Research Topics
Species | ADRIAN VINCENT LEESummaryAffiliation: Baylor College of Medicine Country: USA Publications
Research Grants
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Publications
Disruption of steroid and prolactin receptor patterning in the mammary gland correlates with a block in lobuloalveolar developmentSandra L Grimm
Department of Molecular and Cellular Biology, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
Mol Endocrinol 16:2675-91. 2002..Together, these data suggest that C/EBPbeta is a master regulator of mammary epithelial cell fate and that the correct spatial pattern of PR and PrlR expression is a critical determinant of hormone-regulated cell proliferation...- Rapid induction of IGF-IR signaling in normal and tumor tissue following intravenous injection of IGF-I in miceA V Lee
The Breast Center, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
Horm Metab Res 35:651-5. 2003..This study shows how IV IGF injection can be used to examine the signaling mechanisms used by IGF-IR, in both normal mammary tissue and during tumor growth, and may provide a model for the characterization of IGF inhibitors... 
Location, location, location: regulation of breast cancer progression by the microenvironmentAdrian V Lee
Breast Center, Baylor College of Medicine and The Methodist Hospital, Houston, Texas, USA
Breast Cancer Res 6:279-80. 2004- Cross-talk among estrogen receptor, epidermal growth factor, and insulin-like growth factor signaling in breast cancerA V Lee
Breast Center, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
Clin Cancer Res 7:4429s-4435s; discussion 4411s-4412s. 2001..In this review, we will highlight our current understanding of the molecular mechanisms of cross-talk between ER and growth-factor-signaling pathways... - 26th Annual San Antonio Breast Cancer Symposium, San Antonio, Texas, USA, 3-6 December 2003: update on preclinical and translational researchAdrian V Lee
Breast Center, Baylor College of Medicine and The Methodist Hospital, Houston, Texas, USA
Breast Cancer Res 6:E10. 2004..This report will summarize preclinical and translational highlights from the meeting... - Developmental and hormonal signals dramatically alter the localization and abundance of insulin receptor substrate proteins in the mammary glandA V Lee
The Breast Center, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
Endocrinology 144:2683-94. 2003..These data indicate that IRS undergo complex developmental and hormonal regulation in the mammary gland, and that IRS-1 is more likely to regulate mammary function in lactating mice than in virgin or pregnant mice... - Progesterone receptor-B regulation of insulin-like growth factor-stimulated cell migration in breast cancer cells via insulin receptor substrate-2Yasir H Ibrahim
Department of Medicine, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA
Mol Cancer Res 6:1491-8. 2008.... 
Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancerChad J Creighton
Dan L Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Breast Cancer Res 12:R40. 2010..We thus examined whether deregulated PI3K signaling in luminal ER+ breast tumors is associated with ER level and activity and intrinsic molecular subtype...- Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud developmentBrandy M Heckman
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Dev Biol 309:137-49. 2007..These results indicate that IGF signaling through p190-B and IRS proteins is critical for mammary bud formation and ensuing epithelial-mesenchymal interactions necessary to sustain mammary bud morphogenesis... - Insulin-like growth factor-I inhibits progesterone receptor expression in breast cancer cells via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway: progesterone receptor as a potential indicator of growth factor activity in breaXiaojiang Cui
Breast Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Mol Endocrinol 17:575-88. 2003.... - Insulin-like growth factor-I activates gene transcription programs strongly associated with poor breast cancer prognosisChad J Creighton
Breast Center, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
J Clin Oncol 26:4078-85. 2008..To more clearly elucidate the role of IGF in human breast cancer, we identified and then examined gene expression patterns of IGF-I-treated breast cancer cells... - The growth hormone receptor antagonist pegvisomant blocks both mammary gland development and MCF-7 breast cancer xenograft growthJana Divisova
