Research TopicsSpecies | THERESA KOEHLERSummaryAffiliation: Baylor College of Medicine Country: USA Publications
Research Grants
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Publications
Bacillus anthracis physiology and geneticsTheresa M Koehler
Department of Microbiology and Molecular Genetics, The University of Texas, Houston Health Science Center, Houston, TX, United States
Mol Aspects Med 30:386-96. 2009..cereus group. The developmental nature of B. anthracis and its pathogenic (mammalian host) and environmental (soil) lifestyles of make it an interesting model for study of niche-specific bacterial gene expression and physiology...- Control of anthrax toxin gene expression by the transition state regulator abrBElke Saile
Department of Microbiology and Molecular Genetics, The University of Texas-Houston Health Science Center Medical School, Houston, Texas 77030, USA
J Bacteriol 184:370-80. 2002..subtilis, the B. anthracis abrB gene is negatively regulated by spo0A. Our findings tie anthrax toxin gene expression to the complex network of postexponential phase adaptive responses that have been well studied in B. subtilis... 
Intrinsic curvature associated with the coordinately regulated anthrax toxin gene promotersMaria Hadjifrangiskou
Department of Microbiology and Molecular Genetics, University of Texas Houston Health Science Center, 6431 Fannin Street, Houston, TX 77030, USA
Microbiology 154:2501-12. 2008..These findings suggest that the structural topology of the DNA plays an important role in the control of anthrax toxin gene expression...- Beta-lactamase gene expression in a penicillin-resistant Bacillus anthracis strainYahua Chen
Department of Microbiology and Molecular Genetics, University of Texas Houston Medical School, Houston, Texas 77030, USA
Antimicrob Agents Chemother 48:4873-7. 2004..In a penicillin-resistant clinical isolate, both genes are highly transcribed, but bla1 is the major contributor to high-level resistance to ampicillin. Differential expression of the bla genes is dependent upon strain background... - Capsule synthesis by Bacillus anthracis is required for dissemination in murine inhalation anthraxMelissa Drysdale
Department of Microbiology and Molecular Genetics, The University of Texas Houston Health Science Center, Houston, TX 77030, USA
EMBO J 24:221-7. 2005.... - An extracytoplasmic function sigma factor controls beta-lactamase gene expression in Bacillus anthracis and other Bacillus cereus group speciesCana L Ross
Department of Microbiology and Molecular Genetics, University of Texas Houston Medical School, Houston, Texas 77030, USA
J Bacteriol 191:6683-93. 2009..anthracis contains the genes necessary for sensing beta-lactam antibiotics, the B. anthracis sigP and rsiP gene products are not sufficient for bla induction... - Bacillus anthracis multiplication, persistence, and genetic exchange in the rhizosphere of grass plantsElke Saile
Department of Microbiology and Molecular Genetics, University of Texas-Houston Medical School, 6431 Fannin St, JFB 1.765, Houston, TX 77030, USA
Appl Environ Microbiol 72:3168-74. 2006..anthracis can survive as a saprophyte outside of the host. The data suggest that horizontal gene transfer in the rhizosphere of grass plants may play a role in the evolution of the Bacillus cereus group species... - plcR papR-independent expression of anthrolysin O by Bacillus anthracisCana L Ross
Department of Microbiology and Molecular Genetics, University of Texas Houston Medical School, 6431 Fannin St, JFB 1 765, Houston, TX 77030, USA
J Bacteriol 188:7823-9. 2006..Our data indicate that despite the presence of the transcriptionally active plcR and papR genes in B. anthracis and a PlcR box in the promoter region of the alo gene, alo expression is independent of this control system... - atxA controls Bacillus anthracis capsule synthesis via acpA and a newly discovered regulator, acpBMelissa Drysdale
Department of Microbiology and Molecular Genetics, The University of Texas Houston Health Science Center, Houston, Texas 77030, USA
J Bacteriol 186:307-15. 2004..The data suggest that, in a strain containing both virulence plasmids, atxA is the major regulator of capsule synthesis and controls capBCAD expression indirectly, via positive regulation of acpA and acpB... - Bacillus anthracis sin locus and regulation of secreted proteasesKathryn J Pflughoeft
Department of Microbiology and Molecular Genetics, University of Texas, Houston Health Science Center, 6431 Fannin St, MSB 1 508, Houston, TX 77030, USA
J Bacteriol 193:631-9. 2011..Our data are consistent with a model in which InhA1 protease levels are controlled at the transcriptional level by SinR and at the posttranslational level by camelysin... - Beta-lactamase genes of the penicillin-susceptible Bacillus anthracis Sterne strainYahua Chen
Department of Microbiology and Molecular Genetics, The University of Texas Houston Health Science Center Medical School, 6431 Fannin Street, Houston, TX 77030, USA
J Bacteriol 185:823-30. 2003..anthracis Sterne strain encode functional beta-lactamases of different types, but gene expression is usually not sufficient to confer resistance to beta-lactam agents...
Research Grants
- VIRULENCE GENE EXPRESSION BY BACILLUS ANTHRACISTHERESA KOEHLER; Fiscal Year: 2007..anthracis determinants that impact B. anthracis infection in a mouse model for inhalation anthrax. Such determinants are potential targets for therapeutic intervention and/or possible components for new subunit vaccines. ..
- VIRULENCE GENE EXPRESSION BY BACILLUS ANTHRACISTHERESA KOEHLER; Fiscal Year: 2002..These studies will provide information relevant to the pathogenesis of anthrax disease and increase knowledge concerning host-parasite relationships and signal transduction. ..
- VIRULENCE GENE EXPRESSION BY BACILLUS ANTHRACISTheresa M Koehler; Fiscal Year: 2010..anthracis is an ideal model for multiple features of host-pathogen interactions, environmental signaling in bacteria, and other aspects of bacterial physiology. ..