Therese A Kosten

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. ncbi request reprint BDNF levels and genotype are associated with antipsychotic-induced weight gain in patients with chronic schizophrenia
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Neuropsychopharmacology 33:2200-5. 2008
  2. doi request reprint Sex and litter effects on anxiety and DNA methylation levels of stress and neurotrophin genes in adolescent rats
    Therese A Kosten
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030 Michael E DeBakey Veteran s Affairs Medical Center, 2002 Holcombe Blvd, Houston, TX 77030
    Dev Psychobiol 56:392-406. 2014
  3. doi request reprint Predicting extinction and reinstatement of alcohol and sucrose self-administration in outbred rats
    Therese A Kosten
    Menninger Department of Psychiatry and BehavioralSciences, Baylor College of Medicine and Michael E DeBakey VeteransAffairs Medical Center, Houston, Texas 77030, USA
    Exp Clin Psychopharmacol 21:245-51. 2013
  4. pmc A morphine conjugate vaccine attenuates the behavioral effects of morphine in rats
    Therese A Kosten
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, United States
    Prog Neuropsychopharmacol Biol Psychiatry 45:223-9. 2013
  5. pmc Early life manipulations alter learning and memory in rats
    Therese A Kosten
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Neurosci Biobehav Rev 36:1985-2006. 2012
  6. ncbi request reprint Strain differences in maintenance of cocaine self-administration and their relationship to novelty activity responses
    Therese A Kosten
    Michael E DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA
    Behav Neurosci 121:380-8. 2007
  7. ncbi request reprint Neonatal handling alters learning in adult male and female rats in a task-specific manner
    Therese A Kosten
    Menninger Department of Psychiatry, Baylor College of Medicine and the Michael E DeBakey VA Medical Center, Houston, TX 77030, USA
    Brain Res 1154:144-53. 2007
  8. ncbi request reprint Memory impairments and hippocampal modifications in adult rats with neonatal isolation stress experience
    Therese A Kosten
    Menninger Department of Psychiatry, Baylor College of Medicine and the Michael E DeBakey VA Medical Center, Research Service Line 151, 2002 Holcombe Blvd, Houston, TX 77030, USA
    Neurobiol Learn Mem 88:167-76. 2007
  9. pmc Pharmacologically targeting the P2rx4 gene on maintenance and reinstatement of alcohol self-administration in rats
    Therese A Kosten
    Baylor College of Medicine, Michael E DeBakey Veterans Administration Medical Center, Houston, TX 77030, United States
    Pharmacol Biochem Behav 98:533-8. 2011
  10. pmc Immediate and enduring effects of neonatal isolation on maternal behavior in rats
    Therese A Kosten
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, United States
    Int J Dev Neurosci 28:53-61. 2010

Collaborators

Detail Information

Publications69

  1. ncbi request reprint BDNF levels and genotype are associated with antipsychotic-induced weight gain in patients with chronic schizophrenia
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Neuropsychopharmacology 33:2200-5. 2008
    ..Our results suggest that variation in the BDNF gene may be a risk factor for weight gain in male patients with schizophrenia on long-term antipsychotic treatment, and decreased BDNF levels may be associated with weight gain in females...
  2. doi request reprint Sex and litter effects on anxiety and DNA methylation levels of stress and neurotrophin genes in adolescent rats
    Therese A Kosten
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030 Michael E DeBakey Veteran s Affairs Medical Center, 2002 Holcombe Blvd, Houston, TX 77030
    Dev Psychobiol 56:392-406. 2014
    ..Few differences were seen for Bdnf. LGC modified some sex differences in behavior. © 2013 Wiley Periodicals, Inc. © 2013 Wiley Periodicals, Inc. Dev Psychobiol 56: 392-406, 2014. ..
  3. doi request reprint Predicting extinction and reinstatement of alcohol and sucrose self-administration in outbred rats
    Therese A Kosten
    Menninger Department of Psychiatry and BehavioralSciences, Baylor College of Medicine and Michael E DeBakey VeteransAffairs Medical Center, Houston, Texas 77030, USA
    Exp Clin Psychopharmacol 21:245-51. 2013
    ..Results from this exploratory study provide clues for future experimental studies...
