivalent mechanism in membrane localization of CISK... - Construction of HA-1-DC nucleic-acid vaccine and induction of specific cytotoxic T lymphocytesYaya Wang
Tumor Blood Center, First Affiliated Hospital, Guangzhou Medical College, Guangzhou 510230, China
J Huazhong Univ Sci Technolog Med Sci 27:261-4. 2007..The cytotoxicty of inducing CTLs was higher than the control group. It was suggested that minor histocompatibility antigen HA-1 could be considered as a target of immunotherapy against leukemia after HSCT... - Site-selective DNA cleavage by a novel complex of copper-conjugate of Phen and polyamide containing N-methylimidazole ringsDan Liu
Beijing National Laboratory for Molecular Sciences, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
Bioorg Med Chem Lett 16:5032-5. 2006.... - Interaction of Skp1 with CENP-E at the midbody is essential for cytokinesisDan Liu
Division of Cellular Dynamics, Hefei National Laboratory and University of Science and Technology of China, Hefei, China 230027
Biochem Biophys Res Commun 345:394-402. 2006..We hypothesize that CENP-E degradation is essential for faithful mitotic exit and the proteolysis of CENP-E is mediated by SCF via a direct Skp1 link... - Upregulation of 14-3-3 isoforms in acute rat myocardial injuries induced by burn and lipopolysaccharideMing He
Jiangxi Provincial Key Laboratory of Molecular Medicine at the Second Affiliated Hospital, Department of Pharmacology, Nanchang University School of Medicine, Nanchang, PR China
Clin Exp Pharmacol Physiol 33:374-80. 2006..In contrast, 14-3-3eta mRNA had a slight increase without significance. 4. Our results suggest that 14-3-3 may play a role in both acute and subacute (postburn infectious) phases of severe burn... - Inhibition of human telomerase reverse transcriptase in hep-2 cells using short hairpin RNA expression vectorsShi ming Chen
Department of Otolaryngology Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, China
Arch Otolaryngol Head Neck Surg 132:200-5. 2006..Our objective was to investigate the effect of short hairpin RNA (shRNA) on hTERT expression and telomerase activity in laryngeal cancer cells... - Inhibitory effects of sasanquasaponin on over-expression of ICAM-1 and on enhancement of capillary permeability induced by burns in ratsQiren Huang
Department of Pharmacology, Jiangxi Medical College, Ba Yi Road 603, Nanchang 330006, PR China
Burns 31:637-42. 2005..These results suggest that SQS, developed from Chinese traditional herbs, might be effective in decreasing inflammation induced by burns... - A BMP-mediated transcriptional cascade involving Cash1 and Tlx-3 specifies first-order relay sensory neurons in the developing hindbrainAmata Hornbruch
Genes and Development Research Group, Department of Cell Biology and Anatomy, Institute of Maternal and Child Health, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, Canada
Mech Dev 122:900-13. 2005.... - beta4GalT-II increases cisplatin-induced apoptosis in HeLa cells depending on its Golgi localizationJianhai Jiang
Key Laboratory of Glycoconjuates Research, Ministry of Public Health and State Key Laboratory of Genetic Engineering and Gene Research Center, Shanghai Medical College of Fudan University, Shanghai 200032, People s Republic of China
Biochem Biophys Res Commun 358:41-6. 2007.... - Silencing of mouse hepatic lanosterol 14-alpha demethylase down-regulated plasma low-density lipoprotein cholesterol levels by short-term treatment of siRNABaoshan Xu
State Key Laboratories for AgroBiotechnology and Department of Animal Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing, P R China
Biol Pharm Bull 31:1182-91. 2008..It indicated that there was a cholesterol levels link-modulation system between cholesterol synthetic pathway through CYP51 and cholesterol transport pathway through LDLR in vivo... - The identification and structural characterization of C7orf24 as gamma-glutamyl cyclotransferase. An essential enzyme in the gamma-glutamyl cycleAaron J Oakley
Research School of Chemistry, Australian National University, Canberra, Australian Capital Territory 2601, Australia
