S M Hyder

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. ncbi Interaction of human estrogen receptors alpha and beta with the same naturally occurring estrogen response elements
    S M Hyder
    Department of Integrative Biology, Pharmacology and Physiology, University of Texas Medical School, Houston 77030, USA
    Biochem Pharmacol 57:597-601. 1999
  2. ncbi Induction of the angiogenic factor VEGF in the uterus by the antiprogestin onapristone
    S M Hyder
    Department of Integrative Biology and Pharmacology, University of Texas Health Sciences Center, 6431 Fannin Street, Houston, TX 77030, USA
    Cancer Lett 156:101-7. 2000
  3. ncbi Selective inhibition of estrogen-regulated gene expression in vivo by the pure antiestrogen ICI 182,780
    S M Hyder
    Department of Integrative Biology, Pharmacology, and Physiology, University of Texas Health Sciences Center, Houston 77225, USA
    Cancer Res 57:2547-9. 1997
  4. ncbi Progestin regulation of vascular endothelial growth factor in human breast cancer cells
    S M Hyder
    Department of Integrative Biology, Pharmacology and Physiology, University of Texas Health Sciences Center Houston, 77225, USA
    Cancer Res 58:392-5. 1998
  5. ncbi Triphenylethylene antiestrogens induce uterine vascular endothelial growth factor expression via their partial estrogen agonist activity
    S M Hyder
    Department of Integrative Biology, Pharmacology and Physiology, University of Texas Health Sciences Center Houston, 77225, USA
    Cancer Lett 120:165-71. 1997
  6. ncbi Pharmacological and endogenous progestins induce vascular endothelial growth factor expression in human breast cancer cells
    S M Hyder
    Department of Integrative Biology and Pharmacology, University of Texas Health Science Center Houston, Houston, TX 77030, USA
    Int J Cancer 92:469-73. 2001
  7. ncbi Regulation of vascular endothelial growth factor expression by estrogens and progestins
    S M Hyder
    Department of Integrative Biology and Pharmacology, University of Texas Houston Medical School, Houston, Texas 77225, USA
    Environ Health Perspect 108:785-90. 2000
  8. ncbi Identification of functional estrogen response elements in the gene coding for the potent angiogenic factor vascular endothelial growth factor
    S M Hyder
    Department of Integrative Biology and Pharmacology, University of Texas Health Sciences Center, Houston 77030, USA
    Cancer Res 60:3183-90. 2000
  9. ncbi In vitro interaction of uterine estrogen receptor with the estrogen response element present in the 3'-flanking region of the murine c-fos protooncogene
    S M Hyder
    Department of Pharmacology, University of Texas Medical School, Houston 77225
    J Steroid Biochem Mol Biol 48:69-79. 1994
  10. ncbi Phorbol ester inhibition of estrogen-induced uterine deoxyribonucleic acid synthesis
    J L Kirkland
    Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    Biol Reprod 58:778-85. 1998