Department of Medicine, Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
Breast Cancer Res Treat 98:315-27. 2006..This data supports previous studies indicating a role for GH/IGF in mammary gland development, and suggests that pegvisomant maybe useful for the prevention and/or treatment of estrogen receptor positive breast cancer... - Estrogen receptor-positive, progesterone receptor-negative breast cancer: association with growth factor receptor expression and tamoxifen resistanceGrazia Arpino
Breast Center, Baylor College of Medicine, The Methodist Hospital, Houston, TX, USA
J Natl Cancer Inst 97:1254-61. 2005..As in laboratory models, lack of PR expression in ER+ tumors may be a surrogate marker of aberrant growth factor signaling that could contribute to the tamoxifen resistance observed in these tumors... - Mammary tumorigenesis and metastasis caused by overexpression of insulin receptor substrate 1 (IRS-1) or IRS-2Robert K Dearth
Breast Cancer, Baylor College of Medicine and Methodist Hospital, Department of Medicine, Houston, TX 77030, USA
Mol Cell Biol 26:9302-14. 2006..This study defines IRSs as oncogene proteins in vivo and provides new models to develop inhibitors against IRSs for anticancer therapy... - Liver-specific overexpression of the insulin-like growth factor-I enhances somatic growth and partially prevents the effects of growth hormone deficiencyLan Liao
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Endocrinology 147:3877-88. 2006..Higher circulating levels of IGF-I can stimulate somatic growth and lean mass and improve glucose tolerance... - New mechanisms of signal transduction inhibitor action: receptor tyrosine kinase down-regulation and blockade of signal transactivationAdrian V Lee
Department of Medicine, Breast Center, Baylor College of Medicine, Houston, Texas 77030, USA
Clin Cancer Res 9:516S-23S. 2003..This review will highlight how recent studies using these STIs have elucidated novel mechanisms of STI action that may be used in the development of new therapeutic strategies for the treatment of cancer... - The type I insulin-like growth factor receptor pathway: a key player in cancer therapeutic resistanceAngelo J Casa
Breast Center, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
Front Biosci 13:3273-87. 2008..It concludes with a description of approaches to target IGF-IR and argues that inhibition of IGF signaling, in conjunction with standard therapies, may enhance the response of cancer cells to multiple modalities... - Decreased lactation capacity and altered milk composition in insulin receptor substrate null mice is associated with decreased maternal body mass and reduced insulin-dependent phosphorylation of mammary AktDarryl L Hadsell
Department of Pediatrics, The Breast Center, Baylor College of Medicine, USDAS ARS Chiuldren s Nutrition Research Center, 1100 Bates Street, Houston, TX 77030, USA
J Endocrinol 194:327-36. 2007.... - Biology of progesterone receptor loss in breast cancer and its implications for endocrine therapyXiaojiang Cui
Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
J Clin Oncol 23:7721-35. 2005..Finally, we will consider the clinical implications of these observations... - BMS-536924 reverses IGF-IR-induced transformation of mammary epithelial cells and causes growth inhibition and polarization of MCF7 cellsBeate C Litzenburger
Lester and Sue Smith Breast Center, Department of Medicine and Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Clin Cancer Res 15:226-37. 2009.... - Epidermal growth factor induces insulin receptor substrate-2 in breast cancer cells via c-Jun NH(2)-terminal kinase/activator protein-1 signaling to regulate cell migrationXiaojiang Cui
Breast Center, Departments of Medicine and Molecular and Cellular Biology, Baylor College of Medicine and Methodist Hospital, Houston, Texas 77030, USA
Cancer Res 66:5304-13. 2006..Because AP-1 activity is involved in breast cancer progression, our work may also suggest IRS-2 as a useful marker for aggressive breast cancer... - Progesterone crosstalks with insulin-like growth factor signaling in breast cancer cells via induction of insulin receptor substrate-2Xiaojiang Cui
Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
Oncogene 22:6937-41. 2003..Taken together, our data suggest that IRS-2 may play an important role in crosstalk between progesterone and the IGFs in breast cancer cells... - Estrogen-mediated down-regulation of E-cadherin in breast cancer cellsSteffi Oesterreich
