Research Topics
Genomes and Genes
| G KarsentySummaryAffiliation: Baylor College of Medicine Country: USA Publications
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Detail Information
Publications
Reaching a genetic and molecular understanding of skeletal developmentGerard Karsenty
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
Dev Cell 2:389-406. 2002..This review addresses the role of the principal growth factors and transcription factors affecting these different processes and presents, in several cases, the genetic cascade leading to cell differentiation...- The central regulation of bone remodelingG Karsenty
Baylor College of Medicine, Department of Molecular and Human Genetics, One Baylor Plaza, Houston, TX 77030, USA
Trends Endocrinol Metab 11:437-9. 2000..The recent development of molecular endocrinology uncovers a common, central regulation of bone formation, body weight and reproduction mediated by leptin... - The complexities of skeletal biologyGerard Karsenty
Baylor College of Medicine, Bone Disease Program of Texas, One Baylor Plaza, Houston, Texas 77030, USA
Nature 423:316-8. 2003..By so doing this progress has affected our understanding of diseases and suggested in many instances new therapeutic opportunities... - Transcriptional regulation of osteoblast differentiation during developmentG Karsenty
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Front Biosci 3:d834-7. 1998..These result demonstrate that Osf2/Cbfa1 is an osteoblast-specific transcriptional activator of osteoblast differentiation whose function is non redundant with the function of other gene products during development... - Cbfa1 contributes to the osteoblast-specific expression of type I collagen genesB Kern
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
J Biol Chem 276:7101-7. 2001..Thus, our results suggest that Cbfa1 is one of the positive regulators of the osteoblast-specific expression of both type I collagen genes... - Knock-in of nuclear localised beta-galactosidase reveals that the tyrosine phosphatase Ptprv is specifically expressed in cells of the bone collarR Dacquin
Baylor College of Medicine, Department of Molecular and Human Genetics and Bone Disease Program of Texas, Houston, Texas, USA
Dev Dyn 229:826-34. 2004..The specificity of Ptprv expression in these cells may be a useful tool to elucidate their role in the transition of skeletal elements from cartilage template to bone... - Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient miceS Takeda
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Genes Dev 15:467-81. 2001..These results identify Cbfa1 as a hypertrophic chondrocyte differentiation factor and provide a genetic argument for a common regulation of osteoblast and chondrocyte differentiation mediated by Cbfa1... - Leptin regulation of bone resorption by the sympathetic nervous system and CARTFlorent Elefteriou
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Nature 434:514-20. 2005..Our study establishes that leptin-regulated neural pathways control both aspects of bone remodelling, and demonstrates that integrity of sympathetic signalling is necessary for the increase in bone resorption caused by gonadal failure... - [Bone mass regulation by leptin: a hypothalamic control of bone formation]F Elefteriou
Département de génétique moléculaire et humaine, Bone Disease Program of Texas, Baylor College of Medicine, Houston, 77030 Texas, Etats Unis
Pathol Biol (Paris) 52:148-53. 2004..Conversely, beta-blockers increased bone formation and bone mass and blunt the bone loss induced by ovariectomy... - A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic developmentP Ducy
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Genes Dev 13:1025-36. 1999.... - Reversible skeletal abnormalities in gamma-glutamyl transpeptidase-deficient miceRegis Levasseur
Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Endocrinology 144:2761-4. 2003..These results establish the importance of cysteine metabolism for the regulation of bone remodeling and longitudinal growth... - CBFA1 mutation analysis and functional correlation with phenotypic variability in cleidocranial dysplasiaG Zhou
Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, BCM225, 630E, Houston, TX 77030, USA
Hum Mol Genet 8:2311-6. 1999..Together these data show that variable loss of function due to alterations in the runt and PST domains of CBFA1 may give rise to clinical variability, including classic CCD, mild CCD and isolated primary dental anomalies... - Leptin inhibits bone formation through a hypothalamic relay: a central control of bone massP Ducy
