Research Topics
Genomes and Genes
| Adrian V LeeSummaryAffiliation: Baylor College of Medicine Country: USA Publications
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Detail Information
Publications
New mechanisms of signal transduction inhibitor action: receptor tyrosine kinase down-regulation and blockade of signal transactivationAdrian V Lee
Department of Medicine, Breast Center, Baylor College of Medicine, Houston, Texas 77030, USA
Clin Cancer Res 9:516S-23S. 2003..This review will highlight how recent studies using these STIs have elucidated novel mechanisms of STI action that may be used in the development of new therapeutic strategies for the treatment of cancer...- Progesterone receptor-B regulation of insulin-like growth factor-stimulated cell migration in breast cancer cells via insulin receptor substrate-2Yasir H Ibrahim
Department of Medicine, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA
Mol Cancer Res 6:1491-8. 2008.... - Mammary tumorigenesis and metastasis caused by overexpression of insulin receptor substrate 1 (IRS-1) or IRS-2Robert K Dearth
Breast Cancer, Baylor College of Medicine and Methodist Hospital, Department of Medicine, Houston, TX 77030, USA
Mol Cell Biol 26:9302-14. 2006..This study defines IRSs as oncogene proteins in vivo and provides new models to develop inhibitors against IRSs for anticancer therapy... - BMS-536924 reverses IGF-IR-induced transformation of mammary epithelial cells and causes growth inhibition and polarization of MCF7 cellsBeate C Litzenburger
Lester and Sue Smith Breast Center, Department of Medicine and Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Clin Cancer Res 15:226-37. 2009.... - Biology of progesterone receptor loss in breast cancer and its implications for endocrine therapyXiaojiang Cui
Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
J Clin Oncol 23:7721-35. 2005..Finally, we will consider the clinical implications of these observations... - Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancerChad J Creighton
Dan L Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Breast Cancer Res 12:R40. 2010..We thus examined whether deregulated PI3K signaling in luminal ER+ breast tumors is associated with ER level and activity and intrinsic molecular subtype... - Estrogen-mediated down-regulation of E-cadherin in breast cancer cellsSteffi Oesterreich
The Breast Center, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
Cancer Res 63:5203-8. 2003..We propose that estrogen-mediated down-regulation of E-cadherin is a novel way of reducing E-cadherin levels in estrogen receptor-positive breast cancer... - The growth hormone receptor antagonist pegvisomant blocks both mammary gland development and MCF-7 breast cancer xenograft growthJana Divisova
Department of Medicine, Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
Breast Cancer Res Treat 98:315-27. 2006..This data supports previous studies indicating a role for GH/IGF in mammary gland development, and suggests that pegvisomant maybe useful for the prevention and/or treatment of estrogen receptor positive breast cancer... - Histone deacetylase 7 and FoxA1 in estrogen-mediated repression of RPRMSimeen Malik
Department of Molecular and Cellular Biology, 3 Baylor College of Medicine, Houston, Texas 77030, USA
Mol Cell Biol 30:399-412. 2010.... - Oncogenic transformation by the signaling adaptor proteins insulin receptor substrate (IRS)-1 and IRS-2Robert K Dearth
Breast Center, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
Cell Cycle 6:705-13. 2007..In this review we will discuss the role of IRSs in both transformation and cancer progression... - High IGF-IR activity in triple-negative breast cancer cell lines and tumorgrafts correlates with sensitivity to anti-IGF-IR therapyBeate C Litzenburger
Lester and Sue Smith Breast Center and Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, USA
Clin Cancer Res 17:2314-27. 2011..We tested whether the IGF signature was affected by anti-IGF-I receptor (IGF-IR) inhibitors and whether the IGF signature correlated with response to a dual anti-IGF-IR/insulin receptor (InsR) inhibitor, BMS-754807... - Disruption of scaffold attachment factor B1 leads to TBX2 up-regulation, lack of p19ARF induction, lack of senescence, and cell immortalizationKlaudia M Dobrzycka
Department of Medicine, The Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
Cancer Res 66:7859-63. 2006..SAFB1 loss also caused lack of contact inhibition, increased foci formation, and increased oncogene-induced anchorage-independent growth. These findings suggest that SAFB1 is a novel player in cellular immortalization and transformation... - Structure-function analysis of the estrogen receptor alpha corepressor scaffold attachment factor-B1: identification of a potent transcriptional repression domainSteven M Townson
