X Lin

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. ncbi Smad6 recruits transcription corepressor CtBP to repress bone morphogenetic protein-induced transcription
    Xia Lin
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, One Baylor Plaza, Room 131D, Houston, TX 77030, USA
    Mol Cell Biol 23:9081-93. 2003
  2. ncbi Abrogation of transforming growth factor-beta signaling in pancreatic cancer
    Xia Lin
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, Room 131D, Houston, Texas 77030, USA
    World J Surg 29:312-6. 2005
  3. ncbi Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling
    X Lin
    Departments of Surgery and Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 275:36818-22. 2000
  4. ncbi Direct interaction of c-Myc with Smad2 and Smad3 to inhibit TGF-beta-mediated induction of the CDK inhibitor p15(Ink4B)
    Xin Hua Feng
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cell 9:133-43. 2002
  5. ncbi Fluorescent probes attached to Cys 35 or Cys 84 in cardiac troponin C are differentially sensitive to Ca(2+)-dependent events in vitro and in situ
    J A Putkey
    Department of Biochemistry and Molecular Biology, University of Texas Medical School, Houston 77225, USA
    Biochemistry 36:970-8. 1997
  6. ncbi Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta
    X H Feng
    Departments of Growth and Development and Anatomy, and Programs in Cell Biology and Developmental Biology, University of California, San Francisco, CA 94143 0640, USA
    EMBO J 19:5178-93. 2000
  7. ncbi SUMO-1/Ubc9 promotes nuclear accumulation and metabolic stability of tumor suppressor Smad4
    Xia Lin
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 278:31043-8. 2003
  8. ncbi Critical regulation of TGFbeta signaling by Hsp90
    Katharine H Wrighton
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 105:9244-9. 2008
  9. ncbi Opposed regulation of corepressor CtBP by SUMOylation and PDZ binding
    Xia Lin
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cell 11:1389-96. 2003
  10. ncbi Small C-terminal domain phosphatases dephosphorylate the regulatory linker regions of Smad2 and Smad3 to enhance transforming growth factor-beta signaling
    Katharine H Wrighton
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Biol Chem 281:38365-75. 2006

Research Grants

  1. Regulation of SMAD2 Signaling by SMP1 Phosphatase
    Xia Lin; Fiscal Year: 2007
  2. Control of SnoN Activity by SUMO modification
    Xia Lin; Fiscal Year: 2006

