Research Topics
Genomes and Genes | Yunfu LinSummaryAffiliation: Baylor College of Medicine Country: USA Publications
| Collaborators
|
Detail Information
Publications
Transcription-induced DNA toxicity at trinucleotide repeats: double bubble is troubleYunfu Lin
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX USA
Cell Cycle 10:611-8. 2011..Transcription-induced DNA toxicity may have profound biological consequences, with particular relevance to repeat-associated neurodegenerative diseases...- Topoisomerase 1 and single-strand break repair modulate transcription-induced CAG repeat contraction in human cellsLeroy Hubert
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Mol Cell Biol 31:3105-12. 2011..These studies broaden the scope of pathways involved in transcription-induced CAG repeat instability and begin to define their interrelationships... 
Diverse effects of individual mismatch repair components on transcription-induced CAG repeat instability in human cellsYunfu Lin
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
DNA Repair (Amst) 8:878-85. 2009....- Dnmt1 deficiency promotes CAG repeat expansion in the mouse germlineVincent Dion
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, USDA Children s Nutrition Research Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Hum Mol Genet 17:1306-17. 2008..These results are consistent with normal epigenetic changes during germline development contributing to intergenerational instability of CAG repeats in mice and in humans... - Xpa deficiency reduces CAG trinucleotide repeat instability in neuronal tissues in a mouse model of SCA1Leroy Hubert
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Hum Mol Genet 20:4822-30. 2011..These results validate our original findings in cultured human cells and suggest that transcription may induce NER-dependent TNR instability in neuronal tissues in humans... - Convergent transcription through a long CAG tract destabilizes repeats and induces apoptosisYunfu Lin
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Mol Cell Biol 30:4435-51. 2010..Convergent transcription through a CAG repeat represents a novel mechanism for triggering a cellular stress response, one that is initiated by events at a single locus in the genome and resembles the response to DNA damage... - Genome-wide demethylation promotes triplet repeat instability independently of homologous recombinationVincent Dion
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
DNA Repair (Amst) 7:313-20. 2008..The subtle influences of demethylation on HR at the Aprt locus are not sufficient to account for its dramatic effects on repeat instability. We conclude that 5-aza-CdR promotes triplet repeat instability independently of HR... - Zinc-finger directed double-strand breaks within CAG repeat tracts promote repeat instability in human cellsDavid Mittelman
Verna and Marrs McLean Department of Biochemistry and Molecular Biology and Graduate Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 106:9607-12. 2009..These studies identify a ZFN as a useful reagent for characterizing the effects of DSBs on CAG repeats in cells... - Hsp90 modulates CAG repeat instability in human cellsDavid Mittelman
Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Cell Stress Chaperones 15:753-9. 2010..The capacity of Hsp90 to modulate repeat-tract lengths suggests that the chaperone, in addition to exposing cryptic variation, might facilitate the expression of new phenotypes through induction of novel genetic variation... - R loops stimulate genetic instability of CTG.CAG repeatsYunfu Lin
Baylor College of Medicine, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, One Baylor Plaza, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 107:692-7. 2010..DNA hybrid. These studies demonstrate that persistent hybrids between the nascent RNA transcript and the template DNA strand at CTG.CAG tracts promote instability of DNA trinucleotide repeats... - Transcription destabilizes triplet repeatsYunfu Lin
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Mol Carcinog 48:350-61. 2009.... - Transcription-induced CAG repeat contraction in human cells is mediated in part by transcription-coupled nucleotide excision repairYunfu Lin
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Mol Cell Biol 27:6209-17. 2007..We integrate these observations into a tentative pathway for transcription-induced CAG repeat instability that can account for the contractions observed here and potentially for the contractions and expansions seen with human diseases... 
Transcription promotes contraction of CAG repeat tracts in human cellsYunfu Lin
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, One Baylor Plaza, Texas 77030, USA
Nat Struct Mol Biol 13:179-80. 2006..These results define a pathway for CAG.CTG repeat contraction that is initiated by transcription, depends on elements of mismatch and nucleotide-excision repair and does not require DNA replication...- Mdm2 deficiency suppresses MYCN-Driven neuroblastoma tumorigenesis in vivoZaowen Chen
Texas Children s Cancer Center and Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA
Neoplasia 11:753-62. 2009..In summary, we provided evidence for a crucial role for direct inhibition of p53 by MDM2 and suppression of the p19(ARF)/p53 axis in neuroblastoma tumorigenesis, supporting the development of therapies targeting these pathways... - Nucleotide excision repair, mismatch repair, and R-loops modulate convergent transcription-induced cell death and repeat instabilityYunfu Lin
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America
PLoS ONE 7:e46807. 2012..These observations link the mechanisms of convergent transcription-induced repeat instability and convergent transcription-induced cell death, suggesting that a common structure may trigger both outcomes... - A novel selectable system for detecting expansion of CAG.CTG repeats in mammalian cellsYunfu Lin
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Mutat Res 572:123-31. 2005..Using this selection system, we can select for expansion to as few as 39 repeats. Thus, this assay can monitor expansions across the critical boundary from the longest lengths of normal alleles to the shortest lengths of disease alleles...