Departments of Medicine, The Breast Center, Baylor College of Medicine and Methodist Hospital, Houston, Texas 77030, USA
J Biol Chem 279:26074-81. 2004..We propose a model in which SAFB1 represses ERalpha activity via indirect association with histone deacetylation and interaction with the basal transcription machinery... - Insulin-like growth factor-I activates gene transcription programs strongly associated with poor breast cancer prognosisChad J Creighton
Breast Center, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
J Clin Oncol 26:4078-85. 2008..To more clearly elucidate the role of IGF in human breast cancer, we identified and then examined gene expression patterns of IGF-I-treated breast cancer cells... - Scaffold Attachment Factor B1 (SAFB1) heterozygosity does not influence Wnt-1 or DMBA-induced tumorigenesisBenny Abraham Kaipparettu
Lester and Sue Smith Breast Center, Departments of Medicine, Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA
Mol Cancer 8:15. 2009..Therefore, we asked whether SAFB1 heterozygosity would influence tumor development and progression in MMTV-Wnt-1 oncomice or DMBA induced tumorigenicity, in a manner consistent with haploinsufficiency of the remaining allele... - Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud developmentBrandy M Heckman
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Dev Biol 309:137-49. 2007..These results indicate that IGF signaling through p190-B and IRS proteins is critical for mammary bud formation and ensuing epithelial-mesenchymal interactions necessary to sustain mammary bud morphogenesis... - Epidermal growth factor induces insulin receptor substrate-2 in breast cancer cells via c-Jun NH(2)-terminal kinase/activator protein-1 signaling to regulate cell migrationXiaojiang Cui
Breast Center, Departments of Medicine and Molecular and Cellular Biology, Baylor College of Medicine and Methodist Hospital, Houston, Texas 77030, USA
Cancer Res 66:5304-13. 2006..Because AP-1 activity is involved in breast cancer progression, our work may also suggest IRS-2 as a useful marker for aggressive breast cancer... - Estrogen receptor DNA binding is not required for estrogen-induced breast cell growthDavid G DeNardo
Department of Molecular and Cellular Biology, and Breast Center, Baylor College of Medicine, Houston, TX, USA
Mol Cell Endocrinol 277:13-25. 2007..These results demonstrate that ER DNA binding is not absolutely required for estrogen to induce breast cancer cell growth... - The type I insulin-like growth factor receptor pathway: a key player in cancer therapeutic resistanceAngelo J Casa
Breast Center, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
Front Biosci 13:3273-87. 2008..It concludes with a description of approaches to target IGF-IR and argues that inhibition of IGF signaling, in conjunction with standard therapies, may enhance the response of cancer cells to multiple modalities... - Liver-specific overexpression of the insulin-like growth factor-I enhances somatic growth and partially prevents the effects of growth hormone deficiencyLan Liao
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Endocrinology 147:3877-88. 2006..Higher circulating levels of IGF-I can stimulate somatic growth and lean mass and improve glucose tolerance... - Scaffold attachment factor B1 functions in development, growth, and reproductionMargarita Ivanova
Department of Medicine, Baylor College of Medicine, Breast Center, One Baylor Plaza, Houston, TX 77030, USA
Mol Cell Biol 25:2995-3006. 2005..Together, these in vivo findings establish a critical role for SAFB1 in development, growth regulation, and reproduction... - Parity-induced decrease in systemic growth hormone alters mammary gland signaling: a potential role in pregnancy protection from breast cancerRobert K Dearth
Breast Center, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Cancer Prev Res (Phila) 3:312-21. 2010..Therefore, although the parity reduction in circulating GH does not affect circulating IGF-I levels, it is possible that reduced GH acts directly at the mammary gland and may play a role in pregnancy protection from breast cancer... - Nuclear IRS-1 predicts tamoxifen response in patients with early breast cancerIlenia Migliaccio
Lester and Sue Smith Breast Center, Baylor College of Medicine, One Baylor Plaza, BCM 600, Room N1110, Houston, TX 77030, USA
Breast Cancer Res Treat 123:651-60. 2010..0001) when compared with patients with PR-/IRS-1- tumors. In conclusion, nuclear IRS-1 may be a useful marker to predict tamoxifen response in patients with early breast cancer, particularly when assessed in combination with PR... - Decreased lactation capacity and altered milk composition in insulin receptor substrate null mice is associated with decreased maternal body mass and reduced insulin-dependent phosphorylation of mammary AktDarryl L Hadsell