The Breast Center, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
Cancer Res 63:5203-8. 2003..We propose that estrogen-mediated down-regulation of E-cadherin is a novel way of reducing E-cadherin levels in estrogen receptor-positive breast cancer... - AIB1/SRC-3 deficiency affects insulin-like growth factor I signaling pathway and suppresses v-Ha-ras-induced breast cancer initiation and progression in miceShao Qing Kuang
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Cancer Res 64:1875-85. 2004..These results suggest that a more effective strategy to control breast cancer is to target AIB1-mediated and ovarian hormone-initiated pathways... - Overexpression of des(1-3) insulin-like growth factor 1 in the mammary glands of transgenic mice delays the loss of milk production with prolonged lactationDarryl L Hadsell
USDA ARS Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
Biol Reprod 73:1116-25. 2005.... - Constitutively active type I insulin-like growth factor receptor causes transformation and xenograft growth of immortalized mammary epithelial cells and is accompanied by an epithelial-to-mesenchymal transition mediated by NF-kappaB and snailHyun Jung Kim
Baylor College of Medicine, Breast Center MS 600, One Baylor Plaza, Room N1110, Houston, TX 77030, USA
Mol Cell Biol 27:3165-75. 2007..This study places IGF-IR among a small group of oncogenes that, when overexpressed alone, can confer in vivo tumorigenic growth of MCF10A cells and indicates the hierarchy in the mechanism of IGF-IR-induced EMT... - Regulatory nodes that integrate and coordinate signaling as potential targets for breast cancer therapyXiaojiang Cui
Breast Center, Baylor College of Medicine, Houston, Texas, USA
Clin Cancer Res 10:396S-401S. 2004.... - Growth hormone and insulin-like growth factor-I in the transition from normal mammary development to preneoplastic mammary lesionsDavid L Kleinberg
Neuroendocrine Unit, Department of Medicine, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
Endocr Rev 30:51-74. 2009.... - Scaffold attachment factor B1 functions in development, growth, and reproductionMargarita Ivanova
Department of Medicine, Baylor College of Medicine, Breast Center, One Baylor Plaza, Houston, TX 77030, USA
Mol Cell Biol 25:2995-3006. 2005..Together, these in vivo findings establish a critical role for SAFB1 in development, growth regulation, and reproduction... - Structure-function analysis of the estrogen receptor alpha corepressor scaffold attachment factor-B1: identification of a potent transcriptional repression domainSteven M Townson
Departments of Medicine, The Breast Center, Baylor College of Medicine and Methodist Hospital, Houston, Texas 77030, USA
J Biol Chem 279:26074-81. 2004..We propose a model in which SAFB1 represses ERalpha activity via indirect association with histone deacetylation and interaction with the basal transcription machinery... - Progesterone receptor loss correlates with human epidermal growth factor receptor 2 overexpression in estrogen receptor-positive breast cancerHyun-Jung Kim
Breast Center, Baylor College of Medicine and The Methodist Hospital, Houston, TX 77030, USA
Clin Cancer Res 12:1013s-1018s. 2006.... - Parity-induced decrease in systemic growth hormone alters mammary gland signaling: a potential role in pregnancy protection from breast cancerRobert K Dearth
Breast Center, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Cancer Prev Res (Phila) 3:312-21. 2010..Therefore, although the parity reduction in circulating GH does not affect circulating IGF-I levels, it is possible that reduced GH acts directly at the mammary gland and may play a role in pregnancy protection from breast cancer... - A sequence-level map of chromosomal breakpoints in the MCF-7 breast cancer cell line yields insights into the evolution of a cancer genomeOliver A Hampton
Bioinformatics Research Laboratory, Baylor College of Medicine, Houston, Texas 77030, USA
Genome Res 19:167-77. 2009..We show that knock-down of SULF2 in cell lines causes tumorigenic phenotypes, including increased proliferation, enhanced survival, and increased anchorage-independent growth... - Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastasesShuying Liu
