Grzegorz Ira

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. pmc Defective resection at DNA double-strand breaks leads to de novo telomere formation and enhances gene targeting
    Woo Hyun Chung
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS Genet 6:e1000948. 2010
  2. doi request reprint DNA breakage drives nuclear search
    Grzegorz Ira
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Cell Biol 14:448-50. 2012
  3. pmc Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation
    Xuefeng Chen
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    Nat Struct Mol Biol 18:1015-9. 2011
  4. pmc The Fun30 nucleosome remodeller promotes resection of DNA double-strand break ends
    Xuefeng Chen
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nature 489:576-80. 2012
  5. pmc Pif1 helicase and Polδ promote recombination-coupled DNA synthesis via bubble migration
    Marenda A Wilson
    Baylor College of Medicine, Department of Molecular and Human Genetics, One Baylor Plaza, Houston, Texas 77030, USA
    Nature 502:393-6. 2013
  6. pmc A microhomology-mediated break-induced replication model for the origin of human copy number variation
    P J Hastings
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS Genet 5:e1000327. 2009
  7. pmc Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends
    Zhu Zhu
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Cell 134:981-94. 2008
  8. pmc Human nuclease/helicase DNA2 alleviates replication stress by promoting DNA end resection
    Guang Peng
    Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA
    Cancer Res 72:2802-13. 2012
  9. pmc Mechanisms of change in gene copy number
    P J Hastings
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nat Rev Genet 10:551-64. 2009

Collaborators

  • Sang Eun Lee
  • P J Hastings
  • Wei Zhang
  • Susan M Rosenberg
  • Xuewen Pan
  • Xuefeng Chen
  • Woo Hyun Chung
  • Zhu Zhu
  • Alma Papusha
  • Marenda A Wilson
  • Guang Peng
  • Patrick Sung
  • Hengyao Niu
  • Anna Malkova
  • Eun Yong Shim
  • Peter Chi
  • YoungHo Kwon
  • Ryan Mayle
  • Yuanyuan Xu
  • Jiangwu Tang
  • Yun Yong Park
  • Hui Ju Hsieh
  • Chia Dwo Chu
  • Kaifu Chen
  • Mei Ren Pan
  • Xiaotian Zhang
  • Shiaw Yih Lin
  • Ju Seog Lee
  • Isabelle Bedrosian
  • Hui Dai
  • Dandan Cui
  • Robert Yu Lin Tsai

Detail Information

Publications9

  1. pmc Defective resection at DNA double-strand breaks leads to de novo telomere formation and enhances gene targeting
    Woo Hyun Chung
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS Genet 6:e1000948. 2010
    ..Altogether these data establish a new role for processive resection in the fidelity of DSB repair...
  2. doi request reprint DNA breakage drives nuclear search
    Grzegorz Ira
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Cell Biol 14:448-50. 2012
    ..Break mobility requires resection and recombination enzymes, as well as damage-checkpoint components...
  3. pmc Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation
    Xuefeng Chen
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    Nat Struct Mol Biol 18:1015-9. 2011
    ..Poorly recruited dna2T4A S17A S237A and dna2ΔN248 mutant proteins promote resection only in the presence of Exo1, suggesting cross-talk between Dna2- and Exo1-dependent resection pathways...
  4. pmc The Fun30 nucleosome remodeller promotes resection of DNA double-strand break ends
    Xuefeng Chen
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nature 489:576-80. 2012
    ..Together these data suggest that Fun30 helps to overcome the inhibitory effect of Rad9 on DNA resection...
  5. pmc Pif1 helicase and Polδ promote recombination-coupled DNA synthesis via bubble migration
    Marenda A Wilson
    Baylor College of Medicine, Department of Molecular and Human Genetics, One Baylor Plaza, Houston, Texas 77030, USA
    Nature 502:393-6. 2013
    ..Our results uncover a novel function of Pif1 and provide insights into the mechanism of HR. ..
  6. pmc A microhomology-mediated break-induced replication model for the origin of human copy number variation
    P J Hastings
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS Genet 5:e1000327. 2009
    ....
  7. pmc Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends
    Zhu Zhu
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Cell 134:981-94. 2008
    ..These results provide important insights into the early steps of DSB repair in eukaryotes...
  8. pmc Human nuclease/helicase DNA2 alleviates replication stress by promoting DNA end resection
    Guang Peng
    Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA
    Cancer Res 72:2802-13. 2012
    ..Our findings therefore indicate that enhanced activity of DSB resection likely constitutes one mechanism whereby precancerous and cancerous cells might alleviate replication stress...
  9. pmc Mechanisms of change in gene copy number
    P J Hastings
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nat Rev Genet 10:551-64. 2009
    ..For example, cellular stress might induce repair of broken replication forks to switch from high-fidelity homologous recombination to non-homologous repair, thus promoting copy number change...