Richard Kellermayer

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. pmc Prenatal methyl-donor supplementation augments colitis in young adult mice
    Sabina A Mir
    Section of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Baylor College of Medicine, Texas Children s Hospital, Department of Agriculture ARS Children s Nutrition Research Center, Houston, Texas, United States of America
    PLoS ONE 8:e73162. 2013
  2. pmc Human metastable epiallele candidates link to common disorders
    R Alan Harris
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA
    Epigenetics 8:157-63. 2013
  3. pmc Epigenetics and the developmental origins of inflammatory bowel diseases
    Richard Kellermayer
    Department of Pediatrics, Section of Pediatric Gastroenterology, Baylor College of Medicine, Texas Children s Hospital, USDA ARS Children s Nutrition Research Center, Houston, Texas 77030 2399, USA
    Can J Gastroenterol 26:909-15. 2012
  4. pmc Microbiota separation and C-reactive protein elevation in treatment-naïve pediatric granulomatous Crohn disease
    Richard Kellermayer
    Department of Pediatrics, Baylor College of Medicine, USDA ARS Children s Nutrition Research Center, Texas Children s Hospital, Houston, USA
    J Pediatr Gastroenterol Nutr 55:243-50. 2012
  5. pmc Colonic mucosal DNA methylation, immune response, and microbiome patterns in Toll-like receptor 2-knockout mice
    Richard Kellermayer
    Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030 2399, USA
    FASEB J 25:1449-60. 2011
  6. pmc Epigenetic maturation in colonic mucosa continues beyond infancy in mice
    Richard Kellermayer
    Department of Pediatrics, Baylor College of Medicine, USDA ARS Children s Nutrition Research Center, Houston, TX 77030, USA
    Hum Mol Genet 19:2168-76. 2010
  7. pmc Cellulose supplementation early in life ameliorates colitis in adult mice
    Dorottya Nagy-Szakál
    Section of Pediatric Gastroenterology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
    PLoS ONE 8:e56685. 2013
  8. pmc Monotonous diets protect against acute colitis in mice: epidemiologic and therapeutic implications
    Dorottya Nagy-Szakál
    Department of Pediatrics, Baylor College of Medicine, USDA ARS Children s Nutrition Research Center, Texas Children s Hospital, Houston, TX 77030 2399, USA
    J Pediatr Gastroenterol Nutr 56:544-50. 2013
  9. pmc Maternal methyl-donor supplementation induces prolonged murine offspring colitis susceptibility in association with mucosal epigenetic and microbiomic changes
    Tiffany D Schaible
    Department of Pediatrics, Baylor College of Medicine, Texas Children s Hospital, USDA ARS Children s Nutrition Research Center, Houston, TX, USA
    Hum Mol Genet 20:1687-96. 2011
  10. pmc SMAD4 haploinsufficiency associates with augmented colonic inflammation in select humans and mice
    Reka Szigeti
    Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA
    Ann Clin Lab Sci 42:401-8. 2012

