Research Topics
Genomes and Genes | Wei Dong LESummaryAffiliation: Baylor College of Medicine Country: USA Publications
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Publications
Protective role of heme oxygenase-1 in oxidative stress-induced neuronal injuryW D Le
Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
J Neurosci Res 56:652-8. 1999..These findings support the importance of HO-1 in protecting neurons against oxidative stress-induced injury...- Mutations in NR4A2 associated with familial Parkinson diseaseWei Dong LE
Department of Neurology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Nat Genet 33:85-9. 2003..Additionally, mutations in NR4A2 affect transcription of the gene encoding tyrosine hydroxylase. These data suggest that mutations in NR4A2 can cause dopaminergic dysfunction, associated with Parkinson disease... - Minocycline: neuroprotective mechanisms in Parkinson's diseaseM Thomas
Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
Curr Pharm Des 10:679-86. 2004..In this review, we present the current experimental evidence for the potential use of tetracycline derivative, minocycline, as a neuroprotective agent in PD... - Heterogeneous phenotype in a family with compound heterozygous parkin gene mutationsHao Deng
Department of Neurology, Baylor College of Medicine, Houston, Tex 77030, USA
Arch Neurol 63:273-7. 2006..Mutations in the parkin gene (PRKN) cause autosomal recessive early-onset Parkinson disease (EOPD)... - Genetic analysis of the GABRA1 gene in patients with essential tremorHao Deng
Department of Neurology, Baylor College of Medicine, 6501 Fannin Street, Houston, TX 77030, USA
Neurosci Lett 401:16-9. 2006..Since the 156T>C variant appears to be not pathogenically relevant, our results suggest that missense, nonsense or splice site mutation in the coding region of the GABRA1 gene is not a major genetic cause of ET in Caucasian subjects... - Genetic analysis of parkin co-regulated gene (PACRG) in patients with early-onset parkinsonismHao Deng
Department of Neurology, Baylor College of Medicine, 6501 Fannin Street, Houston, TX 77030, USA
Neurosci Lett 382:297-9. 2005..Since none of these variations appear to be pathogenically relevant, our results suggest that mutation of PACRG plays little or no role in the development of EOP... - Association of NRH:quinone oxidoreductase 2 gene promoter polymorphism with higher gene expression and increased susceptibility to Parkinson's diseaseWei Wang
Department of Pharmacology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
J Gerontol A Biol Sci Med Sci 63:127-34. 2008..The results suggest that the association of the D promoter with Parkinson's disease may be due to an increase in expression of the NQO2 gene... - A family with Parkinson disease, essential tremor, bell palsy, and parkin mutationsHao Deng
Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
Arch Neurol 64:421-4. 2007..Mutations in the parkin gene cause autosomal recessive early-onset Parkinson disease (EOPD). The A265G variant in the HS1 binding protein 3 gene (HS1BP3) is common in essential tremor (ET)... - Neuroprotective effects and mechanisms of exercise in a chronic mouse model of Parkinson's disease with moderate neurodegenerationYuen Sum Lau
Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204, USA
Eur J Neurosci 33:1264-74. 2011..Therefore, modifying lifestyle with increased exercise activity would be a non-pharmacological neuroprotective approach for averting neurodegenerative processes, as demonstrated in experimental chronic parkinsonism... - Genetic study of an American family with DYT3 dystonia (lubag)Hao Deng
Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
Neurosci Lett 448:180-3. 2008..In contrast, TAF1 and CXCR3 gene expression in peripheral blood lymphocytes is not a suitable surrogate disease marker for DYT3... - Mechanisms of apoptosis in human retinal pigment epithelium induced by TNF-alpha in conditions of heavy metal ion deficiencyJun Hai Yang
Department of Ophthalmology, Baylor College of Medicine, Houston, Texas, USA
Invest Ophthalmol Vis Sci 46:1039-46. 2005..To investigate the mechanism underlying apoptosis in retinal pigment epithelium (RPE) induced by TNF-alpha in conditions of heavy metal ion deficiency... - Immunoglobulin Fc gamma receptor promotes immunoglobulin uptake, immunoglobulin-mediated calcium increase, and neurotransmitter release in motor neuronsHabib A Mohamed
Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
