Research Topics
Genomes and Genes | Yi Ping LiSummaryAffiliation: Baylor College of Medicine Country: USA Publications
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Publications
Cytokine responses in primary chicken embryo intestinal cells infected with Campylobacter jejuni strains of human and chicken origin and the expression of bacterial virulence-associated genesYi Ping Li
Department of Poultry, Fish and Fur Animals, National Veterinary Institute VET, Technical University of Denmark DTU, Hangøvej 2, DK 8200 Aarhus N, Denmark
BMC Microbiol 8:107. 2008..jejuni strains of human and chicken origins and the production of pro-inflammatory cytokines as well as the expression of the bacterial virulence-associated genes during co-cultivation...- TIMP3: a physiological regulator of adult myogenesisHuijie Liu
Department of Integrative Biology and Pharmacology, University of Texas Health Science Center, Houston, TX 77030, USA
J Cell Sci 123:2914-21. 2010..In addition, downregulation of TIMP3 is mediated by the myogenesis-promoting microRNA miR-206. Thus, TIMP3 is a physiological regulator of myogenic differentiation... - TNF-alpha is a mitogen in skeletal muscleYi Ping Li
Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Suite 520B, Houston, TX 77030, USA
Am J Physiol Cell Physiol 285:C370-6. 2003..Our data suggest that TNF-alpha activates satellite cells to enter the cell cycle and accelerates G1-to-S phase transition, and these actions may involve activation of early response genes via SRF... - TNF-alpha acts via p38 MAPK to stimulate expression of the ubiquitin ligase atrogin1/MAFbx in skeletal muscleYi Ping Li
Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
FASEB J 19:362-70. 2005..These data suggest that TNF-alpha acts via p38 to increase atrogin1/MAFbx gene expression in skeletal muscle... - Role of TNF-{alpha} signaling in regeneration of cardiotoxin-injured muscleShuen Ei Chen
Department of Medicine, Baylor College of Medicine, One Baylor Plaza 520B, Houston, TX 77030, USA
Am J Physiol Cell Physiol 289:C1179-87. 2005..Functional studies demonstrated an attenuated recovery of contractile force in injured p55(-/-)p75(-/-) soleus. These data suggest that TNF-alpha signaling plays a critical regulatory role in muscle regeneration... - TACE release of TNF-alpha mediates mechanotransduction-induced activation of p38 MAPK and myogenesisMei Zhan
Department of Medicine, Baylor College of Medicine, One Baylor Plaza 520B, Houston, TX 77030, USA
J Cell Sci 120:692-701. 2007..These results indicate that posttranscriptional activation of TACE mediates the mechanotransduction that activates p38-dependent myogenesis via the release of TNF-alpha... - Fatiguing exercise reduces DNA binding activity of NF-kappaB in skeletal muscle nucleiWilliam J Durham
Pulmonary and Critical Care Medicine Section, Baylor College of Medicine, Houston, Texas 77030, USA
J Appl Physiol 97:1740-5. 2004..These data provide no support for our original hypothesis. Instead, acute fatiguing exercise appears to decrease NF-kappaB activity in muscle under a variety of conditions... - TNF-alpha regulates myogenesis and muscle regeneration by activating p38 MAPKShuen Ei Chen
Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
Am J Physiol Cell Physiol 292:C1660-71. 2007..These results indicate that TNF-alpha regulates myogenesis and muscle regeneration as a key activator of p38... - C/EBP? mediates tumour-induced ubiquitin ligase atrogin1/MAFbx upregulation and muscle wastingGuohua Zhang
Department of Integrative Biology and Pharmacology, University of Texas Health Science Center, Houston, TX 77030, USA
EMBO J 30:4323-35. 2011..Therefore, activation of the p38? MAPK-C/EBP? signalling pathway appears a key component of the pathogenesis of LLC tumour-induced cachexia... - Beta3-integrin mediates satellite cell differentiation in regenerating mouse muscleHuijie Liu
Department of Integrative Biology and Pharmacology, University of Texas Health, Science Center, Houston, TX 77030, USA
FASEB J 25:1914-21. 2011..Thus, ?3-integrin is a mediator of satellite cell differentiation in regenerating muscle... - Curcumin prevents lipopolysaccharide-induced atrogin-1/MAFbx upregulation and muscle mass lossBingwen Jin
Department of Medicine, Section of Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, TX 77030, USA
J Cell Biochem 100:960-9. 2007..These results indicate that curcumin is effective in blocking LPS-induced loss of muscle mass through the inhibition of p38-mediated upregulation of atrogin-1/MAFbx... - Progressive nuclear factor-kappaB activation resistant to inhibition by contraction and curcumin in mdx miceWilliam J Durham
Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Muscle Nerve 34:298-303. 2006.... - Toll-like receptor 4 mediates lipopolysaccharide-induced muscle catabolism via coordinate activation of ubiquitin-proteasome and autophagy-lysosome pathwaysAlexander Doyle