Collaborators

Detail Information

Publications22

  1. pmc Prenatal methyl-donor supplementation augments colitis in young adult mice
    Sabina A Mir
    Section of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Baylor College of Medicine, Texas Children s Hospital, Department of Agriculture ARS Children s Nutrition Research Center, Houston, Texas, United States of America
    PLoS ONE 8:e73162. 2013
    ..Our results show that prenatal nutritional programming can modulate the mammalian host to harbor a colitogenic microbiome. These findings may be relevant for the nutritional developmental origins of IBD. ..
  2. pmc Human metastable epiallele candidates link to common disorders
    R Alan Harris
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA
    Epigenetics 8:157-63. 2013
    ..The presented compendium of ME candidates may accelerate our understanding of the epigenetic origins of common human disorders...
  3. pmc Epigenetics and the developmental origins of inflammatory bowel diseases
    Richard Kellermayer
    Department of Pediatrics, Section of Pediatric Gastroenterology, Baylor College of Medicine, Texas Children s Hospital, USDA ARS Children s Nutrition Research Center, Houston, Texas 77030 2399, USA
    Can J Gastroenterol 26:909-15. 2012
    ..The present review focuses on the emerging paradigm shift considering IBD to originate from critical environmental effects during pre- and postnatal development...
  4. pmc Microbiota separation and C-reactive protein elevation in treatment-naïve pediatric granulomatous Crohn disease
    Richard Kellermayer
    Department of Pediatrics, Baylor College of Medicine, USDA ARS Children s Nutrition Research Center, Texas Children s Hospital, Houston, USA
    J Pediatr Gastroenterol Nutr 55:243-50. 2012
    ..The cause of granulomas in CD is unknown and their association with the intestinal microbiota has not been addressed with high-throughput methodologies...
  5. pmc Colonic mucosal DNA methylation, immune response, and microbiome patterns in Toll-like receptor 2-knockout mice
    Richard Kellermayer
    Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030 2399, USA
    FASEB J 25:1449-60. 2011
    ..This manuscript highlights the intimate interrelationships between expression of immune-related genes and immunity pathways in the host with compositional and functional differences of the mammalian microbiome...
  6. pmc Epigenetic maturation in colonic mucosa continues beyond infancy in mice
    Richard Kellermayer
    Department of Pediatrics, Baylor College of Medicine, USDA ARS Children s Nutrition Research Center, Houston, TX 77030, USA
    Hum Mol Genet 19:2168-76. 2010
    ..Transcript Profiling: Gene Expression Omnibus (http://www.ncbi.nlm.nih.gov/geo/), accession numbers: GSE18031 (DNA methylation arrays), GSE19506 (gene expression arrays)...
  7. pmc Cellulose supplementation early in life ameliorates colitis in adult mice
    Dorottya Nagy-Szakál
    Section of Pediatric Gastroenterology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
    PLoS ONE 8:e56685. 2013
    ..These findings emphasize the transient protective effect of dietary cellulose in the mammalian large bowel and highlight the potential role of dietary fibers in amelioration of intestinal inflammation...
  8. pmc Monotonous diets protect against acute colitis in mice: epidemiologic and therapeutic implications
    Dorottya Nagy-Szakál
    Department of Pediatrics, Baylor College of Medicine, USDA ARS Children s Nutrition Research Center, Texas Children s Hospital, Houston, TX 77030 2399, USA
    J Pediatr Gastroenterol Nutr 56:544-50. 2013
    ....
  9. pmc Maternal methyl-donor supplementation induces prolonged murine offspring colitis susceptibility in association with mucosal epigenetic and microbiomic changes
    Tiffany D Schaible
    Department of Pediatrics, Baylor College of Medicine, Texas Children s Hospital, USDA ARS Children s Nutrition Research Center, Houston, TX, USA
    Hum Mol Genet 20:1687-96. 2011
    ..These findings underscore that epigenomic reprogramming relevant to mammalian colitis can occur during early development in response to maternal dietary modifications...
  10. pmc SMAD4 haploinsufficiency associates with augmented colonic inflammation in select humans and mice
    Reka Szigeti
    Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA
    Ann Clin Lab Sci 42:401-8. 2012
    ..These findings may reveal implications not only towards colonic inflammation in the setting of SMAD4 haploinsufficiency, but for colorectal cancer as well...
  11. pmc Genome-wide peripheral blood leukocyte DNA methylation microarrays identified a single association with inflammatory bowel diseases
    R Alan Harris
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    Inflamm Bowel Dis 18:2334-41. 2012
    ..We investigated whether DNA methylation might be connected with IBD in peripheral blood leukocyte (PBL) DNA by utilizing genome-wide microarrays...