  4. pmc A morphine conjugate vaccine attenuates the behavioral effects of morphine in rats
    Therese A Kosten
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, United States
    Prog Neuropsychopharmacol Biol Psychiatry 45:223-9. 2013
    ..This suggests that morphine entry into the brain was reduced or slowed. These results provide support for KLH-6-SM as a candidate vaccine for opioid dependence...
  5. pmc Early life manipulations alter learning and memory in rats
    Therese A Kosten
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Neurosci Biobehav Rev 36:1985-2006. 2012
    ..Thus, the relationship between early life experiences and adulthood learning and memory performance is multifaceted and decidedly task-dependent...
  6. ncbi request reprint Strain differences in maintenance of cocaine self-administration and their relationship to novelty activity responses
    Therese A Kosten
    Michael E DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA
    Behav Neurosci 121:380-8. 2007
    ..Maintenance studies of cocaine self-administration rather than acquisition may better reflect vulnerability to addiction...
  7. ncbi request reprint Neonatal handling alters learning in adult male and female rats in a task-specific manner
    Therese A Kosten
    Menninger Department of Psychiatry, Baylor College of Medicine and the Michael E DeBakey VA Medical Center, Houston, TX 77030, USA
    Brain Res 1154:144-53. 2007
    ..These data suggest that neonatal handling alters learning and memory in a task-specific manner that may reflect alterations in emotional reactivity or differential effects of the manipulation on unknown neurohormonal mechanisms...
  8. ncbi request reprint Memory impairments and hippocampal modifications in adult rats with neonatal isolation stress experience
    Therese A Kosten
    Menninger Department of Psychiatry, Baylor College of Medicine and the Michael E DeBakey VA Medical Center, Research Service Line 151, 2002 Holcombe Blvd, Houston, TX 77030, USA
    Neurobiol Learn Mem 88:167-76. 2007
    ....
  9. pmc Pharmacologically targeting the P2rx4 gene on maintenance and reinstatement of alcohol self-administration in rats
    Therese A Kosten
    Baylor College of Medicine, Michael E DeBakey Veterans Administration Medical Center, Houston, TX 77030, United States
    Pharmacol Biochem Behav 98:533-8. 2011
    ..Caution is warranted due to modest specificity on behavior reinforced by alcohol, some reduction in general activity levels, and the lack of dose-response effects...
  10. pmc Immediate and enduring effects of neonatal isolation on maternal behavior in rats
    Therese A Kosten
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, United States
    Int J Dev Neurosci 28:53-61. 2010
    ..Neonatal isolation alters maternal behavior that, in turn, may shape neurobehavioral responses of offspring including effects on maternal care. Such changes may reflect epigenetic effects resulting from changes in maternal behavior...
  11. doi request reprint Sex differences in non-reinforced responding for cocaine
    Therese A Kosten
    Menninger Department of Psychiatry, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Drug Alcohol Abuse 34:473-88. 2008
    ..In contrast, responding for cocaine in males appears driven by drug delivery...
  12. doi request reprint Brain-derived neurotrophic factor levels and its Val66Met gene polymorphism predict tardive dyskinesia treatment response to Ginkgo biloba
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas, USA
    Biol Psychiatry 72:700-6. 2012
    ..We hypothesized that treatment with EGb-761 would increase serum BDNF levels and reduce TD, particularly among schizophrenia patients who have the BDNF valine 66 to methionine (Val66Met) genotype (Val/Val)...
  13. pmc BDNF Val66Met variant and smoking in a Chinese population
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 7:e53295. 2012
    ..However, the findings must be interpreted with caution because of the relatively small sample size for an association study. Results should be confirmed in a larger cohort...
  14. doi request reprint Gender differences in never-medicated first-episode schizophrenia and medicated chronic schizophrenia patients
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texasm, USA
    J Clin Psychiatry 73:1025-33. 2012
    ..The aims of this study were to compare gender differences in clinical features and cognitive functioning in first-episode and chronic schizophrenia among Han Chinese inpatients...
  15. doi request reprint Thioredoxin, a novel oxidative stress marker and cognitive performance in chronic and medicated schizophrenia versus healthy controls
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA
    Schizophr Res 143:301-6. 2013
    ..The differential association of TRX and cognitive performance in schizophrenia and controls may be related to the impaired oxidative stress status of schizophrenia patients...
