Genomes and Genes
Affiliation: Baylor College of Medicine
- DNA breakage drives nuclear searchGrzegorz Ira
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Nat Cell Biol 14:448-50. 2012..Break mobility requires resection and recombination enzymes, as well as damage-checkpoint components...
- The Fun30 nucleosome remodeller promotes resection of DNA double-strand break endsXuefeng Chen
Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Nature 489:576-80. 2012..Together these data suggest that Fun30 helps to overcome the inhibitory effect of Rad9 on DNA resection...
- Human nuclease/helicase DNA2 alleviates replication stress by promoting DNA end resectionGuang Peng
Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA
Cancer Res 72:2802-13. 2012..Our findings therefore indicate that enhanced activity of DSB resection likely constitutes one mechanism whereby precancerous and cancerous cells might alleviate replication stress...
- Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylationXuefeng Chen
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
Nat Struct Mol Biol 18:1015-9. 2011..Poorly recruited dna2T4A S17A S237A and dna2ΔN248 mutant proteins promote resection only in the presence of Exo1, suggesting cross-talk between Dna2- and Exo1-dependent resection pathways...