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Cell 100:197-207. 2000..This study identifies leptin as a potent inhibitor of bone formation acting through the central nervous system and therefore describes the central nature of bone mass control and its disorders... - Monosodium glutamate-sensitive hypothalamic neurons contribute to the control of bone massFlorent Elefteriou
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Endocrinology 144:3842-7. 2003..It also indicates that NPY deficiency does not affect bone mass... - Leptin controls bone formation through a hypothalamic relayG Karsenty
Baylor College of Medicine, Houston, Texas 77030, USA
Recent Prog Horm Res 56:401-15. 2001..This result revealed that bone remodeling, like most other homeostatic functions, is under hypothalamic control. The nature of the signal downstream of the hypothalamus is unknown but current experiments are attempting to identify it... - Leptin regulates bone formation via the sympathetic nervous systemShu Takeda
Department of Molecular and Human Genetics, One Baylor Plaza, Houston, TX 77030, USA
Cell 111:305-17. 2002..None of these manipulations affects body weight. This study demonstrates a leptin-dependent neuronal regulation of bone formation with potential therapeutic implications for osteoporosis... - Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasiaB Lee
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Nat Genet 16:307-10. 1997..Thus, these results together suggest that CCD is produced by haploinsufficiency of OSF2/CBFA1 and provide direct genetic evidence that the phenotype is secondary to an alteration of osteoblast differentiation... - Genetic ablation of parathyroid glands reveals another source of parathyroid hormoneT Gunther
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Nature 406:199-203. 2000..Thus, Gcm2 deletion uncovers an auxiliary mechanism for the regulation of calcium homeostasis in the absence of parathyroid glands. We propose that this backup mechanism may be a general feature of endocrine regulation... - The hypothalamic control of bone mass, implication for the treatment of osteoporosisG Karsenty
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Ann Endocrinol (Paris) 67:123. 2006 - Genetic control of skeletal developmentG Karsenty
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
Novartis Found Symp 232:6-17; discussion 17-22. 2001..Our current knowledge in each of these areas of skeleton biology will be presented in broad terms to set the course for other presentations during the symposium... - Prostate cancer cells induce osteoblast differentiation through a Cbfa1-dependent pathwayJ Yang
Department of Genitourinary Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
Cancer Res 61:5652-9. 2001..Moreover, it allows to screen for therapeutic agents blocking the osteoblast response to prostate cancer... - Central control of bone formationS Takeda
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
J Bone Miner Metab 19:195-8. 2001..This finding also has therapeutic implications... - Characterization of Osf1, an osteoblast-specific transcription factor binding to a critical cis-acting element in the mouse Osteocalcin promotersT Schinke
Department of Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
J Biol Chem 274:30182-9. 1999.... - Minireview: transcriptional control of osteoblast differentiationG Karsenty
Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Endocrinology 142:2731-3. 2001..Although other transcription factors are likely to be involved in osteoblast differentiation, Cbfal, by the multiplicity of the role that it plays, can be viewed as the central regulator of intramembranous and endochondral ossification... - Two domains unique to osteoblast-specific transcription factor Osf2/Cbfa1 contribute to its transactivation function and its inability to heterodimerize with CbfbetaK Thirunavukkarasu
Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Mol Cell Biol 18:4197-208. 1998..Thus, our results uncover the unique functional organization of Osf2 by identifying functional domains not shared with other Runt-related proteins that largely control its transactivation and heterodimerization abilities... - Identification of novel genes expressed during metanephric induction through single-cell library screeningJ M Abidari
Scott Department of Urology, Department of Molecular and Human Genetics, and Department of Pediatrics, Baylor College of Medicine, and Texas Children s Hospital, Houston, Texas 77030, USA
Kidney Int 57:2221-8. 2000..These findings suggest that Bmp7 controls the expression of genes important for nephrogenesis, but the identity of these genes has remained largely undetermined... - Serum leptin level is a regulator of bone massF Elefteriou
