Research Topics
Species | Nicola A HananiaSummaryAffiliation: Baylor College of Medicine Country: USA Publications
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Publications
The safety and effects of the beta-blocker, nadolol, in mild asthma: an open-label pilot studyNicola A Hanania
Section of Pulmonary and Critical Care Medicine, Baylor College of Medicine, 1504 Taub Loop, Houston, TX 77030, USA
Pulm Pharmacol Ther 21:134-41. 2008..Our findings warrant further testing in future larger trials...
Update on the pharmacologic therapy for chronic obstructive pulmonary diseaseNicola A Hanania
Asthma Clinical Research Center, Section of Pulmonary and Critical Care Medicine, Baylor College of Medicine, 1504 Taub Loop, Houston, TX 77030, USA
Clin Chest Med 28:589-607, vi-vii. 2007..Combining a long-acting beta-agonist with an inhaled corticosteroid is more effective than either agent alone. Several novel therapies are in different stages of development...- Clinical implications of the intrinsic efficacy of beta-adrenoceptor drugs in asthma: full, partial and inverse agonismNicola A Hanania
Section of Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, TX 77030, USA
Curr Opin Pulm Med 16:1-5. 2010..We review the role of beta2-AR agonist intrinsic efficacy in asthma treatment focusing on recent literature... 
Determinants of depression in the ECLIPSE chronic obstructive pulmonary disease cohortNicola A Hanania
Section of Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, TX 77030, USA
Am J Respir Crit Care Med 183:604-11. 2011..Depression is prevalent in patients with chronic obstructive pulmonary disease (COPD); however, its etiology and relationship to the clinical features of COPD are not well understood...- COPD in the elderly patientNicola A Hanania
Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Baylor College of Medicine, 1504 Taub Loop, Houston, TX 77030, USA
Semin Respir Crit Care Med 31:596-606. 2010..Lastly, adverse effects from medications prescribed for treatment of COPD may be more pervasive in elderly patients... - Pharmacologic interventions in chronic obstructive pulmonary disease: bronchodilatorsNicola A Hanania
Section of Pulmonary and Critical Care Medicine, Baylor College of Medicine, 1504 Taub Loop, Houston, Texas 77030, USA
Proc Am Thorac Soc 4:526-34. 2007..Several novel bronchodilators are now in different stages of development for use alone or in combination with other agents... - The role of intrinsic efficacy in determining response to a beta2-agonist in acute severe asthmaNicola A Hanania
Department of Medicine, Baylor College of Medicine, Houston, TX, USA
Respir Med 101:1007-14. 2007..Current guidelines recommend repeated doses of albuterol for the emergency treatment of acute asthma. However, approximately one-third of patients show little or no initial response to this partial beta(2)-agonist... - Acute bronchodilator responsiveness and health outcomes in COPD patients in the UPLIFT trialNicola A Hanania
Section of Pulmonary, Critical Care and Sleep Medicine, Baylor College of Medicine, Houston, TX, USA
Respir Res 12:6. 2011..Debate continues as to whether acute bronchodilator responsiveness (BDR) predicts long-term outcomes in COPD. Furthermore, there is no consensus on a threshold for BDR... - Efficacy and safety of nebulized formoterol as add-on therapy in COPD patients receiving maintenance tiotropium bromide: Results from a 6-week, randomized, placebo-controlled, clinical trialNicola A Hanania
Baylor College of Medicine, Houston, Texas 77030, USA
Drugs 69:1205-16. 2009..The addition of nebulized formoterol to tiotropium in maintenance treatment of COPD provided clinically meaningful, statistically significant and sustained improvements in pulmonary function without additional adverse effects... - Prevalence of airway obstruction assessed by lung function questionnaireMatthew L Mintz
Department of Medicine, George Washington University School of Medicine, Washington, DC, USA
Mayo Clin Proc 86:375-81. 2011..To estimate the prevalence of unidentified chronic obstructive pulmonary disease (COPD) and determine the screening accuracy of the Lung Function Questionnaire (LFQ)... - The challenge of differentiating asthma from chronic obstructive pulmonary diseaseNicola A Hanania
Baylor College of Medicine, Houston, TX, USA
Manag Care 14:9-15; discussion 24-6. 2005 - Benefits of adding fluticasone propionate/salmeterol to tiotropium in moderate to severe COPDNicola A Hanania