Department of Pediatrics, The Breast Center, Baylor College of Medicine, USDAS ARS Chiuldren s Nutrition Research Center, 1100 Bates Street, Houston, TX 77030, USA
J Endocrinol 194:327-36. 2007.... - Estrogen and insulin-like growth factor-I (IGF-I) independently down-regulate critical repressors of breast cancer growthAngelo J Casa
Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
Breast Cancer Res Treat 132:61-73. 2012..This may be important clinically, as tumors with active ER? and IGF-IR signaling may require co-targeting of both pathways... - Estrogen receptor-positive, progesterone receptor-negative breast cancer: association with growth factor receptor expression and tamoxifen resistanceGrazia Arpino
Breast Center, Baylor College of Medicine, The Methodist Hospital, Houston, TX, USA
J Natl Cancer Inst 97:1254-61. 2005..As in laboratory models, lack of PR expression in ER+ tumors may be a surrogate marker of aberrant growth factor signaling that could contribute to the tamoxifen resistance observed in these tumors... - Molecular profiles of progesterone receptor loss in human breast tumorsChad J Creighton
Dan L Duncan Cancer Center Division of Biostatistics, Baylor College of Medicine, Houston, TX 77030, USA
Breast Cancer Res Treat 114:287-99. 2009..Patient prognosis and response to endocrine therapy in breast cancer correlate with protein expression of both estrogen receptor (ER) and progesterone receptor (PR), with poorer outcome in patients with ER+/PR- compared to ER+/PR+ tumors... - Progesterone receptor loss correlates with human epidermal growth factor receptor 2 overexpression in estrogen receptor-positive breast cancerHyun-Jung Kim
Breast Center, Baylor College of Medicine and The Methodist Hospital, Houston, TX 77030, USA
Clin Cancer Res 12:1013s-1018s. 2006.... - Growth hormone and insulin-like growth factor-I in the transition from normal mammary development to preneoplastic mammary lesionsDavid L Kleinberg
Neuroendocrine Unit, Department of Medicine, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
Endocr Rev 30:51-74. 2009.... - Constitutively active type I insulin-like growth factor receptor causes transformation and xenograft growth of immortalized mammary epithelial cells and is accompanied by an epithelial-to-mesenchymal transition mediated by NF-kappaB and snailHyun Jung Kim
Baylor College of Medicine, Breast Center MS 600, One Baylor Plaza, Room N1110, Houston, TX 77030, USA
Mol Cell Biol 27:3165-75. 2007..This study places IGF-IR among a small group of oncogenes that, when overexpressed alone, can confer in vivo tumorigenic growth of MCF10A cells and indicates the hierarchy in the mechanism of IGF-IR-induced EMT... - A moderate elevation of circulating levels of IGF-I does not alter ErbB2 induced mammary tumorigenesisRobert K Dearth
Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
BMC Cancer 11:377. 2011..The purpose of this study was to assess the ability of circulating IGF-I to independently initiate mammary tumorigenesis and/or accelerate the progression of ErbB2 mediated mammary tumor growth... - Novel egg white-based 3-D cell culture systemBenny Abraham Kaipparettu
Department of Medicine, Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
Biotechniques 45:165-8, 170-1. 2008..Thus, this finding lays the foundation for significantly increased, cost-effective use of 3-D cultures in cell biology... - Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastasesShuying Liu
Department of Systems Biology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Cancer Cell 15:539-50. 2009..Thus, ATX and LPA receptors can contribute to the initiation and progression of breast cancer... - AIB1/SRC-3 deficiency affects insulin-like growth factor I signaling pathway and suppresses v-Ha-ras-induced breast cancer initiation and progression in miceShao Qing Kuang
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Cancer Res 64:1875-85. 2004..These results suggest that a more effective strategy to control breast cancer is to target AIB1-mediated and ovarian hormone-initiated pathways... - Altered mammary gland development in the p53+/m mouse, a model of accelerated agingCatherine E Gatza
Interdepartmental Graduate Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Dev Biol 313:130-41. 2008..These data indicate that appropriate levels of p53 activity are important in regulating mammary gland ductal morphogenesis, in part through regulation of the IGF-1 pathway... - Long-range massively parallel mate pair sequencing detects distinct mutations and similar patterns of structural mutability in two breast cancer cell linesOliver A Hampton
