Jason I Herschkowitz

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. pmc The functional loss of the retinoblastoma tumour suppressor is a common event in basal-like and luminal B breast carcinomas
    Jason I Herschkowitz
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, 27599, USA
    Breast Cancer Res 10:R75. 2008
  2. doi request reprint Mouse models of triple negative [basal-like/claudin low] breast cancer
    Jason I Herschkowitz
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Breast Dis 32:63-71. 2010
  3. doi request reprint MicroRNAs add an additional layer to the complexity of cell signaling
    Jason I Herschkowitz
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Sci Signal 4:jc5. 2011
  4. pmc Predicting drug responsiveness in human cancers using genetically engineered mice
    Jerry Usary
    Lineberger Comprehensive Cancer Center, Department of Genetics, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Clin Cancer Res 19:4889-99. 2013
  5. pmc Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer
    Aleix Prat
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, 27599, USA
    Breast Cancer Res 12:R68. 2010
  6. pmc Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes
    Joseph H Taube
    Department of Molecular Pathology, University of Texas M D Anderson Cancer Center, Houston, TX 77054, USA
    Proc Natl Acad Sci U S A 107:15449-54. 2010
  7. pmc Epigenetic silencing of microRNA-203 is required for EMT and cancer stem cell properties
    Joseph H Taube
    1 Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA 2 Metastasis Research Center, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA 3 Center for Stem Cells and Developmental Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Sci Rep 3:2687. 2013
  8. pmc Fibroblast growth factor receptor signaling dramatically accelerates tumorigenesis and enhances oncoprotein translation in the mouse mammary tumor virus-Wnt-1 mouse model of breast cancer
    Adam C Pond
    Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 70:4868-79. 2010
  9. pmc Comparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cells
    Jason I Herschkowitz
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 109:2778-83. 2012
  10. pmc Small players with big roles: microRNAs as targets to inhibit breast cancer progression
    Stephanie B Greene
    Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Curr Drug Targets 11:1059-73. 2010

Collaborators

Detail Information

Publications15

  1. pmc The functional loss of the retinoblastoma tumour suppressor is a common event in basal-like and luminal B breast carcinomas
    Jason I Herschkowitz
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, 27599, USA
    Breast Cancer Res 10:R75. 2008
    ....
  2. doi request reprint Mouse models of triple negative [basal-like/claudin low] breast cancer
    Jason I Herschkowitz
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Breast Dis 32:63-71. 2010
    ..These mouse models serve as useful tools for the study of disease biology and represent a valuable resource for the evaluation of experimental therapeutics...
  3. doi request reprint MicroRNAs add an additional layer to the complexity of cell signaling
    Jason I Herschkowitz
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Sci Signal 4:jc5. 2011
    ..Their biological properties of redundancy, multiplicity, and rapid responsiveness make these small noncoding RNAs important regulators of cell signaling...
  4. pmc Predicting drug responsiveness in human cancers using genetically engineered mice
    Jerry Usary
    Lineberger Comprehensive Cancer Center, Department of Genetics, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Clin Cancer Res 19:4889-99. 2013
    ..These mouse models offer advantages including precise genetics and an intact microenvironment/immune system...
  5. pmc Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer
    Aleix Prat
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, 27599, USA
    Breast Cancer Res 12:R68. 2010
    ..Here, we comprehensively characterize the recently identified claudin-low tumor subtype...
  6. pmc Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes
    Joseph H Taube
    Department of Molecular Pathology, University of Texas M D Anderson Cancer Center, Houston, TX 77054, USA
    Proc Natl Acad Sci U S A 107:15449-54. 2010
    ..Additionally, the expression level of FOXC1, another EMT inducer, correlates strongly with poor survival of breast cancer patients...
  7. pmc Epigenetic silencing of microRNA-203 is required for EMT and cancer stem cell properties
    Joseph H Taube
    1 Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA 2 Metastasis Research Center, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA 3 Center for Stem Cells and Developmental Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Sci Rep 3:2687. 2013
    ..Our data suggest that restoring miR-203 expression levels may inhibit metastasis and combat deregulated Wnt signaling. ..
  8. pmc Fibroblast growth factor receptor signaling dramatically accelerates tumorigenesis and enhances oncoprotein translation in the mouse mammary tumor virus-Wnt-1 mouse model of breast cancer
    Adam C Pond
    Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 70:4868-79. 2010
    ..Further, they reveal protein translation initiation factors as potential therapeutic targets for human breast cancers with alterations in FGF signaling...
  9. pmc Comparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cells
    Jason I Herschkowitz
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 109:2778-83. 2012
    ....
  10. pmc Small players with big roles: microRNAs as targets to inhibit breast cancer progression
    Stephanie B Greene
    Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Curr Drug Targets 11:1059-73. 2010
    ..Ultimately, miRNAs should provide both important prognostic biomarkers as well as new targetable molecules for the treatment of breast cancer...
  11. pmc FOXC2 expression links epithelial-mesenchymal transition and stem cell properties in breast cancer
    Brett G Hollier
    Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 73:1981-92. 2013
    ..Thus, FOXC2 or its associated gene expression program may provide an effective target for anti-EMT-based therapies for the treatment of claudin-low/basal B breast tumors or other EMT-/CSC-enriched tumors...
  12. pmc The ups and downs of miR-205: identifying the roles of miR-205 in mammary gland development and breast cancer
    Stephanie B Greene
    Program in Developmental Biology, Baylor College of Medicine, Houston, TX, USA
    RNA Biol 7:300-4. 2010
    ..The role that miR-205 plays in directing stem cell fate is still unknown...
  13. pmc Noncoding RNAs involved in mammary gland development and tumorigenesis: there's a long way to go
    Amy N Shore
    Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
    J Mammary Gland Biol Neoplasia 17:43-58. 2012
    ..In addition, we will review the contributions of lncRNAs to the stepwise progression of tumorigenesis, highlighting the role of lncRNAs in breast cancer...
  14. pmc Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features
    Chad J Creighton
    Department of Molecular and Cellular Biology, Division of Biostatistics, Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 106:13820-5. 2009
    ..Targeting proteins involved in EMT may provide a therapeutic strategy for eliminating surviving cells to prevent recurrence and improve long-term survival in breast cancer patients...
  15. pmc The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo
    Kristen L Meerbrey
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 108:3665-70. 2011
    ..This feature allows isolation of cell populations that exhibit a potent, inducible target knockdown in vitro and in vivo that can be used in human xenotransplantation models to examine cancer drug targets...