Department of Integrative Biology and Pharmacology, University of Texas Health Science Center, Houston, TX 77030, USA
FASEB J 25:99-110. 2011..Furthermore, TLR4 knockout or p38 MAPK inhibition abolishes LPS-induced muscle proteolysis. Thus, TLR4 mediates LPS-induced muscle catabolism via coordinate activation of the ubiquitin-proteasome and the autophagy-lysosomal pathways... - Activation of the ubiquitin-proteasome pathway in the diaphragm in chronic obstructive pulmonary diseaseCoen A C Ottenheijm
Department of Pulmonary Diseases, 454, Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands
Am J Respir Crit Care Med 174:997-1002. 2006..In the present study we hypothesized that the loss of contractile protein content is associated with activation of the ubiquitin-proteasome pathway in the diaphragm of patients with mild to moderate COPD... - Hydrogen peroxide stimulates ubiquitin-conjugating activity and expression of genes for specific E2 and E3 proteins in skeletal muscle myotubesYi-Ping Li
Baylor Coll Med, Houston, TX
Am J Physiol Cell Physiol 285:C806-12. 2003..These results suggest that ROS stimulate protein catabolism in skeletal muscle by upregulating the ubiquitin conjugation system... - TNF-alpha increases ubiquitin-conjugating activity in skeletal muscle by up-regulating UbcH2/E220kYi-Ping Li
Baylor Coll Med, Houston, TX
FASEB J 17:1048-57. 2003..Thus, UbcH2 up-regulation is a novel response to TNF-alpha/NF-kappaB signaling in skeletal muscle that appears to be essential for the increased ubiquitin conjugation induced by this cytokine... - [Molecular cloning and expression analysis of a novel human gene ZNF18]Li Li Guo
Biomedical Research Institute, College of Life Sciences, Beijing Normal University, Beijing 100875, China
Yi Chuan 27:523-30. 2005..0, especially in the embryo heart at E10.5. These expression results suggest that ZNF18 may play an important role in the development of embryo heart... - Activation of sterol regulatory element-binding protein 1c and fatty acid synthase transcription by hepatitis C virus non-structural protein 2Jae Ku Oem
Vaccine and Infectious Disease Organization VIDO, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E3, Canada
J Gen Virol 89:1225-30. 2008..Taken together, our results suggest that HCV NS2 can upregulate the transcription of SREBP-1c and FAS, and thus is probably a contributing factor for HCV-associated steatosis... - RGS10-null mutation impairs osteoclast differentiation resulting from the loss of [Ca2+]i oscillation regulationShuying Yang
Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts 02115, USA
Genes Dev 21:1803-16. 2007..RGS10 provides a potential therapeutic target for the treatment of bone diseases... - Haploinsuffciency for Znf9 in Znf9+/- mice is associated with multiorgan abnormalities resembling myotonic dystrophyWei Chen
Department of Cytokine Biology, The Forsyth Institute, Boston, MA 02115, USA
J Mol Biol 368:8-17. 2007..Znf9 transgenic mice raised Znf9 and Clc1 expression and rescued the myotonic dystrophy phenotype in Znf9+/- mice. Our results suggest that the Znf9 haploinsufficiency contributes to the myotonic dystrophy phenotype in Znf9+/- mice... - Novel pycnodysostosis mouse model uncovers cathepsin K function as a potential regulator of osteoclast apoptosis and senescenceWei Chen
Department of Cytokine Biology, The Forsyth Institute and Harvard School of Dental Medicine, 140 The Fenway, Boston, MA 02115, USA
Hum Mol Genet 16:410-23. 2007..The finding of this novel cathepsin K function provides insight into the pathomechanism of pycnodysostosis and may provide new drug targets for diseases involved in OC-related abnormal bone homeostasis... - Atrophic remodeling of the heart in vivo simultaneously activates pathways of protein synthesis and degradationPeter Razeghi
Division of Cardiology, University of Texas Houston-Medical School, Houston, Tex 77030, USA
Circulation 108:2536-41. 2003..The simultaneous activation of the mTOR pathway suggests active remodeling, involving both protein synthesis and degradation... - Human osteopetroses and the osteoclast V-H+-ATPase enzyme systemKalu U E Ogbureke
Department of Oral Biology, Maxillofacial Pathology School of Dentistry, Medical College of Georgia, Augusta, Georgia 30912, USA
Front Biosci 10:2940-54. 2005.... - Molecular cloning, developmental expression, promoter analysis and functional characterization of the mouse CNBP geneKen Shimizu
Department of Cytokine Biology, The Forsyth Institute, Boston, MA 02115, USA
Gene 307:51-62. 2003..Our finds suggest that CNBP may play an important role in cell proliferation and tissue patterning during anterior-posterior axis, craniofacial and limb development by targeting c-Myc...
Research Grants
- Mechanisms of Muscle WastingYi Ping Li; Fiscal Year: 2007..The achievement of these three aims will facilitate our long-term goal: to develop effective therapeutic strategies in the treatment of myriad patients with cachexic muscle wasting. ..