Graduate Program in Structural and Computational Biology and Molecular Biophysics, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA
Cancer Genet 204:447-57. 2011.... - Regulatory nodes that integrate and coordinate signaling as potential targets for breast cancer therapyXiaojiang Cui
Breast Center, Baylor College of Medicine, Houston, Texas, USA
Clin Cancer Res 10:396S-401S. 2004.... - Disruption of steroid and prolactin receptor patterning in the mammary gland correlates with a block in lobuloalveolar developmentSandra L Grimm
Department of Molecular and Cellular Biology, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
Mol Endocrinol 16:2675-91. 2002..Together, these data suggest that C/EBPbeta is a master regulator of mammary epithelial cell fate and that the correct spatial pattern of PR and PrlR expression is a critical determinant of hormone-regulated cell proliferation... - Progesterone crosstalks with insulin-like growth factor signaling in breast cancer cells via induction of insulin receptor substrate-2Xiaojiang Cui
Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
Oncogene 22:6937-41. 2003..Taken together, our data suggest that IRS-2 may play an important role in crosstalk between progesterone and the IGFs in breast cancer cells... - Overexpression of des(1-3) insulin-like growth factor 1 in the mammary glands of transgenic mice delays the loss of milk production with prolonged lactationDarryl L Hadsell
USDA ARS Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
Biol Reprod 73:1116-25. 2005.... - 26th Annual San Antonio Breast Cancer Symposium, San Antonio, Texas, USA, 3-6 December 2003: update on preclinical and translational researchAdrian V Lee
Breast Center, Baylor College of Medicine and The Methodist Hospital, Houston, Texas, USA
Breast Cancer Res 6:E10. 2004..This report will summarize preclinical and translational highlights from the meeting... - SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressorSteven M Townson
Breast Center, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
J Biol Chem 278:20059-68. 2003..Our findings suggest that evolutionary duplication of the SAFB gene has allowed it to retain crucial functions, but also to gain novel functions in the cytoplasm and/or nucleus... - A sequence-level map of chromosomal breakpoints in the MCF-7 breast cancer cell line yields insights into the evolution of a cancer genomeOliver A Hampton
Bioinformatics Research Laboratory, Baylor College of Medicine, Houston, Texas 77030, USA
Genome Res 19:167-77. 2009..We show that knock-down of SULF2 in cell lines causes tumorigenic phenotypes, including increased proliferation, enhanced survival, and increased anchorage-independent growth... - Insulin receptor substrates (IRSs) and breast tumorigenesisBonita Tak Yee Chan
Lester and Sue Smith Breast Center, Department of Medicine and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA
J Mammary Gland Biol Neoplasia 13:415-22. 2008..In this review we will discuss the roles of IRSs in mammary gland development and breast cancer... - Insulin-like growth factor-I inhibits progesterone receptor expression in breast cancer cells via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway: progesterone receptor as a potential indicator of growth factor activity in breaXiaojiang Cui
Breast Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Mol Endocrinol 17:575-88. 2003.... - Serine-derivatized gadonanotubes as magnetic nanoprobes for intracellular labelingAmy A Hassan
Breast Center, Department of Medicine and Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Contrast Media Mol Imaging 5:34-8. 2010..Cell pellets derived from the ser-GNT labeled cells give bright T(1)-weighted MR images, confirming that the ser-GNTs are a promising new nanoprobe technology for magnetic cell labeling and possibly for in vivo cellular trafficking... - Location, location, location: regulation of breast cancer progression by the microenvironmentAdrian V Lee
Breast Center, Baylor College of Medicine and The Methodist Hospital, Houston, Texas, USA
Breast Cancer Res 6:279-80. 2004 - Forkhead box A1 (FOXA1) is a key mediator of insulin-like growth factor I (IGF-I) activityAdam S Potter
Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas 77030, USA
J Cell Biochem 113:110-21. 2012..Together, these results demonstrate that IGF-I can increase the stability of FOXA1 protein expression and place it as a critical mediator of IGF-I regulation of gene expression and IGF-I-mediated biological responses... - Estrogen receptor regulates insulin-like growth factor-I receptor gene expression in breast tumor cells: involvement of transcription factor Sp1Sharon Maor
Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
J Endocrinol 191:605-12. 2006..Dysregulated expression of the IGF-IR gene may have pathologic consequences with relevance in breast cancer etiology... - Novel role of the RET finger protein in estrogen receptor-mediated transcription in MCF-7 cellsSteven M Townson
Department of Human Genetics, Virginia Commonwealth University and Massey Cancer Center, Sanger Hall, Richmond, VA 23219, USA
Biochem Biophys Res Commun 349:540-8. 2006..Taken together, our study provides further evidence that coactivation and corepression are integrally linked processes and that RFP is a component of an ESR1 regulatory complex... - Local insulin-like growth factor-II mediates prolactin-induced mammary gland developmentRussell C Hovey
Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 1402, USA
Mol Endocrinol 17:460-71. 2003..Together, these data demonstrate a role for IGF-II as a mediator of PRL action in the mouse mammary gland during ductal branching and alveolar development... - A dominant negative type I insulin-like growth factor receptor inhibits metastasis of human cancer cellsDeepali Sachdev
Department of Medicine and Cancer Center, University of Minnesota, Minnesota 55455, USA
J Biol Chem 279:5017-24. 2004..Our data show that IGF1R can regulate several aspects of the malignant phenotype. In these cells, metastasis but not proliferation requires IGF1R function... - The WT1 Wilms' tumor suppressor gene product interacts with estrogen receptor-alpha and regulates IGF-I receptor gene transcription in breast cancer cellsNaama Reizner
Department of Clinical Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
J Mol Endocrinol 35:135-44. 2005.... - Increases in estrogen receptor-alpha concentration in breast cancer cells promote serine 118/104/106-independent AF-1 transactivation and growth in the absence of estrogenAmy M Fowler
Department of Physiology, University of Wisconsin-Madison, Madison, Wisconsin, USA
FASEB J 18:81-93. 2004..Further, they describe a potential mechanism whereby increases in ERalpha concentration may provide a proliferative advantage by augmenting ERalpha function regardless of ligand status... - Proceedings of the Third International Conference on Recent Advances and Future Directions in Endocrine Manipulation of Breast Cancer: conference summary statementSteven E Come
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
Clin Cancer Res 10:327S-330S. 2004 - Tumor development by transgenic expression of a constitutively active insulin-like growth factor I receptorJoan M Carboni
Oncology Drug Discovery and Discovery Toxicology, Bristol Myers Squibb Research Institute, Princeton, New Jersey 08534, USA
Cancer Res 65:3781-7. 2005..This new model should provide new opportunities for further understanding how aberrant IGF-IR signaling leads to tumorigenesis and for optimizing novel antagonists of the receptor kinase... - Bisphenol-A and estradiol exert novel gene regulation in human MCF-7 derived breast cancer cellsDavid W Singleton
Department of Cell Biology, Neurobiology and Anatomy, Vontz Center for Molecular Studies, University of Cincinnati College of Medicine, 3125 Eden Avenue, Cincinnati, OH 45267-0521, USA
Mol Cell Endocrinol 221:47-55. 2004..Taken together these data illustrate novel gene regulation by BPA and E2, which has implications for in vivo actions and previous reports of additive and synergistic effects on breast cancer cell growth... - Proceedings of the Fifth International Conference on Recent Advances and Future Directions in Endocrine Therapy for Breast Cancer: conference summary statementSteven E Come
Breast Cancer Program, Beth Israel Deaconess Medical Center/Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
Clin Cancer Res 12:997s-1000s. 2006 - Gene expression profiling reveals novel regulation by bisphenol-A in estrogen receptor-alpha-positive human cellsDavid W Singleton
Department of Cell Biology, Neurobiology, and Anatomy, Vontz Center for Molecular Studies, University of Cincinnati, 3125 Eden Avenue, Cincinnati, OH 45267-0521, USA
Environ Res 100:86-92. 2006..5-fold by BPA. These results reveal novel effects by BPA and E2, raising interesting possibilities regarding the role of endocrine disruptors in sexual development... - Second International Conference on Recent Advances and Future Directions in Endocrine Manipulation of Breast Cancer: summary consensus statementSteven E Come
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Clin Cancer Res 9:443S-6S. 2003 - Insights into the role of progesterone receptors in breast cancerSuzanne A W Fuqua
J Clin Oncol 23:931-2; author reply 932-3. 2005