Research Topics
| Richard A HrachovySummaryAffiliation: Baylor College of Medicine Country: USA Publications
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Detail Information
Publications
The EEG in selected generalized seizuresRichard A Hrachovy
Peter Kellaway Section of Neurophysiology, Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
J Clin Neurophysiol 23:312-32. 2006....- Infantile epileptic encephalopathy with hypsarrhythmia (infantile spasms/West syndrome)Richard A Hrachovy
Peter Kellaway Section of Neurophysiology, Department of Neurology and Division of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, U S A
J Clin Neurophysiol 20:408-25. 2003..Finally, the treatment of patients with infantile spasms and their long-term outcome are briefly reviewed... - Automated detection of videotaped neonatal seizures of epileptic originNicolaos B Karayiannis
Department of Electrical and Computer Engineering, University of Houston, and Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas 77204 4005, USA
Epilepsia 47:966-80. 2006.... - Automated detection of videotaped neonatal seizures based on motion tracking methodsNicolaos B Karayiannis
Department of Electrical and Computer Engineering, University of Houston, Houston, Texas, USA
J Clin Neurophysiol 23:521-31. 2006..The performance targets of the second phase of the project may be achieved by combining the quantitative features described in this paper with those obtained by analyzing motion strength signals produced by motion segmentation methods... 
Kv4.2 knockout mice demonstrate increased susceptibility to convulsant stimulationL Forbes S Barnwell
Department of Neurology, Baylor College of Medicine, Houston, Texas, USA
Epilepsia 50:1741-51. 2009..In these studies, we evaluated young adult Kv4.2 knockout mice for spontaneous seizures and the response to convulsant stimulation in the whole animal in vivo and in hippocampal slices in vitro...- High frequency EEG activity associated with ictal events in an animal model of infantile spasmsJames D Frost
Department of Neurology Neuroscience, Baylor College of Medicine, Houston, Texas, USA
Epilepsia 52:53-62. 2011..EEG recordings were digitally sampled at 2,048 Hz. HF EEG activity (20-900 Hz) was quantified using compressed spectral arrays and band-pass filtering... - Automated detection of videotaped neonatal seizures based on motion segmentation methodsNicolaos B Karayiannis
Department of Electrical and Computer Engineering, University of Houston, N308 Engineering Building 1, and Michael E DeBakey Veterans Affairs Medical Center, Houston, TX 77204 4005, USA
Clin Neurophysiol 117:1585-94. 2006..This study was aimed at the development of a seizure detection system by training neural networks using quantitative motion information extracted by motion segmentation methods from short video recordings of infants monitored for seizures... - Electroencephalographic seizures after neonatal cardiac surgery with high-flow cardiopulmonary bypassDean B Andropoulos
MHCM, Texas Children s Hospital and Baylor College of Medicine, 6621 Fannin, WT 17417B, Houston, TX 77030, USA
Anesth Analg 110:1680-5. 2010..We performed video/EEG monitoring before and for 72 hours after neonatal cardiac surgery, using a high-flow CPB protocol and cerebral oxygenation monitoring, to ascertain incidence, severity, and factors associated with EEG seizures... - A new animal model of infantile spasms with unprovoked persistent seizuresChong L Lee
The Cain Foundation Laboratories, and Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
Epilepsia 49:298-307. 2008..Progress toward understanding the pathophysiology of this disorder and the development of effective therapies has been hindered by the lack of a relevant animal model. We report here the creation of such a model... - A triplet repeat expansion genetic mouse model of infantile spasms syndrome, Arx(GCG)10+7, with interneuronopathy, spasms in infancy, persistent seizures, and adult cognitive and behavioral impairmentMaureen G Price
Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
J Neurosci 29:8752-63. 2009..This mouse model narrows the range of critical pathogenic elements within brain inhibitory networks essential to recreate this complex neurodevelopmental syndrome... - Intact vs. impaired ictal sensorium: does it affect outcome of psychogenic nonepileptic events following disclosure of diagnosis?David K Chen
Peter Kellaway Section of Neurophysiology, Department of Neurology, Baylor College of Medicine, Houston, TX, USA