  16. doi request reprint Low BDNF is associated with cognitive impairment in chronic patients with schizophrenia
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA
    Psychopharmacology (Berl) 222:277-84. 2012
    ..Schizophrenia has a range of cognitive deficits that may evolve from decreased BDNF, and this study examines this association of BDNF with cognitive deficits in schizophrenia...
  17. ncbi request reprint Disrupted antioxidant enzyme activity and elevated lipid peroxidation products in schizophrenic patients with tardive dyskinesia
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Tex, USA
    J Clin Psychiatry 68:754-60. 2007
    ..However, the relationship between antioxidant enzymes, lipid peroxidation products, and the severity of TD symptoms has not been determined within a single patient group...
  18. doi request reprint Gender differences in the prevalence, risk and clinical correlates of tardive dyskinesia in Chinese schizophrenia
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Psychopharmacology (Berl) 205:647-54. 2009
    ..This study examined gender-specific relationships between TD and symptom levels in schizophrenia among Han Chinese, which have previously received little systematic study...
  19. doi request reprint Lower serum cytokine levels in smokers than nonsmokers with chronic schizophrenia on long-term treatment with antipsychotics
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, VA Medical Center, Houston, TX 77030, USA
    Psychopharmacology (Berl) 201:383-9. 2008
    ..The purpose of this study was to determine any differences in cytokine profiles in smokers and nonsmokers with schizophrenia and whether there were any relationships among altered cytokine profiles and psychopathological symptoms...
  20. doi request reprint The novel oxidative stress marker thioredoxin is increased in first-episode schizophrenic patients
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Schizophr Res 113:151-7. 2009
    ..Lower TRX levels in chronic patients treated with antipsychotics may have implications for treatment outcome...
  21. doi request reprint Superoxide dismutase and cytokines in chronic patients with schizophrenia: association with psychopathology and response to antipsychotics
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Psychopharmacology (Berl) 204:177-84. 2009
    ..These abnormalities may improve during antipsychotic drug treatment that reduces symptoms in schizophrenic patients...
  22. doi request reprint Increased S100B serum levels in schizophrenic patients with tardive dyskinesia: association with dyskinetic movements
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas, USA
    J Psychiatr Res 44:429-33. 2010
    ..Serum S100B levels were positively correlated with AIMS scores in patients with TD. These data suggest that increased S100B levels may be related to neuro-degeneration, associated with TD pathophysiology...
  23. doi request reprint Plasma total antioxidant status and cognitive impairments in schizophrenia
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA
    Schizophr Res 139:66-72. 2012
    ..Our findings suggest that oxidative stress may be involved in the pathophysiology of schizophrenia, and its associated cognitive impairment...
  24. doi request reprint Short-term tropisetron treatment and cognitive and P50 auditory gating deficits in schizophrenia
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, USA
    Am J Psychiatry 169:974-81. 2012
    ..The authors examined multiple dosages of tropisetron, a partial agonist at the nAChR, for short-term effects on cognition and P50 deficits in schizophrenia...
  25. doi request reprint Smoking and tardive dyskinesia in male patients with chronic schizophrenia
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA
    Prog Neuropsychopharmacol Biol Psychiatry 35:1765-9. 2011
    ..Thus, smoking was not associated with TD in male Chinese schizophrenics, but consistent with previous reports, older patients with a longer duration of illness and more hospitalizations showed greater severity of TD...
  26. pmc A vaccine against methamphetamine attenuates its behavioral effects in mice
    Xiaoyun Y Shen
    Immunology Allergy and Rheumatology, Department of Medicine, The Michael E Debakey Veteran s Medical Affairs Center, Houston, TX 77030, United States
    Drug Alcohol Depend 129:41-8. 2013
    ..We tested whether a conjugate vaccine against MA (succinyl-methamphetamine-keyhole limpet hemocyanin carrier protein; SMA-KLH) would generate MA antibodies and alter MA-induced behaviors...
  27. pmc Cigarette smoking in male patients with chronic schizophrenia in a Chinese population: prevalence and relationship to clinical phenotypes
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 7:e30937. 2012
    ..Further, smokers with schizophrenia may display fewer negative symptoms and possibly less parkinsonism than non-smokers with schizophrenia...
