Jason D Heaney

Summary

Affiliation: Baylor College of Medicine
Country: USA

Publications

  1. pmc Germ cell pluripotency, premature differentiation and susceptibility to testicular teratomas in mice
    Jason D Heaney
    Department of Genetics, Case Western Reserve University, Cleveland, OH 44106, USA
    Development 139:1577-86. 2012
  2. pmc Contrasting effects of Deadend1 (Dnd1) gain and loss of function mutations on allelic inheritance, testicular cancer, and intestinal polyposis
    Jennifer L Zechel
    Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland OH 44106, USA
    BMC Genet 14:54. 2013
  3. pmc Loss of the transmembrane but not the soluble kit ligand isoform increases testicular germ cell tumor susceptibility in mice
    Jason D Heaney
    Department of Genetics and Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Cancer Res 68:5193-7. 2008
  4. pmc Deletion of eIF2beta suppresses testicular cancer incidence and causes recessive lethality in agouti-yellow mice
    Jason D Heaney
    Department of Genetics, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44120, USA
    Hum Mol Genet 18:1395-404. 2009
  5. pmc Transgenerational epigenetic effects of the Apobec1 cytidine deaminase deficiency on testicular germ cell tumor susceptibility and embryonic viability
    Vicki R Nelson
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 109:E2766-73. 2012
  6. doi request reprint Testicular germ cell tumors in mice: new ways to study a genetically complex trait
    Jason D Heaney
    Department of Genetics, Case Western Reserve University, Cleveland, OH, USA
    Methods Mol Biol 450:211-31. 2008
  7. ncbi request reprint Trans-generational epistasis between Dnd1Ter and other modifier genes controls susceptibility to testicular germ cell tumors
    Man Yee J Lam
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Hum Mol Genet 16:2233-40. 2007

Collaborators

Detail Information

Publications7

  1. pmc Germ cell pluripotency, premature differentiation and susceptibility to testicular teratomas in mice
    Jason D Heaney
    Department of Genetics, Case Western Reserve University, Cleveland, OH 44106, USA
    Development 139:1577-86. 2012
    ..These results show that deregulation of the mitotic-meiotic switch in XY germ cells contributes to teratoma initiation...
  2. pmc Contrasting effects of Deadend1 (Dnd1) gain and loss of function mutations on allelic inheritance, testicular cancer, and intestinal polyposis
    Jennifer L Zechel
    Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland OH 44106, USA
    BMC Genet 14:54. 2013
    ..To test the hypothesis that he Dnd1Ter allele is a loss-of-function mutation; we characterized the consequences of a genetically-engineered loss-of-function mutation in mice, and compared these results with those for Dnd1Ter...
  3. pmc Loss of the transmembrane but not the soluble kit ligand isoform increases testicular germ cell tumor susceptibility in mice
    Jason D Heaney
    Department of Genetics and Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Cancer Res 68:5193-7. 2008
    ....
  4. pmc Deletion of eIF2beta suppresses testicular cancer incidence and causes recessive lethality in agouti-yellow mice
    Jason D Heaney
    Department of Genetics, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44120, USA
    Hum Mol Genet 18:1395-404. 2009
    ..These results show that germ cell development and TGCT pathogenesis are sensitive to the availability of the eIF2 translation initiation complex and to changes in the rate of translation...
  5. pmc Transgenerational epigenetic effects of the Apobec1 cytidine deaminase deficiency on testicular germ cell tumor susceptibility and embryonic viability
    Vicki R Nelson
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 109:E2766-73. 2012
    ..These results suggest that Apobec1 plays a central role in controlling TGCT susceptibility in both a conventional and a transgenerational manner...
  6. doi request reprint Testicular germ cell tumors in mice: new ways to study a genetically complex trait
    Jason D Heaney
    Department of Genetics, Case Western Reserve University, Cleveland, OH, USA
    Methods Mol Biol 450:211-31. 2008
    ..We discuss the application of modifier genes in genetic interaction tests and sensitized polygenic trait analyses toward the understanding of the complex genetics and biology of TGCT susceptibility in mice...
  7. ncbi request reprint Trans-generational epistasis between Dnd1Ter and other modifier genes controls susceptibility to testicular germ cell tumors
    Man Yee J Lam
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Hum Mol Genet 16:2233-40. 2007
    ....