Section of Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, TX, USA
Respir Med 106:91-101. 2012..In this study we evaluated the efficacy and safety of fluticasone/salmeterol (FSC) (250/50 mcg twice daily) when added to tiotropium (18 mcg once daily) (TIO) in subjects with symptomatic moderate to severe COPD... - Optimizing maintenance therapy for chronic obstructive pulmonary disease: strategies for improving patient-centered outcomesNicola A Hanania
Section of Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
Clin Ther 29:2121-33. 2007..Published practice guidelines and treatment algorithms for COPD are designed to increase awareness of the problem and improve patient care; however, <40% of subjects diagnosed with COPD are receiving appropriate maintenance therapy... - The safety and efficacy of arformoterol and formoterol in COPDNicola A Hanania
Baylor College of Medicine, Houston, Texas, USA
COPD 7:17-31. 2010..7 to -6.8). In this 6-month study, arformoterol and formoterol were well-tolerated, and their use was associated with improvement in pulmonary function and health status in subjects with COPD with no apparent development of tolerance... - Glucose and pyruvate metabolism in severe chronic obstructive pulmonary diseaseChristina C Kao
Department of Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine, Baylor College of Medicine, Houston, Texas, USA
J Appl Physiol 112:42-7. 2012..However, no difference in glucose conversion to lactate via pyruvate reduction is observed... - The impact of inhaled corticosteroid and long-acting beta-agonist combination therapy on outcomes in COPDNicola A Hanania
Section of Pulmonary and Critical Care Medicine, Asthma Clinical Research Center, Baylor College of Medicine, 1504 Taub Loop, Houston, TX 77030, USA
Pulm Pharmacol Ther 21:540-50. 2008..Additional relevant references were identified from the reference lists of selected papers. Only studies that compared a combined LABA+ICS therapy with its monotherapy components were selected for inclusion in this manuscript... - Acute asthma in pregnancyNicola A Hanania
Section of Pulmonary and Critical Care Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX, USA
Crit Care Med 33:S319-24. 2005..CONCLUSIONS: Asthma can complicate the course of pregnancy, and pregnancy can worsen asthma control in some women. Optimal management of asthma during pregnancy is key in ensuring the safety of the mother and the fetus... - The efficacy and safety of fluticasone propionate (250 microg)/salmeterol (50 microg) combined in the Diskus inhaler for the treatment of COPDNicola A Hanania
Baylor College of Medicine, Pulmonary Critical Care, Ben Taub General Hospital, 1504 Taub Loop, Houston, TX 77030, USA
Chest 124:834-43. 2003.... - Beta2-adrenoceptor signaling is required for the development of an asthma phenotype in a murine modelLong P Nguyen
Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Science and Research Building 2, Houston, TX 77204, USA
Proc Natl Acad Sci U S A 106:2435-40. 2009.... - beta-Adrenoceptor inverse agonists in asthmaBurton F Dickey
Department of Pulmonary Medicine, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Curr Opin Pharmacol 10:254-9. 2010..Both lung parenchymal and hematopoietic cells appear to be involved in mediating the beneficial effects of beta-AR inverse agonists... - Evaluation of obstructive lung disease with vibration response imagingKalpalatha K Guntupalli
Baylor College of Medicine, Ben Taub General Hospital, 1504 Taub Loop, Houston, Texas 77030, USA
J Asthma 45:923-30. 2008..Lung sound features of synchronization in timing and intensity provide objective data that may further differentiate these two airway disorders... - Anti-inflammatory activities of beta2-agonistsNicola A Hanania
Pulmonary and Critical Care Medicine, Baylor College of Medicine, 1504 Taub Loop Houston 77030, USA
Curr Drug Targets Inflamm Allergy 3:271-7. 2004..However, when given concomitantly with inhaled corticosteroids, beta2-agonists may potentiate the anti-inflammatory effect of corticosteroids, improve asthma control and prevent exacerbations... - Treatments for COPDNicola A Hanania
Pulmonary and Critical Care Medicine, Baylor College of Medicine, 1504 Taub Loop, Houston, TX 77030, USA
Respir Med 99:S28-40. 2005..The challenge will be to develop this base of knowledge in order to shape future research and allow clinicians to deliver tailored COPD management programmes for the growing number of patients afflicted with this disease... - Influenza vaccine in patients with asthmaNicola A Hanania