  28. ncbi request reprint Nicotine dependence, symptoms and oxidative stress in male patients with schizophrenia
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, 2002 Holcombe Boulevard, Houston, TX 77030, USA
    Neuropsychopharmacology 32:2020-4. 2007
    ....
  29. pmc Cognitive and serum BDNF correlates of BDNF Val66Met gene polymorphism in patients with schizophrenia and normal controls
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA
    Hum Genet 131:1187-95. 2012
    ..The association between decreased BDNF serum levels and cognitive impairment in schizophrenia is dependent on the BDNF Val66Met polymorphism...
  30. doi request reprint Increased serum S100B in never-medicated and medicated schizophrenic patients
    Xiang Yang Zhang
    Institute of Psychology, Chinese Academy of Sciences, Beijing, PR China
    J Psychiatr Res 44:1236-40. 2010
    ..The lower S100B levels in chronic than early-stage patients further suggest that antipsychotic treatment may reduce this neurodegeneration...
  31. doi request reprint Association of functional dopamine-beta-hydroxylase (DBH) 19 bp insertion/deletion polymorphism with smoking severity in male schizophrenic smokers
    Xiang Yang Zhang
    Institute of Psychology, Chinese Academy of Sciences, Beijing, PR China
    Schizophr Res 141:48-53. 2012
    ..These results suggest that the DBH 5'-Ins/Del polymorphism may influence smoking severity among schizophrenic smokers...
  32. pmc Pharmacogenetic treatments for drug addiction: cocaine, amphetamine and methamphetamine
    Colin N Haile
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, and Michael E DeBakey VA Medical Center, Houston, Texas 77030, USA
    Am J Drug Alcohol Abuse 35:161-77. 2009
    ..Pharmacogenetics uses genetic variation to predict individual differences in response to medications and holds much promise to improve treatment of addictive disorders...
  33. pmc Hippocampal GluR1 associates with behavior in the elevated plus maze and shows sex differences
    Xiaojun Xiang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Behav Brain Res 222:326-31. 2011
    ..These data not only suggest some potential bases for sex differences in behaviors to which the hippocampus contributes but demonstrate that there is a strong association between hippocampal GluR1 levels and anxiety as assessed with EPM...
  34. pmc Dose-dependent changes in the locomotor responses to methamphetamine in BALB/c mice: low doses induce hypolocomotion
    Rana A K Singh
    Veterans Affairs Medical Center, Houston, TX, USA
    Pharmacol Biochem Behav 103:230-6. 2012
    ..These results show that low and high doses of meth can have opposing effects on locomotor activity. Further, prior exposure to the drug leads to tolerance, rather than sensitization, of the hypolocomotor response to low meth doses...
  35. doi request reprint Effects of risperidone and haloperidol on superoxide dismutase and nitric oxide in schizophrenia
    Xiang Yang Zhang
    Institute of Mental Health, Peking University, Beijing, PR China
    Neuropharmacology 62:1928-34. 2012
    ....
  36. doi request reprint Nicotine dependence and serum BDNF levels in male patients with schizophrenia
    Xiang Yang Zhang
    Center for Biological Psychiatry, Beijing Huilongguan Hospital, Beijing, 100096, China
    Psychopharmacology (Berl) 212:301-7. 2010
    ..The purposes of this study were to compare BDNF levels in smokers to nonsmokers with schizophrenia and examine the association between BDNF levels and psychopathological symptoms...
  37. doi request reprint Cognitive Function, Plasma MnSOD Activity, and MnSOD Ala-9Val Polymorphism in Patients With Schizophrenia and Normal Controls
    Xiang Y Zhang
    To whom correspondence should be addressed Research Building 109, Room 130, 2002 Holcombe Boulevard, Houston, TX 77030, US tel 713 791 1414, fax 713 794 7938, E mail
    Schizophr Bull 40:592-601. 2014
    ..The association between higher MnSOD activity and cognitive impairment in schizophrenia is dependent on the MnSOD Ala-9Val polymorphism. ..