Department of Molecular and Human Genetics, Bone Disease Program of Texas, Baylor College of Medicine, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 101:3258-63. 2004..Taken together, these results indicate that adipocyte-derived circulating leptin is a determinant of bone formation and suggests that leptin antiosteogenic function is conserved in vertebrates... - Deletion of Ku86 causes early onset of senescence in miceH Vogel
Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 96:10770-5. 1999..These data indicate that Ku86-dependent chromosomal metabolism is important for determining the onset of age-specific changes characteristic of senescence in mice... - The family of bone morphogenetic proteinsP Ducy
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77003, USA
Kidney Int 57:2207-14. 2000..This review presents our current knowledge about the functions of BMPs during skeleton development as well as in many other biologic processes... - Cbfa1 is required for epithelial-mesenchymal interactions regulating tooth development in miceR N D'Souza
Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, FIN 00014 University of Helsinki, Finland
Development 126:2911-20. 1999.... - BMP 7 is required for nephrogenesis, eye development, and skeletal patterningG Karsenty
Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston 77030, USA
Ann N Y Acad Sci 785:98-107. 1996.... - Skeletal abnormalities in doubly heterozygous Bmp4 and Bmp7 miceT Katagiri
Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, USA
Dev Genet 22:340-8. 1998..In the limbs, these molecules appear to play a similar role in controlling digit number, possibly through induction of apoptosis in the interdigital and anterior mesenchyme... - The matrix Gla protein gene is a marker of the chondrogenesis cell lineage during mouse developmentG Luo
Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, USA
J Bone Miner Res 10:325-34. 1995..This finding raises the intriguing possibility that MGP may play distinct roles during embryogenesis and in the adult organism... - c-Krox binds to several sites in the promoter of both mouse type I collagen genes. Structure/function study and developmental expression analysisP Galera
Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
J Biol Chem 271:21331-9. 1996..Thus, our findings suggest that c-Krox is one transcription factor controlling the coordinated expression of the two type I collagen genes in skin... - Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiationDonald A Glass
Department of Molecular and Human Genetics, Bone Disease Program of Texas, Houston, 77030, USA
Dev Cell 8:751-64. 2005.... - Canonical Wnt signaling in osteoblasts is required for osteoclast differentiationDonald A Glass
Department of Molecular and Human Genetics, Bone Disease Program of Texas, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Ann N Y Acad Sci 1068:117-30. 2006.... - Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptorMasaki Kato
Department of Molecular and Cellular Biology and Medicine, Baylor College of Medicine, Houston, TX 77030, USA
J Cell Biol 157:303-14. 2002..Moreover, these features recapitulate human osteoporosis-pseudoglioma syndrome, caused by LRP5 inactivation... - Transcription factors in bone: developmental and pathological aspectsXiangli Yang
Dept of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, S930, Houston, TX 77030, USA
Trends Mol Med 8:340-5. 2002..1 and nuclear factor (NF)-kappaB, and chondrocytes, such as Sox proteins. Finally, recent progress in identifying mutations in transcription factors affecting skeletal patterning and development is also described... - Bigenic Cre/loxP, puDeltatk conditional genetic ablationYou Tzung Chen
Program in Developmental Biology, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
Nucleic Acids Res 32:e161. 2004..5 dpc embryos. Crosses between the puDeltatk selector transgenic line and existing cre lines will facilitate numerous temporally regulated tissue-specific ablation experiments... - ATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiaeFlorent Elefteriou
Department of Molecular and Human Genetics, Bone Disease Program of Texas, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Cell Metab 4:441-51. 2006..By showing that ATF4-dependent skeletal dysplasiae are treatable by dietary manipulations, this study reveals a molecular connection between nutrition and skeletal development... - ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry SyndromeXiangli Yang
