E C Holland

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. ncbi Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice
    E C Holland
    Department of Neurosurgery, MD Anderson Cancer Center, Houston, Texas, USA
    Nat Genet 25:55-7. 2000
  2. ncbi Modeling mutations in the G1 arrest pathway in human gliomas: overexpression of CDK4 but not loss of INK4a-ARF induces hyperploidy in cultured mouse astrocytes
    E C Holland
    Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20892 USA
    Genes Dev 12:3644-9. 1998
  3. ncbi A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice
    E C Holland
    Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genes Dev 12:3675-85. 1998
  4. ncbi A mouse model for glioma: biology, pathology, and therapeutic opportunities
    E C Holland
    M D Anderson Cancer Center, Department of Neurosurgery, Houston, Texas 77030, USA
    Toxicol Pathol 28:171-7. 2000
  5. ncbi Astrocytes give rise to oligodendrogliomas and astrocytomas after gene transfer of polyoma virus middle T antigen in vivo
    E C Holland
    Department of Neurosurgery, Graduate Program in Genes and Development, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Am J Pathol 157:1031-7. 2000
  6. ncbi PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo
    C Dai
    Department of Neurosurgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
    Genes Dev 15:1913-25. 2001
  7. ncbi Animal models of cell cycle dysregulation and the pathogenesis of gliomas
    E C Holland
    Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Neurooncol 51:265-76. 2001
  8. ncbi Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice
    E C Holland
    Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 95:1218-23. 1998
  9. ncbi Surgical resection of intrinsic insular tumors: complication avoidance
    F F Lang
    Department of Neurosurgery, The University of Texas M D Anderson Cancer Center, Houston, USA
    J Neurosurg 95:638-50. 2001
  10. ncbi In vivo multiple-mouse imaging at 1.5 T
    S Xu
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Magn Reson Med 49:551-7. 2003

Collaborators

  • R Sawaya
  • Y Li
  • Y Okada
  • Xiaotang Hu
  • C Dai
  • L Uhrbom
  • H Momota
  • E Tchougounova
  • S Xu
  • F F Lang
  • A H Shih
  • M A Edgar
  • B Westermark
  • D Bråsäter
  • M Kastemar
  • C Matei
  • S Soghomonian
  • J A Koutcher
  • K Zakian
  • T P F Gade
  • A A Alfieri
  • D Ballon
  • J Tjuvajev
  • D N Louis
  • C Kalhorn
  • Z L Gokaslan
  • J C Celestino
  • F DeMonte
  • G N Fuller
  • N E Olansen
  • D F Halberg
  • J Hildreth
  • J A Loeb
  • R E Wager
  • M S Quesenberry
  • K Drickamer
  • D C Farrell

Detail Information

Publications15

  1. ncbi Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice
    E C Holland
    Department of Neurosurgery, MD Anderson Cancer Center, Houston, Texas, USA
    Nat Genet 25:55-7. 2000
    ..11), and we show here that Akt activity is increased in most of these tumours, implying that combined activation of these two pathways accurately models the biology of this disease...
  2. ncbi Modeling mutations in the G1 arrest pathway in human gliomas: overexpression of CDK4 but not loss of INK4a-ARF induces hyperploidy in cultured mouse astrocytes
    E C Holland
    Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20892 USA
    Genes Dev 12:3644-9. 1998
    ....
  3. ncbi A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice
    E C Holland
    Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genes Dev 12:3675-85. 1998
    ..The gliomagenic combinations of genetic lesions required in mice are similar to those found in human gliomas...
  4. ncbi A mouse model for glioma: biology, pathology, and therapeutic opportunities
    E C Holland
    M D Anderson Cancer Center, Department of Neurosurgery, Houston, Texas 77030, USA
    Toxicol Pathol 28:171-7. 2000
    ..These genetically defined animal models for gliomas will allow for the testing of therapies that are targeted specifically at the gene products involved in the pathogenesis of gliomas...
  5. ncbi Astrocytes give rise to oligodendrogliomas and astrocytomas after gene transfer of polyoma virus middle T antigen in vivo
    E C Holland
    Department of Neurosurgery, Graduate Program in Genes and Development, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Am J Pathol 157:1031-7. 2000
    ..We conclude that GFAP- expressing astrocytes, with appropriate signaling abnormalities, can serve as the cell of origin for oligodendrogliomas, astrocytomas, or mixed gliomas...
  6. ncbi PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo
    C Dai
    Department of Neurosurgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
    Genes Dev 15:1913-25. 2001
    ..Loss of Ink4a-Arf is not required for PDGF-induced glioma formation but promotes tumor progression toward a more malignant phenotype...
  7. ncbi Animal models of cell cycle dysregulation and the pathogenesis of gliomas
    E C Holland
    Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Neurooncol 51:265-76. 2001
    ..The results of these mouse model experiments imply a potentially complex role for cell cycle arrest disruption in human gliomagenesis...
  8. ncbi Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice
    E C Holland
    Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 95:1218-23. 1998
    ..With this system, we have demonstrated that bFGF induces proliferation and migration of glial cells in vivo, without the induction of tumors...
  9. ncbi Surgical resection of intrinsic insular tumors: complication avoidance
    F F Lang
    Department of Neurosurgery, The University of Texas M D Anderson Cancer Center, Houston, USA
    J Neurosurg 95:638-50. 2001
    ....
  10. ncbi In vivo multiple-mouse imaging at 1.5 T
    S Xu
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Magn Reson Med 49:551-7. 2003
    ..The multiple mouse coil is simple in construction and may be implemented without any significant modification to the hardware or software on a clinical scanner...
  11. ncbi Modeling gliomagenesis with somatic cell gene transfer using retroviral vectors
    L Uhrbom
    Department of Cell Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Neurooncol 53:297-305. 2001
    ..The current models provide tumors, which are genetically and histologically similar to their human counterparts, making them attractive to use in drug discovery for treatment of gliomas...
  12. ncbi Glioma models
    C Dai
    Departments of Cell Biology, Neurology, and Neurosurgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
    Biochim Biophys Acta 1551:M19-27. 2001
    ....
  13. ncbi c-Myc and beta-catenin cooperate with loss of p53 to generate multiple members of the primitive neuroectodermal tumor family in mice
    H Momota
    Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Oncogene 27:4392-401. 2008
    ..These data provide insights into the biology and classification of human PNETs and suggest that multiple tumor types or variants can be generated from a fixed set of genetic abnormalities...
  14. ncbi Loss of Arf causes tumor progression of PDGFB-induced oligodendroglioma
    E Tchougounova
    Rudbeck Laboratory, Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden
    Oncogene 26:6289-96. 2007
    ....
  15. ncbi Major and minor forms of the rat liver asialoglycoprotein receptor are independent galactose-binding proteins. Primary structure and glycosylation heterogeneity of minor receptor forms
    D F Halberg
    J Biol Chem 262:9828-38. 1987
    ..The results of these experiments indicate that RHL-1 and RHL-2/3 polypeptides are self-associated into two distinct molecules, each of which has galactose-binding activity...