Collaborators

Detail Information

Publications37

  1. ncbi Smad6 recruits transcription corepressor CtBP to repress bone morphogenetic protein-induced transcription
    Xia Lin
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, One Baylor Plaza, Room 131D, Houston, TX 77030, USA
    Mol Cell Biol 23:9081-93. 2003
    ..We conclude that the nuclear functions and physical interaction of Smad6 and CtBP provide a novel mechanism for the transcriptional regulation by inhibitory Smads...
  2. ncbi Abrogation of transforming growth factor-beta signaling in pancreatic cancer
    Xia Lin
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, Room 131D, Houston, Texas 77030, USA
    World J Surg 29:312-6. 2005
    ..In this review, we summarize recent research progress on TGFbeta signaling and pancreatic cancer...
  3. ncbi Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling
    X Lin
    Departments of Surgery and Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 275:36818-22. 2000
    ..Consistent with these results, Smurf2 potently reduced the transcriptional activity of Smad2. These data suggest that a ubiquitin/proteasome-dependent mechanism is important for proper regulation of TGF-beta signaling...
  4. ncbi Direct interaction of c-Myc with Smad2 and Smad3 to inhibit TGF-beta-mediated induction of the CDK inhibitor p15(Ink4B)
    Xin Hua Feng
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cell 9:133-43. 2002
    ..These results suggest that oncogenic c-Myc promotes cell growth and cancer development partly by inhibiting the growth inhibitory functions of Smads...
  5. ncbi Fluorescent probes attached to Cys 35 or Cys 84 in cardiac troponin C are differentially sensitive to Ca(2+)-dependent events in vitro and in situ
    J A Putkey
    Department of Biochemistry and Molecular Biology, University of Texas Medical School, Houston 77225, USA
    Biochemistry 36:970-8. 1997
    ....
  6. ncbi Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta
    X H Feng
    Departments of Growth and Development and Anatomy, and Programs in Cell Biology and Developmental Biology, University of California, San Francisco, CA 94143 0640, USA
    EMBO J 19:5178-93. 2000
    ..These findings explain the tumor suppressor roles of Smad2 and Smad4 in growth arrest signaling by TGF-beta...
  7. ncbi SUMO-1/Ubc9 promotes nuclear accumulation and metabolic stability of tumor suppressor Smad4
    Xia Lin
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 278:31043-8. 2003
    ....
  8. ncbi Critical regulation of TGFbeta signaling by Hsp90
    Katharine H Wrighton
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 105:9244-9. 2008
    ..Our data reveal an essential level of TGFbeta signaling regulation mediated by Hsp90 by its ability to chaperone TbetaRs and also implicate the use of Hsp90 inhibitors in blocking undesired activation of TGFbeta signaling in diseases...
  9. ncbi Opposed regulation of corepressor CtBP by SUMOylation and PDZ binding
    Xia Lin
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cell 11:1389-96. 2003
    ..This study identifies SUMOylation as a regulatory mechanism underlying CtBP1-dependent transcriptional repression...
  10. ncbi Small C-terminal domain phosphatases dephosphorylate the regulatory linker regions of Smad2 and Smad3 to enhance transforming growth factor-beta signaling
    Katharine H Wrighton
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Biol Chem 281:38365-75. 2006
    ..Taken together, this work identifies the first example of a Smad2/3 linker phosphatase(s) and reveals an important new substrate for SCPs...
  11. ncbi Activation of transforming growth factor-beta signaling by SUMO-1 modification of tumor suppressor Smad4/DPC4
    Xia Lin
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 278:18714-9. 2003
    ..2 promoter. Importantly, SUMO-1 overexpression enhanced TGF-beta-induced transcriptional responses. These findings identify sumoylation as a unique mechanism to modulate Smad4-dependent cellular responses...
  12. ncbi Nuclear export of Smad2 and Smad3 by RanBP3 facilitates termination of TGF-beta signaling
    Fangyan Dai
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Dev Cell 16:345-57. 2009
    ..In conclusion, our study supports a definitive role for RanBP3 in mediating Smad2/3 nuclear export and terminating TGF-beta signaling...
  13. ncbi PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling
    Xia Lin
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    Cell 125:915-28. 2006
    ..This work demonstrates that PPM1A/PP2Calpha, through dephosphorylation of Smad2/3, plays a critical role in terminating TGFbeta signaling...
  14. ncbi Ubiquitination and proteolysis of cancer-derived Smad4 mutants by SCFSkp2
    Min Liang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Room 137D, Houston, TX 77030, USA
    Mol Cell Biol 24:7524-37. 2004
    ..These results suggest an important role for the SCFSkp2 complex in switching cancer mutants of Smad4 to undergo polyubiquitination-dependent degradation...