Department of Molecular and Human Genetics and Bone Disease Program of Texas, Baylor College of Medicine, Houston, TX 77030, USA
Cell 117:387-98. 2004..These findings identify ATF4 as a critical regulator of osteoblast differentiation and function, and indicate that lack of ATF4 phosphorylation by RSK2 may contribute to the skeletal phenotype of CLS... - p53 mutant mice that display early ageing-associated phenotypesStuart D Tyner
Cell and Molecular Biology Program, Baylor College of Medicine, Houston, TX 77030, USA
Nature 415:45-53. 2002..A second line of transgenic mice containing a temperature-sensitive mutant allele of p53 also exhibits early ageing phenotypes. These data suggest that p53 has a role in regulating organismal ageing... - Cart overexpression is the only identifiable cause of high bone mass in melanocortin 4 receptor deficiencyJong Deok Ahn
Department of Molecular and Human Genetics, One Baylor Plaza, Baylor College of Medicine, Houston, Texas 77030, USA
Endocrinology 147:3196-202. 2006..As importantly, they also indicate that CART regulates bone resorption independently of the role it may exert in energy metabolism, suggesting that the neural control of appetite and bone remodeling are independent of each other... - A twist code determines the onset of osteoblast differentiationPeter Bialek
Department of Molecular and Human Genetics, Bone Disease Program of Texas, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Dev Cell 6:423-35. 2004..In vivo mutagenesis confirms the antiosteogenic function of the Twist box. Thus, relief of inhibition by Twist proteins is a mandatory event precluding osteoblast differentiation... - In vivo analysis of Wnt signaling in boneDonald A Glass
Medical Scientist Training Prtogram, Baylor College of Medicine, Houston, TX 77030, USA
Endocrinology 148:2630-4. 2007..These mouse models help establish the canonical Wnt signaling pathway as a major regulator of chondrogenesis, osteoblastogenesis, and osteoclastogenesis. This review will summarize these advances... - Prostate cancer cells-osteoblast interaction shifts expression of growth/survival-related genes in prostate cancer and reduces expression of osteoprotegerin in osteoblastsKarim Fizazi
Departments of Genitourinary Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 9:2587-97. 2003..These data also provide a rationale for developing therapeutic strategies designed to target these molecular changes... - SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiationGergana Dobreva
Max Planck Institute of Immunobiology, Department of Cellular and Molecular Immunology, 79108 Freiburg, Germany
Cell 125:971-86. 2006..Thus, SATB2 acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation... - Calcineurin/NFAT signaling in osteoblasts regulates bone massMonte M Winslow
Program in Immunology, Stanford University, Stanford, California 94305, USA
Dev Cell 10:771-82. 2006..Our results indicate that NFATc1 regulates bone mass by functioning in both osteoblasts and osteoclasts... - Runx2 inhibits chondrocyte proliferation and hypertrophy through its expression in the perichondriumEiichi Hinoi
Department of Genetics and Development, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
Genes Dev 20:2937-42. 2006..This study identifies a transcriptional basis for the inhibition of chondrocyte maturation by perichondrium and reveals that Runx2 fulfills antagonistic functions during chondrogenesis... - Convergence between bone and energy homeostases: leptin regulation of bone massGerard Karsenty
Department of Genetics and Development, Columbia University, New York, New York 10032, USA
Cell Metab 4:341-8. 2006..This review summarizes the genetic and molecular bases of this regulation and discusses its potential clinical implications... - Overexpression of gamma-glutamyltransferase in transgenic mice accelerates bone resorption and causes osteoporosisKiyoshi Hiramatsu
Department of Bone and Joint Disease, Research Institute, National Center for Geriatrics and Gerontology NCGG, 36 3 Gengo, Morioka, Obu, Aichi 474 8522, Japan
Endocrinology 148:2708-15. 2007..Thus, GGT is implicated as being involved in diseases characterized by accelerated osteoclast development and bone destruction and provides a new target for therapeutic intervention... - Endocrine regulation of energy metabolism by the skeletonNa Kyung Lee
Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Cell 130:456-69. 2007..By revealing that the skeleton exerts an endocrine regulation of sugar homeostasis this study expands the biological importance of this organ and our understanding of energy metabolism... - Reciprocal regulation of bone and energy metabolismNa Kyung Lee
Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Trends Endocrinol Metab 19:161-6. 2008..This review highlights the most important salient features of this novel regulation of energy metabolism... - Transcriptional coactivation of bone-specific transcription factor Cbfa1 by TAZCai Bin Cui
Department of Periodontology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Mol Cell Biol 23:1004-13. 2003..These data indicate that TAZ is a transcription coactivator for Cbfa1 and may be involved in the regulation of osteoblast differentiation... - p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodelingXueying Wang
The Institute of Molecular and Cell Biology, Singapore 138673
J Cell Biol 172:115-25. 2006..Thus, these results identify p53 as a novel regulator of osteoblast differentiation, osteoblast-dependent osteoclastogenesis, and bone remodeling... - Rescue of the skeletal phenotype in CasR-deficient mice by transfer onto the Gcm2 null backgroundQisheng Tu
Center for Bone and Mineral Disorders, Duke University Medical Center, Durham, North Carolina 27710, USA
J Clin Invest 111:1029-37. 2003..Double Gcm2- and CasR-deficient mice provide an important model for evaluating the extraparathyroid functions of CasR... - PTHrP and Indian hedgehog control differentiation of growth plate chondrocytes at multiple stepsTatsuya Kobayashi
Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
Development 129:2977-86. 2002..Thus, chondrocyte differentiation is controlled at multiple steps by PTHrP and Ihh through the mutual regulation of their activities... - Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiationSunhwa Kim
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo 113 0033, Japan
Genes Dev 17:1979-91. 2003..Our study provides a unique example in which a latent transcription factor attenuates the activity of another transcription factor in the cytoplasm, and reveals a new regulatory mechanism in bone remodeling... - Bone health in children and adolescents: a symposium at the annual meeting of the Pediatric Academic Societies/Lawson Wilkins Pediatric Endocrine Society, May 2003Catherine M Gordon
Division of Endocrinology, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA
Curr Probl Pediatr Adolesc Health Care 34:226-42. 2004 - Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesisRick B Vega
Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
Cell 119:555-66. 2004..These results establish HDAC4 as a central regulator of chondrocyte hypertrophy and skeletogenesis and suggest general roles for class II HDACs in the control of cellular hypertrophy... - Longevity and lineages: toward the integrative biology of degenerative diseases in heart, muscle, and boneKenneth R Chien
UCSD Institute of Molecular Medicine, UCSD School of Medicine, La Jolla, California 92093, USA
Cell 120:533-44. 2005..These advances form a foundation for new therapeutic strategies to delay the onset of aging-related disorders... - Deficiency of the G-protein alpha-subunit G(s)alpha in osteoblasts leads to differential effects on trabecular and cortical boneAkio Sakamoto
Metabolic Diseases Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 280:21369-75. 2005..Osteoblast-specific G(s)alpha deficiency leads to reduced bone turnover... - Unloading induces osteoblastic cell suppression and osteoclastic cell activation to lead to bone loss via sympathetic nervous systemHisataka Kondo
Department of Molecular Pharmacology, Tokyo Medical and Dental University, Japan
J Biol Chem 280:30192-200. 2005..These observations indicated that sympathetic nervous tone mediates unloading-induced bone loss through suppression of bone formation by osteoblasts and enhancement of resorption by osteoclasts... - An in vivo model to study osteogenic gene regulation: targeting an avian retroviral receptor (TVA) to bone with the bone sialoprotein (BSP) promoterLing Li
Division of Oral Biology, Tufts School of Dental Medicine, Boston, Massachusetts 02111, USA
J Bone Miner Res 20:1403-13. 2005..These studies show that BSP/TVA transgenic mice can be used to target genes to sites of osteogenesis, providing a unique system for studying molecular events associated with bone formation in vivo... - Proteoglycan desulfation determines the efficiency of chondrocyte autophagy and the extent of FGF signaling during endochondral ossificationCarmine Settembre
Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Genes Dev 22:2645-50. 2008..Conversely, in chondrocytes it favors ECM production and autophagy and promotes proliferation and differentiation by limiting FGF signaling. Thus, proteoglycan desulfation is a critical regulator of chondrogenesis...