Division of Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, TX 77030, USA
Expert Rev Vaccines 5:111-8. 2006..In this review, the risk-versus-benefit of influenza vaccination in children and adults with asthma is evaluated, based on the current evidence... - Burden of COPD in a government health care system: a retrospective observational study using data from the US Veterans Affairs populationAmir Sharafkhaneh
Baylor College of Medicine, Houston, TX, USA
Int J Chron Obstruct Pulmon Dis 5:125-32. 2010..Health care utilization and costs among US veterans with chronic obstructive pulmonary disease (COPD) were compared with those in veterans without COPD... - Targeting airway inflammation in asthma: current and future therapiesNicola A Hanania
Pulmonary and Critical Care Medicine, Asthma Clinical Research Center, Baylor College of Medicine, Houston, TX 77030, USA
Chest 133:989-98. 2008..This review provides an overview of the current and future approaches targeting airway inflammation in patients with asthma... - Asthma in the elderly: Current understanding and future research needs--a report of a National Institute on Aging (NIA) workshopNicola A Hanania
Section of Pulmonary and Critical Care Medicine, Asthma Clinical Research Center, Baylor College of Medicine, Houston, Tex, USA
J Allergy Clin Immunol 128:S4-24. 2011.... - Bronchodilator reversibility in COPDNicola A Hanania
Section of Pulmonary and Critical Care Medicine, Asthma Clinical Research Center, Baylor College of Medicine, Houston, TX 77030, USA
Chest 140:1055-63. 2011..This review outlines recent findings about the prevalence and usefulness of bronchodilator reversibility in patients with COPD based on the available literature and proposes areas of future research... - Beta-agonist intrinsic efficacy: measurement and clinical significanceNicola A Hanania
Section of Pulmonary and Critical Care Medicine, Department of Medicine, Baylor College of Medicine and the Houston Veterans Administration Medical Center, Texas 77030, USA
Am J Respir Crit Care Med 165:1353-8. 2002 - Budesonide/formoterol combination in COPD: a US perspectiveAmir Sharafkhaneh
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
Int J Chron Obstruct Pulmon Dis 5:357-66. 2010..In this review, we evaluate available data of the efficacy and safety of this combination in patients with COPD... - Salmeterol stimulation dissociates beta2-adrenergic receptor phosphorylation and internalizationRobert H Moore
Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
Am J Respir Cell Mol Biol 36:254-61. 2007..Defects in these components of salmeterol-induced receptor desensitization may be important determinants of its sustained bronchodilation with chronic use... - The efficacy and safety of the novel long-acting β2 agonist vilanterol in patients with COPD: a randomized placebo-controlled trialNicola A Hanania
Section of Pulmonary and Critical Care, Baylor College of Medicine, Houston, TX 77030, USA
Chest 142:119-27. 2012..This study assessed the dose response, efficacy, and safety of VI at doses of 3 to 50 μg in patients with moderate to severe COPD... - Gender differences of airway dimensions in anatomically matched sites on CT in smokersYu Il Kim
Department of Medicine, National Jewish Health, Denver, CO, USA
COPD 8:285-92. 2011..Multi-detector CT (MDCT) images were analyzed to examine whether gender could explain differences in airway dimensions of anatomically matched airways in smokers... - Omalizumab in severe allergic asthma inadequately controlled with standard therapy: a randomized trialNicola A Hanania
Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Ann Intern Med 154:573-82. 2011..Inhaled corticosteroids (ICS) and long-acting β(2)-agonists (LABAs) are recommended in patients with asthma that is not well-controlled; however, many patients continue to have inadequately controlled asthma despite this therapy... - Safety of chronic obstructive pulmonary disease medications: a primary care perspectiveNicola A Hanania
Pulmonary and Critical Care Medicine, Asthma Clinical Research Center, Baylor College of Medicine, Houston, TX 77030, USA
Postgrad Med 123:72-9. 2011..This article discusses the different medications available for COPD management and the factors affecting their safety based on current evidence... - New bronchodilatorsGarbo Mak