  38. doi request reprint Pharmacogenetic treatments for drug addiction: alcohol and opiates
    Colin N Haile
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Drug Alcohol Abuse 34:355-81. 2008
    ..This review aims to cover these developments in the pharmacotherapy of alcohol and opiates, two addictive drugs for which we have the majority of our FDA approved pharmacotherapies...
  39. ncbi request reprint Repeated unpredictable stress and antidepressants differentially regulate expression of the bcl-2 family of apoptotic genes in rat cortical, hippocampal, and limbic brain structures
    Therese A Kosten
    Department of Psychiatry, Menninger Department of Psychiatry, Baylor College of Medicine and Michael E DeBakey Veterans Affairs, Houston, TX, USA
    Neuropsychopharmacology 33:1545-58. 2008
    ....
  40. ncbi request reprint Serum BDNF levels and weight gain in schizophrenic patients on long-term treatment with antipsychotics
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, VA Medical Center, Houston, TX 77030, USA
    J Psychiatr Res 41:997-1004. 2007
    ..Antipsychotic class exerted differential effects over BDNF levels and BMI gain. Our findings suggest that decreased BDNF levels may be associated with weight gain in female schizophrenic patients on long-term antipsychotic treatment...
  41. pmc Litter gender composition and sex affect maternal behavior and DNA methylation levels of the oprm1 gene in rat offspring
    Yanli Hao
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine Houston, TX, USA
    Front Psychiatry 2:21. 2011
    ....
  42. ncbi request reprint Genetics of dopamine and its contribution to cocaine addiction
    Colin N Haile
    Michael E DeBakey VA Medical Center, and Meninger Department of Psychiatry, Baylor College of Medicine, Houston, TX 77030, USA
    Behav Genet 37:119-45. 2007
    ..Pharmacotherapies may have increased efficacy when targeted to individuals possessing specific genetic polymophisms in dopamine's metabolic and intracellular messenger systems...
  43. ncbi request reprint Sex-selective effects of neonatal isolation on fear conditioning and foot shock sensitivity
    Therese A Kosten
    Yale University, New Haven, CT 06516, USA
    Behav Brain Res 157:235-44. 2005
    ..The sex-specific effect of ISO on context fear may reflect neuronal reorganization in stress responsive areas and/or sex differences in some unconditioned responses...
  44. ncbi request reprint Association of clozapine-induced weight gain with a polymorphism in the leptin promoter region in patients with chronic schizophrenia in a Chinese population
    Xiang Yang Zhang
    Institute of Mental Health, Peking University, People s Republic of China
    J Clin Psychopharmacol 27:246-51. 2007
    ..004, r(2) = 0.16), but not in female patients (P > 0.05). Thus, variation in the leptin gene may be a risk factor for weight gain in male patients with schizophrenia on long-term clozapine treatment...
  45. ncbi request reprint Heightened cocaine and food self-administration in female rats with neonatal isolation experience
    Therese A Kosten
    Division of Substance Abuse, Yale University School of Medicine, VA CT Hospital System, West Haven, CT, USA
    Neuropsychopharmacology 31:70-6. 2006
    ..Neuropsychopharmacology (2006) 31, 70-76. doi:10.1038/sj.npp.1300779; published online 1 June 2005...
  46. ncbi request reprint Neonatal isolation alters the estrous cycle interactions on the acute behavioral effects of cocaine
    Therese A Kosten
    Division of Substance Abuse, Yale University School of Medicine, VA CT Hospital System, West Haven, CT 06516, USA
    Psychoneuroendocrinology 30:753-61. 2005
    ..Neonatal isolation eliminates these effects perhaps reflecting alterations in accumbens monoamine levels or the effects of estrogen on this system...
  47. ncbi request reprint Prazosin, an alpha-1 adrenergic antagonist, reduces cocaine-induced reinstatement of drug-seeking
    Xiang Yang Zhang
    Division of Substance Abuse, Yale University School of Medicine, West Haven, Connecticut 06516, USA
    Biol Psychiatry 57:1202-4. 2005
    ..Norepinephrine is implicated in cocaine's behavioral effects. In this study, we tested the effect of prazosin, an alpha1-adrenergic receptor antagonist, on cocaine-induced reinstatement of drug-seeking behavior...
