Monica J Justice

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. ncbi request reprint The role of quaking in mammalian embryonic development
    Monica J Justice
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza MS227, R804, Houston, Texas 77030, USA
    Adv Exp Med Biol 693:82-92. 2010
  2. ncbi request reprint Point mutations in the melanocortin-4 receptor cause variable obesity in mice
    Thomas P Meehan
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Mamm Genome 17:1162-71. 2006
  3. pmc The zinc finger SET domain gene Prdm14 is overexpressed in lymphoblastic lymphomas with retroviral insertions at Evi32
    E J Dettman
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 3:e3823. 2008
  4. pmc Discovery of candidate disease genes in ENU-induced mouse mutants by large-scale sequencing, including a splice-site mutation in nucleoredoxin
    Melissa K Boles
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    PLoS Genet 5:e1000759. 2009
  5. pmc A point mutation in the gene for asparagine-linked glycosylation 10B (Alg10b) causes nonsyndromic hearing impairment in mice (Mus musculus)
    Frank J Probst
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 8:e80408. 2013
  6. pmc Prdm14 initiates lymphoblastic leukemia after expanding a population of cells resembling common lymphoid progenitors
    E J Dettman
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA
    Oncogene 30:2859-73. 2011
  7. pmc ENU mutagenesis reveals that Notchless homolog 1 (Drosophila) affects Cdkn1a and several members of the Wnt pathway during murine pre-implantation development
    Amy C Lossie
    Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA
    BMC Genet 13:106. 2012
  8. pmc Mutation discovery in mice by whole exome sequencing
    Heather Fairfield
    The Jackson Laboratory, 600 Main St, Bar Harbor, ME 04609, USA
    Genome Biol 12:R86. 2011
  9. pmc Technical approaches for mouse models of human disease
    Monica J Justice
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Dis Model Mech 4:305-10. 2011
  10. pmc Removing the cloak of invisibility: phenotyping the mouse
    Monica J Justice
    Baylor College of Medicine, One Baylor Plaza R804, Houston, TX 77030, USA
    Dis Model Mech 1:109-12. 2008

Detail Information

Publications57

  1. ncbi request reprint The role of quaking in mammalian embryonic development
    Monica J Justice
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza MS227, R804, Houston, Texas 77030, USA
    Adv Exp Med Biol 693:82-92. 2010
    ..This suggests that certain functions may remain conserved in the early embryo throughout the evolution of nonvertebrate and vertebrate organisms and that additional roles for quaking remain to be discovered...
  2. ncbi request reprint Point mutations in the melanocortin-4 receptor cause variable obesity in mice
    Thomas P Meehan
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Mamm Genome 17:1162-71. 2006
    ..Southbeach has less receptor activity and becomes more obese. These mutants will serve as good models for the variability in phenotype in humans carrying mutations in the MC4R gene...
  3. pmc The zinc finger SET domain gene Prdm14 is overexpressed in lymphoblastic lymphomas with retroviral insertions at Evi32
    E J Dettman
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 3:e3823. 2008
    ..Common sites of retroviral insertion (CIS) identify genes causally associated with the development or initiation of lymphoma...
  4. pmc Discovery of candidate disease genes in ENU-induced mouse mutants by large-scale sequencing, including a splice-site mutation in nucleoredoxin
    Melissa K Boles
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    PLoS Genet 5:e1000759. 2009
    ..Our data show that the classical positional mapping approach of disease mutation identification can be extended to large target regions using high-throughput sequencing...
  5. pmc A point mutation in the gene for asparagine-linked glycosylation 10B (Alg10b) causes nonsyndromic hearing impairment in mice (Mus musculus)
    Frank J Probst
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 8:e80408. 2013
    ....
  6. pmc Prdm14 initiates lymphoblastic leukemia after expanding a population of cells resembling common lymphoid progenitors
    E J Dettman
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA
    Oncogene 30:2859-73. 2011
    ..These data provide the first direct evidence for the association of Prdm14 with cancer initiation in an in vivo mouse model and in human lymphoid malignancies, while suggesting mechanisms for Prdm14's mode of action...