Epilepsy Behav 24:30-5. 2012..41, p=0.017) and ensuing (rho=0.43, p=0.015) follow-ups. Our study presents preliminary evidence underscoring the potential clinical significance of ictal sensorial integrity when evaluating patients with PNEE... - Interictal high frequency oscillations in an animal model of infantile spasmsJames D Frost
Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
Neurobiol Dis 46:377-88. 2012..Multiunit firing coincident with HFOs is fully consistent with a neocortical hyperexcitability hypothesis particularly since they both occur at seizure onset... - Video-EEG monitoring in a geriatric veteran populationMakoto Kawai
Peter Kellaway Section of Neurophysiology, Department of Neurology, Baylor College of Medicine, Houston, TX, USA
J Clin Neurophysiol 24:429-32. 2007..Most of the epileptic events captured were temporal lobe seizures. Video-EEG monitoring in the elderly is useful in the characterization of paroxysmal events... - West's syndrome (infantile spasms). Clinical description and diagnosisRichard A Hrachovy
Baylor College of Medicine, Department of Neurology, Houston, TX 77030, USA
Adv Exp Med Biol 497:33-50. 2002..West's syndrome is a serious epileptic syndrome which usually begins in the first year of life. It involves seizures known as "infantile spasms". Dr. Hrachovy describes the disorder and its symptoms... - Altered phosphorylation and localization of the A-type channel, Kv4.2 in status epilepticusJoaquin N Lugo
The Cain Foundation Laboratories, Department of Pediatrics, Houston, Texas, USA
J Neurochem 106:1929-40. 2008..The finding of decreased Kv4.2 levels in hippocampal synaptosomes and surface membranes suggest additional mechanisms for decreasing the dendritic A-current, which could lead to altered intrinsic membrane excitability during SE... - Identifying depression in epilepsy in a busy clinical setting is enhanced with systematic screeningDavid E Friedman
Peter Kellaway Section of Neurophysiology and Baylor Comprehensive Epilepsy Center, Baylor College of Medicine, Houston, TX 77030, USA
Seizure 18:429-33. 2009..The purpose of this study was to determine the effect of using a validated self-reporting depression scale on the ability to detect depression in people with epilepsy receiving care in a busy clinical setting... - Detection of pseudosinusoidal epileptic seizure segments in the neonatal EEG by cascading a rule-based algorithm with a neural networkNicolaos B Karayiannis
Department of Electrical and Computer Engineering, N308 Engineering Building 1, University of Houston, Houston, TX 77204 4005, USA
IEEE Trans Biomed Eng 53:633-41. 2006..The evaluation of the proposed cascaded scheme for the detection of pseudosinusoidal seizure segments reveals its potential as a building block of the automated seizure detection system under development... 
Induction of psychogenic nonepileptic events: success rate influenced by prior induction exposure, ictal semiology, and psychological profilesDavid K Chen
Peter Kellaway Section of Neurophysiology, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA
Epilepsia 52:1063-70. 2011..To evaluate whether certain preinduction clinical characteristics may influence the success rate of induction...- Pathogenesis of infantile spasms: a model based on developmental desynchronizationJames D Frost
Peter Kellaway Section of Neurophysiology, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA
J Clin Neurophysiol 22:25-36. 2005..Thus, this concept is compatible with the observed diversity of pathologic findings and multiplicity of etiological associations observed in infantile spasms patients... - Time interval from a brain insult to the onset of infantile spasmsMary Anne Guggenheim
Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado, USA
Pediatr Neurol 38:34-7. 2008..The findings refute claims that a close temporal association between an immunization and the onset of infantile spasms establishes causation... - A new lethal case of joint contractures, facial abnormalities, pachygyria plus early-onset encephalopathy with a suppression-burst EEG patternMaria P Guerra
Department of Obstetric and Gynaecology, Section of Neonatology and Intensive Care Unit, University Hospital of Modena, Via del Pozzo 71, 41100 Modena, Italy
Eur J Paediatr Neurol 11:318-21. 2007..We describe a male infant who represents an additional case of the same lethal syndrome first described in 1989. The patient also presented an early-onset epileptic encephalopathy with a suppression-burst EEG pattern...