  15. ncbi Regulation of Smad4 sumoylation and transforming growth factor-beta signaling by protein inhibitor of activated STAT1
    Min Liang
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 279:22857-65. 2004
    ..These data demonstrate that PIAS1 protein positively modulates TGF-beta responses as a SUMO E3 ligase for Smad4...
  16. ncbi Resistance to transforming growth factor-beta occurs in the presence of normal Smad activation
    David H Berger
    Department of Surgery, The Baylor College of Medicine, Houston, Tex, USA
    Surgery 132:310-6. 2002
    ..In this study we hypothesized that decreased TGF-beta receptor expression leads to reduced Smad signaling and overexpression of c-Myc in intestinal epithelial (RIE) and transformed intestinal epithelial cells (RIE-Tr) cells...
  17. ncbi Transforming Growth Factor {beta} Can Stimulate Smad1 Phosphorylation Independently of Bone Morphogenic Protein Receptors
    Katharine H Wrighton
    Michael E DeBakey Department of Surgery and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 284:9755-63. 2009
    ..Thus, TGFbeta-mediated Smad1 phosphorylation appears to occur via different receptor complexes in a cell type-specific manner...
  18. ncbi BCL6 represses Smad signaling in transforming growth factor-beta resistance
    Degang Wang
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 68:783-9. 2008
    ..This study provides strong evidence that overexpression of BCL6 contributes to TGF-beta resistance in B-cell lymphoma...
  19. ncbi Erbin inhibits transforming growth factor beta signaling through a novel Smad-interacting domain
    Fangyan Dai
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Room 137D, Houston, TX 77030, USA
    Mol Cell Biol 27:6183-94. 2007
    ..Therefore, these results define Erbin as a novel negative modulator of Smad2/Smad3 functions and expand the physiological role of Erbin to the regulation of TGFbeta signaling...
  20. ncbi Phospho-control of TGF-beta superfamily signaling
    Katharine H Wrighton
    Michael E DeBakey Department of Surgery, Department of Molecular and Cellular Biology and Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA
    Cell Res 19:8-20. 2009
    ..This article illustrates the essential roles of reversible phosphorylation in controlling the strength and duration of TGF-beta signaling and the ensuing physiological responses...
  21. ncbi Protein serine/threonine phosphatase PPM1A dephosphorylates Smad1 in the bone morphogenetic protein signaling pathway
    Xueyan Duan
    Department of Molecular and Cellular Biology, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 281:36526-32. 2006
    ..Collectively, our study suggests that PPM1A plays an important role in controlling BMP signaling through catalyzing Smad dephosphorylation...
  22. ncbi Identification of a human brain-specific gene, calneuron 1, a new member of the calmodulin superfamily
    Y Q Wu
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Genet Metab 72:343-50. 2001
    ....
  23. ncbi Smad2 positively regulates the generation of Th17 cells
    Gustavo J Martinez
    Department of Immunology and Center for Inflammation and Cancer, MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 285:29039-43. 2010
    ..These results demonstrate that Smad2 positively regulates the generation of inflammatory Th17 cells...
  24. ncbi Smad3 differentially regulates the induction of regulatory and inflammatory T cell differentiation
    Gustavo J Martinez
    Department of Immunology, M D Anderson Cancer Center, Houston, Texas 77054, USA
    J Biol Chem 284:35283-6. 2009
    ..These results demonstrate that Smad3 is differentially involved in the reciprocal regulatory and inflammatory T cell generation...
  25. ncbi Termination of TGF-beta superfamily signaling through SMAD dephosphorylation--a functional genomic view
    Xia Lin
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston TX 77030, USA
    J Genet Genomics 34:1-9. 2007
    ..This article briefly reviews how dynamic phosphorylation and dephosphorylation of SMADs control or fine-tune the signaling strength and duration and ultimately the physiological consequences in TGF-beta signaling...
  26. ncbi dSmurf selectively degrades decapentaplegic-activated MAD, and its overexpression disrupts imaginal disc development
    Yao Yun Liang
    Michael E DeBakey Department of Surgery, Department of Molecular and Cellular Biology, Ophthalmology, Program of Developmental Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 278:26307-10. 2003
    ..We conclude that dSmurf specifically targets phosphorylated MAD to proteasome-dependent degradation and regulates DPP signaling during development...
  27. ncbi Human NDUFB9 gene: genomic organization and a possible candidate gene associated with deafness disorder mapped to chromosome 8q13
    X Lin
    Department of Biology and Institute of Molecular Biology, University of Houston, Houston, Tex, USA
    Hum Hered 49:75-80. 1999