  7. pmc ENU mutagenesis reveals that Notchless homolog 1 (Drosophila) affects Cdkn1a and several members of the Wnt pathway during murine pre-implantation development
    Amy C Lossie
    Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA
    BMC Genet 13:106. 2012
    ..Two mutant alleles (l11Jus1 and l11Jus4), which fall into the same complementation group, survive through implantation but fail prior to gastrulation...
  8. pmc Mutation discovery in mice by whole exome sequencing
    Heather Fairfield
    The Jackson Laboratory, 600 Main St, Bar Harbor, ME 04609, USA
    Genome Biol 12:R86. 2011
    ..We found strong candidate mutations for the majority of mutant exomes sequenced, including new models of orofacial clefting, urogenital dysmorphology, kyphosis and autoimmune hepatitis...
  9. pmc Technical approaches for mouse models of human disease
    Monica J Justice
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Dis Model Mech 4:305-10. 2011
    ..Each of these applications will be essential for understanding the diversity that is being discovered within the human population...
  10. pmc Removing the cloak of invisibility: phenotyping the mouse
    Monica J Justice
    Baylor College of Medicine, One Baylor Plaza R804, Houston, TX 77030, USA
    Dis Model Mech 1:109-12. 2008
    ..To assess health will require the ability to perform a broad-based phenotype assessment of every animal until we can understand how the perturbation of one system affects others...
  11. pmc Novel frem1-related mouse phenotypes and evidence of genetic interactions with gata4 and slit3
    Tyler F Beck
    Departments of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 8:e58830. 2013
    ....
  12. pmc A mouse chromosome 4 balancer ENU-mutagenesis screen isolates eleven lethal lines
    Melissa K Boles
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    BMC Genet 10:12. 2009
    ..To functionally annotate the distal region of mouse chromosome 4, we performed an ENU-mutagenesis screen using a balancer chromosome targeted to this region of the genome...
  13. ncbi request reprint Reduced penetrance of craniofacial anomalies as a function of deletion size and genetic background in a chromosome engineered partial mouse model for Smith-Magenis syndrome
    Jiong Yan
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Hum Mol Genet 13:2613-24. 2004
    ..Our mouse models refined the genomic region important for a portion of the SMS phenotype and provided a basis for further molecular analysis of genes associated with SMS...
  14. ncbi request reprint Functional genetic analysis of mouse chromosome 11
    Benjamin T Kile
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nature 425:81-6. 2003
    ..The mutations reveal new defects in haematopoiesis, craniofacial and cardiovascular development, and fertility...
  15. ncbi request reprint Novel lethal mouse mutants produced in balancer chromosome screens
    Kathryn E Hentges
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Gene Expr Patterns 6:653-65. 2006
    ....
  16. ncbi request reprint A new ENU-induced allele of mouse quaking causes severe CNS dysmyelination
    Janice K Noveroske
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, S413, Houston, Texas 77030, USA
    Mamm Genome 16:672-82. 2005
    ..Because the qk(v) allele is a large deletion that affects the expression of three genes, the new neurologic qk(e5) allele is an important addition to this allelic series...
  17. pmc An allelic series of mice reveals a role for RERE in the development of multiple organs affected in chromosome 1p36 deletions
    Bum Jun Kim
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 8:e57460. 2013
    ....
  18. pmc Mutation of l7Rn3 shows that Odz4 is required for mouse gastrulation
    Amy C Lossie
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Genetics 169:285-99. 2005
    ..Together, our data indicate that Odz4 is mutated in the l7Rn3 allele series and performs roles in the mouse brain, heart, and embryonic patterning similar to those of its Drosophila counterpart...
  19. pmc The kinesin related motor protein, Eg5, is essential for maintenance of pre-implantation embryogenesis
    Andrew Castillo
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA
    Biochem Biophys Res Commun 357:694-9. 2007
    ....