J Neurosci Res 69:110-6. 2002..These data suggest that FcgammaRs appear to participate in IgG uptake into motor neurons as well as IgG-mediated increases in intracellular calcium and acetylcholine release from motor axon terminals... - Minocycline and other tetracycline derivatives: a neuroprotective strategy in Parkinson's disease and Huntington's diseaseMadhavi Thomas
Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
Clin Neuropharmacol 26:18-23. 2003 - Biomarkers of neurodegenerative disorders: how good are they?Varun Rachakonda
Department of Neurology, Baylor College of Medicine, Houston, TX, USA
Cell Res 14:347-58. 2004..This article will focus on the most-recent findings of biomarkers belonging to the four mentioned neurodegenerative diseases... - Role of Fcgamma receptors in nigral cell injury induced by Parkinson disease immunoglobulin injection into mouse substantia nigraYi He
Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
Exp Neurol 176:322-7. 2002.... - Collective roles of molecular chaperones in protein degradation pathways associated with neurodegenerative diseasesGuang Rui Luo
Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, China
Curr Pharm Biotechnol 11:180-7. 2010..Therefore, the study of HSPs might shed new light on not only the mechanisms of protein synthesis and degradation, but also the possible therapeutic targets of fibril formation associating diseases... - Epigallocatechin gallate protects dopaminergic neurons against 1-methyl-4- phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity by inhibiting microglial cell activationRui Li
Department of Neurology, People s Hospital of Shaanxi Province, Xi an 710068, China
Nan Fang Yi Ke Da Xue Xue Bao 26:376-80. 2006..To observe whether the dopaminergic neuroprotective effect of (-)-epigallocatechin gallate (EGCG) is associated with its inhibition of microglial cell activation in vivo... - Novel splicing variant of the human orphan nuclear receptor Nurr1 genePing-yi Xu
Department of Neurology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China
Chin Med J (Engl) 117:899-902. 2004..05). CONCLUSION: A novel splicing variant of Nurr1 exists in human non-neuronal tissues and functional assays suggest that the variant may act as an alternate transcription regulator... - Retinal pigment epithelial cells: biological property and application in Parkinson's diseaseMing Ming
Laboratory of Neurogenomics, Institute of Health Sciences, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China
Chin Med J (Engl) 120:416-20. 2007 - Stem cell transplantation: a promising therapy for Parkinson's diseaseYi Wang
Institute of Health Sciences, Shanghai Institutes for Biological Sciences of Chinese Academy of Science and Shanghai Jiao Tong University School of Medicine, 225 South Chongqing Road, Shanghai 200025, China
J Neuroimmune Pharmacol 2:243-50. 2007..Future stem cell research should focus not only on ameliorating the symptoms of Parkinson's disease but also on neuroprotection or neurorescue that can favorably modify the natural course and slow the progression of the disease... - Nitric oxide mediates increased susceptibility to dopaminergic damage in Nurr1 heterozygous miceSyed Z Imam
South Texas Veteran Health Care System and Department of Medicine of UT Health Science, San Antonio, Texas, USA
FASEB J 19:1441-50. 2005.... - (-)-Epigallocatechin gallate inhibits lipopolysaccharide-induced microglial activation and protects against inflammation-mediated dopaminergic neuronal injuryRui Li
Health Science Center, Shanghai Institute for Biological Science, Chinese Academy of Science, Shanghai Second Medical University, Shanghai, Peoples Republic of China
J Neurosci Res 78:723-31. 2004..Our study demonstrates that EGCG is a potent inhibitor of microglial activation and thus is a useful candidate for a therapeutic approach to alleviating microglia-mediated dopaminergic neuronal injury in PD... - Estrogen provides neuroprotection against activated microglia-induced dopaminergic neuronal injury through both estrogen receptor-alpha and estrogen receptor-beta in microgliaXuan Liu
Joint Laboratory of Institute of Biomedical Sciences, Ruijin Hospital, Shanghai Second Medical University, Shanghai, People's Republic of China
J Neurosci Res 81:653-65. 2005..The cytoplasm location of microglial ERbeta suggests the possible involvement of nonclassical effects of estrogen on microglia. Changes in microglial ERbeta expression levels may modulate such effects of estrogen...
Research Grants
- NURR1 EXPRESSION AND DAERGIC DYSFUNCTION RELEVANT TO PDWei Dong LE; Fiscal Year: 2003....
- NURR1 Gene Mutations in Parkinson's DiseaseWeidong Le; Fiscal Year: 2006....