Yunfu Lin

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. pmc Transcription-induced DNA toxicity at trinucleotide repeats: double bubble is trouble
    Yunfu Lin
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX USA
    Cell Cycle 10:611-8. 2011
  2. pmc Topoisomerase 1 and single-strand break repair modulate transcription-induced CAG repeat contraction in human cells
    Leroy Hubert
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Cell Biol 31:3105-12. 2011
  3. pmc Diverse effects of individual mismatch repair components on transcription-induced CAG repeat instability in human cells
    Yunfu Lin
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    DNA Repair (Amst) 8:878-85. 2009
  4. pmc Dnmt1 deficiency promotes CAG repeat expansion in the mouse germline
    Vincent Dion
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, USDA Children s Nutrition Research Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Hum Mol Genet 17:1306-17. 2008
  5. pmc Xpa deficiency reduces CAG trinucleotide repeat instability in neuronal tissues in a mouse model of SCA1
    Leroy Hubert
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Hum Mol Genet 20:4822-30. 2011
  6. pmc Convergent transcription through a long CAG tract destabilizes repeats and induces apoptosis
    Yunfu Lin
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cell Biol 30:4435-51. 2010
  7. pmc Zinc-finger directed double-strand breaks within CAG repeat tracts promote repeat instability in human cells
    David Mittelman
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology and Graduate Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 106:9607-12. 2009
  8. pmc Genome-wide demethylation promotes triplet repeat instability independently of homologous recombination
    Vincent Dion
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    DNA Repair (Amst) 7:313-20. 2008
  9. pmc Transcription destabilizes triplet repeats
    Yunfu Lin
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Carcinog 48:350-61. 2009
  10. pmc Hsp90 modulates CAG repeat instability in human cells
    David Mittelman
    Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Cell Stress Chaperones 15:753-9. 2010

Collaborators

Detail Information

Publications17

  1. pmc Transcription-induced DNA toxicity at trinucleotide repeats: double bubble is trouble
    Yunfu Lin
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX USA
    Cell Cycle 10:611-8. 2011
    ..Transcription-induced DNA toxicity may have profound biological consequences, with particular relevance to repeat-associated neurodegenerative diseases...
  2. pmc Topoisomerase 1 and single-strand break repair modulate transcription-induced CAG repeat contraction in human cells
    Leroy Hubert
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Cell Biol 31:3105-12. 2011
    ..These studies broaden the scope of pathways involved in transcription-induced CAG repeat instability and begin to define their interrelationships...
  3. pmc Diverse effects of individual mismatch repair components on transcription-induced CAG repeat instability in human cells
    Yunfu Lin
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    DNA Repair (Amst) 8:878-85. 2009
    ....
  4. pmc Dnmt1 deficiency promotes CAG repeat expansion in the mouse germline
    Vincent Dion
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, USDA Children s Nutrition Research Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Hum Mol Genet 17:1306-17. 2008
    ..These results are consistent with normal epigenetic changes during germline development contributing to intergenerational instability of CAG repeats in mice and in humans...
  5. pmc Xpa deficiency reduces CAG trinucleotide repeat instability in neuronal tissues in a mouse model of SCA1
    Leroy Hubert
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Hum Mol Genet 20:4822-30. 2011
    ..These results validate our original findings in cultured human cells and suggest that transcription may induce NER-dependent TNR instability in neuronal tissues in humans...
  6. pmc Convergent transcription through a long CAG tract destabilizes repeats and induces apoptosis
    Yunfu Lin
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cell Biol 30:4435-51. 2010
    ..Convergent transcription through a CAG repeat represents a novel mechanism for triggering a cellular stress response, one that is initiated by events at a single locus in the genome and resembles the response to DNA damage...
  7. pmc Zinc-finger directed double-strand breaks within CAG repeat tracts promote repeat instability in human cells
    David Mittelman
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology and Graduate Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 106:9607-12. 2009
    ..These studies identify a ZFN as a useful reagent for characterizing the effects of DSBs on CAG repeats in cells...
  8. pmc Genome-wide demethylation promotes triplet repeat instability independently of homologous recombination
    Vincent Dion
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    DNA Repair (Amst) 7:313-20. 2008
    ..The subtle influences of demethylation on HR at the Aprt locus are not sufficient to account for its dramatic effects on repeat instability. We conclude that 5-aza-CdR promotes triplet repeat instability independently of HR...
  9. pmc Transcription destabilizes triplet repeats
    Yunfu Lin
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Carcinog 48:350-61. 2009
    ....
  10. pmc Hsp90 modulates CAG repeat instability in human cells
    David Mittelman
    Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Cell Stress Chaperones 15:753-9. 2010
    ..The capacity of Hsp90 to modulate repeat-tract lengths suggests that the chaperone, in addition to exposing cryptic variation, might facilitate the expression of new phenotypes through induction of novel genetic variation...
  11. pmc R loops stimulate genetic instability of CTG.CAG repeats
    Yunfu Lin
    Baylor College of Medicine, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 107:692-7. 2010
    ..DNA hybrid. These studies demonstrate that persistent hybrids between the nascent RNA transcript and the template DNA strand at CTG.CAG tracts promote instability of DNA trinucleotide repeats...
  12. pmc Transcription-induced CAG repeat contraction in human cells is mediated in part by transcription-coupled nucleotide excision repair
    Yunfu Lin
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Biol 27:6209-17. 2007
    ..We integrate these observations into a tentative pathway for transcription-induced CAG repeat instability that can account for the contractions observed here and potentially for the contractions and expansions seen with human diseases...
  13. pmc Nucleotide excision repair, mismatch repair, and R-loops modulate convergent transcription-induced cell death and repeat instability
    Yunfu Lin
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 7:e46807. 2012
    ..These observations link the mechanisms of convergent transcription-induced repeat instability and convergent transcription-induced cell death, suggesting that a common structure may trigger both outcomes...
  14. ncbi request reprint Transcription promotes contraction of CAG repeat tracts in human cells
    Yunfu Lin
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, One Baylor Plaza, Texas 77030, USA
    Nat Struct Mol Biol 13:179-80. 2006
    ..These results define a pathway for CAG.CTG repeat contraction that is initiated by transcription, depends on elements of mismatch and nucleotide-excision repair and does not require DNA replication...
  15. pmc Mdm2 deficiency suppresses MYCN-Driven neuroblastoma tumorigenesis in vivo
    Zaowen Chen
    Texas Children s Cancer Center and Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA
    Neoplasia 11:753-62. 2009
    ..In summary, we provided evidence for a crucial role for direct inhibition of p53 by MDM2 and suppression of the p19(ARF)/p53 axis in neuroblastoma tumorigenesis, supporting the development of therapies targeting these pathways...
  16. pmc Repair of chromosomal double-strand breaks by precise ligation in human cells
    William Y Lin
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    DNA Repair (Amst) 12:480-7. 2013
    ..In summary, our results demonstrate that DSBs in human cells are efficiently repaired by precise ligation, which requires classical NHEJ components and is enhanced by p53 and BRCA1...
  17. ncbi request reprint A novel selectable system for detecting expansion of CAG.CTG repeats in mammalian cells
    Yunfu Lin
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mutat Res 572:123-31. 2005
    ..Using this selection system, we can select for expansion to as few as 39 repeats. Thus, this assay can monitor expansions across the critical boundary from the longest lengths of normal alleles to the shortest lengths of disease alleles...