  20. ncbi request reprint Defining the breakpoints of the quaking(viable) mouse mutation reveals a duplication from a Parkin intron
    Jason D Dapper
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Mov Disord 20:1369-74. 2005
    ..This complexity provides insight into a well-studied neurological mutant and may have a role in affecting the phenotype observed...
  21. ncbi request reprint Inactivation of Rai1 in mice recapitulates phenotypes observed in chromosome engineered mouse models for Smith-Magenis syndrome
    Weimin Bi
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Mol Genet 14:983-95. 2005
    ....
  22. pmc Mouse Tenm4 is required for mesoderm induction
    Hisashi Nakamura
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    BMC Dev Biol 13:9. 2013
    ..A series of Tenm4 mouse alleles showing a broad range of phenotypes were isolated after ENU mutagenesis. Here, we examine the timing and features of gastrulation failure in a loss of function allele...
  23. pmc Retroviral insertions in the VISION database identify molecular pathways in mouse lymphoid leukemia and lymphoma
    Keith C Weiser
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mamm Genome 18:709-22. 2007
    ..mouse-genome.bcm.tmc.edu/vision ...
  24. ncbi request reprint Phenotypic characterization of Bbs4 null mice reveals age-dependent penetrance and variable expressivity
    Erica R Eichers
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza Room 604B, Houston, TX 77030, USA
    Hum Genet 120:211-26. 2006
    ..Evaluations of these null mice have uncovered phenotypic features with age-dependent penetrance and variable expressivity, partially recapitulating the human BBS phenotype...
  25. pmc Zic3 is required in the extra-cardiac perinodal region of the lateral plate mesoderm for left-right patterning and heart development
    Zhengxin Jiang
    Department of Molecular and Human Genetics, Texas Children s Hospital, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Hum Mol Genet 22:879-89. 2013
    ....
  26. pmc Genotype, phenotype, and karyotype correlation in the XO mouse model of Turner Syndrome
    Frank J Probst
    Department of Molecular and Human Genetics, Baylor College of Medicine, Room R804, One Baylor Plaza, Houston, TX 77030, USA
    J Hered 99:512-7. 2008
    ..This work lays the foundation for the use of this strain to study Turner Syndrome in particular and the X chromosome in general...
  27. ncbi request reprint Craniofacial, skeletal, and cardiac defects associated with altered embryonic murine Zic3 expression following targeted insertion of a PGK-NEO cassette
    Lirong Zhu
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Front Biosci 12:1680-90. 2007
    ..A six-week old hemizygous mouse was found to have thoraco-cervical ectopia cordis, an extremely rare congenital malformation in humans and for which there is no precedent in a mouse model...
  28. ncbi request reprint Evi3, a zinc-finger protein related to EBFAZ, regulates EBF activity in B-cell leukemia
    Kathryn E Hentges
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Oncogene 24:1220-30. 2005
    ..Further, these data imply that Evi3 misexpression initiates tumorigenesis by perturbing B-cell development via an interaction with EBF...
  29. pmc Deficiency of FRAS1-related extracellular matrix 1 (FREM1) causes congenital diaphragmatic hernia in humans and mice
    Tyler F Beck
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Mol Genet 22:1026-38. 2013
    ..We conclude that FREM1 plays a critical role in the development of the diaphragm and that FREM1 deficiency can cause CDH in both humans and mice...
  30. ncbi request reprint Overexpression of Eg5 causes genomic instability and tumor formation in mice
    Andrew Castillo
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Cancer Res 67:10138-47. 2007
    ....
  31. pmc Deletion of the Parkin coregulated gene causes male sterility in the quaking(viable) mouse mutant
    Diego Lorenzetti
    Graduate Program in Molecular and Human Genetics, Graduate School of Biomedical Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:8402-7. 2004
    ..Remarkably, the mammalian Pacrg protein shares significant sequence similarities with gene products from flagellated protozoans, suggesting that Pacrg may be necessary for proper flagellar formation in many organisms...