Section of Pulmonary, Critical Care and Sleep Medicine, Baylor College of Medicine, Houston, TX, United States
Curr Opin Pharmacol 12:238-45. 2012..Furthermore, existing and novel bronchodilators have become vital components of multiple combination therapies targeting COPD. This review will discuss emerging bronchodilators highlighting preclinical data and available clinical trials... - Age-related differences in clinical outcomes for acute asthma in the United States, 2006-2008Chu Lin Tsai
Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX 77030, USA
J Allergy Clin Immunol 129:1252-1258.e1. 2012..Little is known about the effect of age on acute asthma outcomes... - Immune response to influenza vaccination in children and adults with asthma: effect of corticosteroid therapyNicola A Hanania
Pulmonary and Critical Care Medicine, Baylor College of Medicine, 1504 Taub Loop, Houston, TX 77030, USA
J Allergy Clin Immunol 113:717-24. 2004..However, the effect of maintenance corticosteroid therapy on the immune response to influenza vaccine has received limited evaluation... - Predicting risk of airflow obstruction in primary care: Validation of the lung function questionnaire (LFQ)Nicola A Hanania
Pulmonary and Critical Care Medicine, Baylor College of Medicine, 1504 Taub Loop, Houston, TX 77030, USA
Respir Med 104:1160-70. 2010..Our results confirm the screening accuracy of the LFQ, a simple and effective tool to facilitate early recognition and diagnosis of COPD... - Acute asthma in pregnancyElizabeth S Guy
Section of Pulmonary and Critical Care Medicine, Department of Medicine, Baylor College of Medicine, Ben Taub General Hospital, 1504 Taub Loop, Houston, TX 77030, USA
Crit Care Clin 20:731-45, x. 2004..Treating physicians must overcome the common belief that pregnant women should not take any medications during pregnancy, and they should keep asthma in pregnant women under control to minimize the risk for maternal and fetal hypoxia... - Revisiting asthma control: how should it best be defined?Nicola A Hanania
Pulmonary and Critical Care Medicine, Asthma Clinical Research Center, Baylor College of Medicine, 1504 Taub Loop, Houston, TX 77030, USA
Pulm Pharmacol Ther 20:483-92. 2007..Alternate assessment measures are therefore often needed to assess asthma control and achieve a successful treatment outcome. This review will provide practical guidance relevant to the clinical assessment of asthma control... - Exploring the effects of omalizumab in allergic asthmaNicola A Hanania
1 Section of Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, Texas
Am J Respir Crit Care Med 187:804-11. 2013..Additional studies are required to explore the value of these biomarkers in clinical practice. Clinical trial registered with www.clinicaltrials.gov (NCT00314574)... - Effect of a primary care continuing education program on clinical practice of chronic obstructive pulmonary disease: translating theory into practiceSandra G Adams
Department of Medicine, University of Texas Health Science Center at San Antonio, USA
Mayo Clin Proc 87:862-70. 2012.... - Targeting IgE in asthmaKristin Kuhl
Section of Pulmonary and Critical Care Medicine, Baylor College of Medicine, 1504 Taub Loop, Houston, TX 77030, USA
Curr Opin Pulm Med 18:1-5. 2012..In this review, we describe the role of IgE in asthma and provide an update on the therapeutic implications of targeting this mediator in patients with severe allergic disease. We also outline future needs of research in this area... - Resting energy expenditure and protein turnover are increased in patients with severe chronic obstructive pulmonary diseaseChristina C Kao
Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
Metabolism 60:1449-55. 2011..Increased rates of protein turnover are associated with increased REE and loss of fat-free mass in COPD... - Pathogenesis of emphysema: from the bench to the bedsideAmir Sharafkhaneh
Division of Pulmonary, Critical Care and Sleep Medicine, Baylor College of Medicine, Houston, TX 77030, USA
Proc Am Thorac Soc 5:475-7. 2008..Identification of cellular and molecular mechanisms of COPD pathogenesis is an area of active, ongoing research that may help to determine therapeutic targets for emphysema... - Effect of nebulized arformoterol on airway function in COPD: results from two randomized trialsJohn P Hanrahan
Sepracor Inc, Marlborough, MA 01752, USA
COPD 5:25-34. 2008..Arformoterol, a single isomer long-acting beta(2)-agonist, was developed as an inhalation solution for the maintenance treatment of bronchoconstriction in COPD... - It's about time--directing our attention toward modifying the course of COPDMario Cazzola
