Sunkuk Kwon

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. doi request reprint Noninvasive quantitative imaging of lymph function in mice
    Sunkuk Kwon
    Division of Molecular Imaging, Department of Radiology, Baylor College of Medicine, Houston, TX 77030 3411, USA
    Lymphat Res Biol 5:219-31. 2007
  2. ncbi request reprint Dual-labeled trastuzumab-based imaging agent for the detection of human epidermal growth factor receptor 2 overexpression in breast cancer
    Lakshmi Sampath
    Division of Molecular Imaging, Department of Radiology, Baylor College of Medicine, Houston, TX 77030, USA
    J Nucl Med 48:1501-10. 2007
  3. pmc Albumin-binding domain conjugate for near-infrared fluorescence lymphatic imaging
    Cynthia A Davies-Venn
    The Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030, USA
    Mol Imaging Biol 14:301-14. 2012
  4. doi request reprint Imaging prostate cancer lymph node metastases with a multimodality contrast agent
    Mary A Hall
    Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, Texas, USA
    Prostate 72:129-46. 2012
  5. pmc Functional lymphatic imaging in tumor-bearing mice
    Sunkuk Kwon
    Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, 1825 Pressler Street, SRB 330A, Houston, TX 77030, USA
    J Immunol Methods 360:167-72. 2010
  6. ncbi request reprint Comparison of visible and near-infrared wavelength-excitable fluorescent dyes for molecular imaging of cancer
    Kristen E Adams
    Baylor College of Medicine, Department of Radiology, One Baylor Plaza, MS 360, Houston, Texas 77030, USA
    J Biomed Opt 12:024017. 2007
  7. pmc Lymphatic abnormalities are associated with RASA1 gene mutations in mouse and man
    Patricia E Burrows
    Department of Diagnostic and Interventional Imaging, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 110:8621-6. 2013
  8. ncbi request reprint A new optical and nuclear dual-labeled imaging agent targeting interleukin 11 receptor alpha-chain
    Wei Wang
    Department of Radiology, Division of Molecular Imaging, Baylor College of Medicine, Houston, Texas 77030, USA
    Bioconjug Chem 18:397-402. 2007
  9. pmc In vivo fluorescent optical imaging of cytotoxic T lymphocyte migration using IRDye800CW near-infrared dye
    Aaron E Foster
    Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children s Hospital, 1102 Bates Street, Houston, Texas 77030, USA
    Appl Opt 47:5944-52. 2008
  10. pmc Altered lymphatic function and architecture in salt-induced hypertension assessed by near-infrared fluorescence imaging
    Sunkuk Kwon
    University of Texas Health Science Center, Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, Houston, TX 77030, USA
    J Biomed Opt 17:080504-1. 2012

Collaborators

Detail Information

Publications20

  1. doi request reprint Noninvasive quantitative imaging of lymph function in mice
    Sunkuk Kwon
    Division of Molecular Imaging, Department of Radiology, Baylor College of Medicine, Houston, TX 77030 3411, USA
    Lymphat Res Biol 5:219-31. 2007
    ..Herein, we present a noninvasive and rapid approach to measure lymphatic function in a rodent model using a near-infrared (NIR) dye to minimize background autofluorescence and maximize tissue penetration...
  2. ncbi request reprint Dual-labeled trastuzumab-based imaging agent for the detection of human epidermal growth factor receptor 2 overexpression in breast cancer
    Lakshmi Sampath
    Division of Molecular Imaging, Department of Radiology, Baylor College of Medicine, Houston, TX 77030, USA
    J Nucl Med 48:1501-10. 2007
    ..The stoichiometric ratios "n" and "m" refer to the number of diethylenetriaminepentaacetic acid dianhydride (DTPA) and IRDye 800CW molecules bound per trastuzumab molecule, respectively...
  3. pmc Albumin-binding domain conjugate for near-infrared fluorescence lymphatic imaging
    Cynthia A Davies-Venn
    The Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030, USA
    Mol Imaging Biol 14:301-14. 2012
    ....
  4. doi request reprint Imaging prostate cancer lymph node metastases with a multimodality contrast agent
    Mary A Hall
    Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, Texas, USA
    Prostate 72:129-46. 2012
    ..Pelvic LN dissection is commonly performed during prostatectomy, but often followed by morbid complications. More refined methods for detecting LN invasion are needed...
  5. pmc Functional lymphatic imaging in tumor-bearing mice
    Sunkuk Kwon
    Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, 1825 Pressler Street, SRB 330A, Houston, TX 77030, USA
    J Immunol Methods 360:167-72. 2010
    ..Therefore, transient changes in the regional lymphatic architecture and function that occur with progressive disease, can be imaged using NIR fluorescence, and may provide a new method to stage disease...
  6. ncbi request reprint Comparison of visible and near-infrared wavelength-excitable fluorescent dyes for molecular imaging of cancer
    Kristen E Adams
    Baylor College of Medicine, Department of Radiology, One Baylor Plaza, MS 360, Houston, Texas 77030, USA
    J Biomed Opt 12:024017. 2007
    ..5. Immunohistochemistry shows that EGF causes activation of the EGFr signaling pathway, suggesting that prior to use as a targeting, diagnostic agent, potential deleterious effects should be considered...
  7. pmc Lymphatic abnormalities are associated with RASA1 gene mutations in mouse and man
    Patricia E Burrows
    Department of Diagnostic and Interventional Imaging, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 110:8621-6. 2013
    ....
  8. ncbi request reprint A new optical and nuclear dual-labeled imaging agent targeting interleukin 11 receptor alpha-chain
    Wei Wang
    Department of Radiology, Division of Molecular Imaging, Baylor College of Medicine, Houston, Texas 77030, USA
    Bioconjug Chem 18:397-402. 2007
    ..The cross validation and direct comparison of optical and nuclear imaging of a tumor was achieved using a single injection, and the preliminary results show the conjugate has tumor targeting capabilities in vivo...
  9. pmc In vivo fluorescent optical imaging of cytotoxic T lymphocyte migration using IRDye800CW near-infrared dye
    Aaron E Foster
    Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children s Hospital, 1102 Bates Street, Houston, Texas 77030, USA
    Appl Opt 47:5944-52. 2008
    ..Together, these data suggest that IRDye800CW may be used to study the trafficking of T cells in a small animal model and may have potential as a short-term reporter molecule for human immunotherapy studies...
  10. pmc Altered lymphatic function and architecture in salt-induced hypertension assessed by near-infrared fluorescence imaging
    Sunkuk Kwon
    University of Texas Health Science Center, Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, Houston, TX 77030, USA
    J Biomed Opt 17:080504-1. 2012
    ..Lymphatic contractile function and vessel remodeling occurs in response to salt-induced hypertension suggesting a possible role for the lymphatics in the regulation of vascular blood pressure...
  11. pmc Direct visualization of changes of lymphatic function and drainage pathways in lymph node metastasis of B16F10 melanoma using near-infrared fluorescence imaging
    Sunkuk Kwon
    Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, TX 77030, USA
    Biomed Opt Express 4:967-77. 2013
    ..In addition, this novel technique can be used as a diagnostic method to non-invasively assess lymphatic response as mechanism of therapeutic action...
  12. doi request reprint Assessment of free dye in solutions of dual-labeled antibody conjugates for in vivo molecular imaging
    Melissa B Aldrich
    Division of Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Sciences Center Houston, Houston, TX, USA
    Mol Imaging Biol 13:32-42. 2011
    ..A method for quantifying free dye molecules in antibody conjugate preparations is required for agent batch release and for translation into the clinic...
  13. pmc Human Lymphatic Architecture and Dynamic Transport Imaged Using Near-infrared Fluorescence
    John C Rasmussen
    Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine at the University of Texas Health Science Center at Houston, Houston, TX, USA
    Transl Oncol 3:362-72. 2010
    ....
  14. pmc The role of lymphatics in cancer as assessed by near-infrared fluorescence imaging
    John C Rasmussen
    Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, TX 77030, USA
    Ann Biomed Eng 40:408-21. 2012
    ..We then present recent NIRF lymphatic imaging for non-invasive assessment of lymphatics both in preclinical melanoma models and in human subjects with melanoma...
  15. pmc Characterization of chemical, radiochemical and optical properties of a dual-labeled MMP-9 targeting peptide
    Ali Azhdarinia
    Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, TX 77030, USA
    Bioorg Med Chem 19:3769-76. 2011
    ..This attests to the feasibility of using (68)Ga/NIR for dual-labeling of other peptides or small molecules for multimodality molecular imaging...
  16. pmc Detection of Cancer Metastases with a Dual-labeled Near-Infrared/Positron Emission Tomography Imaging Agent
    Lakshmi Sampath
    Center for Molecular Imaging, Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX, USA
    Transl Oncol 3:307-217. 2010
    ....
  17. pmc Mouse phenotyping with near-infrared fluorescence lymphatic imaging
    Sunkuk Kwon
    Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX 77584, USA
    Biomed Opt Express 2:1403-11. 2011
    ..NIR fluorescence imaging provides a method for quantifying lymphatic function for future studies designed to discern differences in lymphatic function in murine models of human lymphatic disease...
  18. pmc Virus-like particle (VLP) lymphatic trafficking and immune response generation after immunization by different routes
    Rafael Cubas
    Division of Vascular Surgery and Endovascular Therapy, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Frensley Center for Imaging Research, Houston, TX 77030, USA
    J Immunother 32:118-28. 2009
    ..Intradermal immunization showed improved responses and might be a preferable delivery route to use for viral and cancer immunotherapeutic studies involving VLPs...
  19. ncbi request reprint Quantitative imaging of lymph function
    Ruchi Sharma
    Division of Molecular Imaging, Department of Radiology, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Physiol Heart Circ Physiol 292:H3109-18. 2007
    ..Our results suggest that microgram quantities of NIR optical imaging agents and their conjugates have a potential to image lymph function in patients suffering from lymph-related disorders...
  20. ncbi request reprint Imaging dose-dependent pharmacokinetics of an RGD-fluorescent dye conjugate targeted to alpha v beta 3 receptor expressed in Kaposi's sarcoma
    Sunkuk Kwon
    Texas A and M University, TX 77842 3012, USA
    Mol Imaging 4:75-87. 2005
    ..5 nmol/mouse, the uptake no longer increased with dose, suggesting integrin receptor saturation. In normal tissues, the PK uptake parameters were not influenced by Cy5.5-c(KRGDf) dose nor by the preadministration of c(KRGDf)...