Affiliation: Baylor College of Medicine
Singh S, Jangid R, Crowder A, Groves A. Foxi3 transcription factor activity is mediated by a C-terminal transactivation domain and regulated by the Protein Phosphatase 2A (PP2A) complex. Sci Rep. 2018;8:17249 pubmed publisher
..We also show that the transcriptional activity of Foxi3 is regulated by phosphorylation, and that the activity of Foxi3 can be attenuated by its physical interaction with the protein phosphatase 2A (PP2A) complex. ..
Cai T, Groves A. The Role of Atonal Factors in Mechanosensory Cell Specification and Function. Mol Neurobiol. 2015;52:1315-1329 pubmed publisher
Edlund R, Birol O, Groves A. The role of foxi family transcription factors in the development of the ear and jaw. Curr Top Dev Biol. 2015;111:461-95 pubmed publisher
..Foxi transcription factors are critical for formation of the otic placode, survival of the branchial arch neural crest, and developmental remodeling of the branchial arch ectoderm. ..
Cai T, Jen H, Kang H, Klisch T, Zoghbi H, Groves A. Characterization of the transcriptome of nascent hair cells and identification of direct targets of the Atoh1 transcription factor. J Neurosci. 2015;35:5870-83 pubmed publisher
..The identification of candidate Atoh1 target genes is a first step in identifying gene regulatory networks for hair-cell development and may inform future studies on the potential role of Atoh1 in mammalian hair cell regeneration. ..
Li T, Bellen H, Groves A. Using Drosophila to study mechanisms of hereditary hearing loss. Dis Model Mech. 2018;11: pubmed publisher
Groves A, Fekete D. Shaping sound in space: the regulation of inner ear patterning. Development. 2012;139:245-57 pubmed publisher
Groves A, LaBonne C. Setting appropriate boundaries: fate, patterning and competence at the neural plate border. Dev Biol. 2014;389:2-12 pubmed publisher
Gu R, Brown R, Hsu C, Cai T, Crowder A, Piazza V, et al
. Lineage tracing of Sox2-expressing progenitor cells in the mouse inner ear reveals a broad contribution to non-sensory tissues and insights into the origin of the organ of Corti. Dev Biol. 2016;414:72-84 pubmed publisher
..5. Our fate map reveals the organ of Corti derives from a central domain on the medial side of the otocyst and shows that a significant amount of the organ of Corti derives from a Sox2-negative population in this region. ..
Birol O, Ohyama T, Edlund R, Drakou K, Georgiades P, Groves A. The mouse Foxi3 transcription factor is necessary for the development of posterior placodes. Dev Biol. 2016;409:139-151 pubmed publisher
..Our data suggest that Foxi3 is necessary to prime pre-placodal ectoderm for the correct interpretation of inductive signals for the otic and epibranchial placodes. ..