  32. pmc Filamin B represses chondrocyte hypertrophy in a Runx2/Smad3-dependent manner
    Lihua Zheng
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    J Cell Biol 178:121-8. 2007
    ..Thus, Filamin B inhibits Runx2 activity, at least in part, through the Smad3 pathway. Our results uncover the involvement of actin binding proteins during chondrogenesis and provide a molecular basis to a human genetic disease...
  33. pmc Mutations in the cofilin partner Aip1/Wdr1 cause autoinflammatory disease and macrothrombocytopenia
    Benjamin T Kile
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA
    Blood 110:2371-80. 2007
    ..These studies establish an essential requirement for Wdr1 in megakaryocytes and neutrophils, indicating that cofilin-mediated actin dynamics are critically important to the development and function of both cell types...
  34. ncbi request reprint A twist code determines the onset of osteoblast differentiation
    Peter Bialek
    Department of Molecular and Human Genetics, Bone Disease Program of Texas, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Dev Cell 6:423-35. 2004
    ..In vivo mutagenesis confirms the antiosteogenic function of the Twist box. Thus, relief of inhibition by Twist proteins is a mandatory event precluding osteoblast differentiation...
  35. pmc Drosophila Ten-m and filamin affect motor neuron growth cone guidance
    Lihua Zheng
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 6:e22956. 2011
    ..During embryonic development, the expression of Filamin and Ten-m partially overlap in ectodermal cells. These results suggest that Ten-m and Filamin in epidermal cells might together influence growth cone progression...
  36. ncbi request reprint The homeobox gene Hex induces T-cell-derived lymphomas when overexpressed in hematopoietic precursor cells
    Alex George
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Oncogene 22:6764-73. 2003
    ..Our results demonstrate that Hex can act as a T lineage oncogene when misexpressed in hematopoietic precursor cells...
  37. ncbi request reprint A novel mouse model of hypogonadotrophic hypogonadism: N-ethyl-N-nitrosourea-induced gonadotropin-releasing hormone receptor gene mutation
    Andrew J Pask
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Endocrinol 19:972-81. 2005
    ..This is the first report of a mouse with a Gnrhr loss of function mutation. These GnRH-insensitive mice provide a novel animal model for the study of human idiopathic hypogonadotrophic hypogonadism...
  38. ncbi request reprint Visceral endoderm function is regulated by quaking and required for vascular development
    Brenda L Bohnsack
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Genesis 44:93-104. 2006
    ..Although these defects were rescued by exogenous RA, visceral endoderm function or vascular remodeling were not restored. Thus, we conclude that qkI regulates visceral endoderm function, which is critical for vascular remodeling...
  39. ncbi request reprint Checks and balancers: balancer chromosomes to facilitate genome annotation
    Kathryn E Hentges
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Trends Genet 20:252-9. 2004
    ..Balancer mutagenesis screens will provide a systematic functional analysis of the genes on mouse chromosomes, and consequently, will facilitate a functional annotation of the mammalian genome sequence...
  40. ncbi request reprint Quaking is essential for blood vessel development
    Janice K Noveroske
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    Genesis 32:218-30. 2002
    ..Together, these results suggest that quaking plays an essential role in vascular development and that the blood vessel defects are the cause of embryonic death...
  41. doi request reprint Mouse mutagenesis with the chemical supermutagen ENU
    Frank J Probst
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    Methods Enzymol 477:297-312. 2010
    ....
  42. pmc Implementing large-scale ENU mutagenesis screens in North America
    Amander T Clark
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Genetica 122:51-64. 2004
    ..The purpose of this article is to highlight the new projects in North America that are focused on isolating mouse mutations after ENU mutagenesis and phenotype screening...