    ..To identify whether mutations in NDUFB9 are involved in causing the BOR syndrome, we screened 9 BOR families which did not show mutations in the EYA1 gene by heteroduplex analysis; however, no mutations were found...
  28. ncbi Coupling of dephosphorylation and nuclear export of Smads in TGF-beta signaling
    Fangyan Dai
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA
    Methods Mol Biol 647:125-37. 2010
    ..The second step involves nuclear export of dephosphorylated Smad2/3 with the aid of nuclear protein RanBP3 to terminate Smad signaling. This chapter introduces methods for examining nuclear export of Smad2/3 in TGF-beta signaling...
  29. ncbi Smad3 mediates immediate early induction of Id1 by TGF-beta
    Yao Yun Liang
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, BCM 390, Research Tower, Room R711, One Baylor Plaza, Houston, TX 77030, USA
    Cell Res 19:140-8. 2009
    ..Chromatin immunoprecipitation assay confirms that Smad3 and Smad4 bind to the upstream region of the Id1 gene. Our results demonstrate that Smad3, but not Smad2, mediates TGF-beta1-dependent early transcriptional induction of Id1...
  30. ncbi PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation
    Wenjing Sun
    Texas Children s Cancer Center, Department of Pediatrics, Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, United States
    Cell Signal 21:95-102. 2009
    ..These data suggest that PPM1A and PPM1B play an important role in the termination of TNFalpha-mediated NF-kappaB activation through dephosphorylating and inactivating IKKbeta...
  31. ncbi Phosphatase PPM1A regulates phosphorylation of Thr-186 in the Cdk9 T-loop
    Yan Wang
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 283:33578-84. 2008
    ..PPM1B only efficiently dephosphorylated Cdk9 Thr-186 in vitro when 7SK RNA was depleted from P-TEFb. Taken together, our data indicate that PPM1A and to some extent PPM1B are important negative regulators of P-TEFb function...
  32. ncbi Transforming growth factor-beta-independent regulation of myogenesis by SnoN sumoylation
    Katharine H Wrighton
    Michael E DeBakey Department of Surgery and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 282:6517-24. 2007
    ..Our study suggests a novel role for SUMO modification in the regulation of myogenic differentiation...
  33. ncbi Smad ubiquitination regulatory factor-2 in the fibrotic kidney: regulation, target specificity, and functional implication
    Ruoyun Tan
    Department of Medicine, The Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
    Am J Physiol Renal Physiol 294:F1076-83. 2008
    ..It appears that dysregulation of Smurf2 could contribute to an aberrant TGF-beta/Smad signaling in the pathogenesis of kidney fibrosis...
  34. ncbi Bioconjugated nanoparticles for DNA protection from cleavage
    Xiao-xiao He
    State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Institute of Biological Technology, Hunan University, Changsha 410082, P. R. China
    J Am Chem Soc 125:7168-9. 2003
    ....
  35. ncbi C. elegans serine-threonine kinase KIN-29 modulates TGFbeta signaling and regulates body size formation
    Lisa L Maduzia
    Waksman Institute, Department of Molecular Biology and Biochemistry, and Cancer Institute of New Jersey, Rutgers University, Piscataway, NJ 08854 8020, USA
    BMC Dev Biol 5:8. 2005
    ..To identify additional factors that modulate TGFbeta signaling in the Sma/Mab pathway, we have undertaken a genetic screen for small animals and have identified kin-29...
  36. ncbi TGFbeta1 regulation of vimentin gene expression during differentiation of the C2C12 skeletal myogenic cell line requires Smads, AP-1 and Sp1 family members
    Yongzhong Wu
    Department of Biochemistry and the Massey Cancer Center, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298 0614, USA
    Biochim Biophys Acta 1773:427-39. 2007
    ..DNA precipitation and ChIP assays suggest that c-Jun, c-Fos, Smad3 and Sp1/Sp3 interact over this region, but this interaction changes during myogenesis with TGFbeta1 induction...
  37. ncbi Smad7-induced beta-catenin degradation alters epidermal appendage development
    Gangwen Han
    Department of Otolaryngology, Oregon Health and Science University, Portland, 97239, USA
    Dev Cell 11:301-12. 2006
    ..Our data reveal a mechanism for Smad7 in antagonizing Wnt/beta-catenin signaling, thereby shifting the skin differentiation program from forming hair follicles to sebaceous glands...

Research Grants5

  1. Regulation of SMAD2 Signaling by SMP1 Phosphatase
    Xia Lin; Fiscal Year: 2007
    ..The results will be pertinent towards development for a foundation for the rational design of novel therapeutic approaches for prevention and treatment of human cancers and other diseases. ..
  2. Control of SnoN Activity by SUMO modification
    Xia Lin; Fiscal Year: 2006
    ..Finally, the results may also provide a foundation for the rational design of novel therapeutic approaches for prevention and treatment of cancer and musculoskeletal diseases. ..