  48. ncbi request reprint Neurochemical and behavioral responses to cocaine in adult male rats with neonatal isolation experience
    Therese A Kosten
    Division of Substance Abuse, Yale University School of Medicine, VA Connecticut Hospital System, 950 Campbell Avenue, Bldg 5, 3rd Floor, West Haven, CT 06516, USA
    J Pharmacol Exp Ther 314:661-7. 2005
    ..Moreover, that ISO rats are more sensitive to a D(2) antagonist may reflect decreased levels of this receptor type as we showed previously in infant rats...
  49. ncbi request reprint Infant rats with chronic neonatal isolation experience show decreased extracellular serotonin levels in ventral striatum at baseline and in response to cocaine
    Therese A Kosten
    Yale University School of Medicine, Ribicoff Research Facilities, Room S 305 CMHC, 34 Park Street, New Haven, CT 06508, USA
    Brain Res Dev Brain Res 152:19-24. 2004
    ....
  50. ncbi request reprint Neonatal isolation enhances maintenance but not reinstatement of cocaine self-administration in adult male rats
    Xiang Yang Zhang
    Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA
    Psychopharmacology (Berl) 177:391-9. 2005
    ..Previously, we demonstrated that neonatal isolation increases acquisition of cocaine self-administration in adult male rats...
  51. ncbi request reprint Neonatal isolation enhances acquisition of cocaine self-administration and food responding in female rats
    Therese A Kosten
    Department of Psychiatry, Yale University School of Medicine, Room S 305 CMHC, 34 Park Street, New Haven, CT 06508, USA
    Behav Brain Res 151:137-49. 2004
    ..These data confirm and extend our previous findings demonstrating the enduring effects of ISO on adult self-administration behavior and emphasize the importance of measuring behavioral patterns versus intake in acquisition studies...
  52. ncbi request reprint Disulfiram facilitates the development and expression of locomotor sensitization to cocaine in rats
    Colin N Haile
    Department of Neurosurgery, Thomas Jefferson Medical College, Philadelphia, Pennsylvania, USA
    Biol Psychiatry 54:915-21. 2003
    ..Yet few preclinical studies have been performed. This study establishes the effects of DS on locomotor sensitization to cocaine in rats...
  53. ncbi request reprint Strain differences in response to escapable and inescapable novel environments and their ability to predict amphetamine-induced locomotor activity
    Mindy J D Miserendino
    Sacred Heart University, Fairfield, Conn, USA
    Psychopharmacology (Berl) 167:281-90. 2003
    ..Among Lewis and Fischer 344 (F344) inbred rats this association is less clear, perhaps due to strain-selective differences in responses to novelty...
  54. ncbi request reprint Chronic neonatal isolation stress enhances cocaine-induced increases in ventral striatal dopamine levels in rat pups
    Therese A Kosten
    Department of Psychiatry, Yale University School of Medicine, Room S 305 CMHC, 34 Park Street, New Haven, CT 06508, USA
    Brain Res Dev Brain Res 141:109-16. 2003
    ....
  55. ncbi request reprint Cocaine self-administration and locomotor activity are altered in Lewis and F344 inbred rats by RTI 336, a 3-phenyltropane analog that binds to the dopamine transporter
    Colin N Haile
    Department of Psychiatry, Division of Substance Abuse, Yale University School of Medicine, VA CT Hospital System, 950 Campbell Avenue, Building 5 3rd Floor, West Haven CT 06516, USA
    Brain Res 1055:186-95. 2005
    ..Results show that a DAT inhibitor alters cocaine-induced behaviors in a strain-dependent manner. These effects may relate to inherent differences in NAc DAT levels between Lewis and F344 rats...
  56. ncbi request reprint HPA axis function and drug addictive behaviors: insights from studies with Lewis and Fischer 344 inbred rats
    Therese A Kosten
    Yale University School of Medicine, New Haven, CT, USA
    Psychoneuroendocrinology 27:35-69. 2002
    ..g., high and low responders) suggests that a non-monotonic relationship between behavioral sensitivity to drugs and HPA axis responsiveness can explain much of the discrepancies in the literature...