J Biol Chem 283:22031-42. 2008..Mutation of Glu(98) to Ala or Gln completely inactivates the enzyme without altering the overall fold... - E1AF promotes mithramycin A-induced Huh-7 cell apoptosis depending on its DNA-binding domainDan Liu
Key Laboratory of Glycoconjugates Research, Ministry of Public Health and Gene Research Center, Shanghai Medical College of Fudan University, Dongan Road 130, Shanghai 200032, People s Republic of China
Arch Biochem Biophys 477:20-6. 2008..Taken together, E1AF increases mithramycin A-induced Huh-7 cells apoptosis and Bax expression depending on its DNA-binding domain, indicating that E1AF might contribute to the therapeutic efficiency of mithramycin A for hepatoma... - Cdc34-mediated degradation of ATF5 is blocked by cisplatinYuanyan Wei
Gene Research Center, Key Laboratory of Medical Molecular Virology Ministry of Education and Health, Ministry of Public Health, Shanghai Medical College and Institutes of Biomedical Sciences of Fudan University, Shanghai, China
J Biol Chem 283:18773-81. 2008..In summary, a down-regulation of proteasome-mediated degradation of ATF5 might contribute to cisplatin-induced apoptosis, providing a new mechanism of cisplatin-induced apoptosis... - Muscle-specific GSTM2-2 on the luminal side of the sarcoplasmic reticulum modifies RyR ion channel activityLan Wei
Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, PO Box 334, Canberra City, ACT 2601, Australia
Int J Biochem Cell Biol 40:1616-28. 2008..The results indicate that GSTM2-2 is a novel luminal regulator of the RyR channels in the heart... - Identification of beta1,4GalT II as a target gene of p53-mediated HeLa cell apoptosisJin Zhou
Key Laboratory of Glycoconjuates Research, Ministry of Public Health and Gene Research Center, Shanghai Medical College of Fudan University, Shanghai, People s Republic of China
J Biochem 143:547-54. 2008..Collectively, these results suggested that beta1,4GalT II might serve as a target gene of p53 transcription factor during adriamycin-induced HeLa cell apoptosis, which elucidated a new mechanism of p53-mediated cell apoptosis... - [A study on the apoptosis of gastric carcinoma cells induced by arsenic trioxide combined with Ad-IkappaBalphaM]Bing Rong Liu
Department of Digestive Diseases, The Second Affiliated Hospital, Harbin Medical University, Harbin 150086, China
Zhonghua Nei Ke Za Zhi 46:569-72. 2007..To study the activation of nuclear factor-kappaB (NF-kappaB) in gastric carcinoma SGC-7901 cells after treating with As(2)O(3) and the enhancement of the therapeutic effect of As(2)O(3) with recombinant adenovirus IkappaBalphaM... - Functional interaction of E1AF and Sp1 in glioma invasionJianhai Jiang
Key Laboratory of Medical Molecular Virology, Ministry of Education and Health, Gene Research Center, Shanghai Medical College and Institutes of Biomedical Sciences of Fudan University, Shanghai 200032, People s Republic of China
Mol Cell Biol 27:8770-82. 2007..This report describes a new mechanism of glioma invasion involving a cooperative effort between E1AF and Sp1 transcription factors... - Anoxic preconditioning up-regulates 14-3-3 protein expression in neonatal rat cardiomyocytes through extracellular signal-regulated protein kinase 1/2He Ping Chen
Jiangxi Provincial Key Laboratory of Molecular Medicine at the Second Affiliated Hospital, Nanchang University, Nanchang 330006, PR China
Life Sci 81:372-9. 2007..Furthermore, inhibition of the ERK1/2 with PD98059 abolished the 14-3-3 protein up-regulation in cardiomyocytes induced by APC. The results indicate that APC up-regulates 14-3-3 protein expression through the ERK1/2 signaling pathways... - Intracellular Ca2+ and the phospholipid PIP2 regulate the taste transduction ion channel TRPM5Dan Liu
Department of Biological Sciences and Program in Neuroscience, University of Southern California, Los Angeles, CA 90089, USA
Proc Natl Acad Sci U S A 100:15160-5. 2003..TRPM5 channels are nonselective among monovalent cations and not detectably permeable to divalent cations. We propose that the regulation of TRPM5 by Ca2+ mediates sensory activation in the taste system...