  43. ncbi request reprint Mutations in a novel locus on mouse chromosome 11 resulting in male infertility associated with defects in microtubule assembly and sperm tail function
    Amander T Clark
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Biol Reprod 70:1317-24. 2004
    ..The isolation of this allelic series identifies a new locus on mouse chromosome 11 that is required for spermiogenesis and male fertility...
  44. pmc COP9 signalosome subunit 3 is essential for maintenance of cell proliferation in the mouse embryonic epiblast
    Jiong Yan
    Department of Molecular and Human Genetics, Texas Children s Hospital, Houston, Texas 77030, USA
    Mol Cell Biol 23:6798-808. 2003
    ..Therefore, Csn3 is important for maintaining the integrity of the COP9 signalosome and is crucial to maintain the survival of epiblast cells and thus the development of the postimplantation embryo in mice...
  45. ncbi request reprint 18th international mouse genome conference
    Amy C Lossie
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Mamm Genome 16:471-5. 2005
  46. ncbi request reprint Tnfrsf13c (Baffr) is mis-expressed in tumors with murine leukemia virus insertions at Lvis22
    Kathryn E Hentges
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Genomics 80:204-12. 2002
    ..The characterization of these genes in tumor samples will allow a function to be assigned to many novel loci identified by the genome sequencing projects...
  47. pmc A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL)
    Brandi L Carofino
    Interdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Dis Model Mech 6:1494-506. 2013
    ..Furthermore, breeding R26PR to additional Cre lines will allow for the continued development of novel cancer models. ..
  48. pmc TM4SF20 ancestral deletion and susceptibility to a pediatric disorder of early language delay and cerebral white matter hyperintensities
    Wojciech Wiszniewski
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Hum Genet 93:197-210. 2013
    ....
  49. ncbi request reprint Comparative physical maps of the human and mouse Meckel syndrome critical regions
    Kathryn E Hentges
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Mamm Genome 15:252-64. 2004
    ....
  50. ncbi request reprint Evidence for translational regulation of the imprinted Snurf-Snrpn locus in mice
    Ting Fen Tsai
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA
    Hum Mol Genet 11:1659-68. 2002
    ....
  51. pmc A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome
    Christie M Buchovecky
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    Nat Genet 45:1013-20. 2013
    ..Our genetic screen therefore points to cholesterol homeostasis as a potential target for the treatment of patients with Rett syndrome. ..
  52. ncbi request reprint Dmbx1, a novel evolutionarily conserved paired-like homeobox gene expressed in the brain of mouse embryos
    Akihira Ohtoshi
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Mech Dev 110:241-4. 2002
    ..Dmbx1 provides a unique marker of the developing anterior nervous system and should provide a useful molecular resource to elucidate the mechanisms that pattern the vertebrate brain...
  53. ncbi request reprint From the atomic age to the Genome Project
    Monica J Justice
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza S413, Houston, TX 77030, USA
    Genetica 122:3-7. 2004
  54. pmc Oncogenic function for the Dlg1 mammalian homolog of the Drosophila discs-large tumor suppressor
    Kristopher K Frese
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    EMBO J 25:1406-17. 2006
    ..These findings establish the first known function for Dlg1 in virus-mediated cellular transformation and also surprisingly expose a previously unrecognized oncogenic activity encoded by this suspected cellular tumor suppressor gene...
  55. pmc Strain background influences neurotoxicity and behavioral abnormalities in mice expressing the tetracycline transactivator
    Harry J Han
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 32:10574-86. 2012
    ..All model systems have limitations that should be recognized and mitigated where possible; our findings stress the importance of mapping the effects caused by TTA alone when working with tet-off models...
  56. doi request reprint Mouse Mutagenesis Using N-Ethyl-N-Nitrosourea (ENU)
    Andrew P Salinger
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    CSH Protoc 2008:pdb.prot4985. 2008
    ..After treatment with ENU, mice are mated in genetic screens designed to uncover mutations of interest. Screens for dominant, recessive, and modifying mutations can be performed...