  12. pmc Maternal micronutrients can modify colonic mucosal microbiota maturation in murine offspring
    Dorottya Nagy-Szakál
    Section of Pediatric Gastroenterology, Baylor College of Medicine, Texas Children s Hospital, Houston, TX, USA
    Gut Microbes 3:426-33. 2012
    ..Most of these changes were absent or opposite in the maternally supplemented offspring. Nutritionally induced alterations in mucosal microbiota maturation may be contributors to colitis susceptibility in mammals...
  13. pmc Season of conception in rural gambia affects DNA methylation at putative human metastable epialleles
    Robert A Waterland
    Department of Pediatrics, Baylor College of Medicine, USDA ARS Children s Nutrition Research Center, Houston, Texas, United States of America
    PLoS Genet 6:e1001252. 2010
    ..MEs should therefore facilitate an improved understanding of the role of interindividual epigenetic variation in human disease...
  14. ncbi request reprint Further evidence for EpCAM as the gene for congenital tufting enteropathy
    Mamata Sivagnanam
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California San Diego, La Jolla, California, USA
    Am J Med Genet A 152:222-4. 2010
  15. doi request reprint Assessment of DNA methylation at the interferon regulatory factor 5 (IRF5) promoter region in inflammatory bowel diseases
    Alfred Balasa
    Section of Pediatric Gastroenterology, Baylor College of Medicine, Houston, TX 77030 2399, USA
    Int J Colorectal Dis 25:553-6. 2010
    ..Possible CpG site methylation differences in this region between healthy persons and individuals suffering from IBD were also tested...
  16. pmc Clostridium difficile infection in newly diagnosed pediatric inflammatory bowel disease in the mid-southern United States
    Sabina A V Mir
    Section of Pediatric Gastroenterology, Baylor College of Medicine, USDA ARS Children s Nutrition Research Center, Texas Children s Hospital, Houston
    J Pediatr Gastroenterol Nutr 57:487-8. 2013
    ..1%, significantly (P < 0.0001) lower than in Poland, but much higher than in the general population. This work supports the testing for Clostridium difficile in suspected cases of new-onset pediatric IBD...
  17. doi request reprint Duration of disease may predict response to infliximab in pediatric ulcerative colitis
    Sabina A V Mir
    Department of Pediatrics, Section of Pediatric Gastroenterology, Hepatology and Nutrition, USDA ARS Children s Nutrition Research Center, Baylor College of Medicine, Texas Children s Hospital, Houston, TX
    J Clin Gastroenterol 48:248-52. 2014
    ..The purpose of this study was to identify clinical and laboratory parameters, which predict response to IFX in pediatric UC defined by colectomy as the primary outcome measure. Postsurgical complications were examined as well...
  18. pmc The remarkable capacity for gut microbial and host interactions
    Dorottya Nagy-Szakál
    Section of Pediatric Gastroenterology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
    Gut Microbes 2:178-82. 2011
    ..The ultimate challenge for biomedical research in these cases is to find optimal means for the restoration and maintenance of healthy host physiology...
  19. pmc Epigenomic profiling indicates a role for DNA methylation in early postnatal liver development
    Robert A Waterland
    Department of Pediatrics, Baylor College of Medicine, USDA Children s Nutrition Research Center, 1100 Bates St, Ste 5080, Houston, TX 77030, USA
    Hum Mol Genet 18:3026-38. 2009
    ..These in vivo data clearly indicate a role for DNA methylation in mammalian differentiation, and provide the novel insight that critical windows in mammalian developmental epigenetics extend well beyond early embryonic development...
  20. ncbi request reprint Peri-appendiceal inflammation in an 8-year-old child with chronic ulcerative colitis
    Reka Szigeti
    Department of Pathology, Baylor College of Medicine, Houston, Texas, U S A
    Ann Clin Lab Sci 41:288-9. 2011
    ..Here we describe the youngest patient with this manifestation to date and provide a brief review on PARP associated UC...
  21. pmc Steroid responsive eosinophilic gastric outlet obstruction in a child
    Richard Kellermayer
    Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030 2399, USA
    World J Gastroenterol 14:2270-1. 2008
    ..We report a case of eosinophilic gastric outlet obstruction in a child that responded to conservative medical management. A brief review of this clinical entity is also provided...
  22. pmc Transcriptional Read-Through Induction Treatment Trial in Intestinal Failure Induced by an EpCAM Nonsense Mutation
    Mamata Sivagnanam
    Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of California San Diego, La Jolla, Rady Children s Hospital, San Diego, CA 92123, USA
    Case Report Med 2012:173195. 2012
    ..This report highlights the utility of genetic testing not only in respect of diagnostics, prognostics, and family planning, but potential mutation-specific therapeutic considerations as well...