University of Rome Tor Vergata, Department of Internal Medicine, Unit of Respiratory Diseases, Rome, Italy
Respir Med 102:S37-48. 2008..In this review we have considered three approaches toward modifying the course of COPD: smoking cessation, reduction in lung hyperinflation through medical and surgical approaches, and long-term pharmacotherapy... - Nebulized arformoterol in patients with COPD: a 12-week, multicenter, randomized, double-blind, double-dummy, placebo- and active-controlled trialRudolf A Baumgartner
Sepracor Inc, Marlborough, Massachusetts 01752, USA
Clin Ther 29:261-78. 2007.... - Asthma in older adultsSidney S Braman
The Warren Alpert Medical School of Brown University, Division of Pulmonary and Critical Care Medicine, and Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, USA
Clin Chest Med 28:685-702, v. 2007..Adverse effects to commonly used asthma medications are more common in older adults, and careful monitoring of their use and adverse effects is important... - A comparison of levalbuterol with racemic albuterol in the treatment of acute severe asthma exacerbations in adultsRichard Nowak
Department of Emergency Medicine, Henry Ford Hospital, Detroit, MI, USA
Am J Emerg Med 24:259-67. 2006..Lev was well tolerated and compared favorably with Rac in improving airway function, particularly in those who were not on inhaled or oral corticosteroids and in those who had high plasma (S)-albuterol concentrations at presentation... - Comparison of levalbuterol and racemic albuterol in hospitalized patients with acute asthma or COPD: a 2-week, multicenter, randomized, open-label studyJames F Donohue
School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7020, USA
Clin Ther 30:989-1002. 2008..Moreover, it is not clear how the different dosing regimens affect symptom outcomes and health status in hospitalized patients with asthma or COPD... - The role of combination therapy with corticosteroids and long-acting beta2-agonists in the prevention of exacerbations in COPDMario Cazzola
Antonio Cardarelli Hospital, Department of Respiratory Medicine, Unit of Pneumology and Allergology, Naples, Italy
Int J Chron Obstruct Pulmon Dis 1:345-54. 2006..However, when patients with more severe COPD were studied using a combination of budesonide and formoterol, a clear improvement was seen in the overall exacerbation rates compared with the use of a long-acting beta2-agonist alone... - The efficacy and safety of inhaled fluticasone propionate/salmeterol and ipratropium/albuterol for the treatment of chronic obstructive pulmonary disease: an eight-week, multicenter, randomized, double-blind, double-dummy, parallel-group studyBarry Make
National Jewish Medical and Research Center, Denver, Colorado 80206, USA
Clin Ther 27:531-42. 2005..The pathology of chronic obstructive pulmonary disease (COPD) includes both obstructive and inflammatory components... - Selective phosphodiesterase-4 inhibitors in chronic obstructive lung diseaseFrancisco J Soto
Division of Pulmonary and Critical Care Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Curr Opin Pulm Med 11:129-34. 2005..Novel anti-inflammatory therapies such as selective phosphodiesterase 4 (PDE4) inhibitors are in clinical development. Their potential role in the management of COPD is described in this review... - Predicting episodes of poor asthma control in treated patients with asthmaKaren McCoy
Ohio State University, USA
J Allergy Clin Immunol 118:1226-33. 2006..CLINICAL IMPLICATIONS: Simple assessments may be helpful in identifying patients most at risk for future asthma episodes... - One hundred years of chronic obstructive pulmonary disease (COPD)Mario Cazzola
Department of Internal Medicine, Unit of Respiratory Diseases, University of Rome Tor Vergata, Rome, Italy
Respir Med 101:1049-65. 2007..Recent studies have documented the benefits of pulmonary rehabilitation. In addition, non-invasive mechanical ventilation offers new alternatives for patients with acute or chronic failure... - Can we predict depression in COPD?Venkata Rebbapragada
COPD 4:3-4. 2007 - Anxiety and depression in COPD: current understanding, unanswered questions, and research needsJanet Maurer
Chest 134:43S-56S. 2008..CONCLUSION: Future research is needed to address the impact, early detection, and management of anxiety and depression in COPD...