Collaborators

Detail Information

Publications14

  1. ncbi Interaction of human estrogen receptors alpha and beta with the same naturally occurring estrogen response elements
    S M Hyder
    Department of Integrative Biology, Pharmacology and Physiology, University of Texas Medical School, Houston 77030, USA
    Biochem Pharmacol 57:597-601. 1999
    ....
  2. ncbi Induction of the angiogenic factor VEGF in the uterus by the antiprogestin onapristone
    S M Hyder
    Department of Integrative Biology and Pharmacology, University of Texas Health Sciences Center, 6431 Fannin Street, Houston, TX 77030, USA
    Cancer Lett 156:101-7. 2000
    ....
  3. ncbi Selective inhibition of estrogen-regulated gene expression in vivo by the pure antiestrogen ICI 182,780
    S M Hyder
    Department of Integrative Biology, Pharmacology, and Physiology, University of Texas Health Sciences Center, Houston 77225, USA
    Cancer Res 57:2547-9. 1997
    ..This suggests that selective dose-dependent antagonism of estrogen-dependent transcription may be possible in target tissues and tumors...
  4. ncbi Progestin regulation of vascular endothelial growth factor in human breast cancer cells
    S M Hyder
    Department of Integrative Biology, Pharmacology and Physiology, University of Texas Health Sciences Center Houston, 77225, USA
    Cancer Res 58:392-5. 1998
    ....
  5. ncbi Triphenylethylene antiestrogens induce uterine vascular endothelial growth factor expression via their partial estrogen agonist activity
    S M Hyder
    Department of Integrative Biology, Pharmacology and Physiology, University of Texas Health Sciences Center Houston, 77225, USA
    Cancer Lett 120:165-71. 1997
    ..All four compounds increase uterine VEGF and c-fos mRNA levels indicating that the triphenylethylene class of antiestrogens are predominantly agonists for the induction of these genes in the uterus...
  6. ncbi Pharmacological and endogenous progestins induce vascular endothelial growth factor expression in human breast cancer cells
    S M Hyder
    Department of Integrative Biology and Pharmacology, University of Texas Health Science Center Houston, Houston, TX 77030, USA
    Int J Cancer 92:469-73. 2001
    ..This report demonstrates that progestins stimulate VEGF mRNA levels and raises the possibility that anti-progestins may be useful to inhibit proliferation and metastasis in some human breast cancers by blocking VEGF production...
  7. ncbi Regulation of vascular endothelial growth factor expression by estrogens and progestins
    S M Hyder
    Department of Integrative Biology and Pharmacology, University of Texas Houston Medical School, Houston, Texas 77225, USA
    Environ Health Perspect 108:785-90. 2000
    ..These observations suggest that VEGF and other angiogenic factors may represent potential targets for the treatment and prevention of uterine fibroids...
  8. ncbi Identification of functional estrogen response elements in the gene coding for the potent angiogenic factor vascular endothelial growth factor
    S M Hyder
    Department of Integrative Biology and Pharmacology, University of Texas Health Sciences Center, Houston 77030, USA
    Cancer Res 60:3183-90. 2000
    ....
  9. ncbi In vitro interaction of uterine estrogen receptor with the estrogen response element present in the 3'-flanking region of the murine c-fos protooncogene
    S M Hyder
    Department of Pharmacology, University of Texas Medical School, Houston 77225
    J Steroid Biochem Mol Biol 48:69-79. 1994
    ....
  10. ncbi Phorbol ester inhibition of estrogen-induced uterine deoxyribonucleic acid synthesis
    J L Kirkland
    Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    Biol Reprod 58:778-85. 1998
    ..These results suggest that a discrete regulatory event(s) in the pathway of estradiol-induced proliferation is inhibited by PKC activation approximately 6 h after hormonal stimulation...
  11. ncbi Regulation of VEGF in the reproductive tract by sex-steroid hormones
    S M Hyder
    Department of Integrative Biology and Pharmacology, University of Texas Medical School at Houston 77030, USA
    Histol Histopathol 15:325-34. 2000
    ..Such knowledge would allow us to target VEGF for improving human reproductive tract abnormalities, for enhancing implantation and fertility, and for designing drugs for treatment of endocrine dependent cancers...
  12. ncbi The protooncogene c-jun contains an unusual estrogen-inducible enhancer within the coding sequence
    S M Hyder
    Department of Pharmacology, University of Texas Medical School, Houston 77225, USA
    J Biol Chem 270:8506-13. 1995
    ..Coupled with reports of estrogen response elements in c-fos and estrogenic induction of c-fos and c-jun in vivo, these findings also support a role for AP-1 components as early response genes in estrogen-induced proliferation...
  13. ncbi Estradiol rapidly inhibits soluble guanylyl cyclase expression in rat uterus
    J S Krumenacker
    Department of Integrative Biology, Institute of Molecular Medicine, University of Texas Medical School, 6431 Fannin Street, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 98:717-22. 2001
    ..We conclude that sGC plays a vital role in the NO/sGC/cGMP regulatory pathway during conditions of elevated estrogen levels in the rat uterus as a result of the reduction of sGC expression...
  14. ncbi Identification of an estrogen response element in the 3'-flanking region of the murine c-fos protooncogene
    S M Hyder
    Department of Pharmacology, University of Texas Medical School, Houston 77225
    J Biol Chem 267:18047-54. 1992
    ..Based on these studies, we believe the 3'-fos ERE sequence we have identified may be a major cis-acting element involved in the physiological regulation of the gene by estrogens in vivo...