  57. doi request reprint Association between interleukin-6 receptor polymorphism and patients with schizophrenia
    Shilong Sun
    Schizophr Res 102:346-7. 2008
  58. ncbi request reprint Brain-derived neurotrophic factor polymorphisms and smoking in schizophrenia
    Zhi Ren Wang
    Schizophr Res 97:299-301. 2007
  59. ncbi request reprint Lack of association between the BDNF C270T polymorphism and schizophrenia in a Chinese Han population
    Wenjun Li
    Schizophr Res 97:297-8. 2007
  60. ncbi request reprint Association of functional catechol O-methyl transferase (COMT) Val108Met polymorphism with smoking severity and age of smoking initiation in Chinese male smokers
    Song Guo
    Institute of Mental Health, Peking University, Beijing, 100083, China
    Psychopharmacology (Berl) 190:449-56. 2007
    ..Recent evidence also suggests that a COMT polymorphism may be especially important in determining an individual's predisposition to developing nicotine dependence...
  61. ncbi request reprint Previous exposure to cocaine enhances cocaine self-administration in an alpha 1-adrenergic receptor dependent manner
    Xiang Yang Zhang
    Division of Substance Abuse, Yale University School of Medicine, VA CT Hospital System, West Haven, CT 06516, USA
    Neuropsychopharmacology 32:638-45. 2007
    ..These data, along with several recent studies, show further support for the contribution of noradrenergic transmission in the behavioral effects of cocaine...
  62. ncbi request reprint Early life stress impairs fear conditioning in adult male and female rats
    Therese A Kosten
    Department of Psychiatry, Yale University School of Medicine, VA CT Hospital System, 950 Campbell Ave, Building 5, 3rd Floor, West Haven, CT 06516, USA
    Brain Res 1087:142-50. 2006
    ..These opposing effects may reflect developmental differences on stress-induced alterations on hippocampal regulation of the hypothalamic-pituitary-adrenal axis...
  63. ncbi request reprint Neonatal isolation alters estrous cycle effects on ventral striatal extracellular monoamine levels
    Xiang Yang Zhang
    Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
    Prog Neuropsychopharmacol Biol Psychiatry 30:504-11. 2006
    ..Because 5-HT modulates DA and levels of both transmitters are increased by cocaine, this neurochemical effect of ISO may contribute to the ability of ISO to alter the behavioral responses to cocaine as we showed previously...
  64. ncbi request reprint Neonatal isolation is a relevant model for studying the contributions of early life stress to vulnerability to drug abuse: response to Marmendal et al. (2004)
    Therese A Kosten
    Dev Psychobiol 47:108-10. 2005
  65. ncbi request reprint Stress effects in the hippocampus: synaptic plasticity and memory
    Jeansok J Kim
    Department of Psychology, University of Washington, Seattle, WA 98195 1520, USA
    Stress 9:1-11. 2006
    ..This review focuses on endocrine-system-level mechanisms of stress effects in the hippocampus, and how stress, by altering the property of hippocampal plasticity, can subsequently influence hippocampal memory...
  66. doi request reprint The CCR5 32-bp deletion allele is rare in a Chinese population
    Fan Wang
    Schizophr Res 101:341-3. 2008
  67. doi request reprint Association between interleukin-3 receptor alpha polymorphism and schizophrenia in the Chinese population
    Shilong Sun
    Research Center for Neuroscience and MH Radiobiology Research Unit, Jilin University, Changchun, PR China
    Neurosci Lett 440:35-7. 2008
    ..07-1.71; Genotype, chi2=6.85, d.f.=2, p=0.033). Our results indicate a small but significant contribution of the IL3RA polymorphism to susceptibility to schizophrenia, suggesting that the IL3 pathway may be involved in schizophrenia...
  68. ncbi request reprint The potential of dopamine agonists in drug addiction
    Thomas R Kosten
    Yale University School of Medicine, VA Connecticut Healthcare System, Department of Psychiatry, West Haven, CT 06516, USA
    Expert Opin Investig Drugs 11:491-9. 2002
    ..Animal studies also suggest that tailoring treatment to subgroups of patients based on genotype may improve responses...
  69. ncbi request reprint Dual modulation of endocannabinoid transport and fatty acid amide hydrolase protects against excitotoxicity
    David A Karanian
    Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut 06269, USA
    J Neurosci 25:7813-20. 2005
    ..The transporter and FAAH are modulatory sites that may be exploited to enhance cannabinergic signaling for therapeutic purposes...