Department of Systems Biology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Cancer Cell 15:539-50. 2009..Thus, ATX and LPA receptors can contribute to the initiation and progression of breast cancer... - Oncogenic transformation by the signaling adaptor proteins insulin receptor substrate (IRS)-1 and IRS-2Robert K Dearth
Breast Center, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
Cell Cycle 6:705-13. 2007..In this review we will discuss the role of IRSs in both transformation and cancer progression... - Molecular profiles of progesterone receptor loss in human breast tumorsChad J Creighton
Dan L Duncan Cancer Center Division of Biostatistics, Baylor College of Medicine, Houston, TX 77030, USA
Breast Cancer Res Treat 114:287-99. 2009..Patient prognosis and response to endocrine therapy in breast cancer correlate with protein expression of both estrogen receptor (ER) and progesterone receptor (PR), with poorer outcome in patients with ER+/PR- compared to ER+/PR+ tumors... - SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressorSteven M Townson
Breast Center, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
J Biol Chem 278:20059-68. 2003..Our findings suggest that evolutionary duplication of the SAFB gene has allowed it to retain crucial functions, but also to gain novel functions in the cytoplasm and/or nucleus... - Serine-derivatized gadonanotubes as magnetic nanoprobes for intracellular labelingAmy A Hassan
Breast Center, Department of Medicine and Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Contrast Media Mol Imaging 5:34-8. 2010..Cell pellets derived from the ser-GNT labeled cells give bright T(1)-weighted MR images, confirming that the ser-GNTs are a promising new nanoprobe technology for magnetic cell labeling and possibly for in vivo cellular trafficking... - Histone deacetylase 7 and FoxA1 in estrogen-mediated repression of RPRMSimeen Malik
Department of Molecular and Cellular Biology, 3 Baylor College of Medicine, Houston, Texas 77030, USA
Mol Cell Biol 30:399-412. 2010.... - Insulin receptor substrates (IRSs) and breast tumorigenesisBonita Tak Yee Chan
Lester and Sue Smith Breast Center, Department of Medicine and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA
J Mammary Gland Biol Neoplasia 13:415-22. 2008..In this review we will discuss the roles of IRSs in mammary gland development and breast cancer... - Estrogen receptor DNA binding is not required for estrogen-induced breast cell growthDavid G DeNardo
Department of Molecular and Cellular Biology, and Breast Center, Baylor College of Medicine, Houston, TX, USA
Mol Cell Endocrinol 277:13-25. 2007..These results demonstrate that ER DNA binding is not absolutely required for estrogen to induce breast cancer cell growth... - Altered mammary gland development in the p53+/m mouse, a model of accelerated agingCatherine E Gatza
Interdepartmental Graduate Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Dev Biol 313:130-41. 2008..These data indicate that appropriate levels of p53 activity are important in regulating mammary gland ductal morphogenesis, in part through regulation of the IGF-1 pathway... - Scaffold Attachment Factor B1 (SAFB1) heterozygosity does not influence Wnt-1 or DMBA-induced tumorigenesisBenny Abraham Kaipparettu
Lester and Sue Smith Breast Center, Departments of Medicine, Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA
Mol Cancer 8:15. 2009..Therefore, we asked whether SAFB1 heterozygosity would influence tumor development and progression in MMTV-Wnt-1 oncomice or DMBA induced tumorigenicity, in a manner consistent with haploinsufficiency of the remaining allele... - Disruption of scaffold attachment factor B1 leads to TBX2 up-regulation, lack of p19ARF induction, lack of senescence, and cell immortalizationKlaudia M Dobrzycka
Department of Medicine, The Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
Cancer Res 66:7859-63. 2006..SAFB1 loss also caused lack of contact inhibition, increased foci formation, and increased oncogene-induced anchorage-independent growth. These findings suggest that SAFB1 is a novel player in cellular immortalization and transformation...
Research Grants
- IRS1 and 2 Signaling in Mammary Development and CancerAdrian Lee; Fiscal Year: 2006..Knowing their function in normal development may make it possible to understand the dysfunction in abnormal development, and perhaps even to devise interventions to block or reverse the onset of full malignancy. ..
- ER Co-Repressor Function of SAFB in Breast CancerAdrian Lee; Fiscal Year: 2006..abstract_text> ..