Research Topics
Genomes and Genes
| Li JiaoSummaryAffiliation: Baylor College of Medicine Country: USA Publications
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Detail Information
Publications
Dietary intake of vegetables, folate, and antioxidants and the risk of Barrett's esophagusLi Jiao
Houston VA Health Services Research and Development Center of Excellence, Michael E DeBakey Veterans Affairs Medical Center, Houston, TX, USA
Cancer Causes Control 24:1005-14. 2013..Diet is a potentially modifiable risk factor for Barrett's esophagus (BE). We investigated the associations between intakes of fruits and vegetables and risk of BE...
Sleep duration and incidence of colorectal cancer in postmenopausal womenL Jiao
Houston VA Health Services Research Center of Excellence, Michael E DeBakey VA Medical Center, Houston, TX, USA
Br J Cancer 108:213-21. 2013..Circadian disruption has been implicated in colorectal tumorigenesis in experimental studies. We prospectively examined the association between sleep duration and risk of colorectal cancer (CRC)...- Evidence that serum levels of the soluble receptor for advanced glycation end products are inversely associated with pancreatic cancer risk: a prospective studyLi Jiao
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
Cancer Res 71:3582-9. 2011..46 (0.23-0.73), P(trend) = 0.002]. Further adjustment for glucose or insulin levels did not change the observed associations. Our findings suggest that sRAGE is inversely associated with pancreatic cancer risk among Finnish male smokers... - Advanced glycation end products, soluble receptor for advanced glycation end products, and risk of colorectal cancerLi Jiao
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland, USA
Cancer Epidemiol Biomarkers Prev 20:1430-8. 2011..AGEs induce oxidative stress and inflammation via the receptor for AGEs (RAGE) and soluble RAGE (sRAGE) can neutralize the effects mediated by RAGE-ligand engagement... - Body mass index, effect modifiers, and risk of pancreatic cancer: a pooled study of seven prospective cohortsLi Jiao
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Cancer Causes Control 21:1305-14. 2010..To investigate whether the positive association of body mass index (BMI, kg/m(2)) with risk of pancreatic cancer is modified by age, sex, smoking status, physical activity, and history of diabetes... - Interaction of the cytochrome P4501A2, SULT1A1 and NAT gene polymorphisms with smoking and dietary mutagen intake in modification of the risk of pancreatic cancerHideo Suzuki
Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Carcinogenesis 29:1184-91. 2008..These data suggest the existence of gender-specific susceptibility to tobacco carcinogen and dietary mutagen exposure in PC... - Effects of base excision repair gene polymorphisms on pancreatic cancer survivalDonghui Li
Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 1402, USA
Int J Cancer 120:1748-54. 2007..These observations need to be confirmed in a larger study of homogenous patient population... - Available carbohydrates, glycemic load, and pancreatic cancer: is there a link?Cari L Meinhold
National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA
Am J Epidemiol 171:1174-82. 2010..Rather than being causal, the short-term increase in pancreatic cancer risk associated with high available carbohydrate and low fat intake may be capturing dietary changes associated with subclinical disease... - Selected polymorphisms of DNA repair genes and risk of pancreatic cancerLi Jiao
Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Cancer Detect Prev 30:284-91. 2006.... - Significant effect of homologous recombination DNA repair gene polymorphisms on pancreatic cancer survivalDonghui Li
Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77230 1402, USA
Cancer Res 66:3323-30. 2006..These observations suggest that polymorphisms of genes involved in the repair of DNA double-strand breaks significantly affect the clinical outcome of patients with pancreatic cancer... - Haplotype of N-acetyltransferase 1 and 2 and risk of pancreatic cancerLi Jiao
Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Cancer Epidemiol Biomarkers Prev 16:2379-86. 2007..The NAT2*6A/any slow acetylation genotype may be a predisposing factor for pancreatic cancer among diabetics with smoking exposure. Our observations must be confirmed in larger independent studies... - XRCC2 and XRCC3 gene polymorphism and risk of pancreatic cancerLi Jiao
Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Am J Gastroenterol 103:360-7. 2008..We hypothesized that the altered HR repair capacity conferred by single nucleotide polymorphisms (SNPs) would modify individual susceptibility to sporadic pancreatic cancer... - Glutathione S-transferase gene polymorphisms and risk and survival of pancreatic cancerLi Jiao
Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 109:840-8. 2007..The authors hypothesized that genetic variants of glutathione S-transferase (GST) affect detoxification of carcinogens and anticancer agents in the human pancreas and, thus, the risk and survival of pancreatic cancer... - Risk factors for pancreatic cancer: case-control studyManal M Hassan
Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Am J Gastroenterol 102:2696-707. 2007..We evaluated the independent effects of multiple risk factors for pancreatic cancer and determined whether the magnitude of cigarette smoking was modified by other risk factors in men and women... - Polymorphisms of cytochrome P4501A2 and N-acetyltransferase genes, smoking, and risk of pancreatic cancerDonghui Li
Department of Gastrointestinal Medical Oncology, The University of Texas, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 426, Houston, TX 77030, USA
Carcinogenesis 27:103-11. 2006..9, 95% CI: 1.2-6.9) and among females (AOR: 2.5, 95% CI: 1.1-5.7). These data suggest that polymorphisms of the CYP1A2 and NAT1 genes modify the risk of pancreatic cancer... - Single-nucleotide polymorphisms of DNA damage response genes are associated with overall survival in patients with pancreatic cancerTaro Okazaki
Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 14:2042-8. 2008.... - The XPD Asp312Asn and Lys751Gln polymorphisms, corresponding haplotype, and pancreatic cancer riskLi Jiao
Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Unit 426, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Cancer Lett 245:61-8. 2007..24-0.88) (P for interaction=0.03). The (312)Asp-(751)Gln was identified as the putative at risk haplotype. Our study shows that the XPD gene polymorphism could be a genetic risk modifier for smoking-related pancreatic cancer... - Alcohol use and risk of pancreatic cancer: the NIH-AARP Diet and Health StudyLi Jiao
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
Am J Epidemiol 169:1043-51. 2009..41, 95% CI: 1.01, 2.00). These findings suggest a moderately increased pancreatic cancer risk with heavy alcohol use, particularly liquor; however, residual confounding by cigarette smoking cannot be completely excluded... - Significant associations of mismatch repair gene polymorphisms with clinical outcome of pancreatic cancerXiaoqun Dong
Department of Gastrointestinal Medical Oncology, Surgical Oncology, Pathology, and Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
J Clin Oncol 27:1592-9. 2009..DNA mismatch repair (MMR) is critical in maintaining genomic stability and may modulate the cellular response to gemcitabine. We hypothesized that genetic variations in MMR may affect the clinical outcome of patients with pancreatic cancer... - K-ras mutation and p16 and preproenkephalin promoter hypermethylation in plasma DNA of pancreatic cancer patients: in relation to cigarette smokingLi Jiao
Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Pancreas 34:55-62. 2007..To examine the profiles of K-ras mutations and p16 and preproenkephalin (ppENK) promoter hypermethylation and their associations with cigarette smoking in pancreatic cancer patients... - Passive smoking and the use of noncigarette tobacco products in association with risk for pancreatic cancer: a case-control studyManal M Hassan
Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 109:2547-56. 2007..The associations between passive smoking and the use of noncigarette tobacco products with pancreatic cancer are not clear... - A combined healthy lifestyle score and risk of pancreatic cancer in a large cohort studyLi Jiao
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA
Arch Intern Med 169:764-70. 2009..We generated a healthy lifestyle score to investigate their joint effect on risk of pancreatic cancer... - Folate intake, post-folic acid grain fortification, and pancreatic cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening TrialBrietta M Oaks
Nutritional Epidemiology Branch, the Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA
Am J Clin Nutr 91:449-55. 2010..Folate plays a critical role in DNA methylation, synthesis, and repair. Several epidemiologic studies suggest that higher folate intake is associated with decreased pancreatic cancer risk... - Glycemic index, carbohydrates, glycemic load, and the risk of pancreatic cancer in a prospective cohort studyLi Jiao
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852, USA
Cancer Epidemiol Biomarkers Prev 18:1144-51. 2009..The higher risk associated with high free fructose intake needs further confirmation and elucidation... - Single nucleotide polymorphisms of RecQ1, RAD54L, and ATM genes are associated with reduced survival of pancreatic cancerDonghui Li
Department of Gastrointestinal Medical Oncology Unit 426, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1402, USA
J Clin Oncol 24:1720-8. 2006..Our goal was to determine whether single nucleotide polymorphisms (SNPs) in DNA repair genes influence the clinical outcome of pancreatic cancer... - Polymorphisms of phase II xenobiotic-metabolizing and DNA repair genes and in vitro N-ethyl-N-nitrosourea-induced O6-ethylguanine levels in human lymphocytesLi Jiao
Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Mutat Res 627:146-57. 2007..Results from this exploratory study need to be confirmed in other experimental systems... - Sugars in diet and risk of cancer in the NIH-AARP Diet and Health StudyNatasa Tasevska
Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD 20892 7242, USA
Int J Cancer 130:159-69. 2012..Measurement error in FFQ-reported dietary sugars may have limited our ability to obtain more conclusive findings. Statistically significant associations observed for the rare cancers are of interest and warrant further investigation... - Pathway analysis of genome-wide association study data highlights pancreatic development genes as susceptibility factors for pancreatic cancerDonghui Li
Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
Carcinogenesis 33:1384-90. 2012.... - Dietary fatty acids and pancreatic cancer in the NIH-AARP diet and health studyAnne C M Thiebaut
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
J Natl Cancer Inst 101:1001-11. 2009..Previous research relating dietary fat, a modifiable risk factor, to pancreatic cancer has been inconclusive... 
5,10-Methylenetetrahydrofolate reductase polymorphisms and the risk of pancreatic cancerDonghui Li
Department of Gastrointestinal Medical Oncology, Unit 426, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
Cancer Epidemiol Biomarkers Prev 14:1470-6. 2005..23 (0.88-20.3) for heavy drinkers with the TT genotype compared with nondrinkers with the CC/CT genotypes. These observations support a role for folate metabolism in pancreatic cancer, especially among smokers and heavy drinkers...- Plasma soluble receptor for advanced glycation end-products and risk of colorectal adenomaLi Jiao
Houston VA Health Services Research Center of Excellence, Michael E DeBakey VA Medical Center Houston, TX, USA Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine Houston, TX, USA Dan L Duncan Cancer Center, Baylor College of Medicine Houston, TX, USA
Int J Mol Epidemiol Genet 3:294-304. 2012..This study supported the involvement of RAGE-NF-kB related inflammatory mechanism in the formation of colorectal adenoma... - Molecular epidemiology of pancreatic cancerDonghui Li
Department of Gastrointestinal Medical Oncology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 426, Houston, TX 77030, USA
Int J Gastrointest Cancer 33:3-14. 2003.... - Detectable clonal mosaicism and its relationship to aging and cancerKevin B Jacobs
Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, Rockville, Maryland, USA
Nat Genet 44:651-8. 